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Protein

Uveal autoantigen with coiled-coil domains and ankyrin repeats

Gene

Uaca

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1.2 Publications
Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury (By similarity). May be involved in multiple neurite formation (PubMed:23624502).By similarity1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Uveal autoantigen with coiled-coil domains and ankyrin repeats
Alternative name(s):
Nuclear membrane-binding protein
Short name:
Nucling
Gene namesi
Name:Uaca
Synonyms:Kiaa1561
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1919815 Uaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice show a high incidence of inflammatory lesions in preputial glands. Cells around the lesions showed resistance to apoptosis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002316511 – 1411Uveal autoantigen with coiled-coil domains and ankyrin repeatsAdd BLAST1411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei280PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8CGB3
PeptideAtlasiQ8CGB3
PRIDEiQ8CGB3

PTM databases

iPTMnetiQ8CGB3
PhosphoSitePlusiQ8CGB3

Expressioni

Tissue specificityi

Highly expressed in heart, liver, kidney and testis. Weakly expressed in lung and skeletal muscle. Not expressed in brain and spleen.1 Publication

Developmental stagei

First detected at the E9.5 stage in heart at the edge of both sides of the common ventricular chamber and is then progressively increased and restricted to the myocardial wall of left common ventricular chamber of heart.1 Publication

Inductioni

Up-regulated during cardiomyogenic differentiation. By apoptotic stress in a dose-dependent manner.1 Publication

Interactioni

Subunit structurei

Component of the apoptosome complex, composed of APAF1, pro-caspase-9 and UACA. In the complex, it probably interacts directly with APAF1. Interacts with LGALS3, ARF6 and ACTB. Interacts with RAB39A.3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi215442, 4 interactors
IntActiQ8CGB3, 5 interactors
STRINGi10090.ENSMUSP00000062047

Structurei

3D structure databases

ProteinModelPortaliQ8CGB3
SMRiQ8CGB3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati69 – 98ANK 1Add BLAST30
Repeati102 – 131ANK 2Add BLAST30
Repeati135 – 164ANK 3Add BLAST30
Repeati168 – 197ANK 4Add BLAST30
Repeati201 – 230ANK 5Add BLAST30
Repeati234 – 263ANK 6Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili299 – 379Sequence analysisAdd BLAST81
Coiled coili442 – 624Sequence analysisAdd BLAST183
Coiled coili652 – 1380Sequence analysisAdd BLAST729

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IJC6 Eukaryota
COG0666 LUCA
HOGENOMiHOG000147885
HOVERGENiHBG066395
InParanoidiQ8CGB3
PhylomeDBiQ8CGB3
TreeFamiTF331274

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000727 T_SNARE_dom
IPR030227 UACA
PANTHERiPTHR24173:SF23 PTHR24173:SF23, 3 hits
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50192 T_SNARE, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CGB3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKSLKSRLWK QDAPGPTSPS SPTAVASTQS AEWNKYDDRL MKAAERGDVE
60 70 80 90 100
KVSSILAKKG VHPGKLDVEG RSAFHVVASK GNLECLNAIL THGIDVATRD
110 120 130 140 150
SAGRNALHLA AKYGHALCLQ KLLQYNCPTE HVDLQGRTAL HDAVMADCPS
160 170 180 190 200
SIQLLCDHGA SVNAKDIDGR TPLVLATQMC RPTICQLLID RGADVNSRDK
210 220 230 240 250
QNRTALMLGC EYGCRDAVEV LVKNGADLTL LDALGHDSSY YARIGDNLDI
260 270 280 290 300
LNLLKTASEN TNKGRELWRK GPPLQQRNLS HTQDEGSVKS TQREQREPHS
310 320 330 340 350
FQDLEIENED LREKLRKIQQ EQRILLDKVN GLQLQLNEEV MVADDLESER
360 370 380 390 400
EKPKSLLAAK EKQHEESLRT IEALKNRFKY FESDHPGPGS YPSNRKEDML
410 420 430 440 450
HKQGQMYTTE PQCASPGIPP HMHSRSMLRP LELSLPSQTS YSENEILKKE
460 470 480 490 500
LETLRTYYDS AKQDRLKFQN ELAHKVAECK ALALECERVK EDSDEQIKQL
510 520 530 540 550
EDALKDVQKR MYESEGKVKQ MQTHFLALKE HLTNEAATGS HRIIEELREQ
560 570 580 590 600
LKDLKGKYEG ASAEVGKLRS QIKQSEMLVG EFKRDEGRLV EENKRLQKEC
610 620 630 640 650
GTCEVELERR GRRVVELEGQ LKELGAKLAL SVPTEKFESM KSSLSNDINE
660 670 680 690 700
KVKRLAEVGR DYESAQGEIR QLKRDLESVR AQHIRPEEHE QLRSRLEQKS
710 720 730 740 750
GELGKKVSEL TLKNQTLQKD VEKLHADNKL LNQQVHSLTV EMKTRYVPLR
760 770 780 790 800
VSEEMKRSHD VNVEDLNKKL SEATQRYAEK KQEAERLLAE NDKLTKNVSR
810 820 830 840 850
LEAVFVAPEK HEKELMGLKS NIAELKKQLS ELNKKCGEGQ EKIRALMSEN
860 870 880 890 900
SSLKKTLSSQ YVPAKTHEEV KASLNSTVEK TNRALLEAKK RFDDTSQEVS
910 920 930 940 950
KLRDENEVLR RNLENVQNQM KADYVSLEEH SRRMSTVSQS LKEAQEANAA
960 970 980 990 1000
ILADHRQGQE EIVSLHAEIK AQKKELDTIQ ECIKLKYAPL ARLEECERKF
1010 1020 1030 1040 1050
KATEKGLKEQ LSEQTHKCRQ RDEEVKKGKQ ENERLRADLA ALQKELQDRN
1060 1070 1080 1090 1100
ALAEEAREAE RALSGKADEL SKQLKDLSQK YSDVKSEREK LVEEKAKQAS
1110 1120 1130 1140 1150
EILAAQNLLQ KQPVPLEQVE ALKKSLNGTI EQLKEELRSK QRCLEREQQT
1160 1170 1180 1190 1200
VSQLQQLLEN QKNSSVTLAE HLKLKEALEK EVGIMKASLR EKEEESQKKT
1210 1220 1230 1240 1250
KEVSKLQTEV QTTKQALKNL ETREVVDMSK YKATKNDLET QISNLNDKLA
1260 1270 1280 1290 1300
SLNRKYDQAC EEKVSAKDEK ELLHLSIEQE IRDQKERCDK SLTTIMELQQ
1310 1320 1330 1340 1350
RIQESAKQIE AKDNKITELL NDVERLKQAL NGLSQLTYSS GSPTKRQSQL
1360 1370 1380 1390 1400
VDTLQQRVRD LQQQLADADR QHQEVIAIYR THLLSAAQGH MDEDVQAALL
1410
QIIQMRQGLV C
Length:1,411
Mass (Da):160,813
Last modified:April 4, 2006 - v2
Checksum:i0809D2DE9732F879
GO
Isoform 2 (identifier: Q8CGB3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-398: Missing.

Note: No experimental confirmation available.
Show »
Length:1,013
Mass (Da):116,517
Checksum:i13DDD2313B8FED0F
GO
Isoform 3 (identifier: Q8CGB3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-264: G → GGG

Note: No experimental confirmation available.
Show »
Length:1,413
Mass (Da):160,927
Checksum:i89FA7474FDE59D5C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0S7A0A0R4J0S7_MOUSE
Uveal autoantigen with coiled-coil ...
Uaca mCG_127705
1,413Annotation score:
A0A1L1SVG0A0A1L1SVG0_MOUSE
Uveal autoantigen with coiled-coil ...
Uaca
1,411Annotation score:
A0A1L1STY4A0A1L1STY4_MOUSE
Uveal autoantigen with coiled-coil ...
Uaca
1,236Annotation score:

Sequence cautioni

The sequence BAC78213 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD32481 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144V → A in AAH42415 (PubMed:15489334).Curated1
Sequence conflicti353P → L in AAH42415 (PubMed:15489334).Curated1
Sequence conflicti757R → K in AAH42415 (PubMed:15489334).Curated1
Sequence conflicti778A → T in AAH42415 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0178741 – 398Missing in isoform 2. 1 PublicationAdd BLAST398
Alternative sequenceiVSP_017875264G → GGG in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030647 mRNA Translation: BAC78213.1 Different initiation.
AK173203 mRNA Translation: BAD32481.1 Different initiation.
BC042415 mRNA Translation: AAH42415.1
AK087466 mRNA Translation: BAC39886.1
CCDSiCCDS23259.1 [Q8CGB3-3]
RefSeqiNP_082559.1, NM_028283.2
XP_017169098.1, XM_017313609.1
UniGeneiMm.68819

Genome annotation databases

GeneIDi72565
KEGGimmu:72565
UCSCiuc009pzi.1 mouse [Q8CGB3-3]
uc009pzk.1 mouse [Q8CGB3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030647 mRNA Translation: BAC78213.1 Different initiation.
AK173203 mRNA Translation: BAD32481.1 Different initiation.
BC042415 mRNA Translation: AAH42415.1
AK087466 mRNA Translation: BAC39886.1
CCDSiCCDS23259.1 [Q8CGB3-3]
RefSeqiNP_082559.1, NM_028283.2
XP_017169098.1, XM_017313609.1
UniGeneiMm.68819

3D structure databases

ProteinModelPortaliQ8CGB3
SMRiQ8CGB3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215442, 4 interactors
IntActiQ8CGB3, 5 interactors
STRINGi10090.ENSMUSP00000062047

PTM databases

iPTMnetiQ8CGB3
PhosphoSitePlusiQ8CGB3

Proteomic databases

PaxDbiQ8CGB3
PeptideAtlasiQ8CGB3
PRIDEiQ8CGB3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi72565
KEGGimmu:72565
UCSCiuc009pzi.1 mouse [Q8CGB3-3]
uc009pzk.1 mouse [Q8CGB3-1]

Organism-specific databases

CTDi55075
MGIiMGI:1919815 Uaca
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IJC6 Eukaryota
COG0666 LUCA
HOGENOMiHOG000147885
HOVERGENiHBG066395
InParanoidiQ8CGB3
PhylomeDBiQ8CGB3
TreeFamiTF331274

Miscellaneous databases

ChiTaRSiUaca mouse
PROiPR:Q8CGB3
SOURCEiSearch...

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000727 T_SNARE_dom
IPR030227 UACA
PANTHERiPTHR24173:SF23 PTHR24173:SF23, 3 hits
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50192 T_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUACA_MOUSE
AccessioniPrimary (citable) accession number: Q8CGB3
Secondary accession number(s): Q69ZG3, Q7TN77, Q8BJC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: May 23, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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