UniProtKB - Q8CG09 (MRP1_RAT)

BLAST

>sp|Q8CG09|MRP1_RAT Multidrug resistance-associated protein 1 OS=Rattus norvegicus OX=10116 GN=Abcc1 PE=1 SV=2
MALSSFCSSDGSDPLWDWNVTWHTSNPDFTKCFQNTVLTWVPCFYLWSCFPLYFLYLSRH
DRGYIQMTHLNKAKTALGFFLWIICWADLFYSFWERSQGMLLAPVLLVSPTLLGITMLLA
TFLIQFERRKGVQSSGIMLTFWLVALLCALAILRSKIISALKKDAQVDMFRDSAFYLYFT
LVFIQLVLSCFSDSSPLFSETVRDPNPCPESSASFLSRITFWWITGMMVQGYRQPLKSSD
LWSLNKEDTSEEVVPVLVNNWKKECVKSRKQPVRIVYAPPKDPTKPKGSSQLDVNEEVEA
LIVKSSHKDRDPSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPEILELIINFVNDREAP
DWQGYLYTALLFVSACLQTLALHQYFHICFVTGMRIKTAVVGAVYRKALVITNSARKSST
VGEIVNLMSVDAQRFMDLATYINMIWSAPLQVTLALYFLWLNLGPSVLAGVAVMILMVPF
NAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMNIRQEELKVL
KKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDEKNILDAKKAFVSLALFNILRFPLNIL
PMVISSIVQASVSLKRLRIFLSHEELEPDSIERWSIKDGGGMNSITVKNATFTWARDEPP
TLNGITFAIPDGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQN
DSLRENILFGRPLQEHCYKAVMEACALLPDLEILPSGDLTEIGEKGVNLSGGQKQRVSLA
RAVYCNSDIYLLDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVII
VMSGGKISEMGSYQELLDRDGAFAEFVRTYANTEQDLASEDDSKNGVSGLGKESKPVENG
ILVTDAVGKPLQRHLSNSSSHSVVTNQQHSSTAELQKSGVKEETWKLMEADKAQTGQVKL
SVYWNYMKAIGLCISFLSIFLFLCNHVSALASNYWLSLWTDDRPAVNGTQENRNFRLSVY
GALGILQGVAVFGYSMAVSIGGIFASRRLHLDLLQNVLRSPMSFFERTPSGNLVNRFSKE
LDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQ
LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWL
AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIV
AVERLKEYSETEKEASWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEG
GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHNLRFKITIIPQDPVL
FSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVC
LARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTIMDYTRVIV
LDKGEIRECGAPSELLQQRGVFYSMAKDAGLV

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History
Entry version 120 (10 Oct 2018)
Sequence version 2 (24 Jan 2006)
Previous versions | rss
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Protein

Multidrug resistance-associated protein 1

Gene

Abcc1

Organism

Rattus norvegicus (Rat)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	679 – 686	ATP 1PROSITE-ProRule annotation		8
Nucleotide bindingⁱ	1328 – 1335	ATP 2PROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
drug transmembrane transporter activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 17854063
efflux transmembrane transporter activity
Source: RGD
Inferred from direct assayⁱ
- 12423064
glutathione transmembrane transporter activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 12125073
lipid-transporting ATPase activity
Source: RGD
Inferred from direct assayⁱ
- 12867490
long-chain fatty acid transporter activity
Source: RGD
Inferred from direct assayⁱ
- 12867490
oxidoreductase activity Source: InterPro
sphingolipid transporter activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 17050692
xenobiotic transmembrane transporting ATPase activity
Source: RGD
Inferred from direct assayⁱ
- 12867490

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell chemotaxis
Source: RGD
Inferred from mutant phenotypeⁱ
- 17050692
drug export
Source: RGD
Inferred from direct assayⁱ
- 12423064
drug transmembrane transport
Source: RGD
Inferred from mutant phenotypeⁱ
- 17854063
glutathione transmembrane transport
Source: RGD
Inferred from mutant phenotypeⁱ
- 12125073
- 19053318
negative regulation of cell death
Source: RGD
Inferred from direct assayⁱ
- 15198509
negative regulation of neuron death
Source: RGD
Inferred from mutant phenotypeⁱ
- 17141959
phospholipid efflux
Source: RGD
Inferred from mutant phenotypeⁱ
- 17050692
plasma membrane long-chain fatty acid transport
Source: RGD
Inferred from direct assayⁱ
- 12867490
positive regulation of cell migration
Source: RGD
Inferred from mutant phenotypeⁱ
- 17050692
positive regulation of drug transmembrane export
Source: RGD
Inferred from direct assayⁱ
- 15198509
response to drug
Source: RGD
Inferred from direct assayⁱ
- 14641820
response to oxidative stress
Source: RGD
Inferred from mutant phenotypeⁱ
- 11208926
transmembrane transport
Source: RGD
Inferred from direct assayⁱ
- 12423064
xenobiotic transport
Source: RGD
Inferred from mutant phenotypeⁱ
- 12893836

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Transport
Ligand	ATP-binding, Nucleotide-binding

Chemistry databases

SwissLipidsⁱ	SLP:000000405

SwissLipidsⁱ

SLP:000000405

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Multidrug resistance-associated protein 1 Alternative name(s): ATP-binding cassette sub-family C member 1 Leukotriene C(4) transporter Short name: LTC4 transporter
Gene namesⁱ	Name:Abcc1 Synonyms:Mrp1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	3112 Abcc1

RGDⁱ

3112 Abcc1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 33	ExtracellularBy similarityAdd BLAST	33
Transmembraneⁱ	34 – 54	Helical; Name=1PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	55 – 74	CytoplasmicBy similarityAdd BLAST	20
Transmembraneⁱ	75 – 95	Helical; Name=2PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	96 – 100	ExtracellularBy similarity	5
Transmembraneⁱ	101 – 121	Helical; Name=3PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	122 – 133	CytoplasmicBy similarityAdd BLAST	12
Transmembraneⁱ	134 – 154	Helical; Name=4PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	155 – 172	ExtracellularBy similarityAdd BLAST	18
Transmembraneⁱ	173 – 193	Helical; Name=5PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	194 – 317	CytoplasmicBy similarityAdd BLAST	124
Transmembraneⁱ	318 – 338	Helical; Name=6PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	339 – 364	ExtracellularBy similarityAdd BLAST	26
Transmembraneⁱ	365 – 385	Helical; Name=7PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	386 – 441	CytoplasmicBy similarityAdd BLAST	56
Transmembraneⁱ	442 – 462	Helical; Name=8PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	463 – 465	ExtracellularBy similarity	3
Transmembraneⁱ	466 – 486	Helical; Name=9PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	487 – 548	CytoplasmicBy similarityAdd BLAST	62
Transmembraneⁱ	549 – 569	Helical; Name=10PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	570 – 591	ExtracellularBy similarityAdd BLAST	22
Transmembraneⁱ	592 – 612	Helical; Name=11PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	613 – 967	CytoplasmicBy similarityAdd BLAST	355
Transmembraneⁱ	968 – 988	Helical; Name=12PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	989 – 1026	ExtracellularBy similarityAdd BLAST	38
Transmembraneⁱ	1027 – 1047	Helical; Name=13PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	1048 – 1090	CytoplasmicBy similarityAdd BLAST	43
Transmembraneⁱ	1091 – 1111	Helical; Name=14PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	1112	ExtracellularBy similarity	1
Transmembraneⁱ	1113 – 1133	Helical; Name=15PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	1134 – 1204	CytoplasmicBy similarityAdd BLAST	71
Transmembraneⁱ	1205 – 1225	Helical; Name=16PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	1226 – 1227	ExtracellularBy similarity	2
Transmembraneⁱ	1228 – 1248	Helical; Name=17PROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	1249 – 1532	CytoplasmicBy similarityAdd BLAST	284

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	983	L → M: No effect on estradiol glucuronide transport. 1 Publication	1
Mutagenesisⁱ	1090	Q → E: 7.6-fold increase of the estradiol glucuronide transport; when associated with T-1243. Increases doxorubicin inhibition. 1 Publication	1
Mutagenesisⁱ	1101	S → N: 50% increase of estradiol glucuronide transport. 1 Publication	1
Mutagenesisⁱ	1106	V → C: No effect on estradiol glucuronide transport. 1 Publication	1
Mutagenesisⁱ	1243	A → T: 7.6-fold increase of the estradiol glucuronide transport; when associated with E-1090. 1 Publication	1

Chemistry databases

ChEMBLⁱ

CHEMBL5680

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000093354	1 – 1532	Multidrug resistance-associated protein 1Add BLAST		1532

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	19	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	277	PhosphotyrosineBy similarity	1
Modified residueⁱ	290	PhosphoserineBy similarity	1
Modified residueⁱ	504	N6-succinyllysineBy similarity	1
Modified residueⁱ	879	PhosphoserineCombined sources	1
Modified residueⁱ	883	PhosphoserineBy similarity	1
Modified residueⁱ	916	PhosphoserineBy similarity	1
Modified residueⁱ	931	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Glycosylated.

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8CG09
PRIDEⁱ	Q8CG09

PTM databases

iPTMnetⁱ	Q8CG09
PhosphoSitePlusⁱ	Q8CG09

Expressionⁱ

Tissue specificityⁱ

Skeletal muscle, brain, heart, spleen, lung and kidney.1 Publication

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000041695

STRINGⁱ

10116.ENSRNOP00000041695

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8CG09
SMRⁱ	Q8CG09
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	326 – 609	ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST	284
Domainⁱ	645 – 869	ABC transporter 1PROSITE-ProRule annotationAdd BLAST	225
Domainⁱ	975 – 1257	ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST	283
Domainⁱ	1294 – 1528	ABC transporter 2PROSITE-ProRule annotationAdd BLAST	235

Sequence similaritiesⁱ

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0054 Eukaryota COG1132 LUCA
HOVERGENⁱ	HBG108314
InParanoidⁱ	Q8CG09
KEGG Orthology (KO) More...KOⁱ	K05665
PhylomeDBⁱ	Q8CG09

Family and domain databases

Gene3Dⁱ	1.20.1560.10, 2 hits
InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR018170 Aldo/ket_reductase_CS IPR005292 Multidrug-R_assoc IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00664 ABC_membrane, 2 hits PF00005 ABC_tran, 2 hits
SMARTⁱ	View protein in SMART SM00382 AAA, 2 hits
SUPFAMⁱ	SSF52540 SSF52540, 2 hits SSF90123 SSF90123, 2 hits
TIGRFAMsⁱ	TIGR00957 MRP_assoc_pro, 1 hit
PROSITEⁱ	View protein in PROSITE PS50929 ABC_TM1F, 2 hits PS00211 ABC_TRANSPORTER_1, 2 hits PS50893 ABC_TRANSPORTER_2, 2 hits PS00063 ALDOKETO_REDUCTASE_3, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q8CG09-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALSSFCSSD GSDPLWDWNV TWHTSNPDFT KCFQNTVLTW VPCFYLWSCF 
        60         70         80         90        100
PLYFLYLSRH DRGYIQMTHL NKAKTALGFF LWIICWADLF YSFWERSQGM 
       110        120        130        140        150
LLAPVLLVSP TLLGITMLLA TFLIQFERRK GVQSSGIMLT FWLVALLCAL 
       160        170        180        190        200
AILRSKIISA LKKDAQVDMF RDSAFYLYFT LVFIQLVLSC FSDSSPLFSE 
       210        220        230        240        250
TVRDPNPCPE SSASFLSRIT FWWITGMMVQ GYRQPLKSSD LWSLNKEDTS 
       260        270        280        290        300
EEVVPVLVNN WKKECVKSRK QPVRIVYAPP KDPTKPKGSS QLDVNEEVEA 
       310        320        330        340        350
LIVKSSHKDR DPSLFKVLYK TFGPYFLMSF LYKALHDLMM FAGPEILELI 
       360        370        380        390        400
INFVNDREAP DWQGYLYTAL LFVSACLQTL ALHQYFHICF VTGMRIKTAV 
       410        420        430        440        450
VGAVYRKALV ITNSARKSST VGEIVNLMSV DAQRFMDLAT YINMIWSAPL 
       460        470        480        490        500
QVTLALYFLW LNLGPSVLAG VAVMILMVPF NAVMAMKTKT YQVAHMKSKD 
       510        520        530        540        550
NRIKLMNEIL NGIKVLKLYA WELAFQDKVM NIRQEELKVL KKSAYLAAVG 
       560        570        580        590        600
TFTWVCTPFL VALSTFAVFV TVDEKNILDA KKAFVSLALF NILRFPLNIL 
       610        620        630        640        650
PMVISSIVQA SVSLKRLRIF LSHEELEPDS IERWSIKDGG GMNSITVKNA 
       660        670        680        690        700
TFTWARDEPP TLNGITFAIP DGALVAVVGQ VGCGKSSLLS ALLAEMDKVE 
       710        720        730        740        750
GHVTLKGSVA YVPQQAWIQN DSLRENILFG RPLQEHCYKA VMEACALLPD 
       760        770        780        790        800
LEILPSGDLT EIGEKGVNLS GGQKQRVSLA RAVYCNSDIY LLDDPLSAVD 
       810        820        830        840        850
AHVGKHIFEK VVGPMGLLKN KTRILVTHGI SYLPQVDVII VMSGGKISEM 
       860        870        880        890        900
GSYQELLDRD GAFAEFVRTY ANTEQDLASE DDSKNGVSGL GKESKPVENG 
       910        920        930        940        950
ILVTDAVGKP LQRHLSNSSS HSVVTNQQHS STAELQKSGV KEETWKLMEA 
       960        970        980        990       1000
DKAQTGQVKL SVYWNYMKAI GLCISFLSIF LFLCNHVSAL ASNYWLSLWT 
      1010       1020       1030       1040       1050
DDRPAVNGTQ ENRNFRLSVY GALGILQGVA VFGYSMAVSI GGIFASRRLH 
      1060       1070       1080       1090       1100
LDLLQNVLRS PMSFFERTPS GNLVNRFSKE LDTVDSMIPQ VIKMFMGSLF 
      1110       1120       1130       1140       1150
SVIGAVIIIL LATPIAAVII PPLGLVYFFV QRFYVASSRQ LKRLESVSRS 
      1160       1170       1180       1190       1200
PVYSHFNETL LGVSVIRAFE EQERFIRQSD LKVDENQKAY YPSIVANRWL 
      1210       1220       1230       1240       1250
AVRLECVGNC IVLFAALFAV ISRHSLSAGL VGLSVSYSLQ ITAYLNWLVR 
      1260       1270       1280       1290       1300
MSSEMETNIV AVERLKEYSE TEKEASWQIQ ETAPPSTWPH SGRVEFRDYC 
      1310       1320       1330       1340       1350
LRYREDLDLV LKHINVTIEG GEKVGIVGRT GAGKSSLTLG LFRINESAEG 
      1360       1370       1380       1390       1400
EIIIDGINIA KIGLHNLRFK ITIIPQDPVL FSGSLRMNLD PFSQYSDEEV 
      1410       1420       1430       1440       1450
WMALELAHLK GFVSALPDKL NHECAEGGEN LSVGQRQLVC LARALLRKTK 
      1460       1470       1480       1490       1500
ILVLDEATAA VDLETDDLIQ STIRTQFEDS TVLTIAHRLN TIMDYTRVIV 
      1510       1520       1530 
LDKGEIRECG APSELLQQRG VFYSMAKDAG LV

Length:1,532

Mass (Da):171,493

Last modified:January 24, 2006 - v2

Checksum:ⁱ2E6939F63F5A3F68

Isoform 2 (identifier: Q8CG09-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
912-920: Missing.

« Hide

        10         20         30         40         50
MALSSFCSSD GSDPLWDWNV TWHTSNPDFT KCFQNTVLTW VPCFYLWSCF 
        60         70         80         90        100
PLYFLYLSRH DRGYIQMTHL NKAKTALGFF LWIICWADLF YSFWERSQGM 
       110        120        130        140        150
LLAPVLLVSP TLLGITMLLA TFLIQFERRK GVQSSGIMLT FWLVALLCAL 
       160        170        180        190        200
AILRSKIISA LKKDAQVDMF RDSAFYLYFT LVFIQLVLSC FSDSSPLFSE 
       210        220        230        240        250
TVRDPNPCPE SSASFLSRIT FWWITGMMVQ GYRQPLKSSD LWSLNKEDTS 
       260        270        280        290        300
EEVVPVLVNN WKKECVKSRK QPVRIVYAPP KDPTKPKGSS QLDVNEEVEA 
       310        320        330        340        350
LIVKSSHKDR DPSLFKVLYK TFGPYFLMSF LYKALHDLMM FAGPEILELI 
       360        370        380        390        400
INFVNDREAP DWQGYLYTAL LFVSACLQTL ALHQYFHICF VTGMRIKTAV 
       410        420        430        440        450
VGAVYRKALV ITNSARKSST VGEIVNLMSV DAQRFMDLAT YINMIWSAPL 
       460        470        480        490        500
QVTLALYFLW LNLGPSVLAG VAVMILMVPF NAVMAMKTKT YQVAHMKSKD 
       510        520        530        540        550
NRIKLMNEIL NGIKVLKLYA WELAFQDKVM NIRQEELKVL KKSAYLAAVG 
       560        570        580        590        600
TFTWVCTPFL VALSTFAVFV TVDEKNILDA KKAFVSLALF NILRFPLNIL 
       610        620        630        640        650
PMVISSIVQA SVSLKRLRIF LSHEELEPDS IERWSIKDGG GMNSITVKNA 
       660        670        680        690        700
TFTWARDEPP TLNGITFAIP DGALVAVVGQ VGCGKSSLLS ALLAEMDKVE 
       710        720        730        740        750
GHVTLKGSVA YVPQQAWIQN DSLRENILFG RPLQEHCYKA VMEACALLPD 
       760        770        780        790        800
LEILPSGDLT EIGEKGVNLS GGQKQRVSLA RAVYCNSDIY LLDDPLSAVD 
       810        820        830        840        850
AHVGKHIFEK VVGPMGLLKN KTRILVTHGI SYLPQVDVII VMSGGKISEM 
       860        870        880        890        900
GSYQELLDRD GAFAEFVRTY ANTEQDLASE DDSKNGVSGL GKESKPVENG 
       910        920        930        940        950
ILVTDAVGKP LHSVVTNQQH SSTAELQKSG VKEETWKLME ADKAQTGQVK 
       960        970        980        990       1000
LSVYWNYMKA IGLCISFLSI FLFLCNHVSA LASNYWLSLW TDDRPAVNGT 
      1010       1020       1030       1040       1050
QENRNFRLSV YGALGILQGV AVFGYSMAVS IGGIFASRRL HLDLLQNVLR 
      1060       1070       1080       1090       1100
SPMSFFERTP SGNLVNRFSK ELDTVDSMIP QVIKMFMGSL FSVIGAVIII 
      1110       1120       1130       1140       1150
LLATPIAAVI IPPLGLVYFF VQRFYVASSR QLKRLESVSR SPVYSHFNET 
      1160       1170       1180       1190       1200
LLGVSVIRAF EEQERFIRQS DLKVDENQKA YYPSIVANRW LAVRLECVGN 
      1210       1220       1230       1240       1250
CIVLFAALFA VISRHSLSAG LVGLSVSYSL QITAYLNWLV RMSSEMETNI 
      1260       1270       1280       1290       1300
VAVERLKEYS ETEKEASWQI QETAPPSTWP HSGRVEFRDY CLRYREDLDL 
      1310       1320       1330       1340       1350
VLKHINVTIE GGEKVGIVGR TGAGKSSLTL GLFRINESAE GEIIIDGINI 
      1360       1370       1380       1390       1400
AKIGLHNLRF KITIIPQDPV LFSGSLRMNL DPFSQYSDEE VWMALELAHL 
      1410       1420       1430       1440       1450
KGFVSALPDK LNHECAEGGE NLSVGQRQLV CLARALLRKT KILVLDEATA 
      1460       1470       1480       1490       1500
AVDLETDDLI QSTIRTQFED STVLTIAHRL NTIMDYTRVI VLDKGEIREC 
      1510       1520 
GAPSELLQQR GVFYSMAKDA GLV

Note: No experimental confirmation available.

Show »

Length:1,523

Mass (Da):170,496

Checksum:ⁱ15FB4E9C99B7B9AC

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E9PT28	E9PT28_RAT		Multidrug resistance-associated pro... Multidrug resistance-associated protein 1	Abcc1 LOC688708	1,530	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	4	S → R in AAN86532 (PubMed:12423064).Curated	1
Sequence conflictⁱ	4	S → R in AAO44983 (Ref. 4) Curated	1
Sequence conflictⁱ	480	F → S in AAO44983 (Ref. 4) Curated	1
Sequence conflictⁱ	820	N → S in CAB97204 (PubMed:11208926).Curated	1
Sequence conflictⁱ	868	R → P in CAB97204 (PubMed:11208926).Curated	1
Sequence conflictⁱ	916	S → G in CAB97204 (PubMed:11208926).Curated	1
Sequence conflictⁱ	1122	P → T in CAB97204 (PubMed:11208926).Curated	1
Sequence conflictⁱ	1382	S → P in AAN86532 (PubMed:12423064).Curated	1
Sequence conflictⁱ	1473	I → V in AAN86532 (PubMed:12423064).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_017015	912 – 920	Missing in isoform 2. 1 Publication		9

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY170916 mRNA Translation: AAN86532.1 AF487549 mRNA Translation: AAO85437.1 AY174892 mRNA Translation: AAO44983.1 AJ277881 mRNA Translation: CAB97204.1 X96394 mRNA Translation: CAA65258.1
NCBI Reference Sequences More...RefSeqⁱ	NP_071617.2, NM_022281.2 [Q8CG09-1]
UniGeneⁱ	Rn.10495

Genome annotation databases

GeneIDⁱ	24565
KEGGⁱ	rno:24565
UCSC genome browser More...UCSCⁱ	RGD:3112 rat [Q8CG09-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8CG09	Multidrug resistance-associated protein 1		MOUSE		1528	UniRef90_Q8CG09
Multidrug resistance-associated protein 1		RAT		1530
Multidrug resistance-associated protein 1		CRIGR		146
UPI000A31EF9D		MESAU		1737
UPI000B4EFB45		MERUN		1529
+16

Protein	Similar proteins		Species	Score	Length	Source
Q8CG09	Multidrug resistance-associated protein 1	)	HUMAN		1531	UniRef50_P33527
Multidrug resistance-associated protein 1		CANLF		1531
Multidrug resistance-associated protein 1		MACFA		1531
Multidrug resistance-associated protein 1	)	BOVIN		1530
Multidrug resistance-associated protein 1		MOUSE		1528
+807

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY170916 mRNA Translation: AAN86532.1 AF487549 mRNA Translation: AAO85437.1 AY174892 mRNA Translation: AAO44983.1 AJ277881 mRNA Translation: CAB97204.1 X96394 mRNA Translation: CAA65258.1
RefSeqⁱ	NP_071617.2, NM_022281.2 [Q8CG09-1]
UniGeneⁱ	Rn.10495

3D structure databases

ProteinModelPortalⁱ	Q8CG09
SMRⁱ	Q8CG09
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000041695

STRINGⁱ

10116.ENSRNOP00000041695

Chemistry databases

ChEMBLⁱ	CHEMBL5680
SwissLipidsⁱ	SLP:000000405

PTM databases

iPTMnetⁱ	Q8CG09
PhosphoSitePlusⁱ	Q8CG09

Proteomic databases

PaxDbⁱ	Q8CG09
PRIDEⁱ	Q8CG09

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	24565
KEGGⁱ	rno:24565
UCSCⁱ	RGD:3112 rat [Q8CG09-1]

Organism-specific databases

CTDⁱ	4363
RGDⁱ	3112 Abcc1

Phylogenomic databases

eggNOGⁱ	KOG0054 Eukaryota COG1132 LUCA
HOVERGENⁱ	HBG108314
InParanoidⁱ	Q8CG09
KOⁱ	K05665
PhylomeDBⁱ	Q8CG09

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8CG09

PROⁱ

PR:Q8CG09

Family and domain databases

Gene3Dⁱ	1.20.1560.10, 2 hits
InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR018170 Aldo/ket_reductase_CS IPR005292 Multidrug-R_assoc IPR027417 P-loop_NTPase
Pfamⁱ	View protein in Pfam PF00664 ABC_membrane, 2 hits PF00005 ABC_tran, 2 hits
SMARTⁱ	View protein in SMART SM00382 AAA, 2 hits
SUPFAMⁱ	SSF52540 SSF52540, 2 hits SSF90123 SSF90123, 2 hits
TIGRFAMsⁱ	TIGR00957 MRP_assoc_pro, 1 hit
PROSITEⁱ	View protein in PROSITE PS50929 ABC_TM1F, 2 hits PS00211 ABC_TRANSPORTER_1, 2 hits PS50893 ABC_TRANSPORTER_2, 2 hits PS00063 ALDOKETO_REDUCTASE_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MRP1_RAT
Accessionⁱ	Q8CG09Primary (citable) accession number: Q8CG09 Secondary accession number(s): Q63346 , Q810E4, Q810G9, Q9JHS0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
	Last sequence update:	January 24, 2006
	Last modified:	October 10, 2018
	This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniProtKB - Q8CG09 (MRP1_RAT)

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Multidrug resistance-associated protein 1

Abcc1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ