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Entry version 146 (12 Aug 2020)
Sequence version 2 (04 Jan 2005)
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Protein

BCL-6 corepressor

Gene

Bcor

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2) (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BCL-6 corepressor
Short name:
BCoR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Bcor
Synonyms:Kiaa1575
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918708, Bcor

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669791 – 1759BCL-6 corepressorAdd BLAST1759

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei336PhosphoserineBy similarity1
Modified residuei340PhosphoserineBy similarity1
Modified residuei365PhosphoserineBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei392N6-acetyllysineBy similarity1
Modified residuei423PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki787Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki873Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1128PhosphothreonineCombined sources1
Modified residuei1131PhosphoserineCombined sources1
Modified residuei1143PhosphoserineCombined sources1
Cross-linki1259Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1293PhosphoserineBy similarity1
Modified residuei1348PhosphoserineCombined sources1
Modified residuei1413PhosphoserineBy similarity1
Cross-linki1417Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8CGN4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CGN4

PeptideAtlas

More...
PeptideAtlasi
Q8CGN4

PRoteomics IDEntifications database

More...
PRIDEi
Q8CGN4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CGN4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CGN4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, liver, lung, skeletal muscle, spleen and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040363, Expressed in ectoplacental cone and 284 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CGN4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CGN4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Isoform 1 may interact with MLLT3/AF9 (PubMed:12776190).

Interacts with BCL6; the interaction is direct. Forms ternary complexes with BCL6 and SMRT/NCOR2 on selected target genes promoters; potently repress expression. Can interact with HDAC1, HDAC3 and HDAC5.

Interacts with PCGF1; the interaction is direct.

Interacts with KDM2B.

Component of an approximately 800 kDa repressive BCOR complex at least composed of BCOR, RYBP, PCGF1, RING1, RNF2/RING2, KDM2B and SKP1 (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
214722, 10 interactors

Database of interacting proteins

More...
DIPi
DIP-29852N

Protein interaction database and analysis system

More...
IntActi
Q8CGN4, 7 interactors

Molecular INTeraction database

More...
MINTi
Q8CGN4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000111175

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8CGN4, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1466 – 1499ANK 1Add BLAST34
Repeati1500 – 1529ANK 2Add BLAST30
Repeati1533 – 1562ANK 3Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni498 – 514Interaction with BCL6By similarityAdd BLAST17
Regioni1638 – 1752Necessary and sufficient for interaction with PCGF1By similarityAdd BLAST115

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BCOR family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RZ5N, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153737

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003863_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CGN4

KEGG Orthology (KO)

More...
KOi
K23215

Identification of Orthologs from Complete Genome Data

More...
OMAi
VPGHTRK

Database of Orthologous Groups

More...
OrthoDBi
85469at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CGN4

TreeFam database of animal gene trees

More...
TreeFami
TF333317

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
3.10.260.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR031628, BCOR
IPR032365, PUFD
IPR038227, PUFD_som_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF15808, BCOR, 1 hit
PF16553, PUFD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CGN4-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSATPLYGN VHSWMNSERV RMCGTSEDRK IPVNDGDASK ARLELREETP
60 70 80 90 100
LSHSVVDTSG AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SGLCGLGSEK
110 120 130 140 150
GREATPSSLS GLGFSSERNP EMQFKPNTPE TVEASAVSGK PPNGFSAIYK
160 170 180 190 200
TPPGIQKSAV ATAESLGLDR PASDKQSPLN INGASYLRLP WVNPYMEGAT
210 220 230 240 250
PAIYPFLDSP NKYSLNMYKA LLPQQSYGLA QPLYSPVCTS GERFLYLPPP
260 270 280 290 300
HYVNPHIPSS LASPMRLSTP SASAAIPPLV HCSDKSLPWK MGVNPGNPVD
310 320 330 340 350
SHSYPHIQNS KQPRVTSAKA VNSGLPGDTA LLLPPSPRPS ARVHLPTQPA
360 370 380 390 400
AETYSEFHKH YPRISTSPSV TLTKPYMTAN SEFSTSRLSN GKYPKALDGG
410 420 430 440 450
DCAQSMPGHT RKTTVQDRKD GGSPPLLEKQ TVTKDVTDKP LDLSSKVVDA
460 470 480 490 500
DASKGDHMKK MAPTVLVHSR AASGLVLSGS EIPKETLSPP GNGCSIYRSE
510 520 530 540 550
IISTAPSSWV VPGPSPNEEN NGKSLSLKNK ALDWAIPQQR SSSCPRMGGT
560 570 580 590 600
DAVVTNVSGS VSSSGRPASA SPAPNANANA DGTKTSRSSV DTTPSVIQHV
610 620 630 640 650
GQPSSTPAKH GGSTSSKGAK ANPEPSFKAS ENGLPPTSIF LSPNEAFRSP
660 670 680 690 700
AIPYPRSYLP YAAPEGIALS PLSLHGKGPV YPHPVLLPNG SLFPGHLAPK
710 720 730 740 750
PGLPYGLHTS RPEFVTYQDA LGLGMVHPML IPHTPIEITK EEKPERRSRS
760 770 780 790 800
HERARYEDPT LRSRFSEMLE ASSTKLHPEV PTDKNLKPNS SWNQGKTGVK
810 820 830 840 850
SDKLVYVDLL REEADTKTDA GAPKAGLVAE NVGQDTEATK PSADPVIQQR
860 870 880 890 900
REFISLREEL GRITDFHESF TFKQASSQPV FSLGKDSGAA GTNKENLGVQ
910 920 930 940 950
VATPFLETAL GSEGPAVTFG KTQEDPKPFC VGGAPPNMDV TPAYTKEGTD
960 970 980 990 1000
EAESNDGKVL KPKPSKLAKR IANSAGYVGD RFKCVTTELY ADSSQLSREQ
1010 1020 1030 1040 1050
RALQMEGLQE DSILCLPAAY CERAMMRFSE LEMKEREGSH PATKDSEVCK
1060 1070 1080 1090 1100
FSPADWERLK GNQEKKPKSV TLEEAIADQN DSERCEYSTG NKHDLFEAPE
1110 1120 1130 1140 1150
DKDLPVEKYF LERPPVSEPP SDQGVVDTPH SPTLRLDRKR KLSGDSTHTE
1160 1170 1180 1190 1200
TAVEELAEDP LKAKRRRISK DDWPEREMTN SSSNHLEDPH CNELTNLKVC
1210 1220 1230 1240 1250
IELTGLHPKK QRHLLHLRER WEQQVSAAES KPGRQSRKEV AQAVQPEVTS
1260 1270 1280 1290 1300
QGTNITEEKP GRKKAEAKGN RGWSEESLKS CDNEQGLPVL SGSPPMKSLS
1310 1320 1330 1340 1350
STNASGKKQT QPSCTPASRL PAKQQKIKES QKTDVLCTGE DEDCQAASPL
1360 1370 1380 1390 1400
QKYTDNIEKP SGKRLCKTKH LIPQESRRSL QITGDYYVEN TDTKMTVRRF
1410 1420 1430 1440 1450
RKRPEPSSDY DLSPPAKQEP KPFDRLQQLL PATQATQLPR SNSPQETTQS
1460 1470 1480 1490 1500
RPMPPEARRL IVNKNAGETL LQRAARLGYE EVVLYCLENK VCDVNHRDNA
1510 1520 1530 1540 1550
GYCALHEACA RGWLNIVRHL LEYGADVNCS AQDGTRPLHD AVENDHLEIV
1560 1570 1580 1590 1600
RLLLSYGADP TLATYSGRTI MKMTHSELME KFLTDYLNDL QGRSEDDTSG
1610 1620 1630 1640 1650
AWEFYGSSVC EPDDESGYDV LANPPGPEDP DEEEDTYSDL FEFEFAESSL
1660 1670 1680 1690 1700
LPCYNIQVSV AQGPRNWLLL SDVLKKLKMS SRIFRSNFPN LEIVTIAEAE
1710 1720 1730 1740 1750
FYRQVSTSLL FSCPKDLEAF NPESKELLDL VEFTNELQTL LGSSVEWLHP

SDTGHENYW
Length:1,759
Mass (Da):192,631
Last modified:January 4, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7FF21CFB3C60D49
GO
Isoform 2 (identifier: Q8CGN4-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1005-1022: Missing.

Show »
Length:1,741
Mass (Da):190,664
Checksum:i6356F262D31FEB72
GO
Isoform 3 (identifier: Q8CGN4-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1171-1204: Missing.

Show »
Length:1,725
Mass (Da):188,678
Checksum:iBC1E474B524049F6
GO
Isoform 4 (identifier: Q8CGN4-4) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1005-1022: Missing.
     1171-1204: Missing.

Show »
Length:1,707
Mass (Da):186,710
Checksum:iEEDAB60D370F5520
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7BEN2F7BEN2_MOUSE
BCL-6 corepressor
Bcor
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XPR4F6XPR4_MOUSE
BCL-6 corepressor
Bcor
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC98208 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti161A → V in AAN85318 (PubMed:12776190).Curated1
Sequence conflicti161A → V in AAN85319 (PubMed:12776190).Curated1
Sequence conflicti161A → V in AAN85320 (PubMed:12776190).Curated1
Sequence conflicti161A → V in AAN85321 (PubMed:12776190).Curated1
Sequence conflicti167G → S in AAN85318 (PubMed:12776190).Curated1
Sequence conflicti167G → S in AAN85319 (PubMed:12776190).Curated1
Sequence conflicti167G → S in AAN85320 (PubMed:12776190).Curated1
Sequence conflicti167G → S in AAN85321 (PubMed:12776190).Curated1
Sequence conflicti731I → V in AAN85318 (PubMed:12776190).Curated1
Sequence conflicti731I → V in AAN85319 (PubMed:12776190).Curated1
Sequence conflicti731I → V in AAN85320 (PubMed:12776190).Curated1
Sequence conflicti731I → V in AAN85321 (PubMed:12776190).Curated1
Sequence conflicti852E → D in BAC35338 (PubMed:16141072).Curated1
Sequence conflicti1424D → G in AAN85318 (PubMed:12776190).Curated1
Sequence conflicti1424D → G in AAN85319 (PubMed:12776190).Curated1
Sequence conflicti1424D → G in AAN85320 (PubMed:12776190).Curated1
Sequence conflicti1424D → G in AAN85321 (PubMed:12776190).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0125581005 – 1022Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_0125591171 – 1204Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY161170 mRNA Translation: AAN85318.1
AY161171 mRNA Translation: AAN85319.1
AY161172 mRNA Translation: AAN85320.1
AY161173 mRNA Translation: AAN85321.1
AK129398 mRNA Translation: BAC98208.1 Different initiation.
AL808012 Genomic DNA No translation available.
BC058656 mRNA Translation: AAH58656.1
AK053309 mRNA Translation: BAC35338.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30021.1 [Q8CGN4-3]
CCDS30022.1 [Q8CGN4-4]
CCDS40872.1 [Q8CGN4-2]
CCDS40873.1 [Q8CGN4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001161793.1, NM_001168321.1 [Q8CGN4-4]
NP_083786.2, NM_029510.3 [Q8CGN4-1]
NP_778209.2, NM_175044.3 [Q8CGN4-2]
NP_778210.2, NM_175045.3 [Q8CGN4-3]
NP_778211.2, NM_175046.3 [Q8CGN4-4]
XP_017174110.1, XM_017318621.1 [Q8CGN4-1]
XP_017174111.1, XM_017318622.1 [Q8CGN4-1]
XP_017174112.1, XM_017318623.1 [Q8CGN4-1]
XP_017174113.1, XM_017318624.1 [Q8CGN4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000043441; ENSMUSP00000048024; ENSMUSG00000040363 [Q8CGN4-4]
ENSMUST00000065143; ENSMUSP00000068618; ENSMUSG00000040363 [Q8CGN4-3]
ENSMUST00000115512; ENSMUSP00000111174; ENSMUSG00000040363 [Q8CGN4-2]
ENSMUST00000115513; ENSMUSP00000111175; ENSMUSG00000040363 [Q8CGN4-1]
ENSMUST00000124033; ENSMUSP00000116258; ENSMUSG00000040363 [Q8CGN4-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
71458

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:71458

UCSC genome browser

More...
UCSCi
uc009sqq.2, mouse [Q8CGN4-1]
uc009sqr.2, mouse [Q8CGN4-3]
uc009sqs.2, mouse [Q8CGN4-2]
uc009sqt.2, mouse [Q8CGN4-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161170 mRNA Translation: AAN85318.1
AY161171 mRNA Translation: AAN85319.1
AY161172 mRNA Translation: AAN85320.1
AY161173 mRNA Translation: AAN85321.1
AK129398 mRNA Translation: BAC98208.1 Different initiation.
AL808012 Genomic DNA No translation available.
BC058656 mRNA Translation: AAH58656.1
AK053309 mRNA Translation: BAC35338.1
CCDSiCCDS30021.1 [Q8CGN4-3]
CCDS30022.1 [Q8CGN4-4]
CCDS40872.1 [Q8CGN4-2]
CCDS40873.1 [Q8CGN4-1]
RefSeqiNP_001161793.1, NM_001168321.1 [Q8CGN4-4]
NP_083786.2, NM_029510.3 [Q8CGN4-1]
NP_778209.2, NM_175044.3 [Q8CGN4-2]
NP_778210.2, NM_175045.3 [Q8CGN4-3]
NP_778211.2, NM_175046.3 [Q8CGN4-4]
XP_017174110.1, XM_017318621.1 [Q8CGN4-1]
XP_017174111.1, XM_017318622.1 [Q8CGN4-1]
XP_017174112.1, XM_017318623.1 [Q8CGN4-1]
XP_017174113.1, XM_017318624.1 [Q8CGN4-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi214722, 10 interactors
DIPiDIP-29852N
IntActiQ8CGN4, 7 interactors
MINTiQ8CGN4
STRINGi10090.ENSMUSP00000111175

PTM databases

iPTMnetiQ8CGN4
PhosphoSitePlusiQ8CGN4

Proteomic databases

jPOSTiQ8CGN4
PaxDbiQ8CGN4
PeptideAtlasiQ8CGN4
PRIDEiQ8CGN4

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24949, 253 antibodies

Genome annotation databases

EnsembliENSMUST00000043441; ENSMUSP00000048024; ENSMUSG00000040363 [Q8CGN4-4]
ENSMUST00000065143; ENSMUSP00000068618; ENSMUSG00000040363 [Q8CGN4-3]
ENSMUST00000115512; ENSMUSP00000111174; ENSMUSG00000040363 [Q8CGN4-2]
ENSMUST00000115513; ENSMUSP00000111175; ENSMUSG00000040363 [Q8CGN4-1]
ENSMUST00000124033; ENSMUSP00000116258; ENSMUSG00000040363 [Q8CGN4-4]
GeneIDi71458
KEGGimmu:71458
UCSCiuc009sqq.2, mouse [Q8CGN4-1]
uc009sqr.2, mouse [Q8CGN4-3]
uc009sqs.2, mouse [Q8CGN4-2]
uc009sqt.2, mouse [Q8CGN4-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54880
MGIiMGI:1918708, Bcor

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG502RZ5N, Eukaryota
GeneTreeiENSGT00940000153737
HOGENOMiCLU_003863_0_0_1
InParanoidiQ8CGN4
KOiK23215
OMAiVPGHTRK
OrthoDBi85469at2759
PhylomeDBiQ8CGN4
TreeFamiTF333317

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
71458, 3 hits in 22 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Bcor, mouse

Protein Ontology

More...
PROi
PR:Q8CGN4
RNActiQ8CGN4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040363, Expressed in ectoplacental cone and 284 other tissues
ExpressionAtlasiQ8CGN4, baseline and differential
GenevisibleiQ8CGN4, MM

Family and domain databases

Gene3Di1.25.40.20, 1 hit
3.10.260.40, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR031628, BCOR
IPR032365, PUFD
IPR038227, PUFD_som_sf
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF15808, BCOR, 1 hit
PF16553, PUFD, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 3 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCOR_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CGN4
Secondary accession number(s): B1AXK3
, B1AXK4, B1AXK5, B1AXK6, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: August 12, 2020
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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