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Protein

Sodium/potassium/calcium exchanger 4

Gene

Slc24a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transports 1 Ca2+ and 1 K+ in exchange for 4 Na+. Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis.2 Publications

Caution

It is uncertain whether Met-1 or Met-18 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

  • amelogenesis Source: UniProtKB
  • calcium ion transmembrane transport Source: GO_Central
  • cellular calcium ion homeostasis Source: GO_Central
  • response to stimulus Source: UniProtKB-KW
  • sensory perception of smell Source: UniProtKB

Keywordsi

Biological processAntiport, Calcium transport, Ion transport, Olfaction, Potassium transport, Sensory transduction, Sodium transport, Symport, Transport
LigandCalcium, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium/calcium exchanger 4
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 4
Solute carrier family 24 member 4
Gene namesi
Name:Slc24a4Imported
Synonyms:Nckx41 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2447362 Slc24a4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini39 – 97ExtracellularCuratedAdd BLAST59
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 142CytoplasmicCuratedAdd BLAST24
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 172ExtracellularCurated9
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 200CytoplasmicCurated7
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 224ExtracellularCurated3
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 457CytoplasmicCuratedAdd BLAST212
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Topological domaini479ExtracellularCurated1
Transmembranei480 – 500HelicalSequence analysisAdd BLAST21
Topological domaini501 – 526CytoplasmicCuratedAdd BLAST26
Transmembranei527 – 547HelicalSequence analysisAdd BLAST21
Topological domaini548 – 557ExtracellularCurated10
Transmembranei558 – 578HelicalSequence analysisAdd BLAST21
Topological domaini579 – 586CytoplasmicCurated8
Transmembranei587 – 607HelicalSequence analysisAdd BLAST21
Topological domaini608 – 622ExtracellularCuratedAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice have a reduced ability to locate an odorous source and lower body weights. The olfactory sensory neurons display defects in response termination and adaptation but have unchanged sensitivity. Mice show severe enamel defects.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000001937439 – 622Sodium/potassium/calcium exchanger 4Add BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8CGQ8
PRIDEiQ8CGQ8

PTM databases

iPTMnetiQ8CGQ8
PhosphoSitePlusiQ8CGQ8

Expressioni

Tissue specificityi

Expressed in late secretory-stage and maturation-stage ameloblasts, with significantly increased expression during the late stages of amelogenesis (at protein level) (PubMed:22677781, PubMed:24621671, PubMed:26247047). Widely expressed in most regions of the brain, including hippocampus, neocortex, thalamus, striatum and olfactory bulb (PubMed:12379639). Expressed in the olfactory sensory neurons (PubMed:22057188).4 Publications

Structurei

3D structure databases

ProteinModelPortaliQ8CGQ8
SMRiQ8CGQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati139 – 179Alpha-1Add BLAST41
Repeati495 – 526Alpha-2Add BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi395 – 404Poly-Pro10

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1307 Eukaryota
ENOG410Y9YY LUCA
HOGENOMiHOG000231933
HOVERGENiHBG054881
InParanoidiQ8CGQ8
KOiK13752
TreeFamiTF318759

Family and domain databases

InterProiView protein in InterPro
IPR004481 K/Na/Ca-exchanger
IPR004837 NaCa_Exmemb
IPR030232 SLC24A4
PANTHERiPTHR10846 PTHR10846, 1 hit
PTHR10846:SF21 PTHR10846:SF21, 1 hit
PfamiView protein in Pfam
PF01699 Na_Ca_ex, 2 hits
TIGRFAMsiTIGR00367 TIGR00367, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CGQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALRGLIRQS KVRRRREMLP QQVGFVCAVL ALVCCASGLF GSLGHKTASA
60 70 80 90 100
GKHVLLDTWR NRKLMAPING TPLAKNCTDP AIHEFPTDLF SNKERQHGAV
110 120 130 140 150
LLHILGALYM FYALAIVCDD FFVPSLEKIC EKLHLSEDVA GATFMAAGSS
160 170 180 190 200
TPELFASVIG VFITHGDVGV GTIVGSAVFN ILCIIGVCGL FAGQVVRLTW
210 220 230 240 250
WAVCRDSVYY TLSVIVLIAF IYDEEIVWWE GLVLIILYVF YILIMKYNMK
260 270 280 290 300
MQTFFTTKQK SIANGNPVSN ELEDGNDLYD GSYDDPSVPL LGQVKEKPPY
310 320 330 340 350
GKTPVVMVDE ILSSSPPKFT FPEAGLRIMI TNKFGPRTRL RMASRIIINE
360 370 380 390 400
RQRLINSANG VNSKPLQNGR HENMENGNVP VENPEDPQQG QEQQPPPQPP
410 420 430 440 450
PPEPESVETV FLSPFSMPEA KGDKAKWVFT WPLIFLLCVT IPNCSKPRWE
460 470 480 490 500
KFFMVTFITA TLWIAVFSYL MVWLVTIIGY TLGIPDVIMG ITFLAAGTSV
510 520 530 540 550
PDCMASLIVA RQGLGDMAVS NTIGSNVFDI LVGLGIPWGL QTMVINYGST
560 570 580 590 600
VKINSRGLVY SVVLLLGSVA LTVLGIHLNK WRLDRKLGIY VLVLYAVFLC
610 620
FSIMIEFNVF TFVNLPMCRE DD
Length:622
Mass (Da):68,974
Last modified:July 27, 2011 - v2
Checksum:i53D25851573F9D27
GO
Isoform 2 (identifier: Q8CGQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-293: Missing.
     574-622: Missing.

Show »
Length:554
Mass (Da):61,118
Checksum:i5DDD9037989FDBBC
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0Z4A0A0R4J0Z4_MOUSE
Sodium/potassium/calcium exchanger ...
Slc24a4
605Annotation score:
F7B0S9F7B0S9_MOUSE
Sodium/potassium/calcium exchanger ...
Slc24a4
603Annotation score:
E9PUL6E9PUL6_MOUSE
Sodium/potassium/calcium exchanger ...
Slc24a4
564Annotation score:

Sequence cautioni

The sequence AAN37415 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC31835 differs from that shown. Probable cloning artifact.Curated
The sequence BAC31835 differs from that shown. Reason: Frameshift at position 31.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti430T → M in BAC31835 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041610275 – 293Missing in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_041611574 – 622Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY156046 mRNA Translation: AAN37415.1 Different initiation.
AK044239 mRNA Translation: BAC31835.1 Sequence problems.
AK044368 mRNA Translation: BAC31887.1
CCDSiCCDS26117.1 [Q8CGQ8-1]
RefSeqiNP_742164.1, NM_172152.2 [Q8CGQ8-1]
UniGeneiMm.312448

Genome annotation databases

GeneIDi238384
KEGGimmu:238384
UCSCiuc007oty.1 mouse [Q8CGQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY156046 mRNA Translation: AAN37415.1 Different initiation.
AK044239 mRNA Translation: BAC31835.1 Sequence problems.
AK044368 mRNA Translation: BAC31887.1
CCDSiCCDS26117.1 [Q8CGQ8-1]
RefSeqiNP_742164.1, NM_172152.2 [Q8CGQ8-1]
UniGeneiMm.312448

3D structure databases

ProteinModelPortaliQ8CGQ8
SMRiQ8CGQ8
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8CGQ8
PhosphoSitePlusiQ8CGQ8

Proteomic databases

PaxDbiQ8CGQ8
PRIDEiQ8CGQ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi238384
KEGGimmu:238384
UCSCiuc007oty.1 mouse [Q8CGQ8-1]

Organism-specific databases

CTDi123041
MGIiMGI:2447362 Slc24a4

Phylogenomic databases

eggNOGiKOG1307 Eukaryota
ENOG410Y9YY LUCA
HOGENOMiHOG000231933
HOVERGENiHBG054881
InParanoidiQ8CGQ8
KOiK13752
TreeFamiTF318759

Miscellaneous databases

PROiPR:Q8CGQ8
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR004481 K/Na/Ca-exchanger
IPR004837 NaCa_Exmemb
IPR030232 SLC24A4
PANTHERiPTHR10846 PTHR10846, 1 hit
PTHR10846:SF21 PTHR10846:SF21, 1 hit
PfamiView protein in Pfam
PF01699 Na_Ca_ex, 2 hits
TIGRFAMsiTIGR00367 TIGR00367, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNCKX4_MOUSE
AccessioniPrimary (citable) accession number: Q8CGQ8
Secondary accession number(s): Q8BLL5, Q8BLL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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