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Protein

Kallikrein-14

Gene

Klk14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis (By similarity).By similarity

Enzyme regulationi

Inhibited by SERPINA1, SERPINC1, SERPINE1, SERPINF2, aprotinin, soybean, trypsin inhibitor and leupeptin. Inhibited by serine protease inhibitor SPINK5. Has an autoproteolytic activity which may have a regulatory effect. Activated by citrate and inhibited by zinc and to a lower extent by manganese (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66Charge relay systemBy similarity1
Active sitei110Charge relay systemBy similarity1
Active sitei203Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiR-MMU-6809371 Formation of the cornified envelope

Protein family/group databases

MEROPSiS01.029

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-14 (EC:3.4.21.-)
Alternative name(s):
Glandular kallikrein KLK14
Short name:
mGK14
Kallikrein related-peptidase 14
Gene namesi
Name:Klk14
Synonyms:Gk14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2447564 Klk14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
PropeptideiPRO_000037834019 – 23Activation peptideBy similarity5
ChainiPRO_000037834124 – 250Kallikrein-14Add BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 67PROSITE-ProRule annotation
Disulfide bondi142 ↔ 209PROSITE-ProRule annotation
Disulfide bondi174 ↔ 188PROSITE-ProRule annotation
Disulfide bondi199 ↔ 224PROSITE-ProRule annotation

Post-translational modificationi

Proteolytic cleavage of the activation peptide produces the active enzyme.By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

MaxQBiQ8CGR5
PaxDbiQ8CGR5
PRIDEiQ8CGR5

PTM databases

PhosphoSitePlusiQ8CGR5

Expressioni

Gene expression databases

BgeeiENSMUSG00000044737
ExpressionAtlasiQ8CGR5 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056935

Structurei

3D structure databases

ProteinModelPortaliQ8CGR5
SMRiQ8CGR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 248Peptidase S1PROSITE-ProRule annotationAdd BLAST225

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118862
HOGENOMiHOG000251820
InParanoidiQ8CGR5
KOiK09622
OMAiSAPKMFL
OrthoDBiEOG091G0AH5
PhylomeDBiQ8CGR5
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CGR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLLLIILQA LAVAIAQSQG DHKIIGGYRC VRNSQPWQVA LQAGPGHRFL
60 70 80 90 100
CGGVLLSDQW VITAAHCARP ILHVALGKHN IRRWEATQQV VRVARQVPHP
110 120 130 140 150
QYQPQAHDND LMLLKLQKKV RLGRAVKTIS VASSCASPGT PCRVSGWGTI
160 170 180 190 200
ASPIARYPTA LQCVNVNIMS EQACHRAYPG IITSGMVCAG VPEGGKDSCQ
210 220 230 240 250
GDSGGPLVCG GQLQGLVSWG MERCAMPGYP GVYANLCNYH SWIQRTMQSN
Length:250
Mass (Da):27,016
Last modified:March 1, 2003 - v1
Checksum:iF62FEBF2290FEBE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152433 Genomic DNA Translation: AAN78421.1
BC128019 mRNA Translation: AAI28020.1
CCDSiCCDS21180.1
RefSeqiNP_777355.1, NM_174866.3
XP_006541018.1, XM_006540955.3
UniGeneiMm.247377

Genome annotation databases

EnsembliENSMUST00000056329; ENSMUSP00000056935; ENSMUSG00000044737
GeneIDi317653
KEGGimmu:317653
UCSCiuc009gni.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKLK14_MOUSE
AccessioniPrimary (citable) accession number: Q8CGR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: March 1, 2003
Last modified: February 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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