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Entry version 123 (16 Jan 2019)
Sequence version 2 (15 Dec 2003)
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Protein

Aflatoxin B1 aldehyde reductase member 2

Gene

Akr7a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. Acts as a 2-carboxybenzaldehyde reductase.1 Publication

Miscellaneous

With 4-nitrobenzaldehyde as substrate, it exhibits a substantially greater specific activity with NADPH than with NADH. Conversely, it has a 1.8-fold higher activity towards succinic semialdehyde with NADH than with NADPH.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Has a low KM for succinic semialdehyde.

      Sites

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei80NADPBy similarity1
      <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei85Proton donorBy similarity1
      <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei113Lowers pKa of active site TyrBy similarity1
      Binding sitei149SubstrateBy similarity1
      Binding sitei205NADPBy similarity1
      Binding sitei258NADPBy similarity1
      Binding sitei268SubstrateBy similarity1
      Binding sitei271SubstrateBy similarity1
      Binding sitei367SubstrateBy similarity1

      Regions

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi179 – 180NADPBy similarity2
      Nucleotide bindingi234 – 244NADPBy similarityAdd BLAST11
      Nucleotide bindingi326 – 334NADPBy similarity9

      <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

      • alditol:NADP+ 1-oxidoreductase activity Source: RGD
      • aldo-keto reductase (NADP) activity Source: RGD

      <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

      Molecular functionOxidoreductase
      LigandNADP

      Enzyme and pathway databases

      SABIO-RK: Biochemical Reaction Kinetics Database

      More...
      SABIO-RKi
      Q8CG45

      <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
      Recommended name:
      Aflatoxin B1 aldehyde reductase member 2 (EC:1.1.1.n11)
      Short name:
      rAFAR2
      Alternative name(s):
      Succinic semialdehyde reductase
      Short name:
      SSA reductase
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
      Name:Akr7a2
      Synonyms:Afar2, Aiar
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
      • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

      Organism-specific databases

      Rat genome database

      More...
      RGDi
      620311 Akr7a2

      <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

      Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

      Keywords - Cellular componenti

      Cytoplasm, Golgi apparatus

      <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

      Molecule processing

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000703771 – 367Aflatoxin B1 aldehyde reductase member 2Add BLAST367

      Amino acid modifications

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40PhosphoserineBy similarity1
      Modified residuei48PhosphothreonineBy similarity1
      Modified residuei136N6-acetyllysineBy similarity1
      Modified residuei244N6-succinyllysineBy similarity1
      Modified residuei263PhosphoserineCombined sources1

      Keywords - PTMi

      Acetylation, Phosphoprotein

      Proteomic databases

      jPOST - Japan Proteome Standard Repository/Database

      More...
      jPOSTi
      Q8CG45

      PaxDb, a database of protein abundance averages across all three domains of life

      More...
      PaxDbi
      Q8CG45

      PRoteomics IDEntifications database

      More...
      PRIDEi
      Q8CG45

      PTM databases

      iPTMnet integrated resource for PTMs in systems biology context

      More...
      iPTMneti
      Q8CG45

      Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

      More...
      PhosphoSitePlusi
      Q8CG45

      <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

      <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

      Homodimer. Heterodimer with AKR7A1.1 Publication

      Protein-protein interaction databases

      The Biological General Repository for Interaction Datasets (BioGrid)

      More...
      BioGridi
      251255, 1 interactor

      STRING: functional protein association networks

      More...
      STRINGi
      10116.ENSRNOP00000024063

      <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

      3D structure databases

      Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

      More...
      ProteinModelPortali
      Q8CG45

      SWISS-MODEL Repository - a database of annotated 3D protein structure models

      More...
      SMRi
      Q8CG45

      Database of comparative protein structure models

      More...
      ModBasei
      Search...

      MobiDB: a database of protein disorder and mobility annotations

      More...
      MobiDBi
      Search...

      <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

      <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

      Phylogenomic databases

      evolutionary genealogy of genes: Non-supervised Orthologous Groups

      More...
      eggNOGi
      ENOG410IDYD Eukaryota
      COG0667 LUCA

      The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

      More...
      HOGENOMi
      HOG000250286

      The HOVERGEN Database of Homologous Vertebrate Genes

      More...
      HOVERGENi
      HBG050576

      InParanoid: Eukaryotic Ortholog Groups

      More...
      InParanoidi
      Q8CG45

      KEGG Orthology (KO)

      More...
      KOi
      K15303

      Database of Orthologous Groups

      More...
      OrthoDBi
      1226539at2759

      Database for complete collections of gene phylogenies

      More...
      PhylomeDBi
      Q8CG45

      TreeFam database of animal gene trees

      More...
      TreeFami
      TF329173

      Family and domain databases

      Conserved Domains Database

      More...
      CDDi
      cd06660 Aldo_ket_red, 1 hit

      Gene3D Structural and Functional Annotation of Protein Families

      More...
      Gene3Di
      3.20.20.100, 1 hit

      Integrated resource of protein families, domains and functional sites

      More...
      InterProi
      View protein in InterPro
      IPR023210 NADP_OxRdtase_dom
      IPR036812 NADP_OxRdtase_dom_sf

      Pfam protein domain database

      More...
      Pfami
      View protein in Pfam
      PF00248 Aldo_ket_red, 1 hit

      Superfamily database of structural and functional annotation

      More...
      SUPFAMi
      SSF51430 SSF51430, 1 hit

      <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

      This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

      Q8CG45-1 [UniParc]FASTAAdd to basket
      « Hide
              10         20         30         40         50
      MLRAVSRAVS RAAVRCAWRS GPSVARPLAM SRSPAPRAVS GAPLRPGTVL
      60 70 80 90 100
      GTMEMGRRMD ASASAATVRA FLERGLNELD TAFMYCDGQS ESILGSLGLG
      110 120 130 140 150
      LGSGDCTVKI ATKANPWDGK SLKPDSVRSQ LETSLKRLQC PRVDLFYLHA
      160 170 180 190 200
      PDHGTPIVET LQACQQLHQE GKFVELGLSN YASWEVAEIY TLCKSNGWIL
      210 220 230 240 250
      PTVYQGMYNA TTRQVETELL PCLRYFGLRF YAYNPLAGGL LTGKYRYEDK
      260 270 280 290 300
      DGKQPEGRFF GNSWSETYRN RFWKEHHFEA IALVEKALKT TYGTSAPSMT
      310 320 330 340 350
      SAALRWMYHH SQLQGTRGDA VILGMSSLEQ LEQNLAATEE GPLEPAVVEA
      360
      FNQAWNVVAH ECPNYFR
      Length:367
      Mass (Da):40,675
      Last modified:December 15, 2003 - v2
      <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA27A3FBB454FEC5
      GO

      <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

      There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
      EntryEntry nameProtein names
      Gene namesLengthAnnotation
      A0A0A0MXY9A0A0A0MXY9_RAT
      Aflatoxin B1 aldehyde reductase mem...
      Akr7a2
      366Annotation score:

      Annotation score:1 out of 5

      <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
      A0A0G2K3V2A0A0G2K3V2_RAT
      Aflatoxin B1 aldehyde reductase mem...
      Akr7a2
      337Annotation score:

      Annotation score:1 out of 5

      <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

      <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

      The sequence AAH61816 differs from that shown. Reason: Erroneous initiation.Curated
      The sequence BAA90396 differs from that shown. Reason: Erroneous initiation.Curated
      The sequence CAC81080 differs from that shown. Reason: Erroneous initiation.Curated

      Experimental Info

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti136K → N in AAN03824 (PubMed:12071861).Curated1
      Sequence conflicti295S → D in AAN03824 (PubMed:12071861).Curated1
      Sequence conflicti299 – 300MT → ND in CAC81080 (PubMed:12879023).Curated2

      Sequence databases

      Select the link destinations:

      EMBL nucleotide sequence database

      More...
      EMBLi

      GenBank nucleotide sequence database

      More...
      GenBanki

      DNA Data Bank of Japan; a nucleotide sequence database

      More...
      DDBJi
      Links Updated
      AF503514 mRNA Translation: AAN03824.1
      BC061816 mRNA Translation: AAH61816.1 Different initiation.
      AJ271883 mRNA Translation: CAC81080.1 Different initiation.
      AB037424 mRNA Translation: BAA90396.1 Different initiation.

      NCBI Reference Sequences

      More...
      RefSeqi
      NP_599234.1, NM_134407.1

      UniGene gene-oriented nucleotide sequence clusters

      More...
      UniGenei
      Rn.8548

      Genome annotation databases

      Database of genes from NCBI RefSeq genomes

      More...
      GeneIDi
      171445

      KEGG: Kyoto Encyclopedia of Genes and Genomes

      More...
      KEGGi
      rno:171445

      UCSC genome browser

      More...
      UCSCi
      RGD:620311 rat

      <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

      <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

      Sequence databases

      Select the link destinations:
      EMBLi
      GenBanki
      DDBJi
      Links Updated
      AF503514 mRNA Translation: AAN03824.1
      BC061816 mRNA Translation: AAH61816.1 Different initiation.
      AJ271883 mRNA Translation: CAC81080.1 Different initiation.
      AB037424 mRNA Translation: BAA90396.1 Different initiation.
      RefSeqiNP_599234.1, NM_134407.1
      UniGeneiRn.8548

      3D structure databases

      ProteinModelPortaliQ8CG45
      SMRiQ8CG45
      ModBaseiSearch...
      MobiDBiSearch...

      Protein-protein interaction databases

      BioGridi251255, 1 interactor
      STRINGi10116.ENSRNOP00000024063

      PTM databases

      iPTMnetiQ8CG45
      PhosphoSitePlusiQ8CG45

      Proteomic databases

      jPOSTiQ8CG45
      PaxDbiQ8CG45
      PRIDEiQ8CG45

      Protocols and materials databases

      Structural Biology KnowledgebaseSearch...

      Genome annotation databases

      GeneIDi171445
      KEGGirno:171445
      UCSCiRGD:620311 rat

      Organism-specific databases

      Comparative Toxicogenomics Database

      More...
      CTDi
      8574
      RGDi620311 Akr7a2

      Phylogenomic databases

      eggNOGiENOG410IDYD Eukaryota
      COG0667 LUCA
      HOGENOMiHOG000250286
      HOVERGENiHBG050576
      InParanoidiQ8CG45
      KOiK15303
      OrthoDBi1226539at2759
      PhylomeDBiQ8CG45
      TreeFamiTF329173

      Enzyme and pathway databases

      SABIO-RKiQ8CG45

      Miscellaneous databases

      Protein Ontology

      More...
      PROi
      PR:Q8CG45

      Family and domain databases

      CDDicd06660 Aldo_ket_red, 1 hit
      Gene3Di3.20.20.100, 1 hit
      InterProiView protein in InterPro
      IPR023210 NADP_OxRdtase_dom
      IPR036812 NADP_OxRdtase_dom_sf
      PfamiView protein in Pfam
      PF00248 Aldo_ket_red, 1 hit
      SUPFAMiSSF51430 SSF51430, 1 hit

      ProtoNet; Automatic hierarchical classification of proteins

      More...
      ProtoNeti
      Search...

      <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

      <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARK72_RAT
      <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CG45
      Secondary accession number(s): Q6P765, Q8K435, Q9JM82
      <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
      Last sequence update: December 15, 2003
      Last modified: January 16, 2019
      This is version 123 of the entry and version 2 of the sequence. See complete history.
      <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
      Annotation programChordata Protein Annotation Program

      <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

      Keywords - Technical termi

      Complete proteome, Direct protein sequencing, Reference proteome

      Documents

      1. SIMILARITY comments
        Index of protein domains and families
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