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Protein

Interferon lambda receptor 1

Gene

Ifnlr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.2 Publications

GO - Molecular functioni

GO - Biological processi

  • cytokine-mediated signaling pathway Source: GO_Central
  • defense response to virus Source: UniProtKB
  • mucosal immune response Source: UniProtKB
  • regulation of defense response to virus by host Source: MGI
  • response to type III interferon Source: UniProtKB

Keywordsi

Molecular functionReceptor
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-MMU-8854691 Interleukin-20 family signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon lambda receptor 1
Short name:
IFN-lambda R1
Alternative name(s):
Cytokine receptor class-II member 12
Cytokine receptor family 2 member 12
Short name:
CRF2-12
Interleukin-28 receptor subunit alpha
Short name:
IL-28 receptor subunit alpha
Short name:
IL-28R-alpha
Short name:
IL-28RA
Gene namesi
Name:Ifnlr1
Synonyms:Il28ra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2429859 Ifnlr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 227ExtracellularSequence analysisAdd BLAST207
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 535CytoplasmicSequence analysisAdd BLAST287

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

The mice are viable and appear to be of normal size, behavior and reproductive ability. There is no effect on the ability to combat vaginal viral infection, but antiviral response evoked by Toll-like reseptor (TLR) stimulation is reduced. Mice also display enhanced rotavirus susceptibility associated with epithelial vacuolization, villus deformation and epithelial cell disruption.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001102021 – 535Interferon lambda receptor 1Add BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi73 ↔ 81By similarity
Disulfide bondi85 ↔ 149By similarity
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi194 ↔ 216By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8CGK5
PRIDEiQ8CGK5

PTM databases

iPTMnetiQ8CGK5
PhosphoSitePlusiQ8CGK5

Expressioni

Gene expression databases

BgeeiENSMUSG00000062157
CleanExiMM_IL28RA
ExpressionAtlasiQ8CGK5 baseline and differential
GenevisibleiQ8CGK5 MM

Interactioni

Subunit structurei

Heterodimer with IL10RB.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074009

Structurei

3D structure databases

ProteinModelPortaliQ8CGK5
SMRiQ8CGK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 121Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJDQ Eukaryota
ENOG410YYBX LUCA
GeneTreeiENSGT00510000048978
HOGENOMiHOG000112989
HOVERGENiHBG052069
InParanoidiQ8CGK5
KOiK05140
OMAiLTFCWDS
OrthoDBiEOG091G0633
PhylomeDBiQ8CGK5
TreeFamiTF336003

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF01108 Tissue_fac, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CGK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRADRWAPL LLFLLQSALG RPRLAPPRNV TLFSQNFTVY LTWLPGLGSP
60 70 80 90 100
PNVTYFVTYQ SYIKTGWRPV EHCAGIKALV CPLMCLKKLN LYSKFKGRVQ
110 120 130 140 150
AASAHGRSPR VESRYLEYLF DVELAPPTLV LTQMEKILRV NATYQLPPCM
160 170 180 190 200
PSLELKYQVE FWKEGLGSKT LFPDTPYGQP VQIPLQQGAS RRHCLSARTV
210 220 230 240 250
YTLIDIKYSQ FSEPSCIFLE APGDKRAVLA MPSLLLLLIA AVAAGVAWKI
260 270 280 290 300
MKGNPWFQGV KTPRALDFSE YRYPVATFQP SGPEFSDDLI LCPQKELTIR
310 320 330 340 350
NRPAPQVRNP ATLQAGPERD STEDEDEDTD YDDDGDSVQP YLERPLFISE
360 370 380 390 400
KPRVMEHSET DESGVDSGGP WTSPVGSDGS SAWDSSDRSW SSTGDSSYKD
410 420 430 440 450
EVGSSSCLDR KEPDQAPCGD WLQEALPCLE FSEDLGTVEE PLKDGLSGWR
460 470 480 490 500
ISGSLSSKRD LAPVEPPVSL QTLTFCWVNN PEGEEEQEDE EEEEEEEEEE
510 520 530
DWESEPKGSN AGCWGTSSVQ RTEVRGRMLG DYLVR
Length:535
Mass (Da):59,976
Last modified:March 1, 2003 - v1
Checksum:i32D12FA52B0BA17E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105H → Q in AAH57856 (PubMed:15489334).Curated1
Sequence conflicti231M → L in AAH57856 (PubMed:15489334).Curated1
Sequence conflicti327E → G in AAH57856 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY184376 mRNA Translation: AAN86129.1
BC057856 mRNA Translation: AAH57856.1
CCDSiCCDS18788.1
RefSeqiNP_777276.3, NM_174851.3
UniGeneiMm.259623

Genome annotation databases

EnsembliENSMUST00000074408; ENSMUSP00000074009; ENSMUSG00000062157
GeneIDi242700
KEGGimmu:242700
UCSCiuc008vgw.2 mouse

Similar proteinsi

Entry informationi

Entry nameiINLR1_MOUSE
AccessioniPrimary (citable) accession number: Q8CGK5
Secondary accession number(s): Q6PEV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: February 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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