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Entry version 120 (02 Dec 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Transcription factor SOX-30

Gene

Sox30

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as both a transcriptional activator and repressor (PubMed:29866902, PubMed:29848638). Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (PubMed:29866902). Binds to its own promoter and activates its own transcription (PubMed:29866902, PubMed:29848638). Required to activate the expression of postmeiotic genes involved in spermiogenesis (PubMed:29866902, PubMed:29848638). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711). Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (By similarity).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi366 – 434HMG boxPROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor SOX-30
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sox30
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1341157, Sox30

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Knockout mice are viable, morphologically normal, but males are sterile (PubMed:29866902, PubMed:29848638). Male mice exhibit small testes and epididymis (PubMed:29848638). Multinuclear syncytia present in the seminiferous tubules, with degenerated multi-chromocenter round spermatids and multinucleated giant cells in the epididymis lumen (PubMed:29848638). Increased numbers of apoptotic cells in the testes and epididymis (PubMed:29848638). Increased expression of CTNNB1, MYC, CCND1, and MMP7 in lung cells (PubMed:29739711). Increase in diplotene spermatocytes in the testes, indicative of defects in the later stages of meiosis (PubMed:29866902). Developmental failure of the large nuclear docking acrosome to develop during the cap phase of spermiogenesis (PubMed:29866902, PubMed:29848638). In addition disruption of proacrosomic vesicle translocation during spermatid differentiation results in the absence of elongating spermatids and therefore viable sperm (PubMed:29866902). No effect on transcription or processing of piRNA precursors (PubMed:29866902).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000487751 – 782Transcription factor SOX-30Add BLAST782

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8CGW4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CGW4

PRoteomics IDEntifications database

More...
PRIDEi
Q8CGW4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CGW4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CGW4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the lung (at protein level) (PubMed:29739711). Expressed in testes (at protein level) (PubMed:10359848, PubMed:29848638). Expressed in preleptotene spermatocytes, round spermatids, and elongated spermatids in the testis (at protein level) (PubMed:29866902). Expressed in pachytene spermatocytes during stages 3 to 8 of spermatogenesis (at protein level) (PubMed:29866902, PubMed:29848638). Increased expression in diplotene spermatocytes at stage 9-11 and in metaphase spermatocytes or secondary spermatocytes at stage 12 (PubMed:29848638). Expressed in ovaries (PubMed:29848638).4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the testes at 13.5 dpc (PubMed:10359848, PubMed:29848638). Also expressed in the mesonephros, metanephros, brain, lung, heart and stomach at 13.5 dpc (PubMed:10359848). Expressed in the testes at 14.5 dpc (PubMed:29848638). Expressed in the ovary at 13.5 and 14.5 dpc (PubMed:29848638). Expressed weakly in the testes at postnatal day 14 (P14), strongly expressed from P21 onwards (PubMed:29866902). Expressed in the nucleus of pachytene spermatocytes in stages 5 to 6 of spermatogenesis (PubMed:29866902). Expressed in round spermatids and increased expression in pachytene spermatocytes in stages 7 to 8 of spermatogenesis (PubMed:29866902). Expressed in the nucleus of diplotene spermatocytes in stages 11 to 12 of spermatogenesis, however expression in the nuclei of spermatids is lost (PubMed:29866902).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced in germline stem cells by retinoic acid.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040489, Expressed in testis and 51 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CGW4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CTNNB1, competitively inhibiting CTNNB1-TCF7L2/TCF4 interaction.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000037519

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8CGW4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CGW4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi6 – 36Pro-richAdd BLAST31
Compositional biasi31 – 126Ala-richAdd BLAST96
Compositional biasi490 – 675Pro-richAdd BLAST186

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0527, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161042

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021249_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CGW4

Identification of Orthologs from Complete Genome Data

More...
OMAi
FIPSPAY

Database of Orthologous Groups

More...
OrthoDBi
369754at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CGW4

TreeFam database of animal gene trees

More...
TreeFami
TF336594

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00505, HMG_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00398, HMG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47095, SSF47095, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50118, HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8CGW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERARPEPPP PPPPPPRQPP RPTPPRPLRP APPAQPVEAA TFRAAAAERS
60 70 80 90 100
QSPSAQATAA MAAVASSCGE AAAAGAQAAG TRRLLQVKPE QVLLLPPGGP
110 120 130 140 150
GVPPAPDEGA AAAAAAAAAA ASSAQARLLQ LRPELLLLPP QSAADGGPCR
160 170 180 190 200
PELHPMQPRT LLVKAEKQEL GAGLDLSVGS RRTTEAGPRA SRAAKLDGTG
210 220 230 240 250
KALDGRRSDE KKAKLEAEEA PRDALKGGEG KSLLAIGEGV IKTEEPDRPR
260 270 280 290 300
DDCRLGTEAT SNGLVHSSKE AILAQPPSAF GPHQQDLRFP LTLHTVPPGA
310 320 330 340 350
RIQFQGPPPS ELIRLSKVPL TPVPIKMQSL LEPSVKIETK DVPLTVLPSD
360 370 380 390 400
AGIPDTPFSK DRNGHVKRPM NAFMVWARIH RPALAKANPA ANNAEISVQL
410 420 430 440 450
GLEWNKLSEE QKKPYYDEAQ KIKEKHREEF PGWVYQPRPG KRKRFPLSVS
460 470 480 490 500
NVFSGTTQNI ISTNPTTIYP YRSPTYSVVI PGLQNTITHP VGEAPPAIQL
510 520 530 540 550
PTPAVQRPSP ITLFQPSVSS TGPVAVPPPS LTPRPSLPPQ RFSGPSQTDI
560 570 580 590 600
HRLPSGSSRS VKRSTPGSLE STTRIPAGAS TAHARFATSP IQPPKEYASV
610 620 630 640 650
STCPRSTPIP PATPIPHSHV YQPPPLGHPA TLFGTPPRFS FHHPYFLPGP
660 670 680 690 700
HYFPSSTCPY SRPPFGYGNF PSSMPECLGY YEDRYQKHEA IFSALNRDYP
710 720 730 740 750
FRDYPDEHTH SEDSRSCESM DGPPYYSSHG HGGEEYLNAM PTLDIGALEN
760 770 780
VFTAPASAPS GVQQVNVTDS DEEEEEKVLR NL
Length:782
Mass (Da):83,938
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D1EEBB17BCB4F41
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY005801 mRNA Translation: AAF99391.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24570.1

NCBI Reference Sequences

More...
RefSeqi
NP_775560.1, NM_173384.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000049038; ENSMUSP00000037519; ENSMUSG00000040489

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
214105

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:214105

UCSC genome browser

More...
UCSCi
uc011xtj.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY005801 mRNA Translation: AAF99391.1
CCDSiCCDS24570.1
RefSeqiNP_775560.1, NM_173384.2

3D structure databases

SMRiQ8CGW4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037519

PTM databases

iPTMnetiQ8CGW4
PhosphoSitePlusiQ8CGW4

Proteomic databases

MaxQBiQ8CGW4
PaxDbiQ8CGW4
PRIDEiQ8CGW4

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1746, 209 antibodies

The DNASU plasmid repository

More...
DNASUi
214105

Genome annotation databases

EnsembliENSMUST00000049038; ENSMUSP00000037519; ENSMUSG00000040489
GeneIDi214105
KEGGimmu:214105
UCSCiuc011xtj.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11063
MGIiMGI:1341157, Sox30

Phylogenomic databases

eggNOGiKOG0527, Eukaryota
GeneTreeiENSGT00940000161042
HOGENOMiCLU_021249_0_0_1
InParanoidiQ8CGW4
OMAiFIPSPAY
OrthoDBi369754at2759
PhylomeDBiQ8CGW4
TreeFamiTF336594

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
214105, 8 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sox30, mouse

Protein Ontology

More...
PROi
PR:Q8CGW4
RNActiQ8CGW4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040489, Expressed in testis and 51 other tissues
GenevisibleiQ8CGW4, MM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
PfamiView protein in Pfam
PF00505, HMG_box, 1 hit
SMARTiView protein in SMART
SM00398, HMG, 1 hit
SUPFAMiSSF47095, SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118, HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSOX30_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CGW4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: December 2, 2020
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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