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Protein

Nucleoside diphosphate-linked moiety X motif 6

Gene

Nudt6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May contribute to the regulation of cell proliferation.By similarity

Miscellaneous

This protein is coded from a FGF2 (BFGF) gene antisense transcript.

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate-linked moiety X motif 6 (EC:3.6.1.-)
Short name:
Nudix motif 6
Alternative name(s):
Antisense basic fibroblast growth factor B
Gene namesi
Name:Nudt6
Synonyms:Asfgf2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2387618 Nudt6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000571081 – 313Nucleoside diphosphate-linked moiety X motif 6Add BLAST313

Proteomic databases

MaxQBiQ8CH40
PaxDbiQ8CH40
PRIDEiQ8CH40

PTM databases

iPTMnetiQ8CH40
PhosphoSitePlusiQ8CH40

Interactioni

Subunit structurei

Monomer and homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096733

Structurei

3D structure databases

ProteinModelPortaliQ8CH40
SMRiQ8CH40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 270Nudix hydrolasePROSITE-ProRule annotationAdd BLAST133

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated

Phylogenomic databases

eggNOGiKOG0648 Eukaryota
ENOG410Z4GH LUCA
HOGENOMiHOG000231274
HOVERGENiHBG052692
InParanoidiQ8CH40
PhylomeDBiQ8CH40

Family and domain databases

InterProiView protein in InterPro
IPR020476 Nudix_hydrolase
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR003293 Nudix_hydrolase6-like
IPR020084 NUDIX_hydrolase_CS
IPR000086 NUDIX_hydrolase_dom
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
PRINTSiPR01356 GFGPROTEIN
PR00502 NUDIXFAMILY
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
PS00893 NUDIX_BOX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q8CH40-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWWVRRTRYW FSTLLYAGGA RLRPGRRTAS GGLETPGSCG AELQGELDRF
60 70 80 90 100
GGVSVHLSRH HTLHGLDAAA FRRLLQAAIQ QWRSDGRIAA WLHIPILQSH
110 120 130 140 150
FIAPAASLGF CFHHAKPHSS TLTLWLGEGP SRLPGYATHQ VGVAGAVFDV
160 170 180 190 200
STRKVLVVQD RNKLKNMWKF PGGLSEPGED IADTAVREVF EETGVKSEFR
210 220 230 240 250
SLLSIRQQHR SPGAFGMSDM YLVCRLQPRS FTINFCQQEC LKCEWIDLEN
260 270 280 290 300
LARTKHTTPI TSRVARLLLY GLREGFDKID LSMEELPAVY TGLFYKLYHR
310
ELPESYKAAT GAD
Length:313
Mass (Da):35,197
Last modified:March 1, 2003 - v1
Checksum:iC6BAC07C54D6B1E7
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3ULU4Q3ULU4_MOUSE
Nucleoside diphosphate-linked moiet...
Nudt6
313Annotation score:
Q8CH41Q8CH41_MOUSE
Anti-sense basic fibroblast growth ...
Nudt6 Asfgf2a
147Annotation score:
A2ACU7A2ACU7_MOUSE
Nucleoside diphosphate-linked moiet...
Nudt6
245Annotation score:
A0A0R4J176A0A0R4J176_MOUSE
Nucleoside diphosphate-linked moiet...
Nudt6
312Annotation score:
A2ACT8A2ACT8_MOUSE
Nucleoside diphosphate-linked moiet...
Nudt6
190Annotation score:
F6WJF1F6WJF1_MOUSE
Nucleoside diphosphate-linked moiet...
Nudt6
126Annotation score:
A0A0G2JE11A0A0G2JE11_MOUSE
Nucleoside diphosphate-linked moiet...
Nudt6
97Annotation score:
A2ACU1A2ACU1_MOUSE
Nucleoside diphosphate-linked moiet...
Nudt6
103Annotation score:
A0A0G2JDN4A0A0G2JDN4_MOUSE
Nucleoside diphosphate-linked moiet...
Nudt6
153Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85D → E in AAH27267 (PubMed:15489334).Curated1
Sequence conflicti182Missing in AAH27267 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453428 mRNA Translation: AAN76848.1
BC027267 mRNA Translation: AAH27267.1
CCDSiCCDS71237.1
RefSeqiNP_705789.1, NM_153561.3
UniGeneiMm.436967
Mm.472818

Genome annotation databases

GeneIDi229228
KEGGimmu:229228

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453428 mRNA Translation: AAN76848.1
BC027267 mRNA Translation: AAH27267.1
CCDSiCCDS71237.1
RefSeqiNP_705789.1, NM_153561.3
UniGeneiMm.436967
Mm.472818

3D structure databases

ProteinModelPortaliQ8CH40
SMRiQ8CH40
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096733

PTM databases

iPTMnetiQ8CH40
PhosphoSitePlusiQ8CH40

Proteomic databases

MaxQBiQ8CH40
PaxDbiQ8CH40
PRIDEiQ8CH40

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi229228
KEGGimmu:229228

Organism-specific databases

CTDi11162
MGIiMGI:2387618 Nudt6

Phylogenomic databases

eggNOGiKOG0648 Eukaryota
ENOG410Z4GH LUCA
HOGENOMiHOG000231274
HOVERGENiHBG052692
InParanoidiQ8CH40
PhylomeDBiQ8CH40

Miscellaneous databases

PROiPR:Q8CH40
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR020476 Nudix_hydrolase
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR003293 Nudix_hydrolase6-like
IPR020084 NUDIX_hydrolase_CS
IPR000086 NUDIX_hydrolase_dom
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
PRINTSiPR01356 GFGPROTEIN
PR00502 NUDIXFAMILY
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
PS00893 NUDIX_BOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUDT6_MOUSE
AccessioniPrimary (citable) accession number: Q8CH40
Secondary accession number(s): Q8R2T3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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