UniProtKB - Q8CGE9 (RGS12_MOUSE)

BLAST

>sp|Q8CGE9|RGS12_MOUSE Regulator of G-protein signaling 12 OS=Mus musculus OX=10090 GN=Rgs12 PE=1 SV=2
MYRAGEPGKRQPGPAPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRAG
DQILAINEINVKKASHEDVVKLIGKCSGVLHMVIAEGTSHVESCSSDEEGGLYEGKGWLR
PKLDSKALGINRAERVVEEVQSGGIFNMIFESSSLCASGPEPLKLKQRSLSESAALRLDA
GQAGLCAPHPSMLSKEDISKVINDDSVFTVGLDSHDDFGLDASILNVAMVVGYLGSIELP
STSSNLEHDSLQAIRGCMRRLRAEQKIHSLVTMKVMHDCVQLVTDRAGVVAEYPAEKLAF
SAVCPDDRRFFGLVTMQTNDDGGLAQEDEGALRTSCHVFMVDPDLFHHKIHQGIARRFGF
ACTADPDTSGCLEFPASSLPVLQFISVLYRDMGELIEGVRARAFLDGDADAHQNNSTSSN
SDSGIGNFNQEEKSNRVLVVDLGGGSSRHGQGSSPGWESGGGRGSQPWSAPWNGAFCHDS
EAGSPLETSPNTDRFWDLTKHSGPVSHMEVPPATLRSSIPPSKRGAAGSSCGFNQRWLPV
HVLQEWQCGHASDQESYTDSTDGWSSVNCGTLPPPMSKIPADRYRVEGSFAQAPLSTQKR
DWSRKAFGMQNLFGPHRNVRKTKEDKKSSKLGRGVALAQTSQRTSARRSFGRSRRFSITR
SLDDLESATVSDGELTGADLKDCISNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLL
QDPVGVRYFSDFLRKEFSEENILFWQACECFSHVPAHDKKELSYRAREIFSKFLCSKATT
PVNIDSQAQLADDILNAPHPDMFKEQQLQIFNLMKFDSYTRFLKSQLYQECVLAEVEGRT
LPDSQQVPSSPASKHSISSDHSNVSTPKKLSGKSKSGRSLNEDVGEEDSEKKRRGAFFSW
SRSRSTGRSQKKKDHGDHAHDAPHANGGLCRRESQGSVSSAGSLDLSEACRTSALEKDKA
AKHCCVHLPDGTSCVVAVKSGFSIKEILSGLCERHGINGAAVDLFLVGGDKPLVLHQDSS
ILATRDLRLEKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLDLGSLLVRLSG
EKEPLDLGAPISSLDGQRVILEERDPSRGKVSTDKQKGAPVKQNSAVNSSPRNHLAMGEE
RTLGKSNSIKIRGENGKSARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSN
RADDQRGLLRKEDLVLPEFLRLPAGSSELALSSPPPVKGYSKRAVTGHGQEGAAQTEESY
SDSPATSPASAQSPCSAYSPGSAHSPGSAHSTPGPPGTTQPGEKPTKPSCVSMVQEGTTQ
AWRRLSPEMEAGGIQTVEDEQVADLTLMGEGDISSPNSTLLPPPPTPQDTPGPPRPGTSR
F

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History
Entry version 132 (07 Nov 2018)
Sequence version 2 (27 Jul 2011)
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Protein

Regulator of G-protein signaling 12

Gene

Rgs12

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.By similarity

GO - Molecular functionⁱ

G-protein alpha-subunit binding Source: MGI
GTPase activator activity Source: MGI
GTPase regulator activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

signal transduction Source: InterPro
termination of G protein-coupled receptor signaling pathway Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation

Molecular function

GTPase activation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Regulator of G-protein signaling 12 Short name: RGS12
Gene namesⁱ	Name:Rgs12
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:1918979 Rgs12

Keywords - Cellular componentⁱ

Cell junction, Cell projection, Cytoplasm, Nucleus, Synapse

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000408474	1 – 1381	Regulator of G-protein signaling 12Add BLAST		1381

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	171	PhosphoserineCombined sources	1
Modified residueⁱ	194	PhosphoserineCombined sources	1
Cross-linkⁱ	195	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	524	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	633	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	661	PhosphoserineCombined sources	1
Modified residueⁱ	671	PhosphoserineCombined sources	1
Modified residueⁱ	850	PhosphoserineCombined sources	1
Modified residueⁱ	879	PhosphoserineCombined sources	1
Modified residueⁱ	943	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8CGE9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8CGE9
PaxDbⁱ	Q8CGE9
PRIDEⁱ	Q8CGE9

PTM databases

iPTMnetⁱ	Q8CGE9
PhosphoSitePlusⁱ	Q8CGE9

Expressionⁱ

Tissue specificityⁱ

Expressed in brain.1 Publication

Developmental stageⁱ

Expressed in germinal vesicle oocyte, metaphase II oocyte and blastocyst (at protein level). Expressed in oocyte.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000029101 Expressed in 201 organ(s), highest expression level in ear
ExpressionAtlasⁱ	Q8CGE9 baseline and differential
Genevisibleⁱ	Q8CGE9 MM

Interactionⁱ

Subunit structureⁱ

Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
BRAF	P15056	2	EBI-7340552,EBI-365980	From Homo sapiens.
Map2k2	Q63932	3	EBI-7340552,EBI-397724

GO - Molecular functionⁱ

G-protein alpha-subunit binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	Q8CGE9, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q8CGE9
STRINGⁱ	10090.ENSMUSP00000030984

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8CGE9
SMRⁱ	Q8CGE9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	21 – 98	PDZPROSITE-ProRule annotationAdd BLAST	78
Domainⁱ	223 – 390	PIDPROSITE-ProRule annotationAdd BLAST	168
Domainⁱ	715 – 832	RGSPROSITE-ProRule annotationAdd BLAST	118
Domainⁱ	962 – 1032	RBD 1PROSITE-ProRule annotationAdd BLAST	71
Domainⁱ	1034 – 1104	RBD 2PROSITE-ProRule annotationAdd BLAST	71
Domainⁱ	1187 – 1209	GoLocoPROSITE-ProRule annotationAdd BLAST	23

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	1362 – 1367	Poly-Pro		6

Domainⁱ

The GoLoco domain is necessary for interaction with GNAI1, GNAI2 and GNAI3.By similarity

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119142
HOGENOMⁱ	HOG000049112
HOVERGENⁱ	HBG063299
InParanoidⁱ	Q8CGE9
KEGG Orthology (KO) More...KOⁱ	K16449
OMAⁱ	SAPHPDM
TreeFamⁱ	TF328814

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08742 RGS_RGS12, 1 hit
Gene3Dⁱ	1.10.196.10, 1 hit 2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR003109 GoLoco_motif IPR001478 PDZ IPR036034 PDZ_sf IPR011993 PH-like_dom_sf IPR006020 PTB/PI_dom IPR003116 RBD_dom IPR016137 RGS IPR037880 RGS12_RGS IPR036305 RGS_sf IPR024066 RGS_subdom1/3 IPR029071 Ubiquitin-like_domsf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02188 GoLoco, 1 hit PF00595 PDZ, 1 hit PF02196 RBD, 2 hits PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00390 GoLoco, 1 hit SM00228 PDZ, 1 hit SM00462 PTB, 1 hit SM00455 RBD, 2 hits SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit SSF50156 SSF50156, 1 hit SSF54236 SSF54236, 2 hits
PROSITEⁱ	View protein in PROSITE PS50877 GOLOCO, 1 hit PS50106 PDZ, 1 hit PS01179 PID, 1 hit PS50898 RBD, 2 hits PS50132 RGS, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show all Align All

Q8CGE9-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MYRAGEPGKR QPGPAPPRVR SVEVARGRAG YGFTLSGQAP CVLSCVMRGS 
        60         70         80         90        100
PADFVGLRAG DQILAINEIN VKKASHEDVV KLIGKCSGVL HMVIAEGTSH 
       110        120        130        140        150
VESCSSDEEG GLYEGKGWLR PKLDSKALGI NRAERVVEEV QSGGIFNMIF 
       160        170        180        190        200
ESSSLCASGP EPLKLKQRSL SESAALRLDA GQAGLCAPHP SMLSKEDISK 
       210        220        230        240        250
VINDDSVFTV GLDSHDDFGL DASILNVAMV VGYLGSIELP STSSNLEHDS 
       260        270        280        290        300
LQAIRGCMRR LRAEQKIHSL VTMKVMHDCV QLVTDRAGVV AEYPAEKLAF 
       310        320        330        340        350
SAVCPDDRRF FGLVTMQTND DGGLAQEDEG ALRTSCHVFM VDPDLFHHKI 
       360        370        380        390        400
HQGIARRFGF ACTADPDTSG CLEFPASSLP VLQFISVLYR DMGELIEGVR 
       410        420        430        440        450
ARAFLDGDAD AHQNNSTSSN SDSGIGNFNQ EEKSNRVLVV DLGGGSSRHG 
       460        470        480        490        500
QGSSPGWESG GGRGSQPWSA PWNGAFCHDS EAGSPLETSP NTDRFWDLTK 
       510        520        530        540        550
HSGPVSHMEV PPATLRSSIP PSKRGAAGSS CGFNQRWLPV HVLQEWQCGH 
       560        570        580        590        600
ASDQESYTDS TDGWSSVNCG TLPPPMSKIP ADRYRVEGSF AQAPLSTQKR 
       610        620        630        640        650
DWSRKAFGMQ NLFGPHRNVR KTKEDKKSSK LGRGVALAQT SQRTSARRSF 
       660        670        680        690        700
GRSRRFSITR SLDDLESATV SDGELTGADL KDCISNNSLS SNASLPSVQS 
       710        720        730        740        750
CRRLRERRVA SWAVSFERLL QDPVGVRYFS DFLRKEFSEE NILFWQACEC 
       760        770        780        790        800
FSHVPAHDKK ELSYRAREIF SKFLCSKATT PVNIDSQAQL ADDILNAPHP 
       810        820        830        840        850
DMFKEQQLQI FNLMKFDSYT RFLKSQLYQE CVLAEVEGRT LPDSQQVPSS 
       860        870        880        890        900
PASKHSISSD HSNVSTPKKL SGKSKSGRSL NEDVGEEDSE KKRRGAFFSW 
       910        920        930        940        950
SRSRSTGRSQ KKKDHGDHAH DAPHANGGLC RRESQGSVSS AGSLDLSEAC 
       960        970        980        990       1000
RTSALEKDKA AKHCCVHLPD GTSCVVAVKS GFSIKEILSG LCERHGINGA 
      1010       1020       1030       1040       1050
AVDLFLVGGD KPLVLHQDSS ILATRDLRLE KRTLFRLDLV PINRSVGLKA 
      1060       1070       1080       1090       1100
KPTKPVTEVL RPVVAKYGLD LGSLLVRLSG EKEPLDLGAP ISSLDGQRVI 
      1110       1120       1130       1140       1150
LEERDPSRGK VSTDKQKGAP VKQNSAVNSS PRNHLAMGEE RTLGKSNSIK 
      1160       1170       1180       1190       1200
IRGENGKSAR DPRLSKREES IAKIGKKKYQ KINLDEAEEF FELISKAQSN 
      1210       1220       1230       1240       1250
RADDQRGLLR KEDLVLPEFL RLPAGSSELA LSSPPPVKGY SKRAVTGHGQ 
      1260       1270       1280       1290       1300
EGAAQTEESY SDSPATSPAS AQSPCSAYSP GSAHSPGSAH STPGPPGTTQ 
      1310       1320       1330       1340       1350
PGEKPTKPSC VSMVQEGTTQ AWRRLSPEME AGGIQTVEDE QVADLTLMGE 
      1360       1370       1380 
GDISSPNSTL LPPPPTPQDT PGPPRPGTSR F

Length:1,381

Mass (Da):149,637

Last modified:July 27, 2011 - v2

Checksum:ⁱ8897CD1D249B66C6

Computationally mapped potential isoform sequencesⁱ

There are 11 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	D3Z0G5	D3Z0G5_MOUSE	Regulator of G-protein-signaling 12 Regulator of G-protein-signaling 12	Rgs12	803	Annotation score:
	E9Q1K7	E9Q1K7_MOUSE	Regulator of G-protein-signaling 12 Regulator of G-protein-signaling 12	Rgs12	723	Annotation score:
	E9Q652	E9Q652_MOUSE	Regulator of G-protein-signaling 12 Regulator of G-protein-signaling 12	Rgs12	1,451	Annotation score:
	Q3TTW9	Q3TTW9_MOUSE	Regulator of G-protein-signaling 12 Regulator of G-protein-signaling 12	Rgs12	499	Annotation score:
	D3Z0G7	D3Z0G7_MOUSE	Regulator of G-protein-signaling 12 Regulator of G-protein-signaling 12	Rgs12	793	Annotation score:
	D3Z0G6	D3Z0G6_MOUSE	Regulator of G-protein-signaling 12 Regulator of G-protein-signaling 12	Rgs12	733	Annotation score:
	F7B2U5	F7B2U5_MOUSE	Regulator of G-protein-signaling 12 Regulator of G-protein-signaling 12	Rgs12	236	Annotation score:
	F6YRR2	F6YRR2_MOUSE	Regulator of G-protein-signaling 12 Regulator of G-protein-signaling 12	Rgs12	107	Annotation score:
	D3YXA5	D3YXA5_MOUSE	Regulator of G-protein-signaling 12 Regulator of G-protein-signaling 12	Rgs12	116	Annotation score:
	A0A286YDE1	A0A286YDE1_MOUSE	Regulator of G-protein-signaling 12 Regulator of G-protein-signaling 12	Rgs12	78	Annotation score:
There is more potential isoformShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	536	R → K in AAH40396 (PubMed:15489334).Curated		1
Sequence conflictⁱ	1135	L → S in AAH40396 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC126447 Genomic DNA No translation available. AC133204 Genomic DNA No translation available. BC040396 mRNA Translation: AAH40396.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19222.1
NCBI Reference Sequences More...RefSeqⁱ	NP_775578.2, NM_173402.2
UniGeneⁱ	Mm.196208

Genome annotation databases

Ensemblⁱ	ENSMUST00000030984; ENSMUSP00000030984; ENSMUSG00000029101
GeneIDⁱ	71729
KEGGⁱ	mmu:71729
UCSC genome browser More...UCSCⁱ	uc008xdg.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8CGE9	Regulator of G-protein signaling 12		RAT		1387	UniRef90_O08774
regulator of G-protein signaling 12 isoform X1		MESAU		1457
Regulator of G-protein-signaling 12		MOUSE		1451
UPI000454B977		CRIGR		1462
UPI00077DE856		PERMB		1458
+17

Protein	Similar proteins		Species	Score	Length	Source
Q8CGE9	Isoform 5 of Regulator of G-protein signaling 12		HUMAN		1157	UniRef50_O14924-5
Regulator of G-protein signaling 12		RAT		1387
regulator of G-protein signaling 12		TARSY		1442
Uncharacterized protein		XENLA		1510
Regulator of G protein signaling 12		XENTR		1368
+174

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC126447 Genomic DNA No translation available. AC133204 Genomic DNA No translation available. BC040396 mRNA Translation: AAH40396.1
CCDSⁱ	CCDS19222.1
RefSeqⁱ	NP_775578.2, NM_173402.2
UniGeneⁱ	Mm.196208

3D structure databases

ProteinModelPortalⁱ	Q8CGE9
SMRⁱ	Q8CGE9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8CGE9, 7 interactors
MINTⁱ	Q8CGE9
STRINGⁱ	10090.ENSMUSP00000030984

PTM databases

iPTMnetⁱ	Q8CGE9
PhosphoSitePlusⁱ	Q8CGE9

Proteomic databases

EPDⁱ	Q8CGE9
MaxQBⁱ	Q8CGE9
PaxDbⁱ	Q8CGE9
PRIDEⁱ	Q8CGE9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000030984; ENSMUSP00000030984; ENSMUSG00000029101
GeneIDⁱ	71729
KEGGⁱ	mmu:71729
UCSCⁱ	uc008xdg.2 mouse

Organism-specific databases

CTDⁱ	6002
MGIⁱ	MGI:1918979 Rgs12

Phylogenomic databases

eggNOGⁱ	KOG3589 Eukaryota ENOG410YMJD LUCA
GeneTreeⁱ	ENSGT00760000119142
HOGENOMⁱ	HOG000049112
HOVERGENⁱ	HBG063299
InParanoidⁱ	Q8CGE9
KOⁱ	K16449
OMAⁱ	SAPHPDM
TreeFamⁱ	TF328814

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8CGE9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000029101 Expressed in 201 organ(s), highest expression level in ear
ExpressionAtlasⁱ	Q8CGE9 baseline and differential
Genevisibleⁱ	Q8CGE9 MM

Family and domain databases

CDDⁱ	cd08742 RGS_RGS12, 1 hit
Gene3Dⁱ	1.10.196.10, 1 hit 2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR003109 GoLoco_motif IPR001478 PDZ IPR036034 PDZ_sf IPR011993 PH-like_dom_sf IPR006020 PTB/PI_dom IPR003116 RBD_dom IPR016137 RGS IPR037880 RGS12_RGS IPR036305 RGS_sf IPR024066 RGS_subdom1/3 IPR029071 Ubiquitin-like_domsf
Pfamⁱ	View protein in Pfam PF02188 GoLoco, 1 hit PF00595 PDZ, 1 hit PF02196 RBD, 2 hits PF00615 RGS, 1 hit
PRINTSⁱ	PR01301 RGSPROTEIN
SMARTⁱ	View protein in SMART SM00390 GoLoco, 1 hit SM00228 PDZ, 1 hit SM00462 PTB, 1 hit SM00455 RBD, 2 hits SM00315 RGS, 1 hit
SUPFAMⁱ	SSF48097 SSF48097, 1 hit SSF50156 SSF50156, 1 hit SSF54236 SSF54236, 2 hits
PROSITEⁱ	View protein in PROSITE PS50877 GOLOCO, 1 hit PS50106 PDZ, 1 hit PS01179 PID, 1 hit PS50898 RBD, 2 hits PS50132 RGS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RGS12_MOUSE
Accessionⁱ	Q8CGE9Primary (citable) accession number: Q8CGE9 Secondary accession number(s): E9PXX2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 31, 2011
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - Q8CGE9 (RGS12_MOUSE)

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Regulator of G-protein signaling 12

Rgs12

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ