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Entry version 117 (16 Oct 2019)
Sequence version 2 (27 Jul 2011)
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Protein

SCO-spondin

Gene

Sspo

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5173214 O-glycosylation of TSR domain-containing proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SCO-spondin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sspo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2674311 Sspo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024504318 – 4998SCO-spondinAdd BLAST4981

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi534N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi698N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi771N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi790N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi824N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi866N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1230N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1254 ↔ 1267PROSITE-ProRule annotation
Disulfide bondi1261 ↔ 1280PROSITE-ProRule annotation
Disulfide bondi1274 ↔ 1289PROSITE-ProRule annotation
Disulfide bondi1294 ↔ 1306PROSITE-ProRule annotation
Disulfide bondi1301 ↔ 1319PROSITE-ProRule annotation
Disulfide bondi1313 ↔ 1328PROSITE-ProRule annotation
Disulfide bondi1330 ↔ 1342PROSITE-ProRule annotation
Disulfide bondi1337 ↔ 1355PROSITE-ProRule annotation
Disulfide bondi1349 ↔ 1364PROSITE-ProRule annotation
Disulfide bondi1370 ↔ 1382PROSITE-ProRule annotation
Disulfide bondi1377 ↔ 1395PROSITE-ProRule annotation
Disulfide bondi1389 ↔ 1406PROSITE-ProRule annotation
Disulfide bondi1443 ↔ 1455PROSITE-ProRule annotation
Disulfide bondi1450 ↔ 1468PROSITE-ProRule annotation
Disulfide bondi1462 ↔ 1477PROSITE-ProRule annotation
Disulfide bondi1481 ↔ 1494PROSITE-ProRule annotation
Disulfide bondi1488 ↔ 1507PROSITE-ProRule annotation
Disulfide bondi1501 ↔ 1518PROSITE-ProRule annotation
Glycosylationi1528N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1534 ↔ 1544PROSITE-ProRule annotation
Disulfide bondi1539 ↔ 1557PROSITE-ProRule annotation
Disulfide bondi1551 ↔ 1572PROSITE-ProRule annotation
Disulfide bondi1584 ↔ 1620PROSITE-ProRule annotation
Disulfide bondi1588 ↔ 1625PROSITE-ProRule annotation
Glycosylationi1598N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1599 ↔ 1610PROSITE-ProRule annotation
Disulfide bondi1640 ↔ 1680PROSITE-ProRule annotation
Disulfide bondi1644 ↔ 1685PROSITE-ProRule annotation
Disulfide bondi1654 ↔ 1664PROSITE-ProRule annotation
Glycosylationi1687N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1772 ↔ 1811PROSITE-ProRule annotation
Disulfide bondi1783 ↔ 1787PROSITE-ProRule annotation
Disulfide bondi1821 ↔ 1826PROSITE-ProRule annotation
Glycosylationi1892N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1989N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2092 ↔ 2104PROSITE-ProRule annotation
Disulfide bondi2099 ↔ 2117PROSITE-ProRule annotation
Disulfide bondi2111 ↔ 2126PROSITE-ProRule annotation
Disulfide bondi2243 ↔ 2255PROSITE-ProRule annotation
Disulfide bondi2250 ↔ 2268PROSITE-ProRule annotation
Disulfide bondi2262 ↔ 2277PROSITE-ProRule annotation
Disulfide bondi2300 ↔ 2312PROSITE-ProRule annotation
Disulfide bondi2307 ↔ 2325PROSITE-ProRule annotation
Disulfide bondi2319 ↔ 2334PROSITE-ProRule annotation
Disulfide bondi2337 ↔ 2373PROSITE-ProRule annotation
Disulfide bondi2348 ↔ 2352PROSITE-ProRule annotation
Disulfide bondi2383 ↔ 2388PROSITE-ProRule annotation
Disulfide bondi2403 ↔ 2440PROSITE-ProRule annotation
Disulfide bondi2407 ↔ 2445PROSITE-ProRule annotation
Disulfide bondi2418 ↔ 2430PROSITE-ProRule annotation
Glycosylationi2481N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2530N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2552 ↔ 2590PROSITE-ProRule annotation
Disulfide bondi2563 ↔ 2567PROSITE-ProRule annotation
Disulfide bondi2600 ↔ 2604PROSITE-ProRule annotation
Disulfide bondi2620 ↔ 2658PROSITE-ProRule annotation
Disulfide bondi2624 ↔ 2663PROSITE-ProRule annotation
Disulfide bondi2640 ↔ 2648PROSITE-ProRule annotation
Disulfide bondi2678 ↔ 2713PROSITE-ProRule annotation
Disulfide bondi2682 ↔ 2718PROSITE-ProRule annotation
Disulfide bondi2693 ↔ 2703PROSITE-ProRule annotation
Glycosylationi2772N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2802N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2821 ↔ 2859PROSITE-ProRule annotation
Disulfide bondi2832 ↔ 2836PROSITE-ProRule annotation
Disulfide bondi2869 ↔ 2874PROSITE-ProRule annotation
Glycosylationi2897N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2952N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2999N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3009N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3031 ↔ 3080PROSITE-ProRule annotation
Disulfide bondi3035 ↔ 3085PROSITE-ProRule annotation
Disulfide bondi3046 ↔ 3070PROSITE-ProRule annotation
Disulfide bondi3100 ↔ 3137PROSITE-ProRule annotation
Disulfide bondi3104 ↔ 3142PROSITE-ProRule annotation
Disulfide bondi3115 ↔ 3127PROSITE-ProRule annotation
Glycosylationi3146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3235N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3256 ↔ 3299PROSITE-ProRule annotation
Disulfide bondi3260 ↔ 3305PROSITE-ProRule annotation
Disulfide bondi3271 ↔ 3283PROSITE-ProRule annotation
Glycosylationi3301N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3320 ↔ 3355PROSITE-ProRule annotation
Disulfide bondi3323 ↔ 3362PROSITE-ProRule annotation
Disulfide bondi3333 ↔ 3345PROSITE-ProRule annotation
Glycosylationi3357N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3435N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3462N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3493 ↔ 3523PROSITE-ProRule annotation
Disulfide bondi3497 ↔ 3528PROSITE-ProRule annotation
Disulfide bondi3508 ↔ 3513PROSITE-ProRule annotation
Glycosylationi3638N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3669 ↔ 3707PROSITE-ProRule annotation
Disulfide bondi3673 ↔ 3712PROSITE-ProRule annotation
Disulfide bondi3685 ↔ 3697PROSITE-ProRule annotation
Glycosylationi3761N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3794 ↔ 3830PROSITE-ProRule annotation
Disulfide bondi3805 ↔ 3809PROSITE-ProRule annotation
Disulfide bondi3843 ↔ 3848PROSITE-ProRule annotation
Disulfide bondi3863 ↔ 3900PROSITE-ProRule annotation
Disulfide bondi3867 ↔ 3905PROSITE-ProRule annotation
Disulfide bondi3878 ↔ 3890PROSITE-ProRule annotation
Glycosylationi3986N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4007 ↔ 4043PROSITE-ProRule annotation
Disulfide bondi4018 ↔ 4022PROSITE-ProRule annotation
Disulfide bondi4053 ↔ 4058PROSITE-ProRule annotation
Disulfide bondi4112 ↔ 4149PROSITE-ProRule annotation
Disulfide bondi4116 ↔ 4154PROSITE-ProRule annotation
Disulfide bondi4127 ↔ 4139PROSITE-ProRule annotation
Disulfide bondi4169 ↔ 4207PROSITE-ProRule annotation
Disulfide bondi4173 ↔ 4212PROSITE-ProRule annotation
Disulfide bondi4184 ↔ 4195PROSITE-ProRule annotation
Glycosylationi4196N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4216 ↔ 4253PROSITE-ProRule annotation
Disulfide bondi4227 ↔ 4229PROSITE-ProRule annotation
Disulfide bondi4263 ↔ 4268PROSITE-ProRule annotation
Glycosylationi4267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4408N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4463N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4466 ↔ 4500PROSITE-ProRule annotation
Disulfide bondi4477 ↔ 4481PROSITE-ProRule annotation
Disulfide bondi4510 ↔ 4515PROSITE-ProRule annotation
Glycosylationi4584N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4601N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4606N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4628 ↔ 4663PROSITE-ProRule annotation
Disulfide bondi4632 ↔ 4668PROSITE-ProRule annotation
Disulfide bondi4643 ↔ 4652PROSITE-ProRule annotation
Glycosylationi4716N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4756N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4799N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4806N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4892 ↔ 4952PROSITE-ProRule annotation
Glycosylationi4912N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4918 ↔ 4969PROSITE-ProRule annotation
Disulfide bondi4928 ↔ 4985PROSITE-ProRule annotation
Disulfide bondi4932 ↔ 4987PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8CG65

PRoteomics IDEntifications database

More...
PRIDEi
Q8CG65

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CG65

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CG65

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Subcommissural organ.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Weakly expressed at 14 dpc and 15 dpc in the SCO anlage; increasing progressively until 17 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029797 Expressed in 19 organ(s), highest expression level in diencephalon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CG65 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000131401

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8CG65

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 102EMIAdd BLAST85
Domaini163 – 288VWFD 1PROSITE-ProRule annotationAdd BLAST126
Domaini349 – 404TIL 1Sequence analysisAdd BLAST56
Domaini404 – 496VWFC 1PROSITE-ProRule annotationAdd BLAST93
Domaini443 – 652VWFD 2PROSITE-ProRule annotationAdd BLAST210
Domaini706 – 759TIL 2Sequence analysisAdd BLAST54
Domaini893 – 1097VWFD 3PROSITE-ProRule annotationAdd BLAST205
Domaini1153 – 1209TIL 3Sequence analysisAdd BLAST57
Domaini1253 – 1290LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST38
Domaini1293 – 1328LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST36
Domaini1329 – 1365LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST37
Domaini1369 – 1407LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST39
Domaini1442 – 1478LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST37
Domaini1480 – 1519LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST40
Domaini1533 – 1571LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST39
Domaini1572 – 1626TSP type-1 1PROSITE-ProRule annotationAdd BLAST55
Domaini1628 – 1686TSP type-1 2PROSITE-ProRule annotationAdd BLAST59
Domaini1692 – 1746TIL 4Sequence analysisAdd BLAST55
Domaini1702 – 1741EGF-like 1Add BLAST40
Domaini1742 – 1768EGF-like 2Add BLAST27
Domaini1771 – 1827TSP type-1 3PROSITE-ProRule annotationAdd BLAST57
Domaini1827 – 1887VWFC 2PROSITE-ProRule annotationAdd BLAST61
Domaini1929 – 2085F5/8 type CPROSITE-ProRule annotationAdd BLAST157
Domaini2091 – 2127LDL-receptor class A 8PROSITE-ProRule annotationAdd BLAST37
Domaini2242 – 2278LDL-receptor class A 9PROSITE-ProRule annotationAdd BLAST37
Domaini2299 – 2335LDL-receptor class A 10PROSITE-ProRule annotationAdd BLAST37
Domaini2336 – 2389TSP type-1 4PROSITE-ProRule annotationAdd BLAST54
Domaini2391 – 2446TSP type-1 5PROSITE-ProRule annotationAdd BLAST56
Domaini2468 – 2511TIL 5Sequence analysisAdd BLAST44
Domaini2551 – 2605TSP type-1 6PROSITE-ProRule annotationAdd BLAST55
Domaini2609 – 2664TSP type-1 7PROSITE-ProRule annotationAdd BLAST56
Domaini2666 – 2719TSP type-1 8PROSITE-ProRule annotationAdd BLAST54
Domaini2820 – 2875TSP type-1 9PROSITE-ProRule annotationAdd BLAST56
Domaini2876 – 2919TSP type-1 10PROSITE-ProRule annotationAdd BLAST44
Domaini2926 – 2978TIL 6Sequence analysisAdd BLAST53
Domaini3019 – 3086TSP type-1 11PROSITE-ProRule annotationAdd BLAST68
Domaini3088 – 3143TSP type-1 12PROSITE-ProRule annotationAdd BLAST56
Domaini3151 – 3201TIL 7Sequence analysisAdd BLAST51
Domaini3244 – 3306TSP type-1 13PROSITE-ProRule annotationAdd BLAST63
Domaini3308 – 3363TSP type-1 14PROSITE-ProRule annotationAdd BLAST56
Domaini3365 – 3421TIL 8Sequence analysisAdd BLAST57
Domaini3481 – 3529TSP type-1 15PROSITE-ProRule annotationAdd BLAST49
Domaini3657 – 3713TSP type-1 16PROSITE-ProRule annotationAdd BLAST57
Domaini3727 – 3779TSP type-1 17PROSITE-ProRule annotationAdd BLAST53
Domaini3793 – 3849TSP type-1 18PROSITE-ProRule annotationAdd BLAST57
Domaini3851 – 3906TSP type-1 19PROSITE-ProRule annotationAdd BLAST56
Domaini3909 – 3964TIL 9Sequence analysisAdd BLAST56
Domaini4006 – 4059TSP type-1 20PROSITE-ProRule annotationAdd BLAST54
Domaini4100 – 4155TSP type-1 21PROSITE-ProRule annotationAdd BLAST56
Domaini4157 – 4213TSP type-1 22PROSITE-ProRule annotationAdd BLAST57
Domaini4215 – 4269TSP type-1 23PROSITE-ProRule annotationAdd BLAST55
Domaini4273 – 4328TIL 10Sequence analysisAdd BLAST56
Domaini4465 – 4516TSP type-1 24PROSITE-ProRule annotationAdd BLAST52
Domaini4530 – 4576TIL 11Sequence analysisAdd BLAST47
Domaini4616 – 4669TSP type-1 25PROSITE-ProRule annotationAdd BLAST54
Domaini4671 – 4725TIL 12Sequence analysisAdd BLAST55
Domaini4777 – 4835TIL 13Sequence analysisAdd BLAST59
Domaini4835 – 4893VWFC 3PROSITE-ProRule annotationAdd BLAST59
Domaini4892 – 4991CTCKPROSITE-ProRule annotationAdd BLAST100

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thrombospondin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1215 Eukaryota
KOG1216 Eukaryota
KOG3538 Eukaryota
KOG3611 Eukaryota
ENOG410XNSK LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155829

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000154433

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8CG65

Family and domain databases

Conserved Domains Database

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CDDi
cd00112 LDLa, 8 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.20.100.10, 23 hits
2.60.120.260, 1 hit
4.10.400.10, 9 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006207 Cys_knot_C
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR030119 SCO-spondin
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D

The PANTHER Classification System

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PANTHERi
PTHR11339:SF358 PTHR11339:SF358, 3 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF08742 C8, 3 hits
PF00754 F5_F8_type_C, 1 hit
PF00057 Ldl_recept_a, 7 hits
PF01826 TIL, 13 hits
PF00090 TSP_1, 22 hits
PF00093 VWC, 1 hit
PF00094 VWD, 3 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00261 LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00832 C8, 3 hits
SM00192 LDLa, 10 hits
SM00209 TSP1, 25 hits
SM00214 VWC, 4 hits
SM00215 VWC_out, 9 hits
SM00216 VWD, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 1 hit
SSF57424 SSF57424, 9 hits
SSF57567 SSF57567, 14 hits
SSF82895 SSF82895, 24 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01225 CTCK_2, 1 hit
PS01186 EGF_2, 2 hits
PS50022 FA58C_3, 1 hit
PS01209 LDLRA_1, 8 hits
PS50068 LDLRA_2, 10 hits
PS50092 TSP1, 25 hits
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 2 hits
PS51233 VWFD, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8CG65-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPLALLFGM LWTQANGHWC EQIETVHVEE EVTPRQEDLV PCTSLYHYSR
60 70 80 90 100
LGWQLDLSWS GRVGLTRPPA LGLCAIYKPP ETRPATWNRT VRACCPGWGG
110 120 130 140 150
AHCTDALAET SPKGHCFVTW HCQPLAGSAN SSAGSLEDPA DELGVWPLTL
160 170 180 190 200
NDPILFPGMS LQWQGDWLVL SGGLGVVVRL DRSSSISISV DHEFWGRTQG
210 220 230 240 250
LCGLYNGRPE DDFVEPGGGL ATLAATFGNS WKLPGSEPGC LDAVEVAWGC
260 270 280 290 300
ESLLGGTLTD LEAVKLQAQA QDMCHQLLEG PFWQCHGQVQ PDEYHETCLF
310 320 330 340 350
AYCVGATAGN GPEGQLEAVC ATFANYAQAC ARQHIYVHWR KPGFCERVCP
360 370 380 390 400
GGQLYSDCVS SCPPSCSAVA QGEEGSCGKE CVSGCECPTG LFWDGALCVP
410 420 430 440 450
AAHCPCYHRR QRYAPGDTVK QQCNPCVCQD GRWHCAQALC PAECAVGGDG
460 470 480 490 500
HYFTFDGRSF FFRGTPGCHY SLVQDSVKGQ LLVVLEHGAC DTGSCLHALS
510 520 530 540 550
VFLGNTHIQL RYSGAVLVDG EDVDLPWIGV EGFNISWASS TFLLLHWPGA
560 570 580 590 600
WVLWGVAEPA AYITLDPRHA YQVQGLCGTF TWKQQDDFLT PAGDIETSVT
610 620 630 640 650
AFASKFQVSG DGRCPLVDKS PLFCSSYSQH LTFTEAACAI LHGHAFQECH
660 670 680 690 700
GLVDREPFRL RCLEAVCGCA PGRDCLCPVL SAYTRHCAQE GVLLQWRNET
710 720 730 740 750
LCPVSCPGGQ VYQECAPVCG HHCGEPEDCK ELGICVAGCN CPPGLLWDLE
760 770 780 790 800
GQCVPPSMCH CQFGGHRYTI NTTTVRDCSH CICQERGLWN CTAHHCPRQW
810 820 830 840 850
ALCPRELIYV PGACLLTCDS PRANHSCWAG STDGCVCPPG TVLLDKHCVS
860 870 880 890 900
PDLCPCRHNG QWYPPNATIQ EDCNICVCQG QRWHCTGQRC SGWCQASGAP
910 920 930 940 950
HYVTFDGLVF TFPGACEYLL VREAGGRFSV SVQNLPCGAS GLTCTKALVV
960 970 980 990 1000
RLDSTVVHML RGQAVTVNGV SIRLPKVYTG PGLSLHHAGL FLLLTTRLGL
1010 1020 1030 1040 1050
TLLWDGGTRV LVQLSPHFHG RVAGLCGNFD SDASNDLRSR QGVLEPTAEL
1060 1070 1080 1090 1100
TAHSWRLNPL CPEPGDLPHP VNAHRANWAR ARCEVILQPI FAPCHTEVPP
1110 1120 1130 1140 1150
QQYYEWCVYD ACGCDTGGDC ECLCSAIATY ADECARHRHH VRWRSQELCP
1160 1170 1180 1190 1200
LQCEGGQVYE PCGSTCPPTC HDHHSELRWH CQVITCVEGC FCPEGTLLHG
1210 1220 1230 1240 1250
GACMKLAACP CEWQGSFFPP GTVLQKDCGN CTCQGSQWHC DRGGAPCEDM
1260 1270 1280 1290 1300
EPGCAEGETL CRENGHCVPL EWLCDNQDDC GDGSDEEGCA TSVCGEGQMS
1310 1320 1330 1340 1350
CQSGHCLPLS LICDGQDDCG DGTDEQGCLC PHGSLACADG RCLPPALLCN
1360 1370 1380 1390 1400
GHPDCLDAAD EESCLGPVSC ISGEVSCVDG TCVRTIQLCD GVWDCPDGAD
1410 1420 1430 1440 1450
EGPSHCSLPS LPTPPGGIGQ NPSTSSLDTA PSPVGSTSPA SPCSLLEFQC
1460 1470 1480 1490 1500
NSGECTPRGW RCDQEEDCTD GSDELDCGGP CMLYQVPCAH SPHCVSPGQL
1510 1520 1530 1540 1550
CDGVTQCPDG SDEDPDVCEE QSASGGANRT GAPCPEFSCP DGTCIDFLLV
1560 1570 1580 1590 1600
CDGNPDCELA DETEPSLDEQ GCGAWGSWGP WAPCSQTCGS GTRSRNRNCS
1610 1620 1630 1640 1650
TSSLQVLQNC PGLQHQSQAC FTEACPVDGE WSSWSPWSPC SEPCGGTTTR
1660 1670 1680 1690 1700
HRQCRPPQNG GQDCALLPGS THSTRQTSPC PQEGCLNATC FGELVFRTCA
1710 1720 1730 1740 1750
PCPLTCDDIS GQAACPPDRP CSSPGCWCPD GKVLNTEGQC VRPRQCPCLV
1760 1770 1780 1790 1800
DGAHYWPGQR IKMDCQLCFL DCGWSSWSPW AECLGPCSSQ SLQWSFRSPN
1810 1820 1830 1840 1850
NPRLSGHGRQ CRGIHRKARR CQTEACEGCE QWGLMYNVGE RWRGGPCMVC
1860 1870 1880 1890 1900
ECLHSSITHC SPYCPIGSCP QGWVLVEGMG ESCCHCALPE KNQTVIHMTT
1910 1920 1930 1940 1950
PAPAPASAPS PQIGAHLVTY VLPPTADACY SPLGLAGLPM WAPSQHWEHI
1960 1970 1980 1990 2000
TRADPVEAPM AGPGPREGAS AEWHTQPLYL QLDLRRPRNL TGIIVQRAGS
2010 2020 2030 2040 2050
SAAYVSTLSL QFSSDNLQWH NYVNSLSSTL SPPKPSPESS NHMAPEVWTF
2060 2070 2080 2090 2100
DQMVQARYIR VWPHSGHLRD NNQHDIFLWV ELLGLSPLAP LCPGSRHRCA
2110 2120 2130 2140 2150
SGECAPKGGP CDGAVDCDDG SDEEGCGSLH ASTTSRTPAL SPTQPGKFPR
2160 2170 2180 2190 2200
EVSEDLRQGA EAMTSHSPPS SGETAGLIPA SEGTLPVSGQ PMQTLSATST
2210 2220 2230 2240 2250
FPPGAKSLHP GMAAVTVHPP HSVTPGAPVG QTVSPRPFPP MPCGPGQVPC
2260 2270 2280 2290 2300
DVLGCVEQEQ LCDGREDCLD GSDEQHCASA EPFTVPTTAL PGLPASKALC
2310 2320 2330 2340 2350
SPSQLRCGSG ECLPFEHRCD LQVNCQDGSD EDNCVDCVLA PWSGWSDCSR
2360 2370 2380 2390 2400
SCGLGLIFQH RELLRLPLPG GSCLLDQFRS QSCFVQACPV AGAWAEWGPW
2410 2420 2430 2440 2450
TACSVSCGGG HQSRQRSCVD PPPKNGGAPC PGPSHEKAPC NLQLCPGDTD
2460 2470 2480 2490 2500
CEPGLVHVNA ELCQKGLVPP CPPSCLDPEA NRSCSGHCME GCRCPPGLLL
2510 2520 2530 2540 2550
QDSHCLPLSE CPCLVGQKLI QPRLAFLLDN CSQCICEKGT LLCKPGACSQ
2560 2570 2580 2590 2600
SCGWSAWSPW TACDRSCGSG VRARFRSPTN PPVAFGGSPC EGDRQELQAC
2610 2620 2630 2640 2650
YTDCGTEIPG WTPWTSWSSC SQSCLVPGGD PGWRQRSRLC PSSRDTFCPG
2660 2670 2680 2690 2700
EATQEEPCSP PVCPVPSAWG LWASWSTCSA SCNGGIQTRG RSCSGSAPGN
2710 2720 2730 2740 2750
PVCLGPHTQT RDCNMHPCTA QCPGNMVFRS AEQCLEEGGP CPQLCLAQDP
2760 2770 2780 2790 2800
GVECTGSCAP SCNCPPGLFL HNASCLPRSQ CPCQLHGQLY APGAVAHLDC
2810 2820 2830 2840 2850
NNCTCISGEM VCTSKRCPVA CGWSPWTPWS PCSQSCNVGI RRRFRAGTEP
2860 2870 2880 2890 2900
PAAFGGAECQ GPNLDAEFCS LRPCRGPGAA WSSWTPCSVP CGGGYRNRTQ
2910 2920 2930 2940 2950
GSGPHSPIEF STCSLQPCAG PVPGVCPEDQ QWLDCAQGPA SCAHLSIPGE
2960 2970 2980 2990 3000
ANQTCHPGCY CLSGMLLLNN VCVPVQDCPC AHRGRLYSPG SAVHLPCENC
3010 3020 3030 3040 3050
SCISGLITNC SSWPCEEGQP AWSSWTPWSV CSASCNPARR HRHRFCARPP
3060 3070 3080 3090 3100
HRAPFSLVLL TTVAAPTTLC PGPEAEEEPC LLPGCNQAGG WSPWSPWSGC
3110 3120 3130 3140 3150
SRSCGGGLRS RTRACDQPSP QGLGDFCEGP QAQGEACQAQ PCPVTNCSAM
3160 3170 3180 3190 3200
EGAEYSPCGP PCPRSCDDLV HCVWRCQPGC YCPLGKVLSA DGAICVKPSY
3210 3220 3230 3240 3250
CSCLDLLTGK RHHAGTQLMR PDGCNHCTCM EGRLNCTDLP CQVSGDWCPW
3260 3270 3280 3290 3300
SKWTACSQPC RGQTRTRSRA CVCPAPQHGG SPCPEESGGT GVQHQMEACP
3310 3320 3330 3340 3350
NATACPVDGA WSPWGPWSSC DACLGQSYRS RVCSHPPISD GGKPCLGGYQ
3360 3370 3380 3390 3400
QSRPCRNSST LCTDCGGGQD LLPCGQPCPH SCQDLSLGST CQPGSAGCQS
3410 3420 3430 3440 3450
GCGCPPGQLS QDGLCVFPVD CHCHFQPRAM GIPENRSRSV GSTLSSWESL
3460 3470 3480 3490 3500
EPGEVVTGPC DNCTCVAGIL QCHEVPSCPG PGIWSSWGPW EKCSVSCGGG
3510 3520 3530 3540 3550
EQLRSRQCAR PPCPGLAQQS RICHIHVCRE TGCPAGRLYR ECQPSDGCPF
3560 3570 3580 3590 3600
SCAHVTGQVA CFSERCKEGC HCPEGTFQHH VACVQECPCV LTVLLLQELG
3610 3620 3630 3640 3650
LASAALGSYP TLLGDEGKPL GPGVELLPGQ MLQTDCGNCS CVHGKLSCSM
3660 3670 3680 3690 3700
VECSRVHGSF GPWGMWSLCS RSCGGLGTRT RTRQCVLPTL APGGLSCRGP
3710 3720 3730 3740 3750
LQDLEYCFSP ECPGTAGSTV EPVTGLAGGW GPWSPWSPCS HSCTDPAHPA
3760 3770 3780 3790 3800
WRSRTRLCLA NCTVGDSSQE RPCNLPSCAA LLPCPGPGCG SGNCFWTSWA
3810 3820 3830 3840 3850
PWEPCSRSCG VGQQRRLRAY HPPGPGGHWC PDILTAYQER RFCNLRACPV
3860 3870 3880 3890 3900
PGGWSHWSPW SWCDRSCGGG RSLRSRSCSS PPPKNGGTSC VGERHHVRPC
3910 3920 3930 3940 3950
NPMPCEEGCP AGMEMVSCAN HCPYSCSDLQ EGGMCQEDQA CQLGCRCSEG
3960 3970 3980 3990 4000
FLEQDGGCVP VGHCECTDAQ GRSWAPGSQH QDACNNCSCQ AGQLSCTAQL
4010 4020 4030 4040 4050
CSPPAHCAWS HWSAWSSCSH SCGPQGQQSR FRSSTSGSWA LECQKEQSQS
4060 4070 4080 4090 4100
QPCPEVPCPP LCLHEAHLHE LGDNWLHGEC QQCSCTPEGA ICKDTDCAVP
4110 4120 4130 4140 4150
RGWTLWSSWS YCSVSCGGGS QVRTRSCTVS APPHGSLSCE GPDTQTRHCG
4160 4170 4180 4190 4200
QQLCLQKLER CSWGPWGPCS RSCGTGLASR SGSCPCLLTK EDSKCNDTFL
4210 4220 4230 4240 4250
GLDTQACYSG PCQDDCTWGD WSSWTRCSCK VLVQQRYRHQ VPAPGQAGEG
4260 4270 4280 4290 4300
TPCTRLDGHF RPCTIGNCSE DSCPPPFEFQ SCGSPCAGLC ATHLNHRLCQ
4310 4320 4330 4340 4350
DLPPCQPGCY CPKGLLEQAG SCILPEQCNC WHISGEGARV TLAPGDRLQL
4360 4370 4380 4390 4400
GCKECVCRRG ELQCSSQGCE GLLPLTGWSE WSPCGPCLPQ SALAPASRTA
4410 4420 4430 4440 4450
LEGHWPLNTS DLPPPSVTLL ASEQYRHRLC LDPETRRPWA GDPALCTVPL
4460 4470 4480 4490 4500
SQQRLCPDPG ACNDTCQWGP WGPWSPCQMP CSGGFKLRWR VARDTSAGEC
4510 4520 4530 4540 4550
PGPWAQTESC NMGSCPGESC ETRDTVFTLD CANQCPRSCA DLWDGVQCLQ
4560 4570 4580 4590 4600
GPCSPGCRCP PGQLVQDGHC VPISSCRCGL PSANASWELA PTQVVQLDCH
4610 4620 4630 4640 4650
NCTCINGTLM CPHLECPVLG PWSAWSECSA VCGKGTMVRH RSCEEHPDRE
4660 4670 4680 4690 4700
PCQALDLQQW QECNLQACPE CPPGQVLSTC ATMCPSLCSH LWPGTICVRE
4710 4720 4730 4740 4750
PCQLGCGCPG GQLLYNGTCI PPEACPCTQF SLPWGLTLPL EEQARELPSG
4760 4770 4780 4790 4800
TVLTRNCTHC TCQGGAFICS LTDCQECAPG EIWQHGKLGP CEKTCPEMNM
4810 4820 4830 4840 4850
TQAWSNCTEA QAPGCVCQLG YFRSQTGLCV PEDHCECWHH GSPHLPGSEW
4860 4870 4880 4890 4900
QEACESCRCL HGKSVCIRHC PELSCAQGEV IMQEPGSCCP ICQQDTLKEE
4910 4920 4930 4940 4950
PVSCRYLTEL RNLTKGPCHL DQIEVSYCSG HCRSSTNVMT EEPYLQSQCD
4960 4970 4980 4990
CCSYRLDPDS PVRILNLLCP DGHTEPVVLP VIHSCQCSAC QGGDFSKH
Length:4,998
Mass (Da):534,975
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52726F62E3639AEC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q0I4E9Q0I4_MOUSE
SCO-spondin
Sspo
5,144Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RLZ9A0A1D5RLZ9_MOUSE
SCO-spondin
Sspo
5,135Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WNT4A0A087WNT4_MOUSE
SCO-spondin
Sspo
933Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WRI0A0A087WRI0_MOUSE
SCO-spondin
Sspo
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti192H → Q in CAD42654 (PubMed:12909363).Curated1
Sequence conflicti1043V → L in CAD42654 (PubMed:12909363).Curated1
Sequence conflicti1049E → Y in CAD42654 (PubMed:12909363).Curated1
Sequence conflicti1071V → W in CAD42654 (PubMed:12909363).Curated1
Sequence conflicti1080R → P in CAD42654 (PubMed:12909363).Curated1
Sequence conflicti1769F → G in CAD42654 (PubMed:12909363).Curated1
Sequence conflicti3379P → R in CAD42654 (PubMed:12909363).Curated1
Sequence conflicti3412D → H in CAD42654 (PubMed:12909363).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ491857 mRNA Translation: CAD42654.1
AC153815 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000043676; ENSMUSP00000047991; ENSMUSG00000029797

UCSC genome browser

More...
UCSCi
uc009bul.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ491857 mRNA Translation: CAD42654.1
AC153815 Genomic DNA No translation available.

3D structure databases

SMRiQ8CG65
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131401

PTM databases

iPTMnetiQ8CG65
PhosphoSitePlusiQ8CG65

Proteomic databases

PaxDbiQ8CG65
PRIDEiQ8CG65

Genome annotation databases

EnsembliENSMUST00000043676; ENSMUSP00000047991; ENSMUSG00000029797
UCSCiuc009bul.1 mouse

Organism-specific databases

MGIiMGI:2674311 Sspo

Phylogenomic databases

eggNOGiKOG1215 Eukaryota
KOG1216 Eukaryota
KOG3538 Eukaryota
KOG3611 Eukaryota
ENOG410XNSK LUCA
GeneTreeiENSGT00940000155829
HOGENOMiHOG000154433
InParanoidiQ8CG65

Enzyme and pathway databases

ReactomeiR-MMU-5173214 O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sspo mouse

Protein Ontology

More...
PROi
PR:Q8CG65

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000029797 Expressed in 19 organ(s), highest expression level in diencephalon
ExpressionAtlasiQ8CG65 baseline and differential

Family and domain databases

CDDicd00112 LDLa, 8 hits
Gene3Di2.20.100.10, 23 hits
2.60.120.260, 1 hit
4.10.400.10, 9 hits
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR030119 SCO-spondin
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
PANTHERiPTHR11339:SF358 PTHR11339:SF358, 3 hits
PfamiView protein in Pfam
PF08742 C8, 3 hits
PF00754 F5_F8_type_C, 1 hit
PF00057 Ldl_recept_a, 7 hits
PF01826 TIL, 13 hits
PF00090 TSP_1, 22 hits
PF00093 VWC, 1 hit
PF00094 VWD, 3 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00832 C8, 3 hits
SM00192 LDLa, 10 hits
SM00209 TSP1, 25 hits
SM00214 VWC, 4 hits
SM00215 VWC_out, 9 hits
SM00216 VWD, 2 hits
SUPFAMiSSF49785 SSF49785, 1 hit
SSF57424 SSF57424, 9 hits
SSF57567 SSF57567, 14 hits
SSF82895 SSF82895, 24 hits
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit
PS01186 EGF_2, 2 hits
PS50022 FA58C_3, 1 hit
PS01209 LDLRA_1, 8 hits
PS50068 LDLRA_2, 10 hits
PS50092 TSP1, 25 hits
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 2 hits
PS51233 VWFD, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSSPO_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CG65
Secondary accession number(s): E9QMN0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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