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UniProtKB - Q8CH18 (CCAR1_MOUSE)

Protein

Cell division cycle and apoptosis regulator protein 1

Gene

Ccar1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the retinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (By similarity). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938).By similarity2 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, Repressor
Biological processApoptosis, Cell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle and apoptosis regulator protein 1
Alternative name(s):
Cell cycle and apoptosis regulatory protein 1
Short name:
CARP-1
Gene namesi
Name:Ccar1
Synonyms:Carp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1914750 Ccar1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002331491 – 1146Cell division cycle and apoptosis regulator protein 1Add BLAST1146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei453PhosphoserineBy similarity1
Modified residuei624PhosphothreonineBy similarity1
Cross-linki634Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei664PhosphothreonineBy similarity1
Modified residuei682PhosphoserineBy similarity1
Modified residuei694PhosphoserineBy similarity1
Modified residuei858PhosphothreonineBy similarity1
Cross-linki1008Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki1008Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki1063Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1131Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8CH18
PaxDbiQ8CH18
PeptideAtlasiQ8CH18
PRIDEiQ8CH18

PTM databases

iPTMnetiQ8CH18
PhosphoSitePlusiQ8CH18

Expressioni

Gene expression databases

BgeeiENSMUSG00000020074 Expressed in 263 organ(s), highest expression level in pes
CleanExiMM_CCAR1
ExpressionAtlasiQ8CH18 baseline and differential
GenevisibleiQ8CH18 MM

Interactioni

Subunit structurei

Directly interacts with ESR1, NR3C1 and p53/TP53. Interacts (via N-terminus) with CALCOCO1. Interacts with MED1 and GATA1. Interacts with AR and GATA2 (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi212231, 7 interactors
IntActiQ8CH18, 6 interactors
MINTiQ8CH18
STRINGi10090.ENSMUSP00000020268

Structurei

3D structure databases

ProteinModelPortaliQ8CH18
SMRiQ8CH18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini633 – 667SAPPROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 246Interaction with ARBy similarityAdd BLAST246
Regioni200 – 657Interaction with GATA2By similarityAdd BLAST458
Regioni640 – 1146Interaction with GATA11 PublicationAdd BLAST507

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili591 – 615Sequence analysisAdd BLAST25
Coiled coili1029 – 1110Sequence analysisAdd BLAST82

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 287Gln-richAdd BLAST285
Compositional biasi290 – 358Arg-richAdd BLAST69
Compositional biasi670 – 886Glu-richAdd BLAST217

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4246 Eukaryota
ENOG410Z0UJ LUCA
GeneTreeiENSGT00530000063672
HOVERGENiHBG079908
InParanoidiQ8CH18
OMAiMITVNRD
OrthoDBiEOG091G03QV
PhylomeDBiQ8CH18
TreeFamiTF316387

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR025224 CCAR1/CCAR2
IPR025954 DBC1/CARP1_inactive_NUDIX_dom
IPR011992 EF-hand-dom_pair
IPR025223 S1-like_RNA-bd_dom
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
PANTHERiPTHR14304 PTHR14304, 1 hit
PfamiView protein in Pfam
PF14443 DBC1, 1 hit
PF14444 S1-like, 1 hit
PF02037 SAP, 1 hit
SMARTiView protein in SMART
SM01122 DBC1, 1 hit
SM00513 SAP, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50800 SAP, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CH18-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQFGGQKNP PWATQFTATA VSQPAALGVQ QPSLLGASPT IYTQQTALAA 
        60         70         80         90        100
AGLTTQTPAN YQLTQTAALQ QQAAAVLQQQ YSQPQQALYS VQQQLQQPQQ 
       110        120        130        140        150
TILTQPAVAL PTSLSLSTPQ PAAQITVSYP TPRSSQQQTQ PQKQRVFTGV 
       160        170        180        190        200
VTKLHDTFGF VDEDVFFQLG AVKGKTPQVG DRVLVEATYN PNMPFKWNAQ 
       210        220        230        240        250
RIQTLPNQNQ SQTQPLLKTP TAVIQPIVPQ TTFGVQAQPQ PQSLLQAQIS 
       260        270        280        290        300
AASITPLLQT QPQPLLQQPQ QKAGLLQPPV RIVSQPQPAR RLDPPSRFSG 
       310        320        330        340        350
RNDRGDQVPN RKDDRSRERD RERRRSRERS PQRKRSRERS PRRERERSPR 
       360        370        380        390        400
RVRRVVPRYT VQFSKFSLDC PSCDMMELRR RYQNLYIPSD FFDAQFTWVD 
       410        420        430        440        450
AFPLSRPFQL GNYCNFYVMH REVESLEKNM AVLDPPDADH LYSAKVMLMA 
       460        470        480        490        500
SPSMEDLYHK SCALAEDPQD LRDGFQHPAR LVKFLVGMKG KDEAMAIGGH 
       510        520        530        540        550
WSPSLDGPNP EKDPSVLIKT AIRCCKALTG IDLSVCTQWY RFAEIRYHRP 
       560        570        580        590        600
EETHKGRTVP AHVETVVLFF PDVWHCLPTR SEWETLSRGY KQQLVEKLQG 
       610        620        630        640        650
ERKKADGEQD EEEKDDGEVK EIATPTHWSK LDPKAMKVND LRKELESRAL 
       660        670        680        690        700
SSKGLKSQLI ARLTKQLKIE EQKEEQKELE KSEKEEEDED DKKSEDDKEE 
       710        720        730        740        750
EERKRQEEVE RQRQERRYIL PDEPAIIVHP NWAAKSGKFD CSIMSLSVLL 
       760        770        780        790        800
DYRLEDNKEH SFEVSLFAEL FNEMLQRDFG VRIYKSLLSL PEKEDKKDKE 
       810        820        830        840        850
KKSKKEERKD KKEEREDDID EPKPKRRKSG DDKDKKEDRD ERKKEEKRKD 
       860        870        880        890        900
DSKDDDETEE DNNQDEYDPM EAEEAEDEDD DREEEEVKRD DKRDVSRYCK 
       910        920        930        940        950
DRPAKDKEKE KPQMVTVNRD LLMAFVYFDQ SHCGYLLEKD LEEILYTLGL 
       960        970        980        990       1000
HLSRAQVKKL LNKVVLRESC FYRKLTDTSK DDENHEESEA LQEDMLGNRL 
      1010       1020       1030       1040       1050
LLPTPTIKQE SKDGEENVGL IVYNGAMVDV GSLLQKLEKS EKVRAEVEQK 
      1060       1070       1080       1090       1100
LQLLEEKTDE DGKTILNLEN SNKSLSGELR EVKKDLGQLQ ENLEVSENMN 
      1110       1120       1130       1140 
LQFENQLNKT LRNLSTVMDD IHTVLKKDNV KSEDRDEKSK ENGSGV
Length:1,146
Mass (Da):132,060
Last modified:March 1, 2003 - v1
Checksum:i6005A057B4F0BFF0
GO
Isoform 2 (identifier: Q8CH18-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-327: SRERDRERRRSR → RYVLRQCGGLEK
     328-1146: Missing.

Note: No experimental confirmation available.
Show »
Length:327
Mass (Da):35,718
Checksum:i42FF713BD7603559
GO
Isoform 3 (identifier: Q8CH18-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     638-699: Missing.

Note: No experimental confirmation available.
Show »
Length:1,084
Mass (Da):124,746
Checksum:iAB6C39FC58378B7C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P765A0A1W2P765_MOUSE
Cell division cycle and apoptosis r...
Ccar1
198Annotation score:
A0A1W2P7Q7A0A1W2P7Q7_MOUSE
Cell division cycle and apoptosis r...
Ccar1
161Annotation score:
A0A1W2P6V0A0A1W2P6V0_MOUSE
Cell division cycle and apoptosis r...
Ccar1
92Annotation score:

Sequence cautioni

The sequence AAH10199 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH34174 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH39939 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH51052 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH60130 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH79652 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti279P → L in AAH79652 (PubMed:15489334).Curated1
Sequence conflicti558T → A in AAH39939 (PubMed:15489334).Curated1
Sequence conflicti802K → E in BAC37267 (PubMed:16141072).Curated1
Sequence conflicti821E → G in BAC37267 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018054316 – 327SRERD…RRRSR → RYVLRQCGGLEK in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_018055328 – 1146Missing in isoform 2. 1 PublicationAdd BLAST819
Alternative sequenceiVSP_037737638 – 699Missing in isoform 3. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465615 mRNA Translation: AAO17318.1
AK012111 mRNA Translation: BAB28040.2
AK077151 mRNA Translation: BAC36646.1
AK078424 mRNA Translation: BAC37267.1
BC010199 mRNA Translation: AAH10199.1 Sequence problems.
BC034174 mRNA Translation: AAH34174.1 Sequence problems.
BC039939 mRNA Translation: AAH39939.1 Sequence problems.
BC051052 mRNA Translation: AAH51052.1 Sequence problems.
BC060130 mRNA Translation: AAH60130.1 Sequence problems.
BC079652 mRNA Translation: AAH79652.1 Sequence problems.
CCDSiCCDS35922.1 [Q8CH18-1]
RefSeqiNP_080477.1, NM_026201.3 [Q8CH18-1]
XP_006514057.1, XM_006513994.3 [Q8CH18-1]
XP_006514058.1, XM_006513995.3 [Q8CH18-1]
XP_006514059.1, XM_006513996.3 [Q8CH18-1]
XP_006514060.1, XM_006513997.2 [Q8CH18-3]
XP_011241839.1, XM_011243537.2 [Q8CH18-1]
UniGeneiMm.196371

Genome annotation databases

EnsembliENSMUST00000020268; ENSMUSP00000020268; ENSMUSG00000020074 [Q8CH18-1]
ENSMUST00000219527; ENSMUSP00000151895; ENSMUSG00000020074 [Q8CH18-1]
GeneIDi67500
KEGGimmu:67500
UCSCiuc007fja.2 mouse [Q8CH18-1]
uc007fjc.2 mouse [Q8CH18-2]
uc011xff.1 mouse [Q8CH18-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465615 mRNA Translation: AAO17318.1
AK012111 mRNA Translation: BAB28040.2
AK077151 mRNA Translation: BAC36646.1
AK078424 mRNA Translation: BAC37267.1
BC010199 mRNA Translation: AAH10199.1 Sequence problems.
BC034174 mRNA Translation: AAH34174.1 Sequence problems.
BC039939 mRNA Translation: AAH39939.1 Sequence problems.
BC051052 mRNA Translation: AAH51052.1 Sequence problems.
BC060130 mRNA Translation: AAH60130.1 Sequence problems.
BC079652 mRNA Translation: AAH79652.1 Sequence problems.
CCDSiCCDS35922.1 [Q8CH18-1]
RefSeqiNP_080477.1, NM_026201.3 [Q8CH18-1]
XP_006514057.1, XM_006513994.3 [Q8CH18-1]
XP_006514058.1, XM_006513995.3 [Q8CH18-1]
XP_006514059.1, XM_006513996.3 [Q8CH18-1]
XP_006514060.1, XM_006513997.2 [Q8CH18-3]
XP_011241839.1, XM_011243537.2 [Q8CH18-1]
UniGeneiMm.196371

3D structure databases

ProteinModelPortaliQ8CH18
SMRiQ8CH18
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212231, 7 interactors
IntActiQ8CH18, 6 interactors
MINTiQ8CH18
STRINGi10090.ENSMUSP00000020268

PTM databases

iPTMnetiQ8CH18
PhosphoSitePlusiQ8CH18

Proteomic databases

EPDiQ8CH18
PaxDbiQ8CH18
PeptideAtlasiQ8CH18
PRIDEiQ8CH18

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020268; ENSMUSP00000020268; ENSMUSG00000020074 [Q8CH18-1]
ENSMUST00000219527; ENSMUSP00000151895; ENSMUSG00000020074 [Q8CH18-1]
GeneIDi67500
KEGGimmu:67500
UCSCiuc007fja.2 mouse [Q8CH18-1]
uc007fjc.2 mouse [Q8CH18-2]
uc011xff.1 mouse [Q8CH18-3]

Organism-specific databases

CTDi55749
MGIiMGI:1914750 Ccar1

Phylogenomic databases

eggNOGiKOG4246 Eukaryota
ENOG410Z0UJ LUCA
GeneTreeiENSGT00530000063672
HOVERGENiHBG079908
InParanoidiQ8CH18
OMAiMITVNRD
OrthoDBiEOG091G03QV
PhylomeDBiQ8CH18
TreeFamiTF316387

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSiCcar1 mouse
PROiPR:Q8CH18
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020074 Expressed in 263 organ(s), highest expression level in pes
CleanExiMM_CCAR1
ExpressionAtlasiQ8CH18 baseline and differential
GenevisibleiQ8CH18 MM

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR025224 CCAR1/CCAR2
IPR025954 DBC1/CARP1_inactive_NUDIX_dom
IPR011992 EF-hand-dom_pair
IPR025223 S1-like_RNA-bd_dom
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
PANTHERiPTHR14304 PTHR14304, 1 hit
PfamiView protein in Pfam
PF14443 DBC1, 1 hit
PF14444 S1-like, 1 hit
PF02037 SAP, 1 hit
SMARTiView protein in SMART
SM01122 DBC1, 1 hit
SM00513 SAP, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50800 SAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCAR1_MOUSE
AccessioniPrimary (citable) accession number: Q8CH18
Secondary accession number(s): Q05BR1
, Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q9CSR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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