Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

WD repeat-containing protein 47

Gene

Wdr47

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 47
Alternative name(s):
Neuronal enriched MAP interacting protein
Short name:
Nemitin
Gene namesi
Name:Wdr47
Synonyms:Kiaa0893
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2139593 Wdr47

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513981 – 920WD repeat-containing protein 47Add BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei285PhosphothreonineCombined sources1
Modified residuei289PhosphoserineCombined sources1
Modified residuei292PhosphoserineCombined sources1
Modified residuei297PhosphoserineBy similarity1
Modified residuei312PhosphoserineBy similarity1
Modified residuei423PhosphoserineBy similarity1
Modified residuei543PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CGF6
MaxQBiQ8CGF6
PaxDbiQ8CGF6
PeptideAtlasiQ8CGF6
PRIDEiQ8CGF6

PTM databases

iPTMnetiQ8CGF6
PhosphoSitePlusiQ8CGF6

Expressioni

Tissue specificityi

Enriched in the nervous system (at protein level).1 Publication

Developmental stagei

First detected in whole embryos at E11, strong and increasing protein levels are observed in the brain from E14 to early postnatal development. Expression continues into adulthood, though at a substantially decreased level.1 Publication

Gene expression databases

BgeeiENSMUSG00000040389 Expressed in 237 organ(s), highest expression level in retina
CleanExiMM_WDR47
ExpressionAtlasiQ8CGF6 baseline and differential
GenevisibleiQ8CGF6 MM

Interactioni

Subunit structurei

Interacts with MAP1S (via WD repeats).1 Publication

Protein-protein interaction databases

BioGridi221273, 3 interactors
DIPiDIP-58945N
IntActiQ8CGF6, 6 interactors
MINTiQ8CGF6
STRINGi10090.ENSMUSP00000057482

Structurei

3D structure databases

ProteinModelPortaliQ8CGF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 42LisHPROSITE-ProRule annotationAdd BLAST33
Domaini45 – 102CTLHPROSITE-ProRule annotationAdd BLAST58
Repeati605 – 644WD 1Add BLAST40
Repeati660 – 699WD 2Add BLAST40
Repeati707 – 749WD 3Add BLAST43
Repeati754 – 792WD 4Add BLAST39
Repeati799 – 838WD 5Add BLAST40
Repeati841 – 880WD 6Add BLAST40
Repeati887 – 919WD 7Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi426 – 475Gln-richAdd BLAST50

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0641 Eukaryota
ENOG410YF9K LUCA
GeneTreeiENSGT00760000119239
HOGENOMiHOG000231412
HOVERGENiHBG058798
InParanoidiQ8CGF6
OMAiSQQCNGS
OrthoDBiEOG091G08TY
TreeFamiTF312810

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR006595 CTLH_C
IPR006594 LisH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR040067 WDR47
PANTHERiPTHR19863 PTHR19863, 1 hit
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00668 CTLH, 1 hit
SM00667 LisH, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8CGF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAEETVNVK EVEIIKLILD FLNSKKLHIS MLALEKESGV INGLFSDDML
60 70 80 90 100
FLRQLILDGQ WDEVLQFIQP LECMEKFDKK RFRYIILKQK FLEALCVNNA
110 120 130 140 150
MSAEDEPQHL EFTMQEAVQC LHALEEYCPS KDDYSKLCLL LTLPRLTNHA
160 170 180 190 200
EFKDWNPSTA RVHCFEEVCV MVAEFIPADR KLSEAGFKAS NNRLFQLVMK
210 220 230 240 250
GLLYECCVEF CQSKATGEEI TESEVLLGID LLCGNGCDDL DLSLLSWLQN
260 270 280 290 300
LPSSVFSCAF EQKMLNIHVD KLLKPTKAAY ADLLTPLISK LSPYPSSPMR
310 320 330 340 350
RPQSADAYMT RSLNPALDGL TCGLTSHDKR ISDLGNKTSP MSHSFANFHY
360 370 380 390 400
PGVQNLSRSL MLENTECHSI YEESPERSDT PVEAQQPVSS EAMCQGSGLE
410 420 430 440 450
KEPANGAQNP VPAKQEKNEL RDSTEQFQEY YRQRLRYQQH LEQKEQQRQM
460 470 480 490 500
YQQMLLEGGV NQEDGPDQQQ NLTEQFLNRS IQKLGELNIG MDSLGNEVPV
510 520 530 540 550
LNQQCSGSKN NGSNNSSVTS FSTPPQDSSQ RLIHDTANIH TSTPRNPGST
560 570 580 590 600
NHIPFHEDSP CGSQNSSEHS VIKPSPGDSS GNLSRSKGEE DDKSKKQFVC
610 620 630 640 650
INTLEDTQAV RAVAFHPSGS LYAVGSNSKT LRVCAYPEKM DASAHDNPKQ
660 670 680 690 700
PVVRFKRNKH HKGSIYCVAW SPCGQLLATG SNDKYVKVLP FNAETCNATG
710 720 730 740 750
PDLEFSMHDG TIRDLAFMEG PESGGAILIS AGAGDCNIYT TDCQRGQGLH
760 770 780 790 800
ALSGHTGHIL ALYTWSGWMI ASGSQDKTVR FWDLRVPSCV RVVGTTFHGT
810 820 830 840 850
GSAVASVAVD PSGRLLATGQ EDSSCMLYDI RGGRMVQSYH PHSSDVRSVR
860 870 880 890 900
FSPGAHYLLT GSYDMKIKVT DLQGDLTKQL PLMVVGEHKD KVIQCRWHTQ
910 920
DLSFLSSSAD RTVTLWTYSG
Length:920
Mass (Da):102,312
Last modified:July 27, 2011 - v2
Checksum:i401F22FFC00951AA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JFW8A0A0G2JFW8_MOUSE
WD repeat-containing protein 47
Wdr47
53Annotation score:

Sequence cautioni

The sequence BAC65679 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti450M → I in AAH40337 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122397 mRNA Translation: BAC65679.1 Different initiation.
AL683823 Genomic DNA Translation: CAM14496.1
CH466607 Genomic DNA Translation: EDL01977.1
BC040337 mRNA Translation: AAH40337.1
CCDSiCCDS17765.1
RefSeqiNP_852065.2, NM_181400.3
XP_017175308.1, XM_017319819.1
UniGeneiMm.285968

Genome annotation databases

EnsembliENSMUST00000051145; ENSMUSP00000057482; ENSMUSG00000040389
GeneIDi99512
KEGGimmu:99512
UCSCiuc008qzj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122397 mRNA Translation: BAC65679.1 Different initiation.
AL683823 Genomic DNA Translation: CAM14496.1
CH466607 Genomic DNA Translation: EDL01977.1
BC040337 mRNA Translation: AAH40337.1
CCDSiCCDS17765.1
RefSeqiNP_852065.2, NM_181400.3
XP_017175308.1, XM_017319819.1
UniGeneiMm.285968

3D structure databases

ProteinModelPortaliQ8CGF6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221273, 3 interactors
DIPiDIP-58945N
IntActiQ8CGF6, 6 interactors
MINTiQ8CGF6
STRINGi10090.ENSMUSP00000057482

PTM databases

iPTMnetiQ8CGF6
PhosphoSitePlusiQ8CGF6

Proteomic databases

EPDiQ8CGF6
MaxQBiQ8CGF6
PaxDbiQ8CGF6
PeptideAtlasiQ8CGF6
PRIDEiQ8CGF6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051145; ENSMUSP00000057482; ENSMUSG00000040389
GeneIDi99512
KEGGimmu:99512
UCSCiuc008qzj.2 mouse

Organism-specific databases

CTDi22911
MGIiMGI:2139593 Wdr47
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0641 Eukaryota
ENOG410YF9K LUCA
GeneTreeiENSGT00760000119239
HOGENOMiHOG000231412
HOVERGENiHBG058798
InParanoidiQ8CGF6
OMAiSQQCNGS
OrthoDBiEOG091G08TY
TreeFamiTF312810

Miscellaneous databases

ChiTaRSiWdr47 mouse
PROiPR:Q8CGF6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040389 Expressed in 237 organ(s), highest expression level in retina
CleanExiMM_WDR47
ExpressionAtlasiQ8CGF6 baseline and differential
GenevisibleiQ8CGF6 MM

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR006595 CTLH_C
IPR006594 LisH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR040067 WDR47
PANTHERiPTHR19863 PTHR19863, 1 hit
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00668 CTLH, 1 hit
SM00667 LisH, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR47_MOUSE
AccessioniPrimary (citable) accession number: Q8CGF6
Secondary accession number(s): A2AGC7, Q80TP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again