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UniProtKB - Q8CGN4 (BCOR_MOUSE)

>sp|Q8CGN4|BCOR_MOUSE BCL-6 corepressor OS=Mus musculus OX=10090 GN=Bcor PE=1 SV=2
MLSATPLYGNVHSWMNSERVRMCGTSEDRKIPVNDGDASKARLELREETPLSHSVVDTSG
AHRIDGLAALSMDRTGLIREGLRVPGNIVYSGLCGLGSEKGREATPSSLSGLGFSSERNP
EMQFKPNTPETVEASAVSGKPPNGFSAIYKTPPGIQKSAVATAESLGLDRPASDKQSPLN
INGASYLRLPWVNPYMEGATPAIYPFLDSPNKYSLNMYKALLPQQSYGLAQPLYSPVCTS
GERFLYLPPPHYVNPHIPSSLASPMRLSTPSASAAIPPLVHCSDKSLPWKMGVNPGNPVD
SHSYPHIQNSKQPRVTSAKAVNSGLPGDTALLLPPSPRPSARVHLPTQPAAETYSEFHKH
YPRISTSPSVTLTKPYMTANSEFSTSRLSNGKYPKALDGGDCAQSMPGHTRKTTVQDRKD
GGSPPLLEKQTVTKDVTDKPLDLSSKVVDADASKGDHMKKMAPTVLVHSRAASGLVLSGS
EIPKETLSPPGNGCSIYRSEIISTAPSSWVVPGPSPNEENNGKSLSLKNKALDWAIPQQR
SSSCPRMGGTDAVVTNVSGSVSSSGRPASASPAPNANANADGTKTSRSSVDTTPSVIQHV
GQPSSTPAKHGGSTSSKGAKANPEPSFKASENGLPPTSIFLSPNEAFRSPAIPYPRSYLP
YAAPEGIALSPLSLHGKGPVYPHPVLLPNGSLFPGHLAPKPGLPYGLHTSRPEFVTYQDA
LGLGMVHPMLIPHTPIEITKEEKPERRSRSHERARYEDPTLRSRFSEMLEASSTKLHPEV
PTDKNLKPNSSWNQGKTGVKSDKLVYVDLLREEADTKTDAGAPKAGLVAENVGQDTEATK
PSADPVIQQRREFISLREELGRITDFHESFTFKQASSQPVFSLGKDSGAAGTNKENLGVQ
VATPFLETALGSEGPAVTFGKTQEDPKPFCVGGAPPNMDVTPAYTKEGTDEAESNDGKVL
KPKPSKLAKRIANSAGYVGDRFKCVTTELYADSSQLSREQRALQMEGLQEDSILCLPAAY
CERAMMRFSELEMKEREGSHPATKDSEVCKFSPADWERLKGNQEKKPKSVTLEEAIADQN
DSERCEYSTGNKHDLFEAPEDKDLPVEKYFLERPPVSEPPSDQGVVDTPHSPTLRLDRKR
KLSGDSTHTETAVEELAEDPLKAKRRRISKDDWPEREMTNSSSNHLEDPHCNELTNLKVC
IELTGLHPKKQRHLLHLRERWEQQVSAAESKPGRQSRKEVAQAVQPEVTSQGTNITEEKP
GRKKAEAKGNRGWSEESLKSCDNEQGLPVLSGSPPMKSLSSTNASGKKQTQPSCTPASRL
PAKQQKIKESQKTDVLCTGEDEDCQAASPLQKYTDNIEKPSGKRLCKTKHLIPQESRRSL
QITGDYYVENTDTKMTVRRFRKRPEPSSDYDLSPPAKQEPKPFDRLQQLLPATQATQLPR
SNSPQETTQSRPMPPEARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKVCDVNHRDNA
GYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADP
TLATYSGRTIMKMTHSELMEKFLTDYLNDLQGRSEDDTSGAWEFYGSSVCEPDDESGYDV
LANPPGPEDPDEEEDTYSDLFEFEFAESSLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMS
SRIFRSNFPNLEIVTIAEAEFYRQVSTSLLFSCPKDLEAFNPESKELLDLVEFTNELQTL
LGSSVEWLHPSDTGHENYW

Entry version 153 (25 May 2022)
Sequence version 2 (04 Jan 2005)
Previous versions | rss

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Protein

BCL-6 corepressor

Gene

Bcor

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2) (By similarity).

By similarity1 Publication

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator, Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: BCL-6 corepressor Short name: BCoR
Gene namesⁱ	Name:Bcor Synonyms:Kiaa1575
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome X

Organism-specific databases

MGIⁱ	MGI:1918708, Bcor
VEuPathDBⁱ	HostDB:ENSMUSG00000040363

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000066979	1 – 1759	BCL-6 corepressorAdd BLAST		1759

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	336	PhosphoserineBy similarity	1
Modified residueⁱ	340	PhosphoserineBy similarity	1
Modified residueⁱ	365	PhosphoserineBy similarity	1
Modified residueⁱ	367	PhosphoserineBy similarity	1
Modified residueⁱ	392	N6-acetyllysineBy similarity	1
Modified residueⁱ	423	PhosphoserineBy similarity	1
Cross-linkⁱ	787	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	873	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	1128	PhosphothreonineCombined sources	1
Modified residueⁱ	1131	PhosphoserineCombined sources	1
Modified residueⁱ	1143	PhosphoserineCombined sources	1
Cross-linkⁱ	1259	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	1293	PhosphoserineBy similarity	1
Modified residueⁱ	1348	PhosphoserineCombined sources	1
Modified residueⁱ	1413	PhosphoserineBy similarity	1
Cross-linkⁱ	1417	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8CGN4
jPOSTⁱ	Q8CGN4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8CGN4
PaxDbⁱ	Q8CGN4
PeptideAtlas More...PeptideAtlasⁱ	Q8CGN4
PRIDEⁱ	Q8CGN4
ProteomicsDBⁱ	273445 [Q8CGN4-1] 273446 [Q8CGN4-2] 273447 [Q8CGN4-3] 273448 [Q8CGN4-4]

PTM databases

iPTMnetⁱ	Q8CGN4
PhosphoSitePlusⁱ	Q8CGN4

Expressionⁱ

Tissue specificityⁱ

Expressed in heart, liver, lung, skeletal muscle, spleen and testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000040363, Expressed in ectoplacental cone and 289 other tissues
ExpressionAtlasⁱ	Q8CGN4, baseline and differential
Genevisibleⁱ	Q8CGN4, MM

Interactionⁱ

Subunit structureⁱ

Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Isoform 1 may interact with MLLT3/AF9 (PubMed:12776190).

Interacts with BCL6; the interaction is direct. Forms ternary complexes with BCL6 and SMRT/NCOR2 on selected target genes promoters; potently repress expression. Can interact with HDAC1, HDAC3 and HDAC5.

Interacts with PCGF1; the interaction is direct.

Interacts with KDM2B.

Component of an approximately 800 kDa repressive BCOR complex at least composed of BCOR, RYBP, PCGF1, RING1, RNF2/RING2, KDM2B and SKP1 (By similarity).

By similarity2 Publications

Binary interactionsⁱ

Q8CGN4

With	#Exp.	IntAct
Bcl6 [P41183]	2	EBI-1216174,EBI-6253762

GO - Molecular functionⁱ

DNA-binding transcription factor binding Source: MGI
heat shock protein binding Source: MGI
histone deacetylase binding Source: MGI

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	214722, 10 interactors
Database of interacting proteins More...DIPⁱ	DIP-29852N
IntActⁱ	Q8CGN4, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q8CGN4
STRINGⁱ	10090.ENSMUSP00000111175

Miscellaneous databases

RNActⁱ	Q8CGN4, protein

RNActⁱ

Q8CGN4, protein

Structureⁱ

3D structure databases

AlphaFoldDBⁱ	Q8CGN4
SMRⁱ	Q8CGN4
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	1466 – 1499	ANK 1Add BLAST	34
Repeatⁱ	1500 – 1529	ANK 2Add BLAST	30
Repeatⁱ	1533 – 1562	ANK 3Add BLAST	30

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	100 – 120	DisorderedSequence analysisAdd BLAST	21
Regionⁱ	399 – 432	DisorderedSequence analysisAdd BLAST	34
Regionⁱ	498 – 514	Interaction with BCL6By similarityAdd BLAST	17
Regionⁱ	540 – 635	DisorderedSequence analysisAdd BLAST	96
Regionⁱ	739 – 795	DisorderedSequence analysisAdd BLAST	57
Regionⁱ	1079 – 1190	DisorderedSequence analysisAdd BLAST	112
Regionⁱ	1222 – 1334	DisorderedSequence analysisAdd BLAST	113
Regionⁱ	1397 – 1456	DisorderedSequence analysisAdd BLAST	60
Regionⁱ	1612 – 1635	DisorderedSequence analysisAdd BLAST	24
Regionⁱ	1638 – 1752	Necessary and sufficient for interaction with PCGF1By similarityAdd BLAST	115

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	103 – 120	Polar residuesSequence analysisAdd BLAST	18
Compositional biasⁱ	540 – 621	Polar residuesSequence analysisAdd BLAST	82
Compositional biasⁱ	739 – 764	Basic and acidic residuesSequence analysisAdd BLAST	26
Compositional biasⁱ	1079 – 1109	Basic and acidic residuesSequence analysisAdd BLAST	31
Compositional biasⁱ	1132 – 1183	Basic and acidic residuesSequence analysisAdd BLAST	52
Compositional biasⁱ	1242 – 1256	Polar residuesSequence analysisAdd BLAST	15
Compositional biasⁱ	1257 – 1278	Basic and acidic residuesSequence analysisAdd BLAST	22
Compositional biasⁱ	1294 – 1320	Polar residuesSequence analysisAdd BLAST	27
Compositional biasⁱ	1429 – 1452	Polar residuesSequence analysisAdd BLAST	24

Sequence similaritiesⁱ

Belongs to the BCOR family.Curated

Keywords - Domainⁱ

ANK repeat, Repeat

Phylogenomic databases

eggNOGⁱ	ENOG502RZ5N, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000153737
HOGENOMⁱ	CLU_003863_0_0_1
InParanoidⁱ	Q8CGN4
OMAⁱ	CTEEKHP
Database of Orthologous Groups More...OrthoDBⁱ	85469at2759
PhylomeDBⁱ	Q8CGN4
TreeFamⁱ	TF333317

Family and domain databases

Gene3Dⁱ	1.25.40.20, 1 hit 3.10.260.40, 1 hit
InterProⁱ	View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR031628, BCOR IPR032365, PUFD IPR038227, PUFD_som_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796, Ank_2, 1 hit PF15808, BCOR, 1 hit PF16553, PUFD, 1 hit
SMARTⁱ	View protein in SMART SM00248, ANK, 3 hits
SUPFAMⁱ	SSF48403, SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8CGN4-1) [UniParc]FASTA Add to basket

Also known as: A

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSATPLYGN VHSWMNSERV RMCGTSEDRK IPVNDGDASK ARLELREETP 
        60         70         80         90        100
LSHSVVDTSG AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SGLCGLGSEK 
       110        120        130        140        150
GREATPSSLS GLGFSSERNP EMQFKPNTPE TVEASAVSGK PPNGFSAIYK 
       160        170        180        190        200
TPPGIQKSAV ATAESLGLDR PASDKQSPLN INGASYLRLP WVNPYMEGAT 
       210        220        230        240        250
PAIYPFLDSP NKYSLNMYKA LLPQQSYGLA QPLYSPVCTS GERFLYLPPP 
       260        270        280        290        300
HYVNPHIPSS LASPMRLSTP SASAAIPPLV HCSDKSLPWK MGVNPGNPVD 
       310        320        330        340        350
SHSYPHIQNS KQPRVTSAKA VNSGLPGDTA LLLPPSPRPS ARVHLPTQPA 
       360        370        380        390        400
AETYSEFHKH YPRISTSPSV TLTKPYMTAN SEFSTSRLSN GKYPKALDGG 
       410        420        430        440        450
DCAQSMPGHT RKTTVQDRKD GGSPPLLEKQ TVTKDVTDKP LDLSSKVVDA 
       460        470        480        490        500
DASKGDHMKK MAPTVLVHSR AASGLVLSGS EIPKETLSPP GNGCSIYRSE 
       510        520        530        540        550
IISTAPSSWV VPGPSPNEEN NGKSLSLKNK ALDWAIPQQR SSSCPRMGGT 
       560        570        580        590        600
DAVVTNVSGS VSSSGRPASA SPAPNANANA DGTKTSRSSV DTTPSVIQHV 
       610        620        630        640        650
GQPSSTPAKH GGSTSSKGAK ANPEPSFKAS ENGLPPTSIF LSPNEAFRSP 
       660        670        680        690        700
AIPYPRSYLP YAAPEGIALS PLSLHGKGPV YPHPVLLPNG SLFPGHLAPK 
       710        720        730        740        750
PGLPYGLHTS RPEFVTYQDA LGLGMVHPML IPHTPIEITK EEKPERRSRS 
       760        770        780        790        800
HERARYEDPT LRSRFSEMLE ASSTKLHPEV PTDKNLKPNS SWNQGKTGVK 
       810        820        830        840        850
SDKLVYVDLL REEADTKTDA GAPKAGLVAE NVGQDTEATK PSADPVIQQR 
       860        870        880        890        900
REFISLREEL GRITDFHESF TFKQASSQPV FSLGKDSGAA GTNKENLGVQ 
       910        920        930        940        950
VATPFLETAL GSEGPAVTFG KTQEDPKPFC VGGAPPNMDV TPAYTKEGTD 
       960        970        980        990       1000
EAESNDGKVL KPKPSKLAKR IANSAGYVGD RFKCVTTELY ADSSQLSREQ 
      1010       1020       1030       1040       1050
RALQMEGLQE DSILCLPAAY CERAMMRFSE LEMKEREGSH PATKDSEVCK 
      1060       1070       1080       1090       1100
FSPADWERLK GNQEKKPKSV TLEEAIADQN DSERCEYSTG NKHDLFEAPE 
      1110       1120       1130       1140       1150
DKDLPVEKYF LERPPVSEPP SDQGVVDTPH SPTLRLDRKR KLSGDSTHTE 
      1160       1170       1180       1190       1200
TAVEELAEDP LKAKRRRISK DDWPEREMTN SSSNHLEDPH CNELTNLKVC 
      1210       1220       1230       1240       1250
IELTGLHPKK QRHLLHLRER WEQQVSAAES KPGRQSRKEV AQAVQPEVTS 
      1260       1270       1280       1290       1300
QGTNITEEKP GRKKAEAKGN RGWSEESLKS CDNEQGLPVL SGSPPMKSLS 
      1310       1320       1330       1340       1350
STNASGKKQT QPSCTPASRL PAKQQKIKES QKTDVLCTGE DEDCQAASPL 
      1360       1370       1380       1390       1400
QKYTDNIEKP SGKRLCKTKH LIPQESRRSL QITGDYYVEN TDTKMTVRRF 
      1410       1420       1430       1440       1450
RKRPEPSSDY DLSPPAKQEP KPFDRLQQLL PATQATQLPR SNSPQETTQS 
      1460       1470       1480       1490       1500
RPMPPEARRL IVNKNAGETL LQRAARLGYE EVVLYCLENK VCDVNHRDNA 
      1510       1520       1530       1540       1550
GYCALHEACA RGWLNIVRHL LEYGADVNCS AQDGTRPLHD AVENDHLEIV 
      1560       1570       1580       1590       1600
RLLLSYGADP TLATYSGRTI MKMTHSELME KFLTDYLNDL QGRSEDDTSG 
      1610       1620       1630       1640       1650
AWEFYGSSVC EPDDESGYDV LANPPGPEDP DEEEDTYSDL FEFEFAESSL 
      1660       1670       1680       1690       1700
LPCYNIQVSV AQGPRNWLLL SDVLKKLKMS SRIFRSNFPN LEIVTIAEAE 
      1710       1720       1730       1740       1750
FYRQVSTSLL FSCPKDLEAF NPESKELLDL VEFTNELQTL LGSSVEWLHP 

SDTGHENYW

Length:1,759

Mass (Da):192,631

Last modified:January 4, 2005 - v2

Checksum:ⁱC7FF21CFB3C60D49

Isoform 2 (identifier: Q8CGN4-2) [UniParc]FASTA Add to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
1005-1022: Missing.

« Hide

        10         20         30         40         50
MLSATPLYGN VHSWMNSERV RMCGTSEDRK IPVNDGDASK ARLELREETP 
        60         70         80         90        100
LSHSVVDTSG AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SGLCGLGSEK 
       110        120        130        140        150
GREATPSSLS GLGFSSERNP EMQFKPNTPE TVEASAVSGK PPNGFSAIYK 
       160        170        180        190        200
TPPGIQKSAV ATAESLGLDR PASDKQSPLN INGASYLRLP WVNPYMEGAT 
       210        220        230        240        250
PAIYPFLDSP NKYSLNMYKA LLPQQSYGLA QPLYSPVCTS GERFLYLPPP 
       260        270        280        290        300
HYVNPHIPSS LASPMRLSTP SASAAIPPLV HCSDKSLPWK MGVNPGNPVD 
       310        320        330        340        350
SHSYPHIQNS KQPRVTSAKA VNSGLPGDTA LLLPPSPRPS ARVHLPTQPA 
       360        370        380        390        400
AETYSEFHKH YPRISTSPSV TLTKPYMTAN SEFSTSRLSN GKYPKALDGG 
       410        420        430        440        450
DCAQSMPGHT RKTTVQDRKD GGSPPLLEKQ TVTKDVTDKP LDLSSKVVDA 
       460        470        480        490        500
DASKGDHMKK MAPTVLVHSR AASGLVLSGS EIPKETLSPP GNGCSIYRSE 
       510        520        530        540        550
IISTAPSSWV VPGPSPNEEN NGKSLSLKNK ALDWAIPQQR SSSCPRMGGT 
       560        570        580        590        600
DAVVTNVSGS VSSSGRPASA SPAPNANANA DGTKTSRSSV DTTPSVIQHV 
       610        620        630        640        650
GQPSSTPAKH GGSTSSKGAK ANPEPSFKAS ENGLPPTSIF LSPNEAFRSP 
       660        670        680        690        700
AIPYPRSYLP YAAPEGIALS PLSLHGKGPV YPHPVLLPNG SLFPGHLAPK 
       710        720        730        740        750
PGLPYGLHTS RPEFVTYQDA LGLGMVHPML IPHTPIEITK EEKPERRSRS 
       760        770        780        790        800
HERARYEDPT LRSRFSEMLE ASSTKLHPEV PTDKNLKPNS SWNQGKTGVK 
       810        820        830        840        850
SDKLVYVDLL REEADTKTDA GAPKAGLVAE NVGQDTEATK PSADPVIQQR 
       860        870        880        890        900
REFISLREEL GRITDFHESF TFKQASSQPV FSLGKDSGAA GTNKENLGVQ 
       910        920        930        940        950
VATPFLETAL GSEGPAVTFG KTQEDPKPFC VGGAPPNMDV TPAYTKEGTD 
       960        970        980        990       1000
EAESNDGKVL KPKPSKLAKR IANSAGYVGD RFKCVTTELY ADSSQLSREQ 
      1010       1020       1030       1040       1050
RALQRAMMRF SELEMKEREG SHPATKDSEV CKFSPADWER LKGNQEKKPK 
      1060       1070       1080       1090       1100
SVTLEEAIAD QNDSERCEYS TGNKHDLFEA PEDKDLPVEK YFLERPPVSE 
      1110       1120       1130       1140       1150
PPSDQGVVDT PHSPTLRLDR KRKLSGDSTH TETAVEELAE DPLKAKRRRI 
      1160       1170       1180       1190       1200
SKDDWPEREM TNSSSNHLED PHCNELTNLK VCIELTGLHP KKQRHLLHLR 
      1210       1220       1230       1240       1250
ERWEQQVSAA ESKPGRQSRK EVAQAVQPEV TSQGTNITEE KPGRKKAEAK 
      1260       1270       1280       1290       1300
GNRGWSEESL KSCDNEQGLP VLSGSPPMKS LSSTNASGKK QTQPSCTPAS 
      1310       1320       1330       1340       1350
RLPAKQQKIK ESQKTDVLCT GEDEDCQAAS PLQKYTDNIE KPSGKRLCKT 
      1360       1370       1380       1390       1400
KHLIPQESRR SLQITGDYYV ENTDTKMTVR RFRKRPEPSS DYDLSPPAKQ 
      1410       1420       1430       1440       1450
EPKPFDRLQQ LLPATQATQL PRSNSPQETT QSRPMPPEAR RLIVNKNAGE 
      1460       1470       1480       1490       1500
TLLQRAARLG YEEVVLYCLE NKVCDVNHRD NAGYCALHEA CARGWLNIVR 
      1510       1520       1530       1540       1550
HLLEYGADVN CSAQDGTRPL HDAVENDHLE IVRLLLSYGA DPTLATYSGR 
      1560       1570       1580       1590       1600
TIMKMTHSEL MEKFLTDYLN DLQGRSEDDT SGAWEFYGSS VCEPDDESGY 
      1610       1620       1630       1640       1650
DVLANPPGPE DPDEEEDTYS DLFEFEFAES SLLPCYNIQV SVAQGPRNWL 
      1660       1670       1680       1690       1700
LLSDVLKKLK MSSRIFRSNF PNLEIVTIAE AEFYRQVSTS LLFSCPKDLE 
      1710       1720       1730       1740 
AFNPESKELL DLVEFTNELQ TLLGSSVEWL HPSDTGHENY W

Show »

Length:1,741

Mass (Da):190,664

Checksum:ⁱ6356F262D31FEB72

Isoform 3 (identifier: Q8CGN4-3) [UniParc]FASTA Add to basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
1171-1204: Missing.

« Hide

        10         20         30         40         50
MLSATPLYGN VHSWMNSERV RMCGTSEDRK IPVNDGDASK ARLELREETP 
        60         70         80         90        100
LSHSVVDTSG AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SGLCGLGSEK 
       110        120        130        140        150
GREATPSSLS GLGFSSERNP EMQFKPNTPE TVEASAVSGK PPNGFSAIYK 
       160        170        180        190        200
TPPGIQKSAV ATAESLGLDR PASDKQSPLN INGASYLRLP WVNPYMEGAT 
       210        220        230        240        250
PAIYPFLDSP NKYSLNMYKA LLPQQSYGLA QPLYSPVCTS GERFLYLPPP 
       260        270        280        290        300
HYVNPHIPSS LASPMRLSTP SASAAIPPLV HCSDKSLPWK MGVNPGNPVD 
       310        320        330        340        350
SHSYPHIQNS KQPRVTSAKA VNSGLPGDTA LLLPPSPRPS ARVHLPTQPA 
       360        370        380        390        400
AETYSEFHKH YPRISTSPSV TLTKPYMTAN SEFSTSRLSN GKYPKALDGG 
       410        420        430        440        450
DCAQSMPGHT RKTTVQDRKD GGSPPLLEKQ TVTKDVTDKP LDLSSKVVDA 
       460        470        480        490        500
DASKGDHMKK MAPTVLVHSR AASGLVLSGS EIPKETLSPP GNGCSIYRSE 
       510        520        530        540        550
IISTAPSSWV VPGPSPNEEN NGKSLSLKNK ALDWAIPQQR SSSCPRMGGT 
       560        570        580        590        600
DAVVTNVSGS VSSSGRPASA SPAPNANANA DGTKTSRSSV DTTPSVIQHV 
       610        620        630        640        650
GQPSSTPAKH GGSTSSKGAK ANPEPSFKAS ENGLPPTSIF LSPNEAFRSP 
       660        670        680        690        700
AIPYPRSYLP YAAPEGIALS PLSLHGKGPV YPHPVLLPNG SLFPGHLAPK 
       710        720        730        740        750
PGLPYGLHTS RPEFVTYQDA LGLGMVHPML IPHTPIEITK EEKPERRSRS 
       760        770        780        790        800
HERARYEDPT LRSRFSEMLE ASSTKLHPEV PTDKNLKPNS SWNQGKTGVK 
       810        820        830        840        850
SDKLVYVDLL REEADTKTDA GAPKAGLVAE NVGQDTEATK PSADPVIQQR 
       860        870        880        890        900
REFISLREEL GRITDFHESF TFKQASSQPV FSLGKDSGAA GTNKENLGVQ 
       910        920        930        940        950
VATPFLETAL GSEGPAVTFG KTQEDPKPFC VGGAPPNMDV TPAYTKEGTD 
       960        970        980        990       1000
EAESNDGKVL KPKPSKLAKR IANSAGYVGD RFKCVTTELY ADSSQLSREQ 
      1010       1020       1030       1040       1050
RALQMEGLQE DSILCLPAAY CERAMMRFSE LEMKEREGSH PATKDSEVCK 
      1060       1070       1080       1090       1100
FSPADWERLK GNQEKKPKSV TLEEAIADQN DSERCEYSTG NKHDLFEAPE 
      1110       1120       1130       1140       1150
DKDLPVEKYF LERPPVSEPP SDQGVVDTPH SPTLRLDRKR KLSGDSTHTE 
      1160       1170       1180       1190       1200
TAVEELAEDP LKAKRRRISK GLHPKKQRHL LHLRERWEQQ VSAAESKPGR 
      1210       1220       1230       1240       1250
QSRKEVAQAV QPEVTSQGTN ITEEKPGRKK AEAKGNRGWS EESLKSCDNE 
      1260       1270       1280       1290       1300
QGLPVLSGSP PMKSLSSTNA SGKKQTQPSC TPASRLPAKQ QKIKESQKTD 
      1310       1320       1330       1340       1350
VLCTGEDEDC QAASPLQKYT DNIEKPSGKR LCKTKHLIPQ ESRRSLQITG 
      1360       1370       1380       1390       1400
DYYVENTDTK MTVRRFRKRP EPSSDYDLSP PAKQEPKPFD RLQQLLPATQ 
      1410       1420       1430       1440       1450
ATQLPRSNSP QETTQSRPMP PEARRLIVNK NAGETLLQRA ARLGYEEVVL 
      1460       1470       1480       1490       1500
YCLENKVCDV NHRDNAGYCA LHEACARGWL NIVRHLLEYG ADVNCSAQDG 
      1510       1520       1530       1540       1550
TRPLHDAVEN DHLEIVRLLL SYGADPTLAT YSGRTIMKMT HSELMEKFLT 
      1560       1570       1580       1590       1600
DYLNDLQGRS EDDTSGAWEF YGSSVCEPDD ESGYDVLANP PGPEDPDEEE 
      1610       1620       1630       1640       1650
DTYSDLFEFE FAESSLLPCY NIQVSVAQGP RNWLLLSDVL KKLKMSSRIF 
      1660       1670       1680       1690       1700
RSNFPNLEIV TIAEAEFYRQ VSTSLLFSCP KDLEAFNPES KELLDLVEFT 
      1710       1720 
NELQTLLGSS VEWLHPSDTG HENYW

Show »

Length:1,725

Mass (Da):188,678

Checksum:ⁱBC1E474B524049F6

Isoform 4 (identifier: Q8CGN4-4) [UniParc]FASTA Add to basket

Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
1005-1022: Missing.
1171-1204: Missing.

« Hide

        10         20         30         40         50
MLSATPLYGN VHSWMNSERV RMCGTSEDRK IPVNDGDASK ARLELREETP 
        60         70         80         90        100
LSHSVVDTSG AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SGLCGLGSEK 
       110        120        130        140        150
GREATPSSLS GLGFSSERNP EMQFKPNTPE TVEASAVSGK PPNGFSAIYK 
       160        170        180        190        200
TPPGIQKSAV ATAESLGLDR PASDKQSPLN INGASYLRLP WVNPYMEGAT 
       210        220        230        240        250
PAIYPFLDSP NKYSLNMYKA LLPQQSYGLA QPLYSPVCTS GERFLYLPPP 
       260        270        280        290        300
HYVNPHIPSS LASPMRLSTP SASAAIPPLV HCSDKSLPWK MGVNPGNPVD 
       310        320        330        340        350
SHSYPHIQNS KQPRVTSAKA VNSGLPGDTA LLLPPSPRPS ARVHLPTQPA 
       360        370        380        390        400
AETYSEFHKH YPRISTSPSV TLTKPYMTAN SEFSTSRLSN GKYPKALDGG 
       410        420        430        440        450
DCAQSMPGHT RKTTVQDRKD GGSPPLLEKQ TVTKDVTDKP LDLSSKVVDA 
       460        470        480        490        500
DASKGDHMKK MAPTVLVHSR AASGLVLSGS EIPKETLSPP GNGCSIYRSE 
       510        520        530        540        550
IISTAPSSWV VPGPSPNEEN NGKSLSLKNK ALDWAIPQQR SSSCPRMGGT 
       560        570        580        590        600
DAVVTNVSGS VSSSGRPASA SPAPNANANA DGTKTSRSSV DTTPSVIQHV 
       610        620        630        640        650
GQPSSTPAKH GGSTSSKGAK ANPEPSFKAS ENGLPPTSIF LSPNEAFRSP 
       660        670        680        690        700
AIPYPRSYLP YAAPEGIALS PLSLHGKGPV YPHPVLLPNG SLFPGHLAPK 
       710        720        730        740        750
PGLPYGLHTS RPEFVTYQDA LGLGMVHPML IPHTPIEITK EEKPERRSRS 
       760        770        780        790        800
HERARYEDPT LRSRFSEMLE ASSTKLHPEV PTDKNLKPNS SWNQGKTGVK 
       810        820        830        840        850
SDKLVYVDLL REEADTKTDA GAPKAGLVAE NVGQDTEATK PSADPVIQQR 
       860        870        880        890        900
REFISLREEL GRITDFHESF TFKQASSQPV FSLGKDSGAA GTNKENLGVQ 
       910        920        930        940        950
VATPFLETAL GSEGPAVTFG KTQEDPKPFC VGGAPPNMDV TPAYTKEGTD 
       960        970        980        990       1000
EAESNDGKVL KPKPSKLAKR IANSAGYVGD RFKCVTTELY ADSSQLSREQ 
      1010       1020       1030       1040       1050
RALQRAMMRF SELEMKEREG SHPATKDSEV CKFSPADWER LKGNQEKKPK 
      1060       1070       1080       1090       1100
SVTLEEAIAD QNDSERCEYS TGNKHDLFEA PEDKDLPVEK YFLERPPVSE 
      1110       1120       1130       1140       1150
PPSDQGVVDT PHSPTLRLDR KRKLSGDSTH TETAVEELAE DPLKAKRRRI 
      1160       1170       1180       1190       1200
SKGLHPKKQR HLLHLRERWE QQVSAAESKP GRQSRKEVAQ AVQPEVTSQG 
      1210       1220       1230       1240       1250
TNITEEKPGR KKAEAKGNRG WSEESLKSCD NEQGLPVLSG SPPMKSLSST 
      1260       1270       1280       1290       1300
NASGKKQTQP SCTPASRLPA KQQKIKESQK TDVLCTGEDE DCQAASPLQK 
      1310       1320       1330       1340       1350
YTDNIEKPSG KRLCKTKHLI PQESRRSLQI TGDYYVENTD TKMTVRRFRK 
      1360       1370       1380       1390       1400
RPEPSSDYDL SPPAKQEPKP FDRLQQLLPA TQATQLPRSN SPQETTQSRP 
      1410       1420       1430       1440       1450
MPPEARRLIV NKNAGETLLQ RAARLGYEEV VLYCLENKVC DVNHRDNAGY 
      1460       1470       1480       1490       1500
CALHEACARG WLNIVRHLLE YGADVNCSAQ DGTRPLHDAV ENDHLEIVRL 
      1510       1520       1530       1540       1550
LLSYGADPTL ATYSGRTIMK MTHSELMEKF LTDYLNDLQG RSEDDTSGAW 
      1560       1570       1580       1590       1600
EFYGSSVCEP DDESGYDVLA NPPGPEDPDE EEDTYSDLFE FEFAESSLLP 
      1610       1620       1630       1640       1650
CYNIQVSVAQ GPRNWLLLSD VLKKLKMSSR IFRSNFPNLE IVTIAEAEFY 
      1660       1670       1680       1690       1700
RQVSTSLLFS CPKDLEAFNP ESKELLDLVE FTNELQTLLG SSVEWLHPSD 

TGHENYW

Show »

Length:1,707

Mass (Da):186,710

Checksum:ⁱEEDAB60D370F5520

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F7BEN2	F7BEN2_MOUSE	BCL-6 corepressor BCL-6 corepressor	Bcor	125	Annotation score:
F6XPR4	F6XPR4_MOUSE	BCL-6 corepressor BCL-6 corepressor	Bcor	95	Annotation score:

Sequence cautionⁱ

The sequence BAC98208 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	161	A → V in AAN85318 (PubMed:12776190).Curated	1
Sequence conflictⁱ	161	A → V in AAN85319 (PubMed:12776190).Curated	1
Sequence conflictⁱ	161	A → V in AAN85320 (PubMed:12776190).Curated	1
Sequence conflictⁱ	161	A → V in AAN85321 (PubMed:12776190).Curated	1
Sequence conflictⁱ	167	G → S in AAN85318 (PubMed:12776190).Curated	1
Sequence conflictⁱ	167	G → S in AAN85319 (PubMed:12776190).Curated	1
Sequence conflictⁱ	167	G → S in AAN85320 (PubMed:12776190).Curated	1
Sequence conflictⁱ	167	G → S in AAN85321 (PubMed:12776190).Curated	1
Sequence conflictⁱ	731	I → V in AAN85318 (PubMed:12776190).Curated	1
Sequence conflictⁱ	731	I → V in AAN85319 (PubMed:12776190).Curated	1
Sequence conflictⁱ	731	I → V in AAN85320 (PubMed:12776190).Curated	1
Sequence conflictⁱ	731	I → V in AAN85321 (PubMed:12776190).Curated	1
Sequence conflictⁱ	852	E → D in BAC35338 (PubMed:16141072).Curated	1
Sequence conflictⁱ	1424	D → G in AAN85318 (PubMed:12776190).Curated	1
Sequence conflictⁱ	1424	D → G in AAN85319 (PubMed:12776190).Curated	1
Sequence conflictⁱ	1424	D → G in AAN85320 (PubMed:12776190).Curated	1
Sequence conflictⁱ	1424	D → G in AAN85321 (PubMed:12776190).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_012558	1005 – 1022	Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST		18
Alternative sequenceⁱVSP_012559	1171 – 1204	Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST		34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY161170 mRNA Translation: AAN85318.1 AY161171 mRNA Translation: AAN85319.1 AY161172 mRNA Translation: AAN85320.1 AY161173 mRNA Translation: AAN85321.1 AK129398 mRNA Translation: BAC98208.1 Different initiation. AL808012 Genomic DNA No translation available. BC058656 mRNA Translation: AAH58656.1 AK053309 mRNA Translation: BAC35338.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30021.1 [Q8CGN4-3] CCDS30022.1 [Q8CGN4-4] CCDS40872.1 [Q8CGN4-2] CCDS40873.1 [Q8CGN4-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001161793.1, NM_001168321.1 [Q8CGN4-4] NP_083786.2, NM_029510.3 [Q8CGN4-1] NP_778209.2, NM_175044.3 [Q8CGN4-2] NP_778210.2, NM_175045.3 [Q8CGN4-3] NP_778211.2, NM_175046.3 [Q8CGN4-4] XP_017174110.1, XM_017318621.1 [Q8CGN4-1] XP_017174111.1, XM_017318622.1 [Q8CGN4-1] XP_017174112.1, XM_017318623.1 [Q8CGN4-1] XP_017174113.1, XM_017318624.1 [Q8CGN4-1]

Genome annotation databases

Ensemblⁱ	ENSMUST00000043441; ENSMUSP00000048024; ENSMUSG00000040363 [Q8CGN4-4] ENSMUST00000065143; ENSMUSP00000068618; ENSMUSG00000040363 [Q8CGN4-3] ENSMUST00000115512; ENSMUSP00000111174; ENSMUSG00000040363 [Q8CGN4-2] ENSMUST00000115513; ENSMUSP00000111175; ENSMUSG00000040363 [Q8CGN4-1] ENSMUST00000124033; ENSMUSP00000116258; ENSMUSG00000040363 [Q8CGN4-4]
GeneIDⁱ	71458
KEGGⁱ	mmu:71458
UCSC genome browser More...UCSCⁱ	uc009sqq.2, mouse [Q8CGN4-1] uc009sqr.2, mouse [Q8CGN4-3] uc009sqs.2, mouse [Q8CGN4-2] uc009sqt.2, mouse [Q8CGN4-4]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8CGN4	BCL-6 corepressor (Fragment)		MOUSE		95	UniRef100_Q8CGN4
BCL-6 corepressor (Fragment)		MOUSE		125
+1

Protein	Similar proteins		Species	Score	Length	Source
Q8CGN4	BCL-6 corepressor (Fragment)		MOUSE		95	UniRef90_Q8CGN4
BCL6 interacting corepressor		MUSSI		1759
BCL-6 corepressor isoform X3		MUSCR		1725
BCL-6 corepressor (Fragment)		MOUSE		125
BCL6 interacting corepressor		MUSSI		1663
+8

Protein	Similar proteins		Species	Score	Length	Source
Q8CGN4	Isoform 2 of BCL-6 corepressor		HUMAN		1721	UniRef50_Q6W2J9-2
BCL6 corepressor		CALJA		1833
BCL6 corepressor		AOTNA		1761
BCL6 corepressor		CAVPO		1758
BCL6 corepressor		PAPAN		1755
+1259

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY161170 mRNA Translation: AAN85318.1 AY161171 mRNA Translation: AAN85319.1 AY161172 mRNA Translation: AAN85320.1 AY161173 mRNA Translation: AAN85321.1 AK129398 mRNA Translation: BAC98208.1 Different initiation. AL808012 Genomic DNA No translation available. BC058656 mRNA Translation: AAH58656.1 AK053309 mRNA Translation: BAC35338.1
CCDSⁱ	CCDS30021.1 [Q8CGN4-3] CCDS30022.1 [Q8CGN4-4] CCDS40872.1 [Q8CGN4-2] CCDS40873.1 [Q8CGN4-1]
RefSeqⁱ	NP_001161793.1, NM_001168321.1 [Q8CGN4-4] NP_083786.2, NM_029510.3 [Q8CGN4-1] NP_778209.2, NM_175044.3 [Q8CGN4-2] NP_778210.2, NM_175045.3 [Q8CGN4-3] NP_778211.2, NM_175046.3 [Q8CGN4-4] XP_017174110.1, XM_017318621.1 [Q8CGN4-1] XP_017174111.1, XM_017318622.1 [Q8CGN4-1] XP_017174112.1, XM_017318623.1 [Q8CGN4-1] XP_017174113.1, XM_017318624.1 [Q8CGN4-1]

3D structure databases

AlphaFoldDBⁱ	Q8CGN4
SMRⁱ	Q8CGN4
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	214722, 10 interactors
DIPⁱ	DIP-29852N
IntActⁱ	Q8CGN4, 7 interactors
MINTⁱ	Q8CGN4
STRINGⁱ	10090.ENSMUSP00000111175

PTM databases

iPTMnetⁱ	Q8CGN4
PhosphoSitePlusⁱ	Q8CGN4

Proteomic databases

EPDⁱ	Q8CGN4
jPOSTⁱ	Q8CGN4
MaxQBⁱ	Q8CGN4
PaxDbⁱ	Q8CGN4
PeptideAtlasⁱ	Q8CGN4
PRIDEⁱ	Q8CGN4
ProteomicsDBⁱ	273445 [Q8CGN4-1] 273446 [Q8CGN4-2] 273447 [Q8CGN4-3] 273448 [Q8CGN4-4]

Protocols and materials databases

Antibodypediaⁱ	24949, 295 antibodies from 34 providers
The DNASU plasmid repository More...DNASUⁱ	71458

Genome annotation databases

Ensemblⁱ	ENSMUST00000043441; ENSMUSP00000048024; ENSMUSG00000040363 [Q8CGN4-4] ENSMUST00000065143; ENSMUSP00000068618; ENSMUSG00000040363 [Q8CGN4-3] ENSMUST00000115512; ENSMUSP00000111174; ENSMUSG00000040363 [Q8CGN4-2] ENSMUST00000115513; ENSMUSP00000111175; ENSMUSG00000040363 [Q8CGN4-1] ENSMUST00000124033; ENSMUSP00000116258; ENSMUSG00000040363 [Q8CGN4-4]
GeneIDⁱ	71458
KEGGⁱ	mmu:71458
UCSCⁱ	uc009sqq.2, mouse [Q8CGN4-1] uc009sqr.2, mouse [Q8CGN4-3] uc009sqs.2, mouse [Q8CGN4-2] uc009sqt.2, mouse [Q8CGN4-4]

Organism-specific databases

CTDⁱ	54880
MGIⁱ	MGI:1918708, Bcor
VEuPathDBⁱ	HostDB:ENSMUSG00000040363
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG502RZ5N, Eukaryota
GeneTreeⁱ	ENSGT00940000153737
HOGENOMⁱ	CLU_003863_0_0_1
InParanoidⁱ	Q8CGN4
OMAⁱ	CTEEKHP
OrthoDBⁱ	85469at2759
PhylomeDBⁱ	Q8CGN4
TreeFamⁱ	TF333317

Miscellaneous databases

BioGRID-ORCSⁱ	71458, 6 hits in 80 CRISPR screens
ChiTaRSⁱ	Bcor, mouse
Protein Ontology More...PROⁱ	PR:Q8CGN4
RNActⁱ	Q8CGN4, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000040363, Expressed in ectoplacental cone and 289 other tissues
ExpressionAtlasⁱ	Q8CGN4, baseline and differential
Genevisibleⁱ	Q8CGN4, MM

Family and domain databases

Gene3Dⁱ	1.25.40.20, 1 hit 3.10.260.40, 1 hit
InterProⁱ	View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR031628, BCOR IPR032365, PUFD IPR038227, PUFD_som_sf
Pfamⁱ	View protein in Pfam PF12796, Ank_2, 1 hit PF15808, BCOR, 1 hit PF16553, PUFD, 1 hit
SMARTⁱ	View protein in SMART SM00248, ANK, 3 hits
SUPFAMⁱ	SSF48403, SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BCOR_MOUSE
Accessionⁱ	Q8CGN4Primary (citable) accession number: Q8CGN4 Secondary accession number(s): B1AXK3 Q8CGN3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
	Last sequence update:	January 4, 2005
	Last modified:	May 25, 2022
	This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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Supporting data

UniProtKB - Q8CGN4 (BCOR_MOUSE)

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BCL-6 corepressor

Bcor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q8CGN4

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

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PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ