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Protein

Guanine nucleotide-binding protein G(olf) subunit alpha

Gene

Gnal

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi56MagnesiumBy similarity1
Metal bindingi191MagnesiumBy similarity1
Binding sitei353GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 56GTPBy similarity8
Nucleotide bindingi185 – 191GTPBy similarity7
Nucleotide bindingi210 – 214GTPBy similarity5
Nucleotide bindingi279 – 282GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-170660 Adenylate cyclase activating pathway
R-MMU-170670 Adenylate cyclase inhibitory pathway
R-MMU-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(olf) subunit alpha
Alternative name(s):
Adenylate cyclase-stimulating G alpha protein, olfactory type
Gene namesi
Name:Gnal
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:95774 Gnal

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002037332 – 381Guanine nucleotide-binding protein G(olf) subunit alphaAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-palmitoyl glycineBy similarity1
Lipidationi3S-palmitoyl cysteineBy similarity1
Modified residuei178PhosphothreonineCombined sources1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ8CGK7
PaxDbiQ8CGK7
PRIDEiQ8CGK7

PTM databases

iPTMnetiQ8CGK7
PhosphoSitePlusiQ8CGK7
SwissPalmiQ8CGK7

Expressioni

Gene expression databases

BgeeiENSMUSG00000024524 Expressed in 151 organ(s), highest expression level in olfactory epithelium
ExpressionAtlasiQ8CGK7 baseline and differential
GenevisibleiQ8CGK7 MM

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199969, 1 interactor
STRINGi10090.ENSMUSP00000025402

Structurei

3D structure databases

ProteinModelPortaliQ8CGK7
SMRiQ8CGK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family. G(s) subfamily.Curated

Phylogenomic databases

eggNOGiKOG0099 Eukaryota
ENOG410XPC4 LUCA
GeneTreeiENSGT00910000144108
HOGENOMiHOG000038729
HOVERGENiHBG063184
InParanoidiQ8CGK7
KOiK04633
OMAiIDYTPTD
PhylomeDBiQ8CGK7

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR000367 Gprotein_alpha_S
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00443 GPROTEINAS
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8CGK7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCLGNSSKT AEDQGVDEKE RREANKKIEK QLQKERLAYK ATHRLLLLGA
60 70 80 90 100
GESGKSTIVK QMRILHVNGF NPEEKKQKIL DIRKNVKDAI VTIVSAMSTI
110 120 130 140 150
IPPVPLANPE NQFRSDYIKS IAPITDFEYS QEFFDHVKKL WDDEGVKACF
160 170 180 190 200
ERSNEYQLID CAQYFLERID SVSLVDYTPT DQDLLRCRVL TSGIFETRFQ
210 220 230 240 250
VDKVNFHMFD VGGQRDERRK WIQCFNDVTA IIYVAACSSY NMVIREDNNT
260 270 280 290 300
NRLRESLDLF ESIWNNRWLR TISIILFLNK QDMLAEKVLA GKSKIEDYFP
310 320 330 340 350
EYANYTVPED ATPDAGEDPK VTRAKFFIRD LFLRISTATG DGKHYCYPHF
360 370 380
TCAVDTENIR RVFNDCRDII QRMHLKQYEL L
Length:381
Mass (Da):44,308
Last modified:March 1, 2003 - v1
Checksum:iF707E668EC279033
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q66L47Q66L47_MOUSE
Guanine nucleotide binding protein,...
Gnal
448Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY179169 mRNA Translation: AAO03564.1
U38503 mRNA Translation: AAB01734.1
M57635 mRNA Translation: AAA63300.1
CCDSiCCDS29318.1
PIRiA33833
RefSeqiNP_034437.1, NM_010307.3
UniGeneiMm.440746

Genome annotation databases

EnsembliENSMUST00000076605; ENSMUSP00000075908; ENSMUSG00000024524
GeneIDi14680
KEGGimmu:14680
UCSCiuc008flt.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY179169 mRNA Translation: AAO03564.1
U38503 mRNA Translation: AAB01734.1
M57635 mRNA Translation: AAA63300.1
CCDSiCCDS29318.1
PIRiA33833
RefSeqiNP_034437.1, NM_010307.3
UniGeneiMm.440746

3D structure databases

ProteinModelPortaliQ8CGK7
SMRiQ8CGK7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199969, 1 interactor
STRINGi10090.ENSMUSP00000025402

PTM databases

iPTMnetiQ8CGK7
PhosphoSitePlusiQ8CGK7
SwissPalmiQ8CGK7

Proteomic databases

MaxQBiQ8CGK7
PaxDbiQ8CGK7
PRIDEiQ8CGK7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076605; ENSMUSP00000075908; ENSMUSG00000024524
GeneIDi14680
KEGGimmu:14680
UCSCiuc008flt.2 mouse

Organism-specific databases

CTDi2774
MGIiMGI:95774 Gnal

Phylogenomic databases

eggNOGiKOG0099 Eukaryota
ENOG410XPC4 LUCA
GeneTreeiENSGT00910000144108
HOGENOMiHOG000038729
HOVERGENiHBG063184
InParanoidiQ8CGK7
KOiK04633
OMAiIDYTPTD
PhylomeDBiQ8CGK7

Enzyme and pathway databases

ReactomeiR-MMU-170660 Adenylate cyclase activating pathway
R-MMU-170670 Adenylate cyclase inhibitory pathway
R-MMU-381753 Olfactory Signaling Pathway

Miscellaneous databases

ChiTaRSiGnal mouse
PROiPR:Q8CGK7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024524 Expressed in 151 organ(s), highest expression level in olfactory epithelium
ExpressionAtlasiQ8CGK7 baseline and differential
GenevisibleiQ8CGK7 MM

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR000367 Gprotein_alpha_S
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00443 GPROTEINAS
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGNAL_MOUSE
AccessioniPrimary (citable) accession number: Q8CGK7
Secondary accession number(s): Q61020, Q61589
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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