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UniProtKB - Q8CGN4 (BCOR_MOUSE)

Entry version 146 (12 Aug 2020)
Sequence version 2 (04 Jan 2005)
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Protein

BCL-6 corepressor

Gene

Bcor

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2) (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BCL-6 corepressor
Short name:
BCoR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Bcor
Synonyms:Kiaa1575
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1918708, Bcor

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669791 – 1759BCL-6 corepressorAdd BLAST1759

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei336PhosphoserineBy similarity1
Modified residuei340PhosphoserineBy similarity1
Modified residuei365PhosphoserineBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei392N6-acetyllysineBy similarity1
Modified residuei423PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki787Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki873Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1128PhosphothreonineCombined sources1
Modified residuei1131PhosphoserineCombined sources1
Modified residuei1143PhosphoserineCombined sources1
Cross-linki1259Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1293PhosphoserineBy similarity1
Modified residuei1348PhosphoserineCombined sources1
Modified residuei1413PhosphoserineBy similarity1
Cross-linki1417Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8CGN4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8CGN4

PeptideAtlas

More...PeptideAtlasi		Q8CGN4

PRoteomics IDEntifications database

More...PRIDEi		Q8CGN4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8CGN4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8CGN4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, liver, lung, skeletal muscle, spleen and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000040363, Expressed in ectoplacental cone and 284 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8CGN4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8CGN4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Isoform 1 may interact with MLLT3/AF9 (PubMed:12776190).

Interacts with BCL6; the interaction is direct. Forms ternary complexes with BCL6 and SMRT/NCOR2 on selected target genes promoters; potently repress expression. Can interact with HDAC1, HDAC3 and HDAC5.

Interacts with PCGF1; the interaction is direct.

Interacts with KDM2B.

Component of an approximately 800 kDa repressive BCOR complex at least composed of BCOR, RYBP, PCGF1, RING1, RNF2/RING2, KDM2B and SKP1 (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		214722, 10 interactors

Database of interacting proteins

More...DIPi		DIP-29852N

Protein interaction database and analysis system

More...IntActi		Q8CGN4, 7 interactors

Molecular INTeraction database

More...MINTi		Q8CGN4

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000111175

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8CGN4, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1466 – 1499ANK 1Add BLAST34
Repeati1500 – 1529ANK 2Add BLAST30
Repeati1533 – 1562ANK 3Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni498 – 514Interaction with BCL6By similarityAdd BLAST17
Regioni1638 – 1752Necessary and sufficient for interaction with PCGF1By similarityAdd BLAST115

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BCOR family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RZ5N, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153737

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003863_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8CGN4

KEGG Orthology (KO)

More...KOi		K23215

Identification of Orthologs from Complete Genome Data

More...OMAi		VPGHTRK

Database of Orthologous Groups

More...OrthoDBi		85469at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8CGN4

TreeFam database of animal gene trees

More...TreeFami		TF333317

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit
3.10.260.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR031628, BCOR
IPR032365, PUFD
IPR038227, PUFD_som_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 1 hit
PF15808, BCOR, 1 hit
PF16553, PUFD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CGN4-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSATPLYGN VHSWMNSERV RMCGTSEDRK IPVNDGDASK ARLELREETP 
        60         70         80         90        100
LSHSVVDTSG AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SGLCGLGSEK 
       110        120        130        140        150
GREATPSSLS GLGFSSERNP EMQFKPNTPE TVEASAVSGK PPNGFSAIYK 
       160        170        180        190        200
TPPGIQKSAV ATAESLGLDR PASDKQSPLN INGASYLRLP WVNPYMEGAT 
       210        220        230        240        250
PAIYPFLDSP NKYSLNMYKA LLPQQSYGLA QPLYSPVCTS GERFLYLPPP 
       260        270        280        290        300
HYVNPHIPSS LASPMRLSTP SASAAIPPLV HCSDKSLPWK MGVNPGNPVD 
       310        320        330        340        350
SHSYPHIQNS KQPRVTSAKA VNSGLPGDTA LLLPPSPRPS ARVHLPTQPA 
       360        370        380        390        400
AETYSEFHKH YPRISTSPSV TLTKPYMTAN SEFSTSRLSN GKYPKALDGG 
       410        420        430        440        450
DCAQSMPGHT RKTTVQDRKD GGSPPLLEKQ TVTKDVTDKP LDLSSKVVDA 
       460        470        480        490        500
DASKGDHMKK MAPTVLVHSR AASGLVLSGS EIPKETLSPP GNGCSIYRSE 
       510        520        530        540        550
IISTAPSSWV VPGPSPNEEN NGKSLSLKNK ALDWAIPQQR SSSCPRMGGT 
       560        570        580        590        600
DAVVTNVSGS VSSSGRPASA SPAPNANANA DGTKTSRSSV DTTPSVIQHV 
       610        620        630        640        650
GQPSSTPAKH GGSTSSKGAK ANPEPSFKAS ENGLPPTSIF LSPNEAFRSP 
       660        670        680        690        700
AIPYPRSYLP YAAPEGIALS PLSLHGKGPV YPHPVLLPNG SLFPGHLAPK 
       710        720        730        740        750
PGLPYGLHTS RPEFVTYQDA LGLGMVHPML IPHTPIEITK EEKPERRSRS 
       760        770        780        790        800
HERARYEDPT LRSRFSEMLE ASSTKLHPEV PTDKNLKPNS SWNQGKTGVK 
       810        820        830        840        850
SDKLVYVDLL REEADTKTDA GAPKAGLVAE NVGQDTEATK PSADPVIQQR 
       860        870        880        890        900
REFISLREEL GRITDFHESF TFKQASSQPV FSLGKDSGAA GTNKENLGVQ 
       910        920        930        940        950
VATPFLETAL GSEGPAVTFG KTQEDPKPFC VGGAPPNMDV TPAYTKEGTD 
       960        970        980        990       1000
EAESNDGKVL KPKPSKLAKR IANSAGYVGD RFKCVTTELY ADSSQLSREQ 
      1010       1020       1030       1040       1050
RALQMEGLQE DSILCLPAAY CERAMMRFSE LEMKEREGSH PATKDSEVCK 
      1060       1070       1080       1090       1100
FSPADWERLK GNQEKKPKSV TLEEAIADQN DSERCEYSTG NKHDLFEAPE 
      1110       1120       1130       1140       1150
DKDLPVEKYF LERPPVSEPP SDQGVVDTPH SPTLRLDRKR KLSGDSTHTE 
      1160       1170       1180       1190       1200
TAVEELAEDP LKAKRRRISK DDWPEREMTN SSSNHLEDPH CNELTNLKVC 
      1210       1220       1230       1240       1250
IELTGLHPKK QRHLLHLRER WEQQVSAAES KPGRQSRKEV AQAVQPEVTS 
      1260       1270       1280       1290       1300
QGTNITEEKP GRKKAEAKGN RGWSEESLKS CDNEQGLPVL SGSPPMKSLS 
      1310       1320       1330       1340       1350
STNASGKKQT QPSCTPASRL PAKQQKIKES QKTDVLCTGE DEDCQAASPL 
      1360       1370       1380       1390       1400
QKYTDNIEKP SGKRLCKTKH LIPQESRRSL QITGDYYVEN TDTKMTVRRF 
      1410       1420       1430       1440       1450
RKRPEPSSDY DLSPPAKQEP KPFDRLQQLL PATQATQLPR SNSPQETTQS 
      1460       1470       1480       1490       1500
RPMPPEARRL IVNKNAGETL LQRAARLGYE EVVLYCLENK VCDVNHRDNA 
      1510       1520       1530       1540       1550
GYCALHEACA RGWLNIVRHL LEYGADVNCS AQDGTRPLHD AVENDHLEIV 
      1560       1570       1580       1590       1600
RLLLSYGADP TLATYSGRTI MKMTHSELME KFLTDYLNDL QGRSEDDTSG 
      1610       1620       1630       1640       1650
AWEFYGSSVC EPDDESGYDV LANPPGPEDP DEEEDTYSDL FEFEFAESSL 
      1660       1670       1680       1690       1700
LPCYNIQVSV AQGPRNWLLL SDVLKKLKMS SRIFRSNFPN LEIVTIAEAE 
      1710       1720       1730       1740       1750
FYRQVSTSLL FSCPKDLEAF NPESKELLDL VEFTNELQTL LGSSVEWLHP 

SDTGHENYW
Length:1,759
Mass (Da):192,631
Last modified:January 4, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7FF21CFB3C60D49
GO
Isoform 2 (identifier: Q8CGN4-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1005-1022: Missing.

Show »
Length:1,741
Mass (Da):190,664
Checksum:i6356F262D31FEB72
GO
Isoform 3 (identifier: Q8CGN4-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1171-1204: Missing.

Show »
Length:1,725
Mass (Da):188,678
Checksum:iBC1E474B524049F6
GO
Isoform 4 (identifier: Q8CGN4-4) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1005-1022: Missing.
     1171-1204: Missing.

Show »
Length:1,707
Mass (Da):186,710
Checksum:iEEDAB60D370F5520
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7BEN2F7BEN2_MOUSE
BCL-6 corepressor
Bcor
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XPR4F6XPR4_MOUSE
BCL-6 corepressor
Bcor
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC98208 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti161A → V in AAN85318 (PubMed:12776190).Curated1
Sequence conflicti161A → V in AAN85319 (PubMed:12776190).Curated1
Sequence conflicti161A → V in AAN85320 (PubMed:12776190).Curated1
Sequence conflicti161A → V in AAN85321 (PubMed:12776190).Curated1
Sequence conflicti167G → S in AAN85318 (PubMed:12776190).Curated1
Sequence conflicti167G → S in AAN85319 (PubMed:12776190).Curated1
Sequence conflicti167G → S in AAN85320 (PubMed:12776190).Curated1
Sequence conflicti167G → S in AAN85321 (PubMed:12776190).Curated1
Sequence conflicti731I → V in AAN85318 (PubMed:12776190).Curated1
Sequence conflicti731I → V in AAN85319 (PubMed:12776190).Curated1
Sequence conflicti731I → V in AAN85320 (PubMed:12776190).Curated1
Sequence conflicti731I → V in AAN85321 (PubMed:12776190).Curated1
Sequence conflicti852E → D in BAC35338 (PubMed:16141072).Curated1
Sequence conflicti1424D → G in AAN85318 (PubMed:12776190).Curated1
Sequence conflicti1424D → G in AAN85319 (PubMed:12776190).Curated1
Sequence conflicti1424D → G in AAN85320 (PubMed:12776190).Curated1
Sequence conflicti1424D → G in AAN85321 (PubMed:12776190).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0125581005 – 1022Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_0125591171 – 1204Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY161170 mRNA Translation: AAN85318.1
AY161171 mRNA Translation: AAN85319.1
AY161172 mRNA Translation: AAN85320.1
AY161173 mRNA Translation: AAN85321.1
AK129398 mRNA Translation: BAC98208.1 Different initiation.
AL808012 Genomic DNA No translation available.
BC058656 mRNA Translation: AAH58656.1
AK053309 mRNA Translation: BAC35338.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30021.1 [Q8CGN4-3]
CCDS30022.1 [Q8CGN4-4]
CCDS40872.1 [Q8CGN4-2]
CCDS40873.1 [Q8CGN4-1]

NCBI Reference Sequences

More...RefSeqi		NP_001161793.1, NM_001168321.1 [Q8CGN4-4]
NP_083786.2, NM_029510.3 [Q8CGN4-1]
NP_778209.2, NM_175044.3 [Q8CGN4-2]
NP_778210.2, NM_175045.3 [Q8CGN4-3]
NP_778211.2, NM_175046.3 [Q8CGN4-4]
XP_017174110.1, XM_017318621.1 [Q8CGN4-1]
XP_017174111.1, XM_017318622.1 [Q8CGN4-1]
XP_017174112.1, XM_017318623.1 [Q8CGN4-1]
XP_017174113.1, XM_017318624.1 [Q8CGN4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000043441; ENSMUSP00000048024; ENSMUSG00000040363 [Q8CGN4-4]
ENSMUST00000065143; ENSMUSP00000068618; ENSMUSG00000040363 [Q8CGN4-3]
ENSMUST00000115512; ENSMUSP00000111174; ENSMUSG00000040363 [Q8CGN4-2]
ENSMUST00000115513; ENSMUSP00000111175; ENSMUSG00000040363 [Q8CGN4-1]
ENSMUST00000124033; ENSMUSP00000116258; ENSMUSG00000040363 [Q8CGN4-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		71458

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:71458

UCSC genome browser

More...UCSCi		uc009sqq.2, mouse [Q8CGN4-1]
uc009sqr.2, mouse [Q8CGN4-3]
uc009sqs.2, mouse [Q8CGN4-2]
uc009sqt.2, mouse [Q8CGN4-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161170 mRNA Translation: AAN85318.1
AY161171 mRNA Translation: AAN85319.1
AY161172 mRNA Translation: AAN85320.1
AY161173 mRNA Translation: AAN85321.1
AK129398 mRNA Translation: BAC98208.1 Different initiation.
AL808012 Genomic DNA No translation available.
BC058656 mRNA Translation: AAH58656.1
AK053309 mRNA Translation: BAC35338.1
CCDSiCCDS30021.1 [Q8CGN4-3]
CCDS30022.1 [Q8CGN4-4]
CCDS40872.1 [Q8CGN4-2]
CCDS40873.1 [Q8CGN4-1]
RefSeqiNP_001161793.1, NM_001168321.1 [Q8CGN4-4]
NP_083786.2, NM_029510.3 [Q8CGN4-1]
NP_778209.2, NM_175044.3 [Q8CGN4-2]
NP_778210.2, NM_175045.3 [Q8CGN4-3]
NP_778211.2, NM_175046.3 [Q8CGN4-4]
XP_017174110.1, XM_017318621.1 [Q8CGN4-1]
XP_017174111.1, XM_017318622.1 [Q8CGN4-1]
XP_017174112.1, XM_017318623.1 [Q8CGN4-1]
XP_017174113.1, XM_017318624.1 [Q8CGN4-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi214722, 10 interactors
DIPiDIP-29852N
IntActiQ8CGN4, 7 interactors
MINTiQ8CGN4
STRINGi10090.ENSMUSP00000111175

PTM databases

iPTMnetiQ8CGN4
PhosphoSitePlusiQ8CGN4

Proteomic databases

jPOSTiQ8CGN4
PaxDbiQ8CGN4
PeptideAtlasiQ8CGN4
PRIDEiQ8CGN4

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24949, 253 antibodies

Genome annotation databases

EnsembliENSMUST00000043441; ENSMUSP00000048024; ENSMUSG00000040363 [Q8CGN4-4]
ENSMUST00000065143; ENSMUSP00000068618; ENSMUSG00000040363 [Q8CGN4-3]
ENSMUST00000115512; ENSMUSP00000111174; ENSMUSG00000040363 [Q8CGN4-2]
ENSMUST00000115513; ENSMUSP00000111175; ENSMUSG00000040363 [Q8CGN4-1]
ENSMUST00000124033; ENSMUSP00000116258; ENSMUSG00000040363 [Q8CGN4-4]
GeneIDi71458
KEGGimmu:71458
UCSCiuc009sqq.2, mouse [Q8CGN4-1]
uc009sqr.2, mouse [Q8CGN4-3]
uc009sqs.2, mouse [Q8CGN4-2]
uc009sqt.2, mouse [Q8CGN4-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54880
MGIiMGI:1918708, Bcor

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiENOG502RZ5N, Eukaryota
GeneTreeiENSGT00940000153737
HOGENOMiCLU_003863_0_0_1
InParanoidiQ8CGN4
KOiK23215
OMAiVPGHTRK
OrthoDBi85469at2759
PhylomeDBiQ8CGN4
TreeFamiTF333317

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		71458, 3 hits in 22 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Bcor, mouse

Protein Ontology

More...PROi		PR:Q8CGN4
RNActiQ8CGN4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000040363, Expressed in ectoplacental cone and 284 other tissues
ExpressionAtlasiQ8CGN4, baseline and differential
GenevisibleiQ8CGN4, MM

Family and domain databases

Gene3Di1.25.40.20, 1 hit
3.10.260.40, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR031628, BCOR
IPR032365, PUFD
IPR038227, PUFD_som_sf
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF15808, BCOR, 1 hit
PF16553, PUFD, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 3 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCOR_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CGN4
Secondary accession number(s): B1AXK3
, B1AXK4, B1AXK5, B1AXK6, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: August 12, 2020
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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