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Entry version 125 (08 May 2019)
Sequence version 2 (11 Jul 2006)
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Protein

Adhesion G protein-coupled receptor B2

Gene

Adgrb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition (PubMed:12218411).By similarity1 Publication

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Receptor activity is regulated by proteolytic processing. The long N-terminal has a an inhibitory effect on the constitutive signaling activity. Removal of the N-terminal region induces an increase of the receptor activity.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPS protease database

More...
MEROPSi
P02.029

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G protein-coupled receptor B2
Alternative name(s):
Brain-specific angiogenesis inhibitor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Adgrb2
Synonyms:Bai2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2451244 Adgrb2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 930ExtracellularCuratedAdd BLAST910
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei931 – 951Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini952 – 959CytoplasmicCurated8
Transmembranei960 – 980Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini981 – 988ExtracellularCurated8
Transmembranei989 – 1009Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini1010 – 1030CytoplasmicCuratedAdd BLAST21
Transmembranei1031 – 1051Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini1052 – 1072ExtracellularCuratedAdd BLAST21
Transmembranei1073 – 1093Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1094 – 1115CytoplasmicCuratedAdd BLAST22
Transmembranei1116 – 1136Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1137 – 1147ExtracellularCuratedAdd BLAST11
Transmembranei1148 – 1168Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1169 – 1561CytoplasmicCuratedAdd BLAST393

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deficient mice show significant resistance to depression after repeated stress in the social defeat test. Additionally, hippocampal cell proliferation in deficient mice is increased.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024561321 – 1561Adhesion G protein-coupled receptor B2Add BLAST1541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi312 ↔ 346PROSITE-ProRule annotation
Disulfide bondi316 ↔ 352PROSITE-ProRule annotation
Disulfide bondi327 ↔ 336PROSITE-ProRule annotation
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi367 ↔ 402PROSITE-ProRule annotation
Disulfide bondi371 ↔ 407PROSITE-ProRule annotation
Disulfide bondi382 ↔ 392PROSITE-ProRule annotation
Disulfide bondi422 ↔ 457PROSITE-ProRule annotation
Disulfide bondi426 ↔ 462PROSITE-ProRule annotation
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi437 ↔ 447PROSITE-ProRule annotation
Disulfide bondi478 ↔ 513PROSITE-ProRule annotation
Disulfide bondi482 ↔ 518PROSITE-ProRule annotation
Disulfide bondi493 ↔ 503PROSITE-ProRule annotation
Disulfide bondi525 ↔ 560PROSITE-ProRule annotation
Disulfide bondi548 ↔ 578PROSITE-ProRule annotation
Glycosylationi551N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi636N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi861N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi868 ↔ 900PROSITE-ProRule annotation
Disulfide bondi888 ↔ 902PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1345PhosphotyrosineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.By similarity
Proteolytic processes at the GPS domain; this cleavage modulates receptor activity. Additionally, furin is involved in the cleavage at another site, in the middle of the extracellular domain, generating a soluble fragment.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei287 – 288Cleavage; by furinBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CGM1

PRoteomics IDEntifications database

More...
PRIDEi
Q8CGM1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CGM1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CGM1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in the brain. The peak level in the brain is observed 10 days after birth.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Ubiquitous in embryonic tissues, but expression is acutely down-regulated after birth, except in the brain, to a level that is maintained throughout adulthood.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated after hypoxia.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028782 Expressed in 143 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8CGM1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8CGM1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Interacts with GABPB2 (PubMed:16412436). Interacts (via carboxy-terminus) with TAX1BP3. Interacts with GNAZ (By similarity). Interacts with SH3GL2 (PubMed:28891236).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
GABPB1Q065473EBI-8014984,EBI-618165From Homo sapiens.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
231022, 2 interactors

Protein interaction database and analysis system

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IntActi
Q8CGM1, 3 interactors

Molecular INTeraction database

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MINTi
Q8CGM1

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000101638

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CGM1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini300 – 353TSP type-1 1PROSITE-ProRule annotationAdd BLAST54
Domaini355 – 408TSP type-1 2PROSITE-ProRule annotationAdd BLAST54
Domaini410 – 463TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini466 – 519TSP type-1 4PROSITE-ProRule annotationAdd BLAST54
Domaini865 – 917GPSPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi117 – 122Poly-Glu6
Compositional biasi123 – 127Poly-Ala5
Compositional biasi180 – 183Poly-Asn4
Compositional biasi1309 – 1312Poly-Pro4
Compositional biasi1358 – 1361Poly-Gly4
Compositional biasi1419 – 1424Poly-Pro6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEA0 Eukaryota
ENOG4111FBM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160103

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CGM1

KEGG Orthology (KO)

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KOi
K04597

Database of Orthologous Groups

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OrthoDBi
27621at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8CGM1

TreeFam database of animal gene trees

More...
TreeFami
TF331634

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 4 hits
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR008077 GPCR_2_brain_angio_inhib
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00090 TSP_1, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01694 BAIPRECURSOR
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00209 TSP1, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895 SSF82895, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50092 TSP1, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CGM1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPACPLLLS VILSLRLATA FDPAPSACSA LASGVLYGAF SLQDLFPTIA
60 70 80 90 100
SGCSWTLENP DPTKYSLYLR FNRQEQVCTH FAPRLLPLDH YLVNFTCLRP
110 120 130 140 150
GPEEATARAE SEVGRPEEEE EEAAAAASGL ELCGGSGPFT FLHFDKNFVQ
160 170 180 190 200
LCLSAEPSEA PRLLAPAALA FRFVEVLLIN NNNSSQFTCG VLCRWSEECG
210 220 230 240 250
RAAGRACGFA QPGCSCPGEA GANPATTTSP GPPVAHTLSN ALVPGGPAPP
260 270 280 290 300
AEADLHSGSS NDLFTTEMRY GEEPEEEPKV KTQWPRSADE PGLYMAQTGD
310 320 330 340 350
PAAEEWSPWS VCSLTCGQGL QVRTRSCVSS PYGTLCSGPL RETRPCNNSA
360 370 380 390 400
TCPVHGVWEE WGSWSLCSRS CGRGSRSRMR TCVPPQHGGK ACEGPELQTK
410 420 430 440 450
LCSMAACPVE GQWLEWGPWG PCSSSCANGT QQRSRKCSVA GPAWATCAGA
460 470 480 490 500
LTDTRECSNL DCPATDGKWG PWNAWSLCSK TCDTGWQRRF RMCQASGTQG
510 520 530 540 550
YPCEGTGEEV KPCSEKRCPA FHEMCRDEYV MLMTWKRAAA GEIIYNKCPP
560 570 580 590 600
NASGSASRRC LLSAQGVAYW GLPSFARCIS HEYRYLYLSL REHLAKGQRM
610 620 630 640 650
LAGEGMSQVV RSLQELLARR TYYSGDLLFS VDILRNVTDT FKRATYVPSA
660 670 680 690 700
DDVQRFFQVV SFMVDSENKD KWDDAQQVSP GSVHLLRVVE DFIHLVGDAL
710 720 730 740 750
KAFQSSLIVT DNLVISIQRE PISAVSSDIT FPMRGRRGMK DWVRHSEDRL
760 770 780 790 800
FLPKEVLSLS SPGKPATPGA ATAGSPGRGR GPGTVPPGPG HAHQRLLPAD
810 820 830 840 850
PEESSSYFVI GAVLYRTLGL ILPPPRPPLA VTSRVMTVTV RPPTQPPAEP
860 870 880 890 900
LITVELSYII NGTTDPHCAS WDYSRADTNS GDWNTESCQT LETQAAHTRC
910 920 930 940 950
QCQHLSTFAV LAQPPKDLTL ELAGAPSVPL VIGCAVSCMA LLTLLAIYAA
960 970 980 990 1000
FWRFIKSERS IILLNFCLSI LASNILILVG QSRVLSKGVC TMTAAFLHFF
1010 1020 1030 1040 1050
FLSSFCWVLT EAWQSYLAVI GRMRTRLVRK RFLCLGWGLP ALVVAVSVGF
1060 1070 1080 1090 1100
TRTKGYGTSS YCWLSLEGGL LYAFVGPAAV IVLVNMLIGI IVFNKLMARD
1110 1120 1130 1140 1150
GVSDKSKKQR AGSERCPWAS LLLPCSACGA VPSPLLSSAS ARNAMASLWS
1160 1170 1180 1190 1200
SCVVLPLLAL TWMSAVLAMT DRRSVLFQAL FAVFNSAQGF VITAVHCFLR
1210 1220 1230 1240 1250
REVQDVVKCQ MGVCRADESE DSPDSCKNGQ LQILSDFEKD VDLACQTVLF
1260 1270 1280 1290 1300
KEVNTCNPST ITGTLSRLSL DEDEEPKSCL VGPEGGLSFS PLPGNILVPM
1310 1320 1330 1340 1350
AASPGLGEPP PPQETNPVYM CGEGGLRQLD LTWIRQSEPG SEGDYMVLPR
1360 1370 1380 1390 1400
RTLSLQPGGG GTAGEEAPRA RPEGTPRRAA KTVAHTEGYP SFLSVEHSGL
1410 1420 1430 1440 1450
GLGPAYGSLQ NPYGMTFQPP PPTPSARQVP EPGERSRTMP RTVPGSTMKL
1460 1470 1480 1490 1500
GSLERKKLRY SDLDFEKVMH TRKRHSELYH ELNQKFHTFD RYRSQSSAKE
1510 1520 1530 1540 1550
KPSPPGGRPG LSQHRRHQSW STFKSMTLGS LPPKPRERLA LHRTAAWEPT
1560
EPPDGDFQTE V
Length:1,561
Mass (Da):169,863
Last modified:July 11, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B3EB731F619CBA3
GO
Isoform 2 (identifier: Q8CGM1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-353: Missing.

Show »
Length:1,506
Mass (Da):164,063
Checksum:i6164F02425F64DC1
GO
Isoform 3 (identifier: Q8CGM1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1113-1145: SERCPWASLLLPCSACGAVPSPLLSSASARNAM → RLSWNLWGYGSQLCLFPKLPR

Show »
Length:1,549
Mass (Da):169,051
Checksum:i7051D25C930EA7C5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ASC0B1ASC0_MOUSE
Adhesion G protein-coupled receptor...
Adgrb2
1,473Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BWZ2H7BWZ2_MOUSE
Adhesion G protein-coupled receptor...
Adgrb2
1,577Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BX74H7BX74_MOUSE
Adhesion G protein-coupled receptor...
Adgrb2
1,544Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BX92H7BX92_MOUSE
Adhesion G protein-coupled receptor...
Adgrb2
1,489Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti116P → L in AAN86965 (PubMed:12218411).Curated1
Sequence conflicti122Missing in AAN86965 (PubMed:12218411).Curated1
Sequence conflicti386Q → K in AAN86965 (PubMed:12218411).Curated1
Sequence conflicti526R → G in BAE34635 (PubMed:16141072).Curated1
Sequence conflicti674D → G in BAE34635 (PubMed:16141072).Curated1
Sequence conflicti1179A → V in BAE34635 (PubMed:16141072).Curated1
Sequence conflicti1316N → D in BAE25937 (PubMed:16141072).Curated1
Sequence conflicti1467Missing in BAE25937 (PubMed:16141072).Curated1
Sequence conflicti1467Missing in BAE25805 (PubMed:16141072).Curated1
Sequence conflicti1550T → P in AAN86965 (PubMed:12218411).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019762299 – 353Missing in isoform 2. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_0197631113 – 1145SERCP…ARNAM → RLSWNLWGYGSQLCLFPKLP R in isoform 3. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY168407 mRNA Translation: AAN86965.1
AK144268 mRNA Translation: BAE25805.1
AK144559 mRNA Translation: BAE25937.1
AK158735 mRNA Translation: BAE34635.1
AL626774 Genomic DNA No translation available.
BC056926 mRNA Translation: AAH56926.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51309.1 [Q8CGM1-3]
CCDS57300.1 [Q8CGM1-2]
CCDS80164.1 [Q8CGM1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001186625.1, NM_001199696.1 [Q8CGM1-2]
NP_001277643.1, NM_001290714.1
NP_001277644.1, NM_001290715.1 [Q8CGM1-1]
NP_775094.2, NM_173071.3 [Q8CGM1-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000106015; ENSMUSP00000101636; ENSMUSG00000028782 [Q8CGM1-1]
ENSMUST00000106017; ENSMUSP00000101638; ENSMUSG00000028782 [Q8CGM1-3]
ENSMUST00000121049; ENSMUSP00000112869; ENSMUSG00000028782 [Q8CGM1-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
230775

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:230775

UCSC genome browser

More...
UCSCi
uc008uym.3 mouse [Q8CGM1-3]
uc008uyn.3 mouse [Q8CGM1-2]
uc008uyp.1 mouse [Q8CGM1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY168407 mRNA Translation: AAN86965.1
AK144268 mRNA Translation: BAE25805.1
AK144559 mRNA Translation: BAE25937.1
AK158735 mRNA Translation: BAE34635.1
AL626774 Genomic DNA No translation available.
BC056926 mRNA Translation: AAH56926.1
CCDSiCCDS51309.1 [Q8CGM1-3]
CCDS57300.1 [Q8CGM1-2]
CCDS80164.1 [Q8CGM1-1]
RefSeqiNP_001186625.1, NM_001199696.1 [Q8CGM1-2]
NP_001277643.1, NM_001290714.1
NP_001277644.1, NM_001290715.1 [Q8CGM1-1]
NP_775094.2, NM_173071.3 [Q8CGM1-3]

3D structure databases

SMRiQ8CGM1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231022, 2 interactors
IntActiQ8CGM1, 3 interactors
MINTiQ8CGM1
STRINGi10090.ENSMUSP00000101638

Protein family/group databases

MEROPSiP02.029

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiQ8CGM1
PhosphoSitePlusiQ8CGM1

Proteomic databases

PaxDbiQ8CGM1
PRIDEiQ8CGM1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106015; ENSMUSP00000101636; ENSMUSG00000028782 [Q8CGM1-1]
ENSMUST00000106017; ENSMUSP00000101638; ENSMUSG00000028782 [Q8CGM1-3]
ENSMUST00000121049; ENSMUSP00000112869; ENSMUSG00000028782 [Q8CGM1-2]
GeneIDi230775
KEGGimmu:230775
UCSCiuc008uym.3 mouse [Q8CGM1-3]
uc008uyn.3 mouse [Q8CGM1-2]
uc008uyp.1 mouse [Q8CGM1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
576
MGIiMGI:2451244 Adgrb2

Phylogenomic databases

eggNOGiENOG410IEA0 Eukaryota
ENOG4111FBM LUCA
GeneTreeiENSGT00940000160103
InParanoidiQ8CGM1
KOiK04597
OrthoDBi27621at2759
PhylomeDBiQ8CGM1
TreeFamiTF331634

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Adgrb2 mouse

Protein Ontology

More...
PROi
PR:Q8CGM1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028782 Expressed in 143 organ(s), highest expression level in brain
ExpressionAtlasiQ8CGM1 baseline and differential
GenevisibleiQ8CGM1 MM

Family and domain databases

Gene3Di2.20.100.10, 4 hits
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR008077 GPCR_2_brain_angio_inhib
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00090 TSP_1, 4 hits
PRINTSiPR01694 BAIPRECURSOR
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00209 TSP1, 4 hits
SUPFAMiSSF82895 SSF82895, 4 hits
PROSITEiView protein in PROSITE
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50092 TSP1, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRB2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CGM1
Secondary accession number(s): B1ASB7
, B1ASB8, B2FDE3, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: May 8, 2019
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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