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UniProtKB - Q8CH18 (CCAR1_MOUSE)

Entry version 136 (02 Dec 2020)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
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Protein

Cell division cycle and apoptosis regulator protein 1

Gene

Ccar1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the retinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (By similarity). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processApoptosis, Cell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-72163, mRNA Splicing - Major Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell division cycle and apoptosis regulator protein 1
Alternative name(s):
Cell cycle and apoptosis regulatory protein 1
Short name:
CARP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ccar1
Synonyms:Carp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1914750, Ccar1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002331491 – 1146Cell division cycle and apoptosis regulator protein 1Add BLAST1146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei453PhosphoserineBy similarity1
Modified residuei624PhosphothreonineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki634Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei664PhosphothreonineBy similarity1
Modified residuei682PhosphoserineBy similarity1
Modified residuei694PhosphoserineBy similarity1
Modified residuei858PhosphothreonineBy similarity1
Cross-linki1008Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki1008Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki1063Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1131Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8CH18

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8CH18

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8CH18

PeptideAtlas

More...PeptideAtlasi		Q8CH18

PRoteomics IDEntifications database

More...PRIDEi		Q8CH18

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8CH18

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8CH18

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000020074, Expressed in pes and 279 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8CH18, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Directly interacts with ESR1, NR3C1 and p53/TP53.

Interacts (via N-terminus) with CALCOCO1.

Interacts with MED1 and GATA1.

Interacts with AR and GATA2 (By similarity).

By similarity2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		212231, 9 interactors

Protein interaction database and analysis system

More...IntActi		Q8CH18, 6 interactors

Molecular INTeraction database

More...MINTi		Q8CH18

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000020268

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8CH18, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8CH18

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini633 – 667SAPPROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 246Interaction with ARBy similarityAdd BLAST246
Regioni200 – 657Interaction with GATA2By similarityAdd BLAST458
Regioni640 – 1146Interaction with GATA11 PublicationAdd BLAST507

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili591 – 615Sequence analysisAdd BLAST25
Coiled coili1029 – 1110Sequence analysisAdd BLAST82

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3 – 287Gln-richAdd BLAST285
Compositional biasi290 – 358Arg-richAdd BLAST69
Compositional biasi670 – 886Glu-richAdd BLAST217

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4246, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063672

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008030_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8CH18

Identification of Orthologs from Complete Genome Data

More...OMAi		LRYSDMH

Database of Orthologous Groups

More...OrthoDBi		614048at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8CH18

TreeFam database of animal gene trees

More...TreeFami		TF316387

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.720.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025224, CCAR1/CCAR2
IPR025954, DBC1/CARP1_inactive_NUDIX_dom
IPR011992, EF-hand-dom_pair
IPR025223, S1-like_RNA-bd_dom
IPR003034, SAP_dom
IPR036361, SAP_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR14304, PTHR14304, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14443, DBC1, 1 hit
PF14444, S1-like, 1 hit
PF02037, SAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01122, DBC1, 1 hit
SM00513, SAP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit
SSF68906, SSF68906, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50800, SAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CH18-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQFGGQKNP PWATQFTATA VSQPAALGVQ QPSLLGASPT IYTQQTALAA 
        60         70         80         90        100
AGLTTQTPAN YQLTQTAALQ QQAAAVLQQQ YSQPQQALYS VQQQLQQPQQ 
       110        120        130        140        150
TILTQPAVAL PTSLSLSTPQ PAAQITVSYP TPRSSQQQTQ PQKQRVFTGV 
       160        170        180        190        200
VTKLHDTFGF VDEDVFFQLG AVKGKTPQVG DRVLVEATYN PNMPFKWNAQ 
       210        220        230        240        250
RIQTLPNQNQ SQTQPLLKTP TAVIQPIVPQ TTFGVQAQPQ PQSLLQAQIS 
       260        270        280        290        300
AASITPLLQT QPQPLLQQPQ QKAGLLQPPV RIVSQPQPAR RLDPPSRFSG 
       310        320        330        340        350
RNDRGDQVPN RKDDRSRERD RERRRSRERS PQRKRSRERS PRRERERSPR 
       360        370        380        390        400
RVRRVVPRYT VQFSKFSLDC PSCDMMELRR RYQNLYIPSD FFDAQFTWVD 
       410        420        430        440        450
AFPLSRPFQL GNYCNFYVMH REVESLEKNM AVLDPPDADH LYSAKVMLMA 
       460        470        480        490        500
SPSMEDLYHK SCALAEDPQD LRDGFQHPAR LVKFLVGMKG KDEAMAIGGH 
       510        520        530        540        550
WSPSLDGPNP EKDPSVLIKT AIRCCKALTG IDLSVCTQWY RFAEIRYHRP 
       560        570        580        590        600
EETHKGRTVP AHVETVVLFF PDVWHCLPTR SEWETLSRGY KQQLVEKLQG 
       610        620        630        640        650
ERKKADGEQD EEEKDDGEVK EIATPTHWSK LDPKAMKVND LRKELESRAL 
       660        670        680        690        700
SSKGLKSQLI ARLTKQLKIE EQKEEQKELE KSEKEEEDED DKKSEDDKEE 
       710        720        730        740        750
EERKRQEEVE RQRQERRYIL PDEPAIIVHP NWAAKSGKFD CSIMSLSVLL 
       760        770        780        790        800
DYRLEDNKEH SFEVSLFAEL FNEMLQRDFG VRIYKSLLSL PEKEDKKDKE 
       810        820        830        840        850
KKSKKEERKD KKEEREDDID EPKPKRRKSG DDKDKKEDRD ERKKEEKRKD 
       860        870        880        890        900
DSKDDDETEE DNNQDEYDPM EAEEAEDEDD DREEEEVKRD DKRDVSRYCK 
       910        920        930        940        950
DRPAKDKEKE KPQMVTVNRD LLMAFVYFDQ SHCGYLLEKD LEEILYTLGL 
       960        970        980        990       1000
HLSRAQVKKL LNKVVLRESC FYRKLTDTSK DDENHEESEA LQEDMLGNRL 
      1010       1020       1030       1040       1050
LLPTPTIKQE SKDGEENVGL IVYNGAMVDV GSLLQKLEKS EKVRAEVEQK 
      1060       1070       1080       1090       1100
LQLLEEKTDE DGKTILNLEN SNKSLSGELR EVKKDLGQLQ ENLEVSENMN 
      1110       1120       1130       1140 
LQFENQLNKT LRNLSTVMDD IHTVLKKDNV KSEDRDEKSK ENGSGV
Length:1,146
Mass (Da):132,060
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6005A057B4F0BFF0
GO
Isoform 2 (identifier: Q8CH18-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-327: SRERDRERRRSR → RYVLRQCGGLEK
     328-1146: Missing.

Show »
Length:327
Mass (Da):35,718
Checksum:i42FF713BD7603559
GO
Isoform 3 (identifier: Q8CH18-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     638-699: Missing.

Show »
Length:1,084
Mass (Da):124,746
Checksum:iAB6C39FC58378B7C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P765A0A1W2P765_MOUSE
Cell division cycle and apoptosis r...
Ccar1
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P7Q7A0A1W2P7Q7_MOUSE
Cell division cycle and apoptosis r...
Ccar1
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P6V0A0A1W2P6V0_MOUSE
Cell division cycle and apoptosis r...
Ccar1
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH10199 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH34174 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH39939 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH51052 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH60130 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH79652 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti279P → L in AAH79652 (PubMed:15489334).Curated1
Sequence conflicti558T → A in AAH39939 (PubMed:15489334).Curated1
Sequence conflicti802K → E in BAC37267 (PubMed:16141072).Curated1
Sequence conflicti821E → G in BAC37267 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_018054316 – 327SRERD…RRRSR → RYVLRQCGGLEK in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_018055328 – 1146Missing in isoform 2. 1 PublicationAdd BLAST819
Alternative sequenceiVSP_037737638 – 699Missing in isoform 3. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF465615 mRNA Translation: AAO17318.1
AK012111 mRNA Translation: BAB28040.2
AK077151 mRNA Translation: BAC36646.1
AK078424 mRNA Translation: BAC37267.1
BC010199 mRNA Translation: AAH10199.1 Sequence problems.
BC034174 mRNA Translation: AAH34174.1 Sequence problems.
BC039939 mRNA Translation: AAH39939.1 Sequence problems.
BC051052 mRNA Translation: AAH51052.1 Sequence problems.
BC060130 mRNA Translation: AAH60130.1 Sequence problems.
BC079652 mRNA Translation: AAH79652.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35922.1 [Q8CH18-1]

NCBI Reference Sequences

More...RefSeqi		NP_080477.1, NM_026201.3 [Q8CH18-1]
XP_006514057.1, XM_006513994.3 [Q8CH18-1]
XP_006514058.1, XM_006513995.3 [Q8CH18-1]
XP_006514059.1, XM_006513996.3 [Q8CH18-1]
XP_006514060.1, XM_006513997.2 [Q8CH18-3]
XP_011241839.1, XM_011243537.2 [Q8CH18-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000020268; ENSMUSP00000020268; ENSMUSG00000020074 [Q8CH18-1]
ENSMUST00000219527; ENSMUSP00000151895; ENSMUSG00000020074 [Q8CH18-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		67500

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:67500

UCSC genome browser

More...UCSCi		uc007fja.2, mouse [Q8CH18-1]
uc007fjc.2, mouse [Q8CH18-2]
uc011xff.1, mouse [Q8CH18-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465615 mRNA Translation: AAO17318.1
AK012111 mRNA Translation: BAB28040.2
AK077151 mRNA Translation: BAC36646.1
AK078424 mRNA Translation: BAC37267.1
BC010199 mRNA Translation: AAH10199.1 Sequence problems.
BC034174 mRNA Translation: AAH34174.1 Sequence problems.
BC039939 mRNA Translation: AAH39939.1 Sequence problems.
BC051052 mRNA Translation: AAH51052.1 Sequence problems.
BC060130 mRNA Translation: AAH60130.1 Sequence problems.
BC079652 mRNA Translation: AAH79652.1 Sequence problems.
CCDSiCCDS35922.1 [Q8CH18-1]
RefSeqiNP_080477.1, NM_026201.3 [Q8CH18-1]
XP_006514057.1, XM_006513994.3 [Q8CH18-1]
XP_006514058.1, XM_006513995.3 [Q8CH18-1]
XP_006514059.1, XM_006513996.3 [Q8CH18-1]
XP_006514060.1, XM_006513997.2 [Q8CH18-3]
XP_011241839.1, XM_011243537.2 [Q8CH18-1]

3D structure databases

SMRiQ8CH18
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi212231, 9 interactors
IntActiQ8CH18, 6 interactors
MINTiQ8CH18
STRINGi10090.ENSMUSP00000020268

PTM databases

iPTMnetiQ8CH18
PhosphoSitePlusiQ8CH18

Proteomic databases

EPDiQ8CH18
jPOSTiQ8CH18
PaxDbiQ8CH18
PeptideAtlasiQ8CH18
PRIDEiQ8CH18

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2118, 192 antibodies

Genome annotation databases

EnsembliENSMUST00000020268; ENSMUSP00000020268; ENSMUSG00000020074 [Q8CH18-1]
ENSMUST00000219527; ENSMUSP00000151895; ENSMUSG00000020074 [Q8CH18-1]
GeneIDi67500
KEGGimmu:67500
UCSCiuc007fja.2, mouse [Q8CH18-1]
uc007fjc.2, mouse [Q8CH18-2]
uc011xff.1, mouse [Q8CH18-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55749
MGIiMGI:1914750, Ccar1

Phylogenomic databases

eggNOGiKOG4246, Eukaryota
GeneTreeiENSGT00530000063672
HOGENOMiCLU_008030_0_0_1
InParanoidiQ8CH18
OMAiLRYSDMH
OrthoDBi614048at2759
PhylomeDBiQ8CH18
TreeFamiTF316387

Enzyme and pathway databases

ReactomeiR-MMU-72163, mRNA Splicing - Major Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		67500, 5 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ccar1, mouse

Protein Ontology

More...PROi		PR:Q8CH18
RNActiQ8CH18, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000020074, Expressed in pes and 279 other tissues
GenevisibleiQ8CH18, MM

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR025224, CCAR1/CCAR2
IPR025954, DBC1/CARP1_inactive_NUDIX_dom
IPR011992, EF-hand-dom_pair
IPR025223, S1-like_RNA-bd_dom
IPR003034, SAP_dom
IPR036361, SAP_dom_sf
PANTHERiPTHR14304, PTHR14304, 1 hit
PfamiView protein in Pfam
PF14443, DBC1, 1 hit
PF14444, S1-like, 1 hit
PF02037, SAP, 1 hit
SMARTiView protein in SMART
SM01122, DBC1, 1 hit
SM00513, SAP, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
SSF68906, SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50800, SAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCAR1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CH18
Secondary accession number(s): Q05BR1
, Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q9CSR5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2003
Last modified: December 2, 2020
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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