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Protein

Protein phosphatase 1F

Gene

Ppm1f

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi195Manganese 1By similarity1
Metal bindingi195Manganese 2By similarity1
Metal bindingi196Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi357Manganese 2By similarity1
Metal bindingi401Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processApoptosis
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1F (EC:3.1.3.16)
Alternative name(s):
Ca(2+)/calmodulin-dependent protein kinase phosphatase
Short name:
CaM-kinase phosphatase
Short name:
CaMKPase
Gene namesi
Name:Ppm1f
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1918464 Ppm1f

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577591 – 452Protein phosphatase 1FAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei452PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CGA0
MaxQBiQ8CGA0
PaxDbiQ8CGA0
PeptideAtlasiQ8CGA0
PRIDEiQ8CGA0

PTM databases

iPTMnetiQ8CGA0
PhosphoSitePlusiQ8CGA0

Expressioni

Gene expression databases

BgeeiENSMUSG00000026181 Expressed in 250 organ(s), highest expression level in limb
CleanExiMM_PPM1F
GenevisibleiQ8CGA0 MM

Interactioni

Subunit structurei

Associates with FEM1B.By similarity

Protein-protein interaction databases

BioGridi212948, 1 interactor
IntActiQ8CGA0, 3 interactors
MINTiQ8CGA0
STRINGi10090.ENSMUSP00000027373

Structurei

3D structure databases

ProteinModelPortaliQ8CGA0
SMRiQ8CGA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 410PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST258

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi99 – 110Poly-GluAdd BLAST12

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiKOG0698 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00900000140907
HOGENOMiHOG000232094
HOVERGENiHBG053656
InParanoidiQ8CGA0
KOiK17502
OMAiPLPWKAP
OrthoDBiEOG091G08KG
PhylomeDBiQ8CGA0
TreeFamiTF317617

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00331 PP2C_SIG, 1 hit
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CGA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGAAQNSS QMACDSEIPG FLDAFLQDFP APLSLESPLP WKVPGTVLSQ
60 70 80 90 100
EEVEAELIEL ALGFLGSRNA PPSFAVAVTH EAISQLLQTD LSEFKRLPEQ
110 120 130 140 150
EEEEEEEEEE KALVTLLDAK GLARSFFNCL WKVCSQWQKQ VPLTAQAPQW
160 170 180 190 200
QWLVSIHAIR NTRRKMEDRH VSLPAFNHLF GLSDSVHRAY FAVFDGHGGV
210 220 230 240 250
DAARYASVHV HTNASHQPEL RTNPAAALKE AFRLTDEMFL QKAKRERLQS
260 270 280 290 300
GTTGVCALIA GAALHVAWLG DSQVILVQQG RVVKLMEPHK PERQDEKARI
310 320 330 340 350
EALGGFVSLM DCWRVNGTLA VSRAIGDVFQ KPYVSGEADA ASRELTGSED
360 370 380 390 400
YLLLACDGFF DVVPHHEVTG LVHGHLLRHK GNGMRIAEEL VAVARDRGSH
410 420 430 440 450
DNITVMVVFL REPLELLEGG VQGTGDAQAD VGSQDLSTGL SELEISNTSQ

RS
Length:452
Mass (Da):49,611
Last modified:March 1, 2003 - v1
Checksum:i7C8ED2E597F9D1B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154192 mRNA Translation: BAE32429.1
AK164964 mRNA Translation: BAE37981.1
BC042570 mRNA Translation: AAH42570.1
CCDSiCCDS27991.1
RefSeqiNP_789803.1, NM_176833.4
XP_017172613.1, XM_017317124.1
UniGeneiMm.230296

Genome annotation databases

EnsembliENSMUST00000027373; ENSMUSP00000027373; ENSMUSG00000026181
GeneIDi68606
KEGGimmu:68606
UCSCiuc007yjo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPPM1F_MOUSE
AccessioniPrimary (citable) accession number: Q8CGA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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