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Protein

Structural maintenance of chromosomes protein 5

Gene

Smc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi80 – 87ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 5
Short name:
SMC protein 5
Short name:
SMC-5
Short name:
mSMC5
Alternative name(s):
Protein expressed in male leptotene and zygotene spermatocytes 453
Short name:
MLZ-453
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Smc5
Synonyms:Kiaa0594, Smc5l1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2385088 Smc5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002709521 – 1101Structural maintenance of chromosomes protein 5Add BLAST1101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei25PhosphoserineBy similarity1
Modified residuei35PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated.By similarity
Ubiquitinated.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8CG46

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CG46

PeptideAtlas

More...
PeptideAtlasi
Q8CG46

PRoteomics IDEntifications database

More...
PRIDEi
Q8CG46

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CG46

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CG46

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis but not ovary.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in ovary and testis at E15.5.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024943 Expressed in 268 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
MM_SMC5

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CG46 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CG46 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer with SMC6. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. Interacts with NSMCE2. Interacts with SLF2; this interaction induces an association of the SLF1-SLF2 complex with the SMC5-SMC6 complex. Interacts with RAD18; this interaction is increased in a SLF1 or SLF2-dependent manner.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
230460, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000084837

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8CG46

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CG46

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni441 – 644Flexible hingeAdd BLAST204

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili207 – 440Sequence analysisAdd BLAST234
Coiled coili645 – 753Sequence analysisAdd BLAST109
Coiled coili780 – 828Sequence analysisAdd BLAST49
Coiled coili888 – 927Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi991 – 1026Ala/Asp-rich (DA-box)Add BLAST36

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC6, forming a V-shaped heterodimer.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMC family. SMC5 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0979 Eukaryota
COG1196 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074816

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154342

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG093963

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CG46

KEGG Orthology (KO)

More...
KOi
K22803

Identification of Orthologs from Complete Genome Data

More...
OMAi
PNLNMIV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0A1Y

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CG46

TreeFam database of animal gene trees

More...
TreeFami
TF105708

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR003395 RecF/RecN/SMC_N
IPR027131 SMC5

The PANTHER Classification System

More...
PANTHERi
PTHR19306:SF1 PTHR19306:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02463 SMC_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CG46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATPSGKAAP PNPQVSKRSL PRDASSEVPS KRKNSNPLPT LPRPSGTFVE
60 70 80 90 100
GSIVRIAMEN FLTYDICEVS PGPHLNMIIG ANGTGKSSIV CAICLGLAGK
110 120 130 140 150
PAFMGRADKV GFFVKRGCSK GLVEIELFRT SGNLIITREI DVIKNQSFWF
160 170 180 190 200
INKKPVTQKI VEEQVAALNI QVGNLCQFLP QDKVGEFAKL SKIELLEATE
210 220 230 240 250
KSVGPPEMHR YHCELKNFRE KEKQLETSCK EKTEYLEKMV QRNERYKQDV
260 270 280 290 300
ERFYERKRHL DLIEMLEAKR PWVEYENVRQ EYEGVKLIRD RVKEEVRKLK
310 320 330 340 350
EGQIPMTRRI EEIDRQRHTL EVRIKEKSTD IKEASQKCKQ RQDLIERKDR
360 370 380 390 400
QIKELQQALT VKQNEELDRQ KRISNTRKMI EDLQSELKTA ENCENLQPQI
410 420 430 440 450
DTVTNDLRRV QEEKALCEGE IIDKQREKEM LEKQRRSVSD HITRFDNLMN
460 470 480 490 500
QKEDKLRQRY RDTYDAVLWL RNNRDRFKQR VCEPIMLTIN MKDNKNAKYV
510 520 530 540 550
ENHISSNDLR AFVFESQEDM EIFLREVRDN KKLRVNAVIA PKISYADKAP
560 570 580 590 600
SRSLNDLKQY GFFSYLRELF DAPDPVMSYL CCQYHIHEVP VGTERTRERI
610 620 630 640 650
ERVIQETRLK QIYTAEEKYV LKTSVYSNKV ISSNTSLKVA QFLTVTVDLE
660 670 680 690 700
QRRHLEEQLK EMNRQLEAVD SGLAALRDTN RHLELKDNEL RLKKKELLER
710 720 730 740 750
KTRKRQLEQK ISSKLASIRL MEQDTCNLEE EERKASTKIK EINVQKAKLV
760 770 780 790 800
TELTGLVKIC TSFQIQKVDL ILQNTTVISE KNKLEADYMA SSSQLRVTEQ
810 820 830 840 850
QFIELDDNRQ RLLQKCKELM KKARQVCNLS ADQAVPQEFQ TQVPTIPNGH
860 870 880 890 900
SSSPPMAFQD LPNTLDEIDA LLTEERSRAS CFTGLNPSVV EEYSKREVEI
910 920 930 940 950
QQLTEELQGK KVELDEYREN ISQVKERWLN PLKELVEKIN EKFSNFFSSM
960 970 980 990 1000
QCAGEVDLHT ENEEDYDKYG IRIRVKFRSS TQLHELTPHH QSGGERSVST
1010 1020 1030 1040 1050
MLYLMALQEL NRCPFRVVDE INQGMDPINE RRVFEMVVNT ACKENTSQYF
1060 1070 1080 1090 1100
FITPKLLQNL PYSEKMTVLF VYNGPHMLEP NRWNLKAFQR RRRRITFTQP

Q
Length:1,101
Mass (Da):128,813
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71F7D790EE28C427
GO
Isoform 2 (identifier: Q8CG46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     842-856: Missing.
     888-888: S → SV

Note: No experimental confirmation available.
Show »
Length:1,087
Mass (Da):127,382
Checksum:i0394ACA599DE1858
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YDG5A0A286YDG5_MOUSE
Structural maintenance of chromosom...
Smc5
1,011Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH07174 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti545Y → C in AAH07174 (PubMed:12693553).Curated1
Sequence conflicti675A → T in AAH07174 (PubMed:12693553).Curated1
Sequence conflicti842 – 847QVPTIP → VSIKIS in BAC65603 (PubMed:12693553).Curated6

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_022251842 – 856Missing in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_022252888S → SV in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ534941 mRNA Translation: CAD59184.1
BC007174 mRNA Translation: AAH07174.1 Different initiation.
BC038345 mRNA Translation: AAH38345.1
AK122321 Transcribed RNA Translation: BAC65603.3

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37936.1 [Q8CG46-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001239613.1, NM_001252684.1 [Q8CG46-1]
NP_722503.1, NM_153808.2 [Q8CG46-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.23267

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000087556; ENSMUSP00000084837; ENSMUSG00000024943 [Q8CG46-1]
ENSMUST00000223934; ENSMUSP00000153364; ENSMUSG00000024943 [Q8CG46-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
226026

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:226026

UCSC genome browser

More...
UCSCi
uc008haa.2 mouse [Q8CG46-2]
uc008hab.2 mouse [Q8CG46-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ534941 mRNA Translation: CAD59184.1
BC007174 mRNA Translation: AAH07174.1 Different initiation.
BC038345 mRNA Translation: AAH38345.1
AK122321 Transcribed RNA Translation: BAC65603.3
CCDSiCCDS37936.1 [Q8CG46-2]
RefSeqiNP_001239613.1, NM_001252684.1 [Q8CG46-1]
NP_722503.1, NM_153808.2 [Q8CG46-2]
UniGeneiMm.23267

3D structure databases

ProteinModelPortaliQ8CG46
SMRiQ8CG46
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230460, 2 interactors
STRINGi10090.ENSMUSP00000084837

PTM databases

iPTMnetiQ8CG46
PhosphoSitePlusiQ8CG46

Proteomic databases

EPDiQ8CG46
PaxDbiQ8CG46
PeptideAtlasiQ8CG46
PRIDEiQ8CG46

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087556; ENSMUSP00000084837; ENSMUSG00000024943 [Q8CG46-1]
ENSMUST00000223934; ENSMUSP00000153364; ENSMUSG00000024943 [Q8CG46-2]
GeneIDi226026
KEGGimmu:226026
UCSCiuc008haa.2 mouse [Q8CG46-2]
uc008hab.2 mouse [Q8CG46-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23137
MGIiMGI:2385088 Smc5

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG0979 Eukaryota
COG1196 LUCA
GeneTreeiENSGT00550000074816
HOGENOMiHOG000154342
HOVERGENiHBG093963
InParanoidiQ8CG46
KOiK22803
OMAiPNLNMIV
OrthoDBiEOG091G0A1Y
PhylomeDBiQ8CG46
TreeFamiTF105708

Enzyme and pathway databases

ReactomeiR-MMU-3108214 SUMOylation of DNA damage response and repair proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Smc5 mouse

Protein Ontology

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PROi
PR:Q8CG46

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000024943 Expressed in 268 organ(s), highest expression level in testis
CleanExiMM_SMC5
ExpressionAtlasiQ8CG46 baseline and differential
GenevisibleiQ8CG46 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR003395 RecF/RecN/SMC_N
IPR027131 SMC5
PANTHERiPTHR19306:SF1 PTHR19306:SF1, 1 hit
PfamiView protein in Pfam
PF02463 SMC_N, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMC5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CG46
Secondary accession number(s): Q80TW7, Q8CHX5, Q922K3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2003
Last modified: December 5, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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