Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Structural maintenance of chromosomes protein 4

Gene

Smc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi111 – 118ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: UniProtKB
  • single-stranded DNA binding Source: MGI

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • kinetochore organization Source: MGI
  • meiotic chromosome condensation Source: MGI
  • meiotic chromosome segregation Source: MGI
  • mitotic chromosome condensation Source: UniProtKB
  • single strand break repair Source: MGI

Keywordsi

Biological processCell cycle, Cell division, DNA condensation, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2299718 Condensation of Prophase Chromosomes
R-MMU-2514853 Condensation of Prometaphase Chromosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 4
Short name:
SMC protein 4
Short name:
SMC-4
Alternative name(s):
Chromosome-associated polypeptide C
XCAP-C homolog
Gene namesi
Name:Smc4
Synonyms:Capc, Smc4l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1917349 Smc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190081 – 1286Structural maintenance of chromosomes protein 4Add BLAST1286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineBy similarity1
Modified residuei27PhosphoserineBy similarity1
Modified residuei40PhosphoserineBy similarity1
Modified residuei141PhosphoserineBy similarity1
Modified residuei379N6-acetyllysineCombined sources1
Modified residuei677N6-acetyllysineBy similarity1
Modified residuei980PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8CG47
MaxQBiQ8CG47
PaxDbiQ8CG47
PeptideAtlasiQ8CG47
PRIDEiQ8CG47

PTM databases

iPTMnetiQ8CG47
PhosphoSitePlusiQ8CG47
SwissPalmiQ8CG47

Expressioni

Gene expression databases

BgeeiENSMUSG00000034349 Expressed in 331 organ(s), highest expression level in telencephalon
CleanExiMM_SMC4
ExpressionAtlasiQ8CG47 baseline and differential
GenevisibleiQ8CG47 MM

Interactioni

Subunit structurei

Forms a heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Yy1Q008992EBI-6921575,EBI-6921536

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213863, 8 interactors
ComplexPortaliCPX-980 Condensin I complex
CPX-986 Condensin II complex
CORUMiQ8CG47
IntActiQ8CG47, 10 interactors
MINTiQ8CG47
STRINGi10090.ENSMUSP00000047872

Structurei

Secondary structure

11286
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8CG47
SMRiQ8CG47
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8CG47

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini611 – 725SMC hingeAdd BLAST115

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili270 – 589Sequence analysisAdd BLAST320
Coiled coili768 – 1018Sequence analysisAdd BLAST251
Coiled coili1068 – 1133Sequence analysisAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi64 – 69Poly-Pro6
Compositional biasi1189 – 1224Ala/Asp-rich (DA-box)Add BLAST36

Domaini

The SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC2, forming a V-shaped heterodimer.By similarity

Sequence similaritiesi

Belongs to the SMC family. SMC4 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0996 Eukaryota
COG1196 LUCA
GeneTreeiENSGT00900000141094
HOGENOMiHOG000184777
HOVERGENiHBG106696
InParanoidiQ8CG47
KOiK06675
OrthoDBiEOG091G01SY
PhylomeDBiQ8CG47
TreeFamiTF101158

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR003395 RecF/RecN/SMC_N
IPR024704 SMC
IPR010935 SMC_hinge
IPR036277 SMC_hinge_sf
PfamiView protein in Pfam
PF06470 SMC_hinge, 1 hit
PF02463 SMC_N, 1 hit
PIRSFiPIRSF005719 SMC, 1 hit
SMARTiView protein in SMART
SM00968 SMC_hinge, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF75553 SSF75553, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8CG47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRKGTKPST ACHQEEGPPP SQDGAHSDEE MEQPAGEAES AAPAKPPGEE
60 70 80 90 100
LDNRSLEEIL NSIPPPPPPA MASEAGAPRL MITHIVNQNF KSYAGEKVLG
110 120 130 140 150
PFHKRFSCII GPNGSGKSNV IDSMLFVFGY RAQKIRSKKL SVLIHNSDEH
160 170 180 190 200
KDIQSCTVEV HFQKIIDKEG DDYEVLPNSN FYVSRTAYRD STSVYHISGK
210 220 230 240 250
KKTFKDVGNL LRSHGIDLDH NRFLILQGEV EQIAMMKPKG QTEHDEGMLE
260 270 280 290 300
YLEDIIGCGR LNEPIKVLCR RVEILNEHRG EKLNRVKMVE KEKDALEGEK
310 320 330 340 350
NIAIEFLTLE NEMFKKKNHI CQYYIYDLQN RIAEITTQKE KIHEDTKEIT
360 370 380 390 400
EKSNVLSNEM KAKNSAVKDV EKKLNKVTKF IEQNKEKFTQ LDLEDVQVRE
410 420 430 440 450
KLKHATSKAK KLEKQLQKDK EKVEELKSVP AKSKTVINET TTRNNSLEKE
460 470 480 490 500
REKEEKKLKE VMDSLKQETQ GLQKEKEIQE KELMGFNKSV NEARSKMEVA
510 520 530 540 550
QSELDIYLSR HNTAVSQLSK AKEALITASE TLKERKAAIK DINTKLPQTQ
560 570 580 590 600
QELKEKEKEL QKLTQEEINL KSLVHDLFQK VEEAKSSLAM NRSRGKVLDA
610 620 630 640 650
IIQEKKSGRI PGIYGRLGDL GAIDEKYDIA ISSCCHALDY IVVDSIDTAQ
660 670 680 690 700
ECVNFLKKHN IGIATFIGLD KMTVWAKKMS KIQTPENTPR LFDLVKVKNE
710 720 730 740 750
EIRQAFYFAL RDTLVANNLD QATRVAYQRD RRWRVVTLQG QIIEQSGTMS
760 770 780 790 800
GGGSKVMRGR MGSSVIDEIS VEEVNKMESQ LERHSKQAMQ IQEQKVQHEE
810 820 830 840 850
AVVKLRHSER DMRNTLEKFA ASIQGLSEQE EYLCVQIKEL EANVLTTAPD
860 870 880 890 900
RKQQKLLEEN VSVFKKEYDA VAEKAGKVEA EIKRLHNTII DINNRKLKAQ
910 920 930 940 950
QNKLDTINKQ LDECASAITK AQVAIKTADR NLKKAQDSVC RTEKEIKDTE
960 970 980 990 1000
KEINDLKTEL KNIEDKAEEV INNTKTAETS LPEIQKEHRN LLQELKVIQE
1010 1020 1030 1040 1050
NEHALQKDAL SIKLKLEQID GHISEHNSKI KYWQKEISKI KLHPVEDNPV
1060 1070 1080 1090 1100
ETVAVLSQEE LEAIKNPESI TNEIALLEAQ CREMKPNLGA IAEYKKKEDL
1110 1120 1130 1140 1150
YLQRVAELDK ITSERDNFRQ AYEDLRKQRL NEFMAGFYVI TNKLKENYQM
1160 1170 1180 1190 1200
LTLGGDAELE LVDSLDPFSE GIMFSVRPPK KSWKKIFNLS GGEKTLSSLA
1210 1220 1230 1240 1250
LVFALHHYKP TPLYFMDEID AALDFKNVSI VAFYIYEQTK NAQFIIISLR
1260 1270 1280
NNMFEISDRL IGIYKTYNST KSVAVNPKQI ASKGLC
Length:1,286
Mass (Da):146,895
Last modified:March 1, 2003 - v1
Checksum:iCFEAD84199C3CEB5
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q2X6E9Q2X6_MOUSE
Structural maintenance of chromosom...
Smc4
1,261Annotation score:
Q3U763Q3U763_MOUSE
Structural maintenance of chromosom...
Smc4 Smc4l1
337Annotation score:
A0A0A6YXY3A0A0A6YXY3_MOUSE
Structural maintenance of chromosom...
Smc4
109Annotation score:
D6RCX2D6RCX2_MOUSE
Structural maintenance of chromosom...
Smc4
46Annotation score:
A0A0A6YX07A0A0A6YX07_MOUSE
Structural maintenance of chromosom...
Smc4
56Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti454E → V in BAC40608 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ534940 mRNA Translation: CAD59183.1
BC005507 mRNA Translation: AAH05507.1
BC062939 mRNA Translation: AAH62939.1
AK088350 mRNA Translation: BAC40297.1
AK088846 mRNA Translation: BAC40608.2
CCDSiCCDS17401.1
RefSeqiNP_598547.1, NM_133786.3
XP_006502109.1, XM_006502046.2
UniGeneiMm.206841

Genome annotation databases

EnsembliENSMUST00000042901; ENSMUSP00000047872; ENSMUSG00000034349
GeneIDi70099
KEGGimmu:70099
UCSCiuc008pma.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ534940 mRNA Translation: CAD59183.1
BC005507 mRNA Translation: AAH05507.1
BC062939 mRNA Translation: AAH62939.1
AK088350 mRNA Translation: BAC40297.1
AK088846 mRNA Translation: BAC40608.2
CCDSiCCDS17401.1
RefSeqiNP_598547.1, NM_133786.3
XP_006502109.1, XM_006502046.2
UniGeneiMm.206841

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L51X-ray1.51B595-752[»]
ProteinModelPortaliQ8CG47
SMRiQ8CG47
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213863, 8 interactors
ComplexPortaliCPX-980 Condensin I complex
CPX-986 Condensin II complex
CORUMiQ8CG47
IntActiQ8CG47, 10 interactors
MINTiQ8CG47
STRINGi10090.ENSMUSP00000047872

PTM databases

iPTMnetiQ8CG47
PhosphoSitePlusiQ8CG47
SwissPalmiQ8CG47

Proteomic databases

EPDiQ8CG47
MaxQBiQ8CG47
PaxDbiQ8CG47
PeptideAtlasiQ8CG47
PRIDEiQ8CG47

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042901; ENSMUSP00000047872; ENSMUSG00000034349
GeneIDi70099
KEGGimmu:70099
UCSCiuc008pma.1 mouse

Organism-specific databases

CTDi10051
MGIiMGI:1917349 Smc4

Phylogenomic databases

eggNOGiKOG0996 Eukaryota
COG1196 LUCA
GeneTreeiENSGT00900000141094
HOGENOMiHOG000184777
HOVERGENiHBG106696
InParanoidiQ8CG47
KOiK06675
OrthoDBiEOG091G01SY
PhylomeDBiQ8CG47
TreeFamiTF101158

Enzyme and pathway databases

ReactomeiR-MMU-2299718 Condensation of Prophase Chromosomes
R-MMU-2514853 Condensation of Prometaphase Chromosomes

Miscellaneous databases

ChiTaRSiSmc4 mouse
EvolutionaryTraceiQ8CG47
PROiPR:Q8CG47
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034349 Expressed in 331 organ(s), highest expression level in telencephalon
CleanExiMM_SMC4
ExpressionAtlasiQ8CG47 baseline and differential
GenevisibleiQ8CG47 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR003395 RecF/RecN/SMC_N
IPR024704 SMC
IPR010935 SMC_hinge
IPR036277 SMC_hinge_sf
PfamiView protein in Pfam
PF06470 SMC_hinge, 1 hit
PF02463 SMC_N, 1 hit
PIRSFiPIRSF005719 SMC, 1 hit
SMARTiView protein in SMART
SM00968 SMC_hinge, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF75553 SSF75553, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSMC4_MOUSE
AccessioniPrimary (citable) accession number: Q8CG47
Secondary accession number(s): Q8BTS7, Q8BTY9, Q99K21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again