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UniProtKB - Q8CG09 (MRP1_RAT)

Entry version 130 (26 Feb 2020)
Sequence version 2 (24 Jan 2006)
Previous versions | rss
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Protein

Multidrug resistance-associated protein 1

Gene

Abcc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency (PubMed:15129170). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

MK 571 inhibits sphingosine 1-phosphate and leukotriene C4 export.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi679 – 686ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1328 – 1335ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Translocase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-RNO-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-RNO-382556 ABC-family proteins mediated transport

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000405

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug resistance-associated protein 1Curated (EC:7.6.2.2By similarity)
Alternative name(s):
ATP-binding cassette sub-family C member 1
Glutathione-S-conjugate-translocating ATPase ABCC1By similarity (EC:7.6.2.3By similarity)
Leukotriene C(4) transporter
Short name:
LTC4 transporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abcc1Imported
Synonyms:Mrp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...RGDi		3112 Abcc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 33ExtracellularBy similarityAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei34 – 54Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini55 – 74CytoplasmicBy similarityAdd BLAST20
Transmembranei75 – 95Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini96 – 100ExtracellularBy similarity5
Transmembranei101 – 121Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini122 – 133CytoplasmicBy similarityAdd BLAST12
Transmembranei134 – 154Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini155 – 172ExtracellularBy similarityAdd BLAST18
Transmembranei173 – 193Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini194 – 317CytoplasmicBy similarityAdd BLAST124
Transmembranei318 – 338Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini339 – 364ExtracellularBy similarityAdd BLAST26
Transmembranei365 – 385Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini386 – 441CytoplasmicBy similarityAdd BLAST56
Transmembranei442 – 462Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini463 – 465ExtracellularBy similarity3
Transmembranei466 – 486Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini487 – 548CytoplasmicBy similarityAdd BLAST62
Transmembranei549 – 569Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini570 – 591ExtracellularBy similarityAdd BLAST22
Transmembranei592 – 612Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini613 – 967CytoplasmicBy similarityAdd BLAST355
Transmembranei968 – 988Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini989 – 1026ExtracellularBy similarityAdd BLAST38
Transmembranei1027 – 1047Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1048 – 1090CytoplasmicBy similarityAdd BLAST43
Transmembranei1091 – 1111Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1112ExtracellularBy similarity1
Transmembranei1113 – 1133Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1134 – 1204CytoplasmicBy similarityAdd BLAST71
Transmembranei1205 – 1225Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1226 – 1227ExtracellularBy similarity2
Transmembranei1228 – 1248Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1249 – 1532CytoplasmicBy similarityAdd BLAST284

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi983L → M: No effect on estradiol glucuronide transport. 1 Publication1
Mutagenesisi1090Q → E: 7.6-fold increase of the estradiol glucuronide transport; when associated with T-1243. Increases doxorubicin inhibition. 1 Publication1
Mutagenesisi1101S → N: 50% increase of estradiol glucuronide transport. 1 Publication1
Mutagenesisi1106V → C: No effect on estradiol glucuronide transport. 1 Publication1
Mutagenesisi1243A → T: 7.6-fold increase of the estradiol glucuronide transport; when associated with E-1090. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5680

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933541 – 1532Multidrug resistance-associated protein 1Add BLAST1532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei277PhosphotyrosineBy similarity1
Modified residuei290PhosphoserineBy similarity1
Modified residuei504N6-succinyllysineBy similarity1
Modified residuei879PhosphoserineCombined sources1
Modified residuei883PhosphoserineBy similarity1
Modified residuei916PhosphoserineBy similarity1
Modified residuei931PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8CG09

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8CG09

PRoteomics IDEntifications database

More...PRIDEi		Q8CG09

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8CG09

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8CG09

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Skeletal muscle, brain, heart, spleen, lung and kidney.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000041695

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8CG09

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini326 – 609ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini645 – 869ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini975 – 1257ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST283
Domaini1294 – 1528ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0054 Eukaryota
COG1132 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8CG09

KEGG Orthology (KO)

More...KOi		K05665

Database of Orthologous Groups

More...OrthoDBi		138195at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8CG09

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR018170 Aldo/ket_reductase_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00957 MRP_assoc_pro, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits
PS00063 ALDOKETO_REDUCTASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CG09-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALSSFCSSD GSDPLWDWNV TWHTSNPDFT KCFQNTVLTW VPCFYLWSCF 
        60         70         80         90        100
PLYFLYLSRH DRGYIQMTHL NKAKTALGFF LWIICWADLF YSFWERSQGM 
       110        120        130        140        150
LLAPVLLVSP TLLGITMLLA TFLIQFERRK GVQSSGIMLT FWLVALLCAL 
       160        170        180        190        200
AILRSKIISA LKKDAQVDMF RDSAFYLYFT LVFIQLVLSC FSDSSPLFSE 
       210        220        230        240        250
TVRDPNPCPE SSASFLSRIT FWWITGMMVQ GYRQPLKSSD LWSLNKEDTS 
       260        270        280        290        300
EEVVPVLVNN WKKECVKSRK QPVRIVYAPP KDPTKPKGSS QLDVNEEVEA 
       310        320        330        340        350
LIVKSSHKDR DPSLFKVLYK TFGPYFLMSF LYKALHDLMM FAGPEILELI 
       360        370        380        390        400
INFVNDREAP DWQGYLYTAL LFVSACLQTL ALHQYFHICF VTGMRIKTAV 
       410        420        430        440        450
VGAVYRKALV ITNSARKSST VGEIVNLMSV DAQRFMDLAT YINMIWSAPL 
       460        470        480        490        500
QVTLALYFLW LNLGPSVLAG VAVMILMVPF NAVMAMKTKT YQVAHMKSKD 
       510        520        530        540        550
NRIKLMNEIL NGIKVLKLYA WELAFQDKVM NIRQEELKVL KKSAYLAAVG 
       560        570        580        590        600
TFTWVCTPFL VALSTFAVFV TVDEKNILDA KKAFVSLALF NILRFPLNIL 
       610        620        630        640        650
PMVISSIVQA SVSLKRLRIF LSHEELEPDS IERWSIKDGG GMNSITVKNA 
       660        670        680        690        700
TFTWARDEPP TLNGITFAIP DGALVAVVGQ VGCGKSSLLS ALLAEMDKVE 
       710        720        730        740        750
GHVTLKGSVA YVPQQAWIQN DSLRENILFG RPLQEHCYKA VMEACALLPD 
       760        770        780        790        800
LEILPSGDLT EIGEKGVNLS GGQKQRVSLA RAVYCNSDIY LLDDPLSAVD 
       810        820        830        840        850
AHVGKHIFEK VVGPMGLLKN KTRILVTHGI SYLPQVDVII VMSGGKISEM 
       860        870        880        890        900
GSYQELLDRD GAFAEFVRTY ANTEQDLASE DDSKNGVSGL GKESKPVENG 
       910        920        930        940        950
ILVTDAVGKP LQRHLSNSSS HSVVTNQQHS STAELQKSGV KEETWKLMEA 
       960        970        980        990       1000
DKAQTGQVKL SVYWNYMKAI GLCISFLSIF LFLCNHVSAL ASNYWLSLWT 
      1010       1020       1030       1040       1050
DDRPAVNGTQ ENRNFRLSVY GALGILQGVA VFGYSMAVSI GGIFASRRLH 
      1060       1070       1080       1090       1100
LDLLQNVLRS PMSFFERTPS GNLVNRFSKE LDTVDSMIPQ VIKMFMGSLF 
      1110       1120       1130       1140       1150
SVIGAVIIIL LATPIAAVII PPLGLVYFFV QRFYVASSRQ LKRLESVSRS 
      1160       1170       1180       1190       1200
PVYSHFNETL LGVSVIRAFE EQERFIRQSD LKVDENQKAY YPSIVANRWL 
      1210       1220       1230       1240       1250
AVRLECVGNC IVLFAALFAV ISRHSLSAGL VGLSVSYSLQ ITAYLNWLVR 
      1260       1270       1280       1290       1300
MSSEMETNIV AVERLKEYSE TEKEASWQIQ ETAPPSTWPH SGRVEFRDYC 
      1310       1320       1330       1340       1350
LRYREDLDLV LKHINVTIEG GEKVGIVGRT GAGKSSLTLG LFRINESAEG 
      1360       1370       1380       1390       1400
EIIIDGINIA KIGLHNLRFK ITIIPQDPVL FSGSLRMNLD PFSQYSDEEV 
      1410       1420       1430       1440       1450
WMALELAHLK GFVSALPDKL NHECAEGGEN LSVGQRQLVC LARALLRKTK 
      1460       1470       1480       1490       1500
ILVLDEATAA VDLETDDLIQ STIRTQFEDS TVLTIAHRLN TIMDYTRVIV 
      1510       1520       1530 
LDKGEIRECG APSELLQQRG VFYSMAKDAG LV
Length:1,532
Mass (Da):171,493
Last modified:January 24, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E6939F63F5A3F68
GO
Isoform 2 (identifier: Q8CG09-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     912-920: Missing.

Show »
Length:1,523
Mass (Da):170,496
Checksum:i15FB4E9C99B7B9AC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PT28E9PT28_RAT
Multidrug resistance-associated pro...
Abcc1 LOC688708
1,530Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4S → R in AAN86532 (PubMed:12423064).Curated1
Sequence conflicti4S → R in AAO44983 (Ref. 4) Curated1
Sequence conflicti480F → S in AAO44983 (Ref. 4) Curated1
Sequence conflicti820N → S in CAB97204 (PubMed:11208926).Curated1
Sequence conflicti868R → P in CAB97204 (PubMed:11208926).Curated1
Sequence conflicti916S → G in CAB97204 (PubMed:11208926).Curated1
Sequence conflicti1122P → T in CAB97204 (PubMed:11208926).Curated1
Sequence conflicti1382S → P in AAN86532 (PubMed:12423064).Curated1
Sequence conflicti1473I → V in AAN86532 (PubMed:12423064).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017015912 – 920Missing in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY170916 mRNA Translation: AAN86532.1
AF487549 mRNA Translation: AAO85437.1
AY174892 mRNA Translation: AAO44983.1
AJ277881 mRNA Translation: CAB97204.1
X96394 mRNA Translation: CAA65258.1

NCBI Reference Sequences

More...RefSeqi		NP_071617.2, NM_022281.2 [Q8CG09-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		24565

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:24565

UCSC genome browser

More...UCSCi		RGD:3112 rat [Q8CG09-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY170916 mRNA Translation: AAN86532.1
AF487549 mRNA Translation: AAO85437.1
AY174892 mRNA Translation: AAO44983.1
AJ277881 mRNA Translation: CAB97204.1
X96394 mRNA Translation: CAA65258.1
RefSeqiNP_071617.2, NM_022281.2 [Q8CG09-1]

3D structure databases

SMRiQ8CG09
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041695

Chemistry databases

ChEMBLiCHEMBL5680
SwissLipidsiSLP:000000405

PTM databases

iPTMnetiQ8CG09
PhosphoSitePlusiQ8CG09

Proteomic databases

jPOSTiQ8CG09
PaxDbiQ8CG09
PRIDEiQ8CG09

Genome annotation databases

GeneIDi24565
KEGGirno:24565
UCSCiRGD:3112 rat [Q8CG09-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4363
RGDi3112 Abcc1

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
InParanoidiQ8CG09
KOiK05665
OrthoDBi138195at2759
PhylomeDBiQ8CG09

Enzyme and pathway databases

ReactomeiR-RNO-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-RNO-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-RNO-382556 ABC-family proteins mediated transport

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q8CG09

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR018170 Aldo/ket_reductase_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
TIGRFAMsiTIGR00957 MRP_assoc_pro, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits
PS00063 ALDOKETO_REDUCTASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRP1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CG09
Secondary accession number(s): Q63346
, Q810E4, Q810G9, Q9JHS0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: February 26, 2020
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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