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Protein

Solute carrier family 22 member 12

Gene

Slc22a12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions or chloride ions.1 Publication

GO - Molecular functioni

  • PDZ domain binding Source: UniProtKB
  • urate transmembrane transporter activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processIon transport, Transport

Protein family/group databases

TCDBi2.A.1.19.14 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 12
Alternative name(s):
Renal-specific transporter
Short name:
RST
Urate anion exchanger 1
Gene namesi
Name:Slc22a12
Synonyms:Urat1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1195269 Slc22a12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Transmembranei435 – 455HelicalSequence analysisAdd BLAST21
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003079451 – 553Solute carrier family 22 member 12Add BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei534PhosphoserineCombined sources1
Modified residuei542PhosphothreonineCombined sources1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8CFZ5
PaxDbiQ8CFZ5
PeptideAtlasiQ8CFZ5
PRIDEiQ8CFZ5

PTM databases

iPTMnetiQ8CFZ5
PhosphoSitePlusiQ8CFZ5

Expressioni

Tissue specificityi

Detected in kidney (at protein level). Detected in kidney cortex, in proximal tubules.2 Publications

Interactioni

Subunit structurei

Interacts with PDZK1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8CFZ5, 2 interactors
MINTiQ8CFZ5
STRINGi10090.ENSMUSP00000109078

Structurei

3D structure databases

ProteinModelPortaliQ8CFZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIE Eukaryota
ENOG410XSRI LUCA
HOGENOMiHOG000234569
HOVERGENiHBG108433
InParanoidiQ8CFZ5
KOiK08208
PhylomeDBiQ8CFZ5
TreeFamiTF315847

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8CFZ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFPELLDRV GGLGRFQLFQ TVALVTPILW VTTQNMLENF SAAVPHHRCW
60 70 80 90 100
VPLLDNSTSQ ASIPGDLGPD VLLAVSIPPG PDQQPHQCLR FRQPQWQLTE
110 120 130 140 150
SNATATNWSD AATEPCEDGW VYDHSTFRST IVTTWDLVCN SQALRPMAQS
160 170 180 190 200
IFLAGILVGA AVCGHASDRF GRRRVLTWSY LLVSVSGTAA AFMPTFPLYC
210 220 230 240 250
LFRFLLASAV AGVMMNTASL LMEWTSAQGS PLVMTLNALG FSFGQVLTGS
260 270 280 290 300
VAYGVRSWRM LQLAVSAPFF LFFVYSWWLP ESARWLITVG KLDQGLQELQ
310 320 330 340 350
RVAAVNRRKA EGDTLTMEVL RSAMEEEPSR DKAGASLGTL LHTPGLRHRT
360 370 380 390 400
IISMLCWFAF GFTFYGLALD LQALGSNIFL LQALIGIVDF PVKTGSLLLI
410 420 430 440 450
SRLGRRFCQV SFLVLPGLCI LSNILVPHGM GVLRSALAVL GLGCLGGAFT
460 470 480 490 500
CITIFSSELF PTVIRMTAVG LCQVAARGGA MLGPLVRLLG VYGSWMPLLV
510 520 530 540 550
YGVVPVLSGL AALLLPETKN LPLPDTIQDI QKQSVKKVTH DTPDGSILMS

TRL
Length:553
Mass (Da):60,194
Last modified:March 1, 2003 - v1
Checksum:iD331583A8D54DBBF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1I9A0A0R4J1I9_MOUSE
Solute carrier family 22 (Organic a...
Slc22a12 mCG_5040
553Annotation score:
F7A0H7F7A0H7_MOUSE
Solute carrier family 22 member 12
Slc22a12
274Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti407F → L in BAA23875 (PubMed:9409754).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005451 mRNA Translation: BAA23875.1
BC035927 mRNA Translation: AAH35927.1
CCDSiCCDS29505.1
RefSeqiNP_033229.3, NM_009203.3
UniGeneiMm.391146

Genome annotation databases

GeneIDi20521
KEGGimmu:20521
UCSCiuc012bho.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005451 mRNA Translation: BAA23875.1
BC035927 mRNA Translation: AAH35927.1
CCDSiCCDS29505.1
RefSeqiNP_033229.3, NM_009203.3
UniGeneiMm.391146

3D structure databases

ProteinModelPortaliQ8CFZ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CFZ5, 2 interactors
MINTiQ8CFZ5
STRINGi10090.ENSMUSP00000109078

Protein family/group databases

TCDBi2.A.1.19.14 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ8CFZ5
PhosphoSitePlusiQ8CFZ5

Proteomic databases

MaxQBiQ8CFZ5
PaxDbiQ8CFZ5
PeptideAtlasiQ8CFZ5
PRIDEiQ8CFZ5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20521
KEGGimmu:20521
UCSCiuc012bho.1 mouse

Organism-specific databases

CTDi116085
MGIiMGI:1195269 Slc22a12

Phylogenomic databases

eggNOGiENOG410IRIE Eukaryota
ENOG410XSRI LUCA
HOGENOMiHOG000234569
HOVERGENiHBG108433
InParanoidiQ8CFZ5
KOiK08208
PhylomeDBiQ8CFZ5
TreeFamiTF315847

Miscellaneous databases

PROiPR:Q8CFZ5
SOURCEiSearch...

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS22AC_MOUSE
AccessioniPrimary (citable) accession number: Q8CFZ5
Secondary accession number(s): O54778
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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