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Entry version 162 (11 Dec 2019)
Sequence version 2 (05 May 2009)
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Protein

Latent-transforming growth factor beta-binding protein 1

Gene

Ltbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2129379 Molecules associated with elastic fibres
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Latent-transforming growth factor beta-binding protein 12 Publications
Short name:
LTBP-12 Publications
Alternative name(s):
Transforming growth factor beta-1-binding protein 1By similarity
Short name:
TGF-beta1-BP-1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ltbp1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109151 Ltbp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000763724 – 1712Latent-transforming growth factor beta-binding protein 1Add BLAST1689

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi185 ↔ 195PROSITE-ProRule annotation
Disulfide bondi189 ↔ 201PROSITE-ProRule annotation
Disulfide bondi203 ↔ 212PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi339N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi395 ↔ 405PROSITE-ProRule annotation
Disulfide bondi399 ↔ 411PROSITE-ProRule annotation
Disulfide bondi413 ↔ 422PROSITE-ProRule annotation
Glycosylationi416N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi551 ↔ 573PROSITE-ProRule annotation
Disulfide bondi560 ↔ 586PROSITE-ProRule annotation
Disulfide bondi574 ↔ 589PROSITE-ProRule annotation
Glycosylationi612N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi622 ↔ 633PROSITE-ProRule annotation
Disulfide bondi628 ↔ 642PROSITE-ProRule annotation
Disulfide bondi644 ↔ 657PROSITE-ProRule annotation
Disulfide bondi671 ↔ 694PROSITE-ProRule annotation
Disulfide bondi681 ↔ 706PROSITE-ProRule annotation
Disulfide bondi695 ↔ 709PROSITE-ProRule annotation
Disulfide bondi696 ↔ 721PROSITE-ProRule annotation
Disulfide bondi869 ↔ 881PROSITE-ProRule annotation
Disulfide bondi876 ↔ 890PROSITE-ProRule annotation
Disulfide bondi892 ↔ 905PROSITE-ProRule annotation
Disulfide bondi911 ↔ 923PROSITE-ProRule annotation
Disulfide bondi918 ↔ 932PROSITE-ProRule annotation
Disulfide bondi934 ↔ 947PROSITE-ProRule annotation
Disulfide bondi953 ↔ 964PROSITE-ProRule annotation
Disulfide bondi959 ↔ 973PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei966(3R)-3-hydroxyasparagineBy similarity1
Disulfide bondi976 ↔ 988PROSITE-ProRule annotation
Disulfide bondi994 ↔ 1005PROSITE-ProRule annotation
Disulfide bondi1000 ↔ 1014PROSITE-ProRule annotation
Disulfide bondi1017 ↔ 1028PROSITE-ProRule annotation
Disulfide bondi1034 ↔ 1045PROSITE-ProRule annotation
Disulfide bondi1040 ↔ 1054PROSITE-ProRule annotation
Glycosylationi1042N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1056 ↔ 1069PROSITE-ProRule annotation
Disulfide bondi1075 ↔ 1086PROSITE-ProRule annotation
Disulfide bondi1081 ↔ 1095PROSITE-ProRule annotation
Disulfide bondi1097 ↔ 1110PROSITE-ProRule annotation
Disulfide bondi1116 ↔ 1127PROSITE-ProRule annotation
Disulfide bondi1122 ↔ 1136PROSITE-ProRule annotation
Modified residuei1129(3R)-3-hydroxyasparagineBy similarity1
Disulfide bondi1138 ↔ 1151PROSITE-ProRule annotation
Disulfide bondi1157 ↔ 1169PROSITE-ProRule annotation
Disulfide bondi1164 ↔ 1178PROSITE-ProRule annotation
Disulfide bondi1180 ↔ 1192PROSITE-ProRule annotation
Disulfide bondi1198 ↔ 1210PROSITE-ProRule annotation
Disulfide bondi1204 ↔ 1219PROSITE-ProRule annotation
Disulfide bondi1221 ↔ 1234PROSITE-ProRule annotation
Disulfide bondi1240 ↔ 1252PROSITE-ProRule annotation
Glycosylationi1242N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1246 ↔ 1261PROSITE-ProRule annotation
Disulfide bondi1263 ↔ 1276PROSITE-ProRule annotation
Disulfide bondi1282 ↔ 1294PROSITE-ProRule annotation
Disulfide bondi1289 ↔ 1303PROSITE-ProRule annotation
Disulfide bondi1305 ↔ 1319PROSITE-ProRule annotation
Disulfide bondi1340 ↔ 1363PROSITE-ProRule annotation
Disulfide bondi1350 ↔ 1375PROSITE-ProRule annotation
Disulfide bondi1350Interchain (with C-33 in TGFB1); in linked formBy similarity
Glycosylationi1357N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1364 ↔ 1380PROSITE-ProRule annotation
Disulfide bondi1365 ↔ 1392PROSITE-ProRule annotation
Disulfide bondi1375Interchain (with C-33 in TGFB1); in linked formBy similarity
Modified residuei1405PhosphoserineBy similarity1
Disulfide bondi1419 ↔ 1432PROSITE-ProRule annotation
Disulfide bondi1427 ↔ 1441PROSITE-ProRule annotation
Disulfide bondi1443 ↔ 1456PROSITE-ProRule annotation
Disulfide bondi1462 ↔ 1473PROSITE-ProRule annotation
Disulfide bondi1468 ↔ 1482PROSITE-ProRule annotation
Disulfide bondi1484 ↔ 1497PROSITE-ProRule annotation
Disulfide bondi1517 ↔ 1541PROSITE-ProRule annotation
Disulfide bondi1527 ↔ 1553PROSITE-ProRule annotation
Disulfide bondi1542 ↔ 1556PROSITE-ProRule annotation
Disulfide bondi1543 ↔ 1568PROSITE-ProRule annotation
Modified residuei1588PhosphoserineBy similarity1
Modified residuei1607PhosphoserineCombined sources1
Disulfide bondi1616 ↔ 1627PROSITE-ProRule annotation
Disulfide bondi1622 ↔ 1636PROSITE-ProRule annotation
Disulfide bondi1638 ↔ 1651PROSITE-ProRule annotation
Disulfide bondi1657 ↔ 1672PROSITE-ProRule annotation
Disulfide bondi1667 ↔ 1681PROSITE-ProRule annotation
Disulfide bondi1683 ↔ 1696PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Contains hydroxylated asparagine residues.By similarity
Two intrachain disulfide bonds from the TB3 domain are rearranged upon TGFB1 binding, and form interchain bonds with TGFB1 propeptide, anchoring it to the extracellular matrix.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CG19

PeptideAtlas

More...
PeptideAtlasi
Q8CG19

PRoteomics IDEntifications database

More...
PRIDEi
Q8CG19

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CG19

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CG19

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000001870 Expressed in 276 organ(s), highest expression level in cumulus cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CG19 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CG19 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TGFB1; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1, leading to regulate activation of TGF-beta-1. LTBP1 does not bind directly to TGF-beta-1, the active chain of TGFB1.

Interacts (via C-terminal domain) with FBN1 (via N-terminal domain).

Interacts with FBN2.

Interacts with ADAMTSL2.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
234589, 5 interactors

Protein interaction database and analysis system

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IntActi
Q8CG19, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000001927

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8CG19 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CG19

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini181 – 213EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini391 – 423EGF-like 2PROSITE-ProRule annotationAdd BLAST33
Domaini549 – 601TB 1PROSITE-ProRule annotationAdd BLAST53
Domaini618 – 658EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini669 – 721TB 2PROSITE-ProRule annotationAdd BLAST53
Domaini865 – 906EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini907 – 948EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini949 – 989EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini990 – 1029EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1030 – 1070EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1071 – 1111EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1112 – 1152EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1153 – 1193EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1194 – 1235EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1236 – 1277EGF-like 13; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1278 – 1320EGF-like 14; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini1338 – 1392TB 3PROSITE-ProRule annotationAdd BLAST55
Domaini1415 – 1457EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini1458 – 1498EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1515 – 1568TB 4PROSITE-ProRule annotationAdd BLAST54
Domaini1612 – 1652EGF-like 17PROSITE-ProRule annotationAdd BLAST41
Domaini1653 – 1697EGF-like 18; calcium-bindingPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1335 – 14028-Cys3 regionBy similarityAdd BLAST68
Regioni1498 – 1712C-terminal domainBy similarityAdd BLAST215

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi96 – 124Pro-richAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The 8-Cys3 region in the third TB domain mediates the interchain disulfide bond interaction with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LTBP family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217 Eukaryota
ENOG410Z7XK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155823

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CG19

KEGG Orthology (KO)

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KOi
K19559

Identification of Orthologs from Complete Genome Data

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OMAi
PQFPGIV

Database of Orthologous Groups

More...
OrthoDBi
1174178at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CG19

TreeFam database of animal gene trees

More...
TreeFami
TF317514

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.290.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 13 hits
PF00683 TB, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 18 hits
SM00179 EGF_CA, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 5 hits
SSF57581 SSF57581, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 13 hits
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 14 hits
PS01187 EGF_CA, 15 hits
PS51364 TB, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q8CG19-1) [UniParc]FASTAAdd to basket
Also known as: LTBP-1L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGAWLRWGL LLWAGLLAWS AHGRVRRITY VVRPGPGLPA GALPLAGPPR
60 70 80 90 100
TFNVALDARY SRSSTAASSR ALAGPPAERT RRTSQPGGAA LPGLRSPLPP
110 120 130 140 150
EPARPGGPSR QLHSKAGAQT AVTRFAKHGR QVVRSQVQQD AQSAGGSRLQ
160 170 180 190 200
VQQKQQLQGI NVCGGQCCHG WSKPPGSQRC TKPSCVPPCQ NGGMCLRPQL
210 220 230 240 250
CVCKPGSKGK ACEITAAQDT MPPAFGGQNP GSSWAPLEQA AKHTSTKKAD
260 270 280 290 300
TLPRVSPVAQ MTLTLKPKPS MGLSQQIHPQ VAPLSSQNVM IRHGQTQEYL
310 320 330 340 350
LKPKYFPAPK VVSAEQSTEG SFSLRYGQEQ GTAPFQVSNH TGRIKVVFTP
360 370 380 390 400
SICKVTCTKG NCQNSCQKGN TTTLISENGH AADTLTATNF RVVICHLPCM
410 420 430 440 450
NGGQCSSRDK CQCPPNFTGK LCQIPVLGAS MPKLYQHAQQ QGKALGSHVI
460 470 480 490 500
HSTHTLPLTM TSQQGVKVKF PPNIVNIHVK HPPEASVQIH QVSRIDSPGG
510 520 530 540 550
QKVKEAQPGQ SQVSYQGLPV QKTQTVHSTY SHQQLIPHVY PVAAKTQLGR
560 570 580 590 600
CFQETIGSQC GKALPGLSKQ EDCCGTVGTS WGFNKCQKCP KKQSYHGYTQ
610 620 630 640 650
MMECLQGYKR VNNTFCQDIN ECQLQGVCPN GECLNTMGSY RCSCKMGFGP
660 670 680 690 700
DPTFSSCVPD PPVISEEKGP CYRLVSPGRH CMHPLSVHLT KQICCCSVGK
710 720 730 740 750
AWGPHCEKCP LPGTAAFKEI CPGGMGYTVS GVHRRRPIHQ HIGKEAVYVK
760 770 780 790 800
PKNTQPVAKS THPPPLPAKE EPVEALTSSW EHGPRGAEPE VVTAPPEKEI
810 820 830 840 850
PSLDQEKTRL EPGQPQLSPG VSTIHLHPQF PVVVEKTSPP VPVEVAPEAS
860 870 880 890 900
TSSASQVIAP TQVTEINECT VNPDICGAGH CINLPVRYTC ICYEGYKFSE
910 920 930 940 950
QLRKCVDIDE CAQVRHLCSQ GRCENTEGSF LCVCPAGFMA SEEGTNCIDV
960 970 980 990 1000
DECLRPDMCR DGRCINTAGA FRCEYCDSGY RMSRRGYCED IDECLKPSTC
1010 1020 1030 1040 1050
PEEQCVNTPG SYQCVPCTEG FRGWNGQCLD VDECLQPKVC TNGSCTNLEG
1060 1070 1080 1090 1100
SYMCSCHRGY SPTPDHRHCQ DIDECQQGNL CMNGQCRNTD GSFRCTCGQG
1110 1120 1130 1140 1150
YQLSAAKDQC EDIDECEHHH LCSHGQCRNT EGSFQCVCNQ GYRASVLGDH
1160 1170 1180 1190 1200
CEDINECLED SSVCQGGDCI NTAGSYDCTC PDGFQLNDNK GCQDINECAQ
1210 1220 1230 1240 1250
PGLCGSHGEC LNTQGSFHCV CEQGFSISAD GRTCEDIDEC VNNTVCDSHG
1260 1270 1280 1290 1300
FCDNTAGSFR CLCYQGFQAP QDGQGCVDVN ECELLSGVCG EAFCENVEGS
1310 1320 1330 1340 1350
FLCVCADENQ EYSPMTGQCR SRVTEDSGVD RQPREEKKEC YYNLNDASLC
1360 1370 1380 1390 1400
DNVLAPNVTK QECCCTSGAG WGDNCEIFPC PVQGTAEFTE MCPRGKGLVP
1410 1420 1430 1440 1450
AGESSYDTGG ENYKDADECL LFGEEICKNG YCLNTQPGYE CYCKQGTYYD
1460 1470 1480 1490 1500
PVKLQCFDMD ECQDPNSCID GQCVNTEGSY NCFCTHPMVL DASEKRCVQP
1510 1520 1530 1540 1550
TESNEQIEET DVYQDLCWEH LSEEYVCSRP LVGKQTTYTE CCCLYGEAWG
1560 1570 1580 1590 1600
MQCALCPMKD SDDYAQLCNI PVTGRRRPYG RDALVDFSEQ YGPETDPYFI
1610 1620 1630 1640 1650
QDRFLNSFEE LQAEECGILN GCENGRCVRV QEGYTCDCFD GYHLDMAKMT
1660 1670 1680 1690 1700
CVDVNECSEL NNRMSLCKNA KCINTEGSYK CLCLPGYIPS DKPNYCTPLN
1710
SALNLDKESD LE
Length:1,712
Mass (Da):186,717
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB0564112F1F7843
GO
Isoform Short (identifier: Q8CG19-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: LTBP-1S

The sequence of this isoform differs from the canonical sequence as follows:
     1-318: Missing.
     319-336: EGSFSLRYGQEQGTAPFQ → MDTKLMCLLFFLCLPLLL

Show »
Length:1,394
Mass (Da):153,185
Checksum:i0D10BF1FB3B4A85A
GO
Isoform 3 (identifier: Q8CG19-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-318: Missing.
     319-336: EGSFSLRYGQEQGTAPFQ → MDTKLMCLLFFLCLPLLL
     716-768: Missing.

Show »
Length:1,341
Mass (Da):147,418
Checksum:iFB1930C28738FDE5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1B1E2B1B1E2_MOUSE
Latent-transforming growth factor b...
Ltbp1
980Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q4EGK3A0A3Q4EGK3_MOUSE
Latent-transforming growth factor b...
Ltbp1
1,713Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q4L384A0A3Q4L384_MOUSE
Latent-transforming growth factor b...
Ltbp1
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti313S → F in AAN77250 (PubMed:12711388).Curated1
Sequence conflicti506A → T in AAN77250 (PubMed:12711388).Curated1
Sequence conflicti506A → T in AAN77251 (PubMed:12711388).Curated1
Sequence conflicti506A → T in AAC33307 (Ref. 3) Curated1
Sequence conflicti559Q → QQ in AAN77250 (PubMed:12711388).Curated1
Sequence conflicti559Q → QQ in AAC33307 (Ref. 3) Curated1
Sequence conflicti1033E → K in AAC33307 (Ref. 3) Curated1
Sequence conflicti1111E → G in BAC34222 (PubMed:16141072).Curated1
Sequence conflicti1216S → F in BAC34222 (PubMed:16141072).Curated1
Sequence conflicti1631Q → H in AAN77250 (PubMed:12711388).Curated1
Sequence conflicti1631Q → H in AAN77251 (PubMed:12711388).Curated1
Sequence conflicti1659E → G in BAC34222 (PubMed:16141072).Curated1
Sequence conflicti1712E → N in AAC33307 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0369681 – 318Missing in isoform Short and isoform 3. 1 PublicationAdd BLAST318
Alternative sequenceiVSP_036969319 – 336EGSFS…TAPFQ → MDTKLMCLLFFLCLPLLL in isoform Short and isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_036970716 – 768Missing in isoform 3. CuratedAdd BLAST53

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF346465 AF346464 Genomic DNA Translation: AAN77250.1
AF346465 AF346464 Genomic DNA Translation: AAN77251.1
AY143161 Genomic DNA Translation: AAN38831.1
AF022889 mRNA Translation: AAC33307.1
AC118018 Genomic DNA No translation available.
AC126550 Genomic DNA No translation available.
AC154178 Genomic DNA No translation available.
AC154491 Genomic DNA No translation available.
CT033758 Genomic DNA No translation available.
BC094612 mRNA Translation: AAH94612.1
AK050380 mRNA Translation: BAC34222.1
AK080024 mRNA Translation: BAC37808.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28973.1 [Q8CG19-1]
CCDS37694.1 [Q8CG19-2]
CCDS84336.1 [Q8CG19-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001318166.1, NM_001331237.1 [Q8CG19-3]
NP_064303.2, NM_019919.4 [Q8CG19-1]
NP_996841.1, NM_206958.3 [Q8CG19-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000001927; ENSMUSP00000001927; ENSMUSG00000001870 [Q8CG19-1]
ENSMUST00000112514; ENSMUSP00000108133; ENSMUSG00000001870 [Q8CG19-3]
ENSMUST00000112516; ENSMUSP00000108135; ENSMUSG00000001870 [Q8CG19-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
268977

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:268977

UCSC genome browser

More...
UCSCi
uc008dom.2 mouse [Q8CG19-1]
uc008doo.2 mouse [Q8CG19-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346465 AF346464 Genomic DNA Translation: AAN77250.1
AF346465 AF346464 Genomic DNA Translation: AAN77251.1
AY143161 Genomic DNA Translation: AAN38831.1
AF022889 mRNA Translation: AAC33307.1
AC118018 Genomic DNA No translation available.
AC126550 Genomic DNA No translation available.
AC154178 Genomic DNA No translation available.
AC154491 Genomic DNA No translation available.
CT033758 Genomic DNA No translation available.
BC094612 mRNA Translation: AAH94612.1
AK050380 mRNA Translation: BAC34222.1
AK080024 mRNA Translation: BAC37808.1
CCDSiCCDS28973.1 [Q8CG19-1]
CCDS37694.1 [Q8CG19-2]
CCDS84336.1 [Q8CG19-3]
RefSeqiNP_001318166.1, NM_001331237.1 [Q8CG19-3]
NP_064303.2, NM_019919.4 [Q8CG19-1]
NP_996841.1, NM_206958.3 [Q8CG19-2]

3D structure databases

SMRiQ8CG19
ModBaseiSearch...

Protein-protein interaction databases

BioGridi234589, 5 interactors
IntActiQ8CG19, 1 interactor
STRINGi10090.ENSMUSP00000001927

PTM databases

iPTMnetiQ8CG19
PhosphoSitePlusiQ8CG19

Proteomic databases

PaxDbiQ8CG19
PeptideAtlasiQ8CG19
PRIDEiQ8CG19

Genome annotation databases

EnsembliENSMUST00000001927; ENSMUSP00000001927; ENSMUSG00000001870 [Q8CG19-1]
ENSMUST00000112514; ENSMUSP00000108133; ENSMUSG00000001870 [Q8CG19-3]
ENSMUST00000112516; ENSMUSP00000108135; ENSMUSG00000001870 [Q8CG19-2]
GeneIDi268977
KEGGimmu:268977
UCSCiuc008dom.2 mouse [Q8CG19-1]
uc008doo.2 mouse [Q8CG19-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4052
MGIiMGI:109151 Ltbp1

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410Z7XK LUCA
GeneTreeiENSGT00940000155823
InParanoidiQ8CG19
KOiK19559
OMAiPQFPGIV
OrthoDBi1174178at2759
PhylomeDBiQ8CG19
TreeFamiTF317514

Enzyme and pathway databases

ReactomeiR-MMU-2129379 Molecules associated with elastic fibres
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ltbp1 mouse

Protein Ontology

More...
PROi
PR:Q8CG19
RNActiQ8CG19 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000001870 Expressed in 276 organ(s), highest expression level in cumulus cell
ExpressionAtlasiQ8CG19 baseline and differential
GenevisibleiQ8CG19 MM

Family and domain databases

Gene3Di3.90.290.10, 4 hits
InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 13 hits
PF00683 TB, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 18 hits
SM00179 EGF_CA, 16 hits
SUPFAMiSSF57184 SSF57184, 5 hits
SSF57581 SSF57581, 4 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 13 hits
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 14 hits
PS01187 EGF_CA, 15 hits
PS51364 TB, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLTBP1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CG19
Secondary accession number(s): B1B1D9
, B1B1E1, O88349, Q505C9, Q8BNW7, Q8C7F5, Q8CG18, Q8CIR0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 5, 2009
Last modified: December 11, 2019
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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