Bcor

Functionⁱ

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2) (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

heat shock protein binding Source: MGI
histone deacetylase binding Source: MGI
RNA polymerase II regulatory region sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 25331958
transcription corepressor activity
Source: MGI
Inferred from physical interactionⁱ
- 12776190
transcription factor binding Source: MGI
transcription regulatory region DNA binding Source: MGI
ubiquitin-protein transferase activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

heart development Source: MGI
histone H2A monoubiquitination Source: MGI
negative regulation of bone mineralization Source: MGI
negative regulation of histone H3-K36 methylation Source: MGI
negative regulation of histone H3-K4 methylation Source: MGI
negative regulation of tooth mineralization Source: MGI
negative regulation of transcription, DNA-templated Source: MGI
negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 12776190
odontogenesis Source: MGI
roof of mouth development Source: MGI
specification of axis polarity Source: MGI
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator, Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: BCL-6 corepressor Short name: BCoR
Gene namesⁱ	Name:Bcor Synonyms:Kiaa1575
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome X

Organism-specific databases

MGIⁱ	MGI:1918708 Bcor

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000066979	1 – 1759	BCL-6 corepressorAdd BLAST		1759

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	336	PhosphoserineBy similarity	1
Modified residueⁱ	340	PhosphoserineBy similarity	1
Modified residueⁱ	365	PhosphoserineBy similarity	1
Modified residueⁱ	367	PhosphoserineBy similarity	1
Modified residueⁱ	392	N6-acetyllysineBy similarity	1
Modified residueⁱ	423	PhosphoserineBy similarity	1
Cross-linkⁱ	787	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	873	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	1128	PhosphothreonineCombined sources	1
Modified residueⁱ	1131	PhosphoserineCombined sources	1
Modified residueⁱ	1143	PhosphoserineCombined sources	1
Cross-linkⁱ	1259	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	1293	PhosphoserineBy similarity	1
Modified residueⁱ	1348	PhosphoserineCombined sources	1
Modified residueⁱ	1413	PhosphoserineBy similarity	1
Cross-linkⁱ	1417	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q8CGN4
PeptideAtlas More...PeptideAtlasⁱ	Q8CGN4
PRIDEⁱ	Q8CGN4

PTM databases

iPTMnetⁱ	Q8CGN4
PhosphoSitePlusⁱ	Q8CGN4

Expressionⁱ

Tissue specificityⁱ

Expressed in heart, liver, lung, skeletal muscle, spleen and testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000040363
CleanExⁱ	MM_BCOR
ExpressionAtlasⁱ	Q8CGN4 baseline and differential
Genevisibleⁱ	Q8CGN4 MM

Interactionⁱ

Subunit structureⁱ

Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Isoform 1 may interact with MLLT3/AF9 (PubMed:12776190). Interacts with BCL6; the interaction is direct. Forms ternary complexes with BCL6 and SMRT/NCOR2 on selected target genes promoters; potently repress expression. Can interact with HDAC1, HDAC3 and HDAC5. Interacts with PCGF1; the interaction is direct. Interacts with KDM2B. Component of an approximately 800 kDa repressive BCOR complex at least composed of BCOR, RYBP, PCGF1, RING1, RNF2/RING2, KDM2B and SKP1 (By similarity).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Bcl6	P41183	2	EBI-1216174,EBI-6253762

With

Entry

#Exp.

IntAct

Notes

Bcl6

P41183

2

EBI-1216174,EBI-6253762

GO - Molecular functionⁱ

heat shock protein binding Source: MGI
histone deacetylase binding Source: MGI
transcription factor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	214722, 9 interactors
Database of interacting proteins More...DIPⁱ	DIP-29852N
IntActⁱ	Q8CGN4, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q8CGN4
STRINGⁱ	10090.ENSMUSP00000111175

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8CGN4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	1466 – 1499	ANK 1Add BLAST	34
Repeatⁱ	1500 – 1529	ANK 2Add BLAST	30
Repeatⁱ	1533 – 1562	ANK 3Add BLAST	30

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	498 – 514	Interaction with BCL6By similarityAdd BLAST		17
Regionⁱ	1638 – 1752	Necessary and sufficient for interaction with PCGF1By similarityAdd BLAST		115

Sequence similaritiesⁱ

Belongs to the BCOR family.Curated

Keywords - Domainⁱ

ANK repeat, Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IHDH Eukaryota ENOG410YT00 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119090
HOVERGENⁱ	HBG050682
InParanoidⁱ	Q8CGN4
OMAⁱ	ERVRMCG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R1A
PhylomeDBⁱ	Q8CGN4
TreeFamⁱ	TF333317

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit 3.10.260.40, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR031628 BCOR IPR032365 PUFD IPR038227 PUFD_som_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF15808 BCOR, 1 hit PF16553 PUFD, 1 hit
SMARTⁱ	View protein in SMART SM00248 ANK, 3 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 2 hits

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8CGN4-1) [UniParc]FASTA Add to basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSATPLYGN VHSWMNSERV RMCGTSEDRK IPVNDGDASK ARLELREETP 
        60         70         80         90        100
LSHSVVDTSG AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SGLCGLGSEK 
       110        120        130        140        150
GREATPSSLS GLGFSSERNP EMQFKPNTPE TVEASAVSGK PPNGFSAIYK 
       160        170        180        190        200
TPPGIQKSAV ATAESLGLDR PASDKQSPLN INGASYLRLP WVNPYMEGAT 
       210        220        230        240        250
PAIYPFLDSP NKYSLNMYKA LLPQQSYGLA QPLYSPVCTS GERFLYLPPP 
       260        270        280        290        300
HYVNPHIPSS LASPMRLSTP SASAAIPPLV HCSDKSLPWK MGVNPGNPVD 
       310        320        330        340        350
SHSYPHIQNS KQPRVTSAKA VNSGLPGDTA LLLPPSPRPS ARVHLPTQPA 
       360        370        380        390        400
AETYSEFHKH YPRISTSPSV TLTKPYMTAN SEFSTSRLSN GKYPKALDGG 
       410        420        430        440        450
DCAQSMPGHT RKTTVQDRKD GGSPPLLEKQ TVTKDVTDKP LDLSSKVVDA 
       460        470        480        490        500
DASKGDHMKK MAPTVLVHSR AASGLVLSGS EIPKETLSPP GNGCSIYRSE 
       510        520        530        540        550
IISTAPSSWV VPGPSPNEEN NGKSLSLKNK ALDWAIPQQR SSSCPRMGGT 
       560        570        580        590        600
DAVVTNVSGS VSSSGRPASA SPAPNANANA DGTKTSRSSV DTTPSVIQHV 
       610        620        630        640        650
GQPSSTPAKH GGSTSSKGAK ANPEPSFKAS ENGLPPTSIF LSPNEAFRSP 
       660        670        680        690        700
AIPYPRSYLP YAAPEGIALS PLSLHGKGPV YPHPVLLPNG SLFPGHLAPK 
       710        720        730        740        750
PGLPYGLHTS RPEFVTYQDA LGLGMVHPML IPHTPIEITK EEKPERRSRS 
       760        770        780        790        800
HERARYEDPT LRSRFSEMLE ASSTKLHPEV PTDKNLKPNS SWNQGKTGVK 
       810        820        830        840        850
SDKLVYVDLL REEADTKTDA GAPKAGLVAE NVGQDTEATK PSADPVIQQR 
       860        870        880        890        900
REFISLREEL GRITDFHESF TFKQASSQPV FSLGKDSGAA GTNKENLGVQ 
       910        920        930        940        950
VATPFLETAL GSEGPAVTFG KTQEDPKPFC VGGAPPNMDV TPAYTKEGTD 
       960        970        980        990       1000
EAESNDGKVL KPKPSKLAKR IANSAGYVGD RFKCVTTELY ADSSQLSREQ 
      1010       1020       1030       1040       1050
RALQMEGLQE DSILCLPAAY CERAMMRFSE LEMKEREGSH PATKDSEVCK 
      1060       1070       1080       1090       1100
FSPADWERLK GNQEKKPKSV TLEEAIADQN DSERCEYSTG NKHDLFEAPE 
      1110       1120       1130       1140       1150
DKDLPVEKYF LERPPVSEPP SDQGVVDTPH SPTLRLDRKR KLSGDSTHTE 
      1160       1170       1180       1190       1200
TAVEELAEDP LKAKRRRISK DDWPEREMTN SSSNHLEDPH CNELTNLKVC 
      1210       1220       1230       1240       1250
IELTGLHPKK QRHLLHLRER WEQQVSAAES KPGRQSRKEV AQAVQPEVTS 
      1260       1270       1280       1290       1300
QGTNITEEKP GRKKAEAKGN RGWSEESLKS CDNEQGLPVL SGSPPMKSLS 
      1310       1320       1330       1340       1350
STNASGKKQT QPSCTPASRL PAKQQKIKES QKTDVLCTGE DEDCQAASPL 
      1360       1370       1380       1390       1400
QKYTDNIEKP SGKRLCKTKH LIPQESRRSL QITGDYYVEN TDTKMTVRRF 
      1410       1420       1430       1440       1450
RKRPEPSSDY DLSPPAKQEP KPFDRLQQLL PATQATQLPR SNSPQETTQS 
      1460       1470       1480       1490       1500
RPMPPEARRL IVNKNAGETL LQRAARLGYE EVVLYCLENK VCDVNHRDNA 
      1510       1520       1530       1540       1550
GYCALHEACA RGWLNIVRHL LEYGADVNCS AQDGTRPLHD AVENDHLEIV 
      1560       1570       1580       1590       1600
RLLLSYGADP TLATYSGRTI MKMTHSELME KFLTDYLNDL QGRSEDDTSG 
      1610       1620       1630       1640       1650
AWEFYGSSVC EPDDESGYDV LANPPGPEDP DEEEDTYSDL FEFEFAESSL 
      1660       1670       1680       1690       1700
LPCYNIQVSV AQGPRNWLLL SDVLKKLKMS SRIFRSNFPN LEIVTIAEAE 
      1710       1720       1730       1740       1750
FYRQVSTSLL FSCPKDLEAF NPESKELLDL VEFTNELQTL LGSSVEWLHP 

SDTGHENYW

Length:1,759

Mass (Da):192,631

Last modified:January 4, 2005 - v2

Checksum:ⁱC7FF21CFB3C60D49

GO

Isoform 2 (identifier: Q8CGN4-2) [UniParc]FASTA Add to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
1005-1022: Missing.

« Hide

        10         20         30         40         50
MLSATPLYGN VHSWMNSERV RMCGTSEDRK IPVNDGDASK ARLELREETP 
        60         70         80         90        100
LSHSVVDTSG AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SGLCGLGSEK 
       110        120        130        140        150
GREATPSSLS GLGFSSERNP EMQFKPNTPE TVEASAVSGK PPNGFSAIYK 
       160        170        180        190        200
TPPGIQKSAV ATAESLGLDR PASDKQSPLN INGASYLRLP WVNPYMEGAT 
       210        220        230        240        250
PAIYPFLDSP NKYSLNMYKA LLPQQSYGLA QPLYSPVCTS GERFLYLPPP 
       260        270        280        290        300
HYVNPHIPSS LASPMRLSTP SASAAIPPLV HCSDKSLPWK MGVNPGNPVD 
       310        320        330        340        350
SHSYPHIQNS KQPRVTSAKA VNSGLPGDTA LLLPPSPRPS ARVHLPTQPA 
       360        370        380        390        400
AETYSEFHKH YPRISTSPSV TLTKPYMTAN SEFSTSRLSN GKYPKALDGG 
       410        420        430        440        450
DCAQSMPGHT RKTTVQDRKD GGSPPLLEKQ TVTKDVTDKP LDLSSKVVDA 
       460        470        480        490        500
DASKGDHMKK MAPTVLVHSR AASGLVLSGS EIPKETLSPP GNGCSIYRSE 
       510        520        530        540        550
IISTAPSSWV VPGPSPNEEN NGKSLSLKNK ALDWAIPQQR SSSCPRMGGT 
       560        570        580        590        600
DAVVTNVSGS VSSSGRPASA SPAPNANANA DGTKTSRSSV DTTPSVIQHV 
       610        620        630        640        650
GQPSSTPAKH GGSTSSKGAK ANPEPSFKAS ENGLPPTSIF LSPNEAFRSP 
       660        670        680        690        700
AIPYPRSYLP YAAPEGIALS PLSLHGKGPV YPHPVLLPNG SLFPGHLAPK 
       710        720        730        740        750
PGLPYGLHTS RPEFVTYQDA LGLGMVHPML IPHTPIEITK EEKPERRSRS 
       760        770        780        790        800
HERARYEDPT LRSRFSEMLE ASSTKLHPEV PTDKNLKPNS SWNQGKTGVK 
       810        820        830        840        850
SDKLVYVDLL REEADTKTDA GAPKAGLVAE NVGQDTEATK PSADPVIQQR 
       860        870        880        890        900
REFISLREEL GRITDFHESF TFKQASSQPV FSLGKDSGAA GTNKENLGVQ 
       910        920        930        940        950
VATPFLETAL GSEGPAVTFG KTQEDPKPFC VGGAPPNMDV TPAYTKEGTD 
       960        970        980        990       1000
EAESNDGKVL KPKPSKLAKR IANSAGYVGD RFKCVTTELY ADSSQLSREQ 
      1010       1020       1030       1040       1050
RALQRAMMRF SELEMKEREG SHPATKDSEV CKFSPADWER LKGNQEKKPK 
      1060       1070       1080       1090       1100
SVTLEEAIAD QNDSERCEYS TGNKHDLFEA PEDKDLPVEK YFLERPPVSE 
      1110       1120       1130       1140       1150
PPSDQGVVDT PHSPTLRLDR KRKLSGDSTH TETAVEELAE DPLKAKRRRI 
      1160       1170       1180       1190       1200
SKDDWPEREM TNSSSNHLED PHCNELTNLK VCIELTGLHP KKQRHLLHLR 
      1210       1220       1230       1240       1250
ERWEQQVSAA ESKPGRQSRK EVAQAVQPEV TSQGTNITEE KPGRKKAEAK 
      1260       1270       1280       1290       1300
GNRGWSEESL KSCDNEQGLP VLSGSPPMKS LSSTNASGKK QTQPSCTPAS 
      1310       1320       1330       1340       1350
RLPAKQQKIK ESQKTDVLCT GEDEDCQAAS PLQKYTDNIE KPSGKRLCKT 
      1360       1370       1380       1390       1400
KHLIPQESRR SLQITGDYYV ENTDTKMTVR RFRKRPEPSS DYDLSPPAKQ 
      1410       1420       1430       1440       1450
EPKPFDRLQQ LLPATQATQL PRSNSPQETT QSRPMPPEAR RLIVNKNAGE 
      1460       1470       1480       1490       1500
TLLQRAARLG YEEVVLYCLE NKVCDVNHRD NAGYCALHEA CARGWLNIVR 
      1510       1520       1530       1540       1550
HLLEYGADVN CSAQDGTRPL HDAVENDHLE IVRLLLSYGA DPTLATYSGR 
      1560       1570       1580       1590       1600
TIMKMTHSEL MEKFLTDYLN DLQGRSEDDT SGAWEFYGSS VCEPDDESGY 
      1610       1620       1630       1640       1650
DVLANPPGPE DPDEEEDTYS DLFEFEFAES SLLPCYNIQV SVAQGPRNWL 
      1660       1670       1680       1690       1700
LLSDVLKKLK MSSRIFRSNF PNLEIVTIAE AEFYRQVSTS LLFSCPKDLE 
      1710       1720       1730       1740 
AFNPESKELL DLVEFTNELQ TLLGSSVEWL HPSDTGHENY W

Show »

Length:1,741

Mass (Da):190,664

Checksum:ⁱ6356F262D31FEB72

GO

Isoform 3 (identifier: Q8CGN4-3) [UniParc]FASTA Add to basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
1171-1204: Missing.

« Hide

        10         20         30         40         50
MLSATPLYGN VHSWMNSERV RMCGTSEDRK IPVNDGDASK ARLELREETP 
        60         70         80         90        100
LSHSVVDTSG AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SGLCGLGSEK 
       110        120        130        140        150
GREATPSSLS GLGFSSERNP EMQFKPNTPE TVEASAVSGK PPNGFSAIYK 
       160        170        180        190        200
TPPGIQKSAV ATAESLGLDR PASDKQSPLN INGASYLRLP WVNPYMEGAT 
       210        220        230        240        250
PAIYPFLDSP NKYSLNMYKA LLPQQSYGLA QPLYSPVCTS GERFLYLPPP 
       260        270        280        290        300
HYVNPHIPSS LASPMRLSTP SASAAIPPLV HCSDKSLPWK MGVNPGNPVD 
       310        320        330        340        350
SHSYPHIQNS KQPRVTSAKA VNSGLPGDTA LLLPPSPRPS ARVHLPTQPA 
       360        370        380        390        400
AETYSEFHKH YPRISTSPSV TLTKPYMTAN SEFSTSRLSN GKYPKALDGG 
       410        420        430        440        450
DCAQSMPGHT RKTTVQDRKD GGSPPLLEKQ TVTKDVTDKP LDLSSKVVDA 
       460        470        480        490        500
DASKGDHMKK MAPTVLVHSR AASGLVLSGS EIPKETLSPP GNGCSIYRSE 
       510        520        530        540        550
IISTAPSSWV VPGPSPNEEN NGKSLSLKNK ALDWAIPQQR SSSCPRMGGT 
       560        570        580        590        600
DAVVTNVSGS VSSSGRPASA SPAPNANANA DGTKTSRSSV DTTPSVIQHV 
       610        620        630        640        650
GQPSSTPAKH GGSTSSKGAK ANPEPSFKAS ENGLPPTSIF LSPNEAFRSP 
       660        670        680        690        700
AIPYPRSYLP YAAPEGIALS PLSLHGKGPV YPHPVLLPNG SLFPGHLAPK 
       710        720        730        740        750
PGLPYGLHTS RPEFVTYQDA LGLGMVHPML IPHTPIEITK EEKPERRSRS 
       760        770        780        790        800
HERARYEDPT LRSRFSEMLE ASSTKLHPEV PTDKNLKPNS SWNQGKTGVK 
       810        820        830        840        850
SDKLVYVDLL REEADTKTDA GAPKAGLVAE NVGQDTEATK PSADPVIQQR 
       860        870        880        890        900
REFISLREEL GRITDFHESF TFKQASSQPV FSLGKDSGAA GTNKENLGVQ 
       910        920        930        940        950
VATPFLETAL GSEGPAVTFG KTQEDPKPFC VGGAPPNMDV TPAYTKEGTD 
       960        970        980        990       1000
EAESNDGKVL KPKPSKLAKR IANSAGYVGD RFKCVTTELY ADSSQLSREQ 
      1010       1020       1030       1040       1050
RALQMEGLQE DSILCLPAAY CERAMMRFSE LEMKEREGSH PATKDSEVCK 
      1060       1070       1080       1090       1100
FSPADWERLK GNQEKKPKSV TLEEAIADQN DSERCEYSTG NKHDLFEAPE 
      1110       1120       1130       1140       1150
DKDLPVEKYF LERPPVSEPP SDQGVVDTPH SPTLRLDRKR KLSGDSTHTE 
      1160       1170       1180       1190       1200
TAVEELAEDP LKAKRRRISK GLHPKKQRHL LHLRERWEQQ VSAAESKPGR 
      1210       1220       1230       1240       1250
QSRKEVAQAV QPEVTSQGTN ITEEKPGRKK AEAKGNRGWS EESLKSCDNE 
      1260       1270       1280       1290       1300
QGLPVLSGSP PMKSLSSTNA SGKKQTQPSC TPASRLPAKQ QKIKESQKTD 
      1310       1320       1330       1340       1350
VLCTGEDEDC QAASPLQKYT DNIEKPSGKR LCKTKHLIPQ ESRRSLQITG 
      1360       1370       1380       1390       1400
DYYVENTDTK MTVRRFRKRP EPSSDYDLSP PAKQEPKPFD RLQQLLPATQ 
      1410       1420       1430       1440       1450
ATQLPRSNSP QETTQSRPMP PEARRLIVNK NAGETLLQRA ARLGYEEVVL 
      1460       1470       1480       1490       1500
YCLENKVCDV NHRDNAGYCA LHEACARGWL NIVRHLLEYG ADVNCSAQDG 
      1510       1520       1530       1540       1550
TRPLHDAVEN DHLEIVRLLL SYGADPTLAT YSGRTIMKMT HSELMEKFLT 
      1560       1570       1580       1590       1600
DYLNDLQGRS EDDTSGAWEF YGSSVCEPDD ESGYDVLANP PGPEDPDEEE 
      1610       1620       1630       1640       1650
DTYSDLFEFE FAESSLLPCY NIQVSVAQGP RNWLLLSDVL KKLKMSSRIF 
      1660       1670       1680       1690       1700
RSNFPNLEIV TIAEAEFYRQ VSTSLLFSCP KDLEAFNPES KELLDLVEFT 
      1710       1720 
NELQTLLGSS VEWLHPSDTG HENYW

Show »

Length:1,725

Mass (Da):188,678

Checksum:ⁱBC1E474B524049F6

GO

Isoform 4 (identifier: Q8CGN4-4) [UniParc]FASTA Add to basket

Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
1005-1022: Missing.
1171-1204: Missing.

« Hide

        10         20         30         40         50
MLSATPLYGN VHSWMNSERV RMCGTSEDRK IPVNDGDASK ARLELREETP 
        60         70         80         90        100
LSHSVVDTSG AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SGLCGLGSEK 
       110        120        130        140        150
GREATPSSLS GLGFSSERNP EMQFKPNTPE TVEASAVSGK PPNGFSAIYK 
       160        170        180        190        200
TPPGIQKSAV ATAESLGLDR PASDKQSPLN INGASYLRLP WVNPYMEGAT 
       210        220        230        240        250
PAIYPFLDSP NKYSLNMYKA LLPQQSYGLA QPLYSPVCTS GERFLYLPPP 
       260        270        280        290        300
HYVNPHIPSS LASPMRLSTP SASAAIPPLV HCSDKSLPWK MGVNPGNPVD 
       310        320        330        340        350
SHSYPHIQNS KQPRVTSAKA VNSGLPGDTA LLLPPSPRPS ARVHLPTQPA 
       360        370        380        390        400
AETYSEFHKH YPRISTSPSV TLTKPYMTAN SEFSTSRLSN GKYPKALDGG 
       410        420        430        440        450
DCAQSMPGHT RKTTVQDRKD GGSPPLLEKQ TVTKDVTDKP LDLSSKVVDA 
       460        470        480        490        500
DASKGDHMKK MAPTVLVHSR AASGLVLSGS EIPKETLSPP GNGCSIYRSE 
       510        520        530        540        550
IISTAPSSWV VPGPSPNEEN NGKSLSLKNK ALDWAIPQQR SSSCPRMGGT 
       560        570        580        590        600
DAVVTNVSGS VSSSGRPASA SPAPNANANA DGTKTSRSSV DTTPSVIQHV 
       610        620        630        640        650
GQPSSTPAKH GGSTSSKGAK ANPEPSFKAS ENGLPPTSIF LSPNEAFRSP 
       660        670        680        690        700
AIPYPRSYLP YAAPEGIALS PLSLHGKGPV YPHPVLLPNG SLFPGHLAPK 
       710        720        730        740        750
PGLPYGLHTS RPEFVTYQDA LGLGMVHPML IPHTPIEITK EEKPERRSRS 
       760        770        780        790        800
HERARYEDPT LRSRFSEMLE ASSTKLHPEV PTDKNLKPNS SWNQGKTGVK 
       810        820        830        840        850
SDKLVYVDLL REEADTKTDA GAPKAGLVAE NVGQDTEATK PSADPVIQQR 
       860        870        880        890        900
REFISLREEL GRITDFHESF TFKQASSQPV FSLGKDSGAA GTNKENLGVQ 
       910        920        930        940        950
VATPFLETAL GSEGPAVTFG KTQEDPKPFC VGGAPPNMDV TPAYTKEGTD 
       960        970        980        990       1000
EAESNDGKVL KPKPSKLAKR IANSAGYVGD RFKCVTTELY ADSSQLSREQ 
      1010       1020       1030       1040       1050
RALQRAMMRF SELEMKEREG SHPATKDSEV CKFSPADWER LKGNQEKKPK 
      1060       1070       1080       1090       1100
SVTLEEAIAD QNDSERCEYS TGNKHDLFEA PEDKDLPVEK YFLERPPVSE 
      1110       1120       1130       1140       1150
PPSDQGVVDT PHSPTLRLDR KRKLSGDSTH TETAVEELAE DPLKAKRRRI 
      1160       1170       1180       1190       1200
SKGLHPKKQR HLLHLRERWE QQVSAAESKP GRQSRKEVAQ AVQPEVTSQG 
      1210       1220       1230       1240       1250
TNITEEKPGR KKAEAKGNRG WSEESLKSCD NEQGLPVLSG SPPMKSLSST 
      1260       1270       1280       1290       1300
NASGKKQTQP SCTPASRLPA KQQKIKESQK TDVLCTGEDE DCQAASPLQK 
      1310       1320       1330       1340       1350
YTDNIEKPSG KRLCKTKHLI PQESRRSLQI TGDYYVENTD TKMTVRRFRK 
      1360       1370       1380       1390       1400
RPEPSSDYDL SPPAKQEPKP FDRLQQLLPA TQATQLPRSN SPQETTQSRP 
      1410       1420       1430       1440       1450
MPPEARRLIV NKNAGETLLQ RAARLGYEEV VLYCLENKVC DVNHRDNAGY 
      1460       1470       1480       1490       1500
CALHEACARG WLNIVRHLLE YGADVNCSAQ DGTRPLHDAV ENDHLEIVRL 
      1510       1520       1530       1540       1550
LLSYGADPTL ATYSGRTIMK MTHSELMEKF LTDYLNDLQG RSEDDTSGAW 
      1560       1570       1580       1590       1600
EFYGSSVCEP DDESGYDVLA NPPGPEDPDE EEDTYSDLFE FEFAESSLLP 
      1610       1620       1630       1640       1650
CYNIQVSVAQ GPRNWLLLSD VLKKLKMSSR IFRSNFPNLE IVTIAEAEFY 
      1660       1670       1680       1690       1700
RQVSTSLLFS CPKDLEAFNP ESKELLDLVE FTNELQTLLG SSVEWLHPSD 

TGHENYW

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Length:1,707

Mass (Da):186,710

Checksum:ⁱEEDAB60D370F5520

GO

Sequence cautionⁱ

The sequence BAC98208 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	161	A → V in AAN85318 (PubMed:12776190).Curated	1
Sequence conflictⁱ	161	A → V in AAN85319 (PubMed:12776190).Curated	1
Sequence conflictⁱ	161	A → V in AAN85320 (PubMed:12776190).Curated	1
Sequence conflictⁱ	161	A → V in AAN85321 (PubMed:12776190).Curated	1
Sequence conflictⁱ	167	G → S in AAN85318 (PubMed:12776190).Curated	1
Sequence conflictⁱ	167	G → S in AAN85319 (PubMed:12776190).Curated	1
Sequence conflictⁱ	167	G → S in AAN85320 (PubMed:12776190).Curated	1
Sequence conflictⁱ	167	G → S in AAN85321 (PubMed:12776190).Curated	1
Sequence conflictⁱ	731	I → V in AAN85318 (PubMed:12776190).Curated	1
Sequence conflictⁱ	731	I → V in AAN85319 (PubMed:12776190).Curated	1
Sequence conflictⁱ	731	I → V in AAN85320 (PubMed:12776190).Curated	1
Sequence conflictⁱ	731	I → V in AAN85321 (PubMed:12776190).Curated	1
Sequence conflictⁱ	852	E → D in BAC35338 (PubMed:16141072).Curated	1
Sequence conflictⁱ	1424	D → G in AAN85318 (PubMed:12776190).Curated	1
Sequence conflictⁱ	1424	D → G in AAN85319 (PubMed:12776190).Curated	1
Sequence conflictⁱ	1424	D → G in AAN85320 (PubMed:12776190).Curated	1
Sequence conflictⁱ	1424	D → G in AAN85321 (PubMed:12776190).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_012558	1005 – 1022	Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST		18
Alternative sequenceⁱVSP_012559	1171 – 1204	Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST		34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY161170 mRNA Translation: AAN85318.1 AY161171 mRNA Translation: AAN85319.1 AY161172 mRNA Translation: AAN85320.1 AY161173 mRNA Translation: AAN85321.1 AK129398 mRNA Translation: BAC98208.1 Different initiation. AL808012 Genomic DNA No translation available. BC058656 mRNA Translation: AAH58656.1 AK053309 mRNA Translation: BAC35338.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30021.1 [Q8CGN4-3] CCDS30022.1 [Q8CGN4-4] CCDS40872.1 [Q8CGN4-2] CCDS40873.1 [Q8CGN4-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001161793.1, NM_001168321.1 [Q8CGN4-4] NP_083786.2, NM_029510.3 [Q8CGN4-1] NP_778209.2, NM_175044.3 [Q8CGN4-2] NP_778210.2, NM_175045.3 [Q8CGN4-3] NP_778211.2, NM_175046.3 [Q8CGN4-4] XP_017174110.1, XM_017318621.1 [Q8CGN4-1] XP_017174111.1, XM_017318622.1 [Q8CGN4-1] XP_017174112.1, XM_017318623.1 [Q8CGN4-1] XP_017174113.1, XM_017318624.1 [Q8CGN4-1]
UniGeneⁱ	Mm.196328 Mm.440386 Mm.490017

Genome annotation databases

Ensemblⁱ	ENSMUST00000043441; ENSMUSP00000048024; ENSMUSG00000040363 [Q8CGN4-4] ENSMUST00000065143; ENSMUSP00000068618; ENSMUSG00000040363 [Q8CGN4-3] ENSMUST00000115512; ENSMUSP00000111174; ENSMUSG00000040363 [Q8CGN4-2] ENSMUST00000115513; ENSMUSP00000111175; ENSMUSG00000040363 [Q8CGN4-1] ENSMUST00000124033; ENSMUSP00000116258; ENSMUSG00000040363 [Q8CGN4-4]
GeneIDⁱ	71458
KEGGⁱ	mmu:71458
UCSC genome browser More...UCSCⁱ	uc009sqq.2 mouse [Q8CGN4-1] uc009sqr.2 mouse [Q8CGN4-3] uc009sqs.2 mouse [Q8CGN4-2] uc009sqt.2 mouse [Q8CGN4-4]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q8CGN4	BCL-6 corepressor (Fragment)		MOUSE		125
BCL-6 corepressor		CRIGR		1839
BCL-6 corepressor isoform X1		MESAU		1764
UPI000A317EC0		MUSCR		1759
UPI000A312AD9		MUSPA		1758
+15
Q8CGN4-2	UPI000A317385		MUSCR		1741
UPI000A30CA91		MUSPA		1740
UPI000B4EC5BC		MERUN		1740
UPI0000DBEFBE		RAT		1739
UPI000333037C		JACJA		1739
+6
Q8CGN4-3	UPI000A317385		MUSCR		1741
UPI000A30CA91		MUSPA		1740
UPI000B4EC5BC		MERUN		1740
UPI0000DBEFBE		RAT		1739
UPI000333037C		JACJA		1739
+6

Protein	Similar proteins		Species	Score	Length
Q8CGN4	BCL-6 corepressor (Fragment)		HUMAN		1287
Retinoic acid receptor alpha isoform 2 (Fragment)		MACMU		29
RARA isoform 9 (Fragment)		PONAB		186
RARA isoform 8 (Fragment)		PANTR		186
Retinoic acid receptor alpha (Fragment)		CEREL		119
+400

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY161170 mRNA Translation: AAN85318.1 AY161171 mRNA Translation: AAN85319.1 AY161172 mRNA Translation: AAN85320.1 AY161173 mRNA Translation: AAN85321.1 AK129398 mRNA Translation: BAC98208.1 Different initiation. AL808012 Genomic DNA No translation available. BC058656 mRNA Translation: AAH58656.1 AK053309 mRNA Translation: BAC35338.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30021.1 [Q8CGN4-3] CCDS30022.1 [Q8CGN4-4] CCDS40872.1 [Q8CGN4-2] CCDS40873.1 [Q8CGN4-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001161793.1, NM_001168321.1 [Q8CGN4-4] NP_083786.2, NM_029510.3 [Q8CGN4-1] NP_778209.2, NM_175044.3 [Q8CGN4-2] NP_778210.2, NM_175045.3 [Q8CGN4-3] NP_778211.2, NM_175046.3 [Q8CGN4-4] XP_017174110.1, XM_017318621.1 [Q8CGN4-1] XP_017174111.1, XM_017318622.1 [Q8CGN4-1] XP_017174112.1, XM_017318623.1 [Q8CGN4-1] XP_017174113.1, XM_017318624.1 [Q8CGN4-1]
UniGeneⁱ	Mm.196328 Mm.440386 Mm.490017

3D structure databases

ProteinModelPortalⁱ	Q8CGN4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	214722, 9 interactors
Database of interacting proteins More...DIPⁱ	DIP-29852N
IntActⁱ	Q8CGN4, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q8CGN4
STRINGⁱ	10090.ENSMUSP00000111175

PTM databases

iPTMnetⁱ	Q8CGN4
PhosphoSitePlusⁱ	Q8CGN4

Proteomic databases

PaxDbⁱ	Q8CGN4
PeptideAtlas More...PeptideAtlasⁱ	Q8CGN4
PRIDEⁱ	Q8CGN4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000043441; ENSMUSP00000048024; ENSMUSG00000040363 [Q8CGN4-4] ENSMUST00000065143; ENSMUSP00000068618; ENSMUSG00000040363 [Q8CGN4-3] ENSMUST00000115512; ENSMUSP00000111174; ENSMUSG00000040363 [Q8CGN4-2] ENSMUST00000115513; ENSMUSP00000111175; ENSMUSG00000040363 [Q8CGN4-1] ENSMUST00000124033; ENSMUSP00000116258; ENSMUSG00000040363 [Q8CGN4-4]
GeneIDⁱ	71458
KEGGⁱ	mmu:71458
UCSC genome browser More...UCSCⁱ	uc009sqq.2 mouse [Q8CGN4-1] uc009sqr.2 mouse [Q8CGN4-3] uc009sqs.2 mouse [Q8CGN4-2] uc009sqt.2 mouse [Q8CGN4-4]

Organism-specific databases

CTDⁱ	54880
MGIⁱ	MGI:1918708 Bcor
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHDH Eukaryota ENOG410YT00 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119090
HOVERGENⁱ	HBG050682
InParanoidⁱ	Q8CGN4
OMAⁱ	ERVRMCG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R1A
PhylomeDBⁱ	Q8CGN4
TreeFamⁱ	TF333317

Miscellaneous databases

ChiTaRSⁱ	Bcor mouse
Protein Ontology More...PROⁱ	PR:Q8CGN4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000040363
CleanExⁱ	MM_BCOR
ExpressionAtlasⁱ	Q8CGN4 baseline and differential
Genevisibleⁱ	Q8CGN4 MM

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit 3.10.260.40, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR031628 BCOR IPR032365 PUFD IPR038227 PUFD_som_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF15808 BCOR, 1 hit PF16553 PUFD, 1 hit
SMARTⁱ	View protein in SMART SM00248 ANK, 3 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BCOR_MOUSE
Accessionⁱ	Q8CGN4Primary (citable) accession number: Q8CGN4 Secondary accession number(s): B1AXK3 Q8CGN3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
	Last sequence update:	January 4, 2005
	Last modified:	May 23, 2018
	This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

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UniProtKB - Q8CGN4 (BCOR_MOUSE)

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BCL-6 corepressor

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

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Proteomic databases

Protocols and materials databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ