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Entry version 134 (29 Sep 2021)
Sequence version 2 (27 Jul 2011)
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Protein

GDH/6PGL endoplasmic bifunctional protein

Gene

H6pd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes (PubMed:4169027, PubMed:12831846, PubMed:16356929, PubMed:18222920).

Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway (PubMed:4169027, PubMed:12831846, PubMed:18222920).

In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway (PubMed:12831846).

May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate (PubMed:12831846).

The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum (PubMed:12831846, PubMed:16356929, PubMed:17656460, PubMed:18222920).

By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity (PubMed:16356929).

5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=4065 mM for D-glucose (at pH 7.1 in the presence of NADP)1 Publication
  2. KM=725 mM for D-glucose (at pH 7.1 in the presence of NAD)1 Publication
  3. KM=532 mM for D-glucose (at pH 9.6 in the presence of NAD)1 Publication
  4. KM=120 µM for D-glucose 6-phosphate (at pH 9.6 in the presence of NADP)1 Publication
  5. KM=28 µM for D-glucose 6-phosphate (at pH 9.6 in the presence of NAD)1 Publication
  6. KM=66 µM for 2-deoxy-D-glucose 6-phosphate (at pH 7.1 in the presence of NADP)1 Publication
  7. KM=12 µM for 2-deoxy-D-glucose 6-phosphate (at pH 7.1 in the presence of NAD)1 Publication
  8. KM=5.89 mM for 2-deoxy-D-glucose 6-phosphate (at pH 9.6 in the presence of NADP)1 Publication
  9. KM=4.35 mM for 2-deoxy-D-glucose 6-phosphate (at pH 9.6 in the presence of NAD)1 Publication
  10. KM=7 µM for D-galactopyranose 6-phosphate (at pH 7.1 in the presence of NADP)1 Publication
  11. KM=504 µM for D-galactopyranose 6-phosphate (at pH 9.6 in the presence of NADP)1 Publication
  12. KM=223 µM for D-galactopyranose 6-phosphate (at pH 7.1 in the presence of NAD)1 Publication
  13. KM=9 µM for NADP (at pH 7.1 in the presence of galactose 6-phosphate)1 Publication
  14. KM=14 µM for NADP (at pH 9.6 in the presence of galactose 6-phosphate)1 Publication
  15. KM=4 µM for NADP (at pH 9.6 in the presence of D-glucose 6-phosphate)1 Publication
  16. KM=12 µM for NADP (at pH 7.1 in the presence of D-glucose)1 Publication
  17. KM=52 µM for NAD (at pH 7.1 in the presence of D-glucose)1 Publication
  18. KM=47 µM for NADP (at pH 9.6 in the presence of D-glucose)1 Publication
  19. KM=261 µM for NAD (at pH 9.6 in the presence of D-glucose)1 Publication
  20. KM=34 µM for NAD (at pH 7.1 in the presence of D-glucose)1 Publication
  21. KM=72 µM for NAD (at pH 9.6 in the presence of D-glucose)1 Publication

pH dependencei

Optimum pH is 6.0-8.0.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pentose phosphate pathway

This protein is involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).2 Publications This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the pathway pentose phosphate pathway and in Carbohydrate degradation.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).1 Publication This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei146NADPBy similarity1
Binding sitei171NADP; via carbonyl oxygenBy similarity1
Binding sitei171SubstrateBy similarity1
Binding sitei240SubstrateBy similarity1
Binding sitei259SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei264Proton acceptorBy similarity1
Binding sitei357SubstrateBy similarity1
Binding sitei362SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi29 – 36NADPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Multifunctional enzyme, Oxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandNAD, NADP

Enzyme and pathway databases

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q8CFX1

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00115;UER00409

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GDH/6PGL endoplasmic bifunctional protein1 Publication
Including the following 2 domains:
Hexose-6-phosphate dehydrogenase1 Publication
Alternative name(s):
Glucose 1-dehydrogenase1 Publication (EC:1.1.1.471 Publication)
Glucose-6-phosphate dehydrogenase1 Publication (EC:1.1.1.3632 Publications)
6-phosphogluconolactonase1 Publication (EC:3.1.1.311 Publication)
Short name:
6PGL1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:H6pdImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2140356, H6pd

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000028980

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice lacking H6pd are born at the expected Mendelian frequency and do not show overt phenotype (PubMed:16356929). However, they display cellular inability to convert 11-dehydrocorticosterone (11-DHC) to corticosterone and present increased corticosterone to 11-DHC conversion associated with adrenal hyperplasia (PubMed:16356929). Mutant mice also display fasting hypoglycemia and perturbed lipid mobilization that are probably due to the aforementioned effect on corticosterone metabolism and blunted intracellular action of the hormone (PubMed:17656460, PubMed:18218694). Skeletal myopathy associated with a dysregulation of the expression of proteins associated with calcium homeostasis in the sarcoplasmic reticulum and an activation of the unfolded protein response are also observed (PubMed:18222920).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16By similarityAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023679417 – 789GDH/6PGL endoplasmic bifunctional proteinAdd BLAST773

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17Pyrrolidone carboxylic acidBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei205N6-succinyllysineCombined sources1
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei424N6-succinyllysineCombined sources1
Glycosylationi681N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8CFX1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8CFX1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8CFX1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CFX1

PRoteomics IDEntifications database

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PRIDEi
Q8CFX1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
271657

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2334, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8CFX1, 3 sites, 2 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CFX1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CFX1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8CFX1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver (at protein level) (PubMed:4169027). Expressed in muscles (PubMed:18222920). Expressed in adipose tissues (PubMed:18218694).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028980, Expressed in white adipose tissue and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CFX1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CFX1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
221399, 2 interactors

Molecular INTeraction database

More...
MINTi
Q8CFX1

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000030830

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8CFX1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CFX1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni17 – 524Hexose-6-phosphate dehydrogenaseCuratedAdd BLAST508
Regioni201 – 205Substrate bindingBy similarity5
Regioni525 – 538LinkerCuratedAdd BLAST14
Regioni539 – 7896-phosphogluconolactonaseCuratedAdd BLAST251

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0563, Eukaryota
KOG3147, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063435

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018975_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CFX1

Identification of Orthologs from Complete Genome Data

More...
OMAi
GHGSLQY

Database of Orthologous Groups

More...
OrthoDBi
383995at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01400, 6PGL, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005900, 6-phosphogluconolactonase_DevB
IPR001282, G6P_DH
IPR019796, G6P_DH_AS
IPR022675, G6P_DH_C
IPR022674, G6P_DH_NAD-bd
IPR006148, Glc/Gal-6P_isomerase
IPR036291, NAD(P)-bd_dom_sf
IPR037171, NagB/RpiA_transferase-like

The PANTHER Classification System

More...
PANTHERi
PTHR23429, PTHR23429, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02781, G6PD_C, 1 hit
PF00479, G6PD_N, 1 hit
PF01182, Glucosamine_iso, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00079, G6PDHDRGNASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100950, SSF100950, 1 hit
SSF51735, SSF51735, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01198, pgl, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00069, G6P_DEHYDROGENASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8CFX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLAAMCLAL LGCLQAQELK GHVSIILLGA TGDLAKKYLW QGLFQLYLDE
60 70 80 90 100
AGKGHSFSFH GAALTAPQQG QKLMDKVLES LSCPKDLVPS RCDELKGQFL
110 120 130 140 150
QLSQYRQLKT VEDYQTLNKD IETQVQQDGL WEAGRIFYFS VPPFAYADIA
160 170 180 190 200
RNINSSCRPH PGAWLRVVFE KPFGHDHLSA QQLASELGSF FQEEEMYRVD
210 220 230 240 250
HYLGKQAVAQ ILPFRDQNRK ALDGLWNRHH VERVEIILKE TIDAEGRASF
260 270 280 290 300
YEEYGVIRDT LQNHLTEILT LVAMELPLNI SSSAAVLQHK LWAFQALRGL
310 320 330 340 350
QKSSAILGQY QAYSGQVRRE LQKPDGFQSL TPTFAGVLVH IDNLRWEGVP
360 370 380 390 400
FILMSGKALD ERVGYVRIVF KNRAYCTQSE RHWVPEQSRC LPQQIIFYIG
410 420 430 440 450
HGELGHPAIL VSRNLFKPSL PTQKWKEVQD QPGLRLFGRP LSDYYAYRPV
460 470 480 490 500
REQDAYSTLL SHIFHCRKES FITTENLLAS WVFWTPLLDS LAFEVPRPYP
510 520 530 540 550
GGAENGQLLD FEFSGGQLTF SQQQLEVLIP DLGSVPKPSD FQVLGARYRQ
560 570 580 590 600
SPLITAWPEE LISKLASDIE AAAVQAVRHF GKFHLALSGG SSPIALFQQL
610 620 630 640 650
ATGHYSFPWA HTHLWLVDER CVPLSDPDSN FQGLQAHLLQ HVRVPYYNIH
660 670 680 690 700
PMPVHLHQRL CAEEDQGAQT YASEISALVA NSSFDLVLLG MGTDGHTASL
710 720 730 740 750
FPQSPTGLDG DQLVVLTESP FRPHQRMSLS LPLINRAKKV AVLVMGRTKR
760 770 780
EITTLVSRVG HEPKKWPISG VVPLSGQLVW YMDYEAFLG
Length:789
Mass (Da):88,928
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE970CE8B35D3E1E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A7A7A2A7A7_MOUSE
GDH/6PGL endoplasmic bifunctional p...
H6pd
797Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A7A8A2A7A8_MOUSE
GDH/6PGL endoplasmic bifunctional p...
H6pd
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC32260 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti77V → A in BAE35029 (PubMed:16141072).Curated1
Sequence conflicti77V → A in CAQ51682 (PubMed:19468303).Curated1
Sequence conflicti77V → A in AAH42677 (PubMed:15489334).Curated1
Sequence conflicti106R → H in BAE35029 (PubMed:16141072).Curated1
Sequence conflicti106R → H in CAQ51682 (PubMed:19468303).Curated1
Sequence conflicti106R → H in AAH42677 (PubMed:15489334).Curated1
Sequence conflicti285A → T in BAE35029 (PubMed:16141072).Curated1
Sequence conflicti285A → T in CAQ51682 (PubMed:19468303).Curated1
Sequence conflicti285A → T in AAH42677 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK045199 mRNA Translation: BAC32260.1 Different initiation.
AK159373 mRNA Translation: BAE35029.1
AL606914 Genomic DNA Translation: CAM16119.1
CU463327 Genomic DNA Translation: CAQ51682.1
BC042677 mRNA Translation: AAH42677.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS71524.1

NCBI Reference Sequences

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RefSeqi
NP_001277933.1, NM_001291004.1
NP_775547.2, NM_173371.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000084117; ENSMUSP00000081134; ENSMUSG00000028980

Database of genes from NCBI RefSeq genomes

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GeneIDi
100198

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:100198

UCSC genome browser

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UCSCi
uc008vxh.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045199 mRNA Translation: BAC32260.1 Different initiation.
AK159373 mRNA Translation: BAE35029.1
AL606914 Genomic DNA Translation: CAM16119.1
CU463327 Genomic DNA Translation: CAQ51682.1
BC042677 mRNA Translation: AAH42677.1
CCDSiCCDS71524.1
RefSeqiNP_001277933.1, NM_001291004.1
NP_775547.2, NM_173371.4

3D structure databases

SMRiQ8CFX1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi221399, 2 interactors
MINTiQ8CFX1
STRINGi10090.ENSMUSP00000030830

PTM databases

GlyConnecti2334, 2 N-Linked glycans (1 site)
GlyGeniQ8CFX1, 3 sites, 2 N-linked glycans (1 site)
iPTMnetiQ8CFX1
PhosphoSitePlusiQ8CFX1
SwissPalmiQ8CFX1

Proteomic databases

EPDiQ8CFX1
jPOSTiQ8CFX1
MaxQBiQ8CFX1
PaxDbiQ8CFX1
PRIDEiQ8CFX1
ProteomicsDBi271657

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1350, 307 antibodies

The DNASU plasmid repository

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DNASUi
100198

Genome annotation databases

EnsembliENSMUST00000084117; ENSMUSP00000081134; ENSMUSG00000028980
GeneIDi100198
KEGGimmu:100198
UCSCiuc008vxh.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9563
MGIiMGI:2140356, H6pd
VEuPathDBiHostDB:ENSMUSG00000028980

Phylogenomic databases

eggNOGiKOG0563, Eukaryota
KOG3147, Eukaryota
GeneTreeiENSGT00530000063435
HOGENOMiCLU_018975_0_0_1
InParanoidiQ8CFX1
OMAiGHGSLQY
OrthoDBi383995at2759

Enzyme and pathway databases

UniPathwayiUPA00115;UER00409
SABIO-RKiQ8CFX1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
100198, 0 hits in 61 CRISPR screens

Protein Ontology

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PROi
PR:Q8CFX1
RNActiQ8CFX1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028980, Expressed in white adipose tissue and 237 other tissues
ExpressionAtlasiQ8CFX1, baseline and differential
GenevisibleiQ8CFX1, MM

Family and domain databases

CDDicd01400, 6PGL, 1 hit
InterProiView protein in InterPro
IPR005900, 6-phosphogluconolactonase_DevB
IPR001282, G6P_DH
IPR019796, G6P_DH_AS
IPR022675, G6P_DH_C
IPR022674, G6P_DH_NAD-bd
IPR006148, Glc/Gal-6P_isomerase
IPR036291, NAD(P)-bd_dom_sf
IPR037171, NagB/RpiA_transferase-like
PANTHERiPTHR23429, PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781, G6PD_C, 1 hit
PF00479, G6PD_N, 1 hit
PF01182, Glucosamine_iso, 1 hit
PRINTSiPR00079, G6PDHDRGNASE
SUPFAMiSSF100950, SSF100950, 1 hit
SSF51735, SSF51735, 1 hit
TIGRFAMsiTIGR01198, pgl, 1 hit
PROSITEiView protein in PROSITE
PS00069, G6P_DEHYDROGENASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG6PE_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CFX1
Secondary accession number(s): A2A7A9, B2KGW7, Q8BLH1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 27, 2011
Last modified: September 29, 2021
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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