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Entry version 133 (02 Jun 2021)
Sequence version 2 (27 Jul 2011)
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Protein

GDH/6PGL endoplasmic bifunctional protein

Gene

H6pd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes (PubMed:4169027, PubMed:12831846, PubMed:16356929, PubMed:18222920).

Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway (PubMed:4169027, PubMed:12831846, PubMed:18222920).

In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway (PubMed:12831846).

May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate (PubMed:12831846).

The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum (PubMed:12831846, PubMed:16356929, PubMed:17656460, PubMed:18222920).

By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity (PubMed:16356929).

5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=4065 mM for D-glucose (at pH 7.1 in the presence of NADP)1 Publication
  2. KM=725 mM for D-glucose (at pH 7.1 in the presence of NAD)1 Publication
  3. KM=532 mM for D-glucose (at pH 9.6 in the presence of NAD)1 Publication
  4. KM=120 µM for D-glucose 6-phosphate (at pH 9.6 in the presence of NADP)1 Publication
  5. KM=28 µM for D-glucose 6-phosphate (at pH 9.6 in the presence of NAD)1 Publication
  6. KM=66 µM for 2-deoxy-D-glucose 6-phosphate (at pH 7.1 in the presence of NADP)1 Publication
  7. KM=12 µM for 2-deoxy-D-glucose 6-phosphate (at pH 7.1 in the presence of NAD)1 Publication
  8. KM=5.89 mM for 2-deoxy-D-glucose 6-phosphate (at pH 9.6 in the presence of NADP)1 Publication
  9. KM=4.35 mM for 2-deoxy-D-glucose 6-phosphate (at pH 9.6 in the presence of NAD)1 Publication
  10. KM=7 µM for D-galactopyranose 6-phosphate (at pH 7.1 in the presence of NADP)1 Publication
  11. KM=504 µM for D-galactopyranose 6-phosphate (at pH 9.6 in the presence of NADP)1 Publication
  12. KM=223 µM for D-galactopyranose 6-phosphate (at pH 7.1 in the presence of NAD)1 Publication
  13. KM=9 µM for NADP (at pH 7.1 in the presence of galactose 6-phosphate)1 Publication
  14. KM=14 µM for NADP (at pH 9.6 in the presence of galactose 6-phosphate)1 Publication
  15. KM=4 µM for NADP (at pH 9.6 in the presence of D-glucose 6-phosphate)1 Publication
  16. KM=12 µM for NADP (at pH 7.1 in the presence of D-glucose)1 Publication
  17. KM=52 µM for NAD (at pH 7.1 in the presence of D-glucose)1 Publication
  18. KM=47 µM for NADP (at pH 9.6 in the presence of D-glucose)1 Publication
  19. KM=261 µM for NAD (at pH 9.6 in the presence of D-glucose)1 Publication
  20. KM=34 µM for NAD (at pH 7.1 in the presence of D-glucose)1 Publication
  21. KM=72 µM for NAD (at pH 9.6 in the presence of D-glucose)1 Publication

    pH dependencei

    Optimum pH is 6.0-8.0.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pentose phosphate pathway

    This protein is involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).2 Publications This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the pathway pentose phosphate pathway and in Carbohydrate degradation.

    Pathwayi: pentose phosphate pathway

    This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).1 Publication This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei146NADPBy similarity1
    Binding sitei171NADP; via carbonyl oxygenBy similarity1
    Binding sitei171SubstrateBy similarity1
    Binding sitei240SubstrateBy similarity1
    Binding sitei259SubstrateBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei264Proton acceptorBy similarity1
    Binding sitei357SubstrateBy similarity1
    Binding sitei362SubstrateBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi29 – 36NADPBy similarity8

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Multifunctional enzyme, Oxidoreductase
    Biological processCarbohydrate metabolism, Glucose metabolism
    LigandNAD, NADP

    Enzyme and pathway databases

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q8CFX1

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00115;UER00409

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    GDH/6PGL endoplasmic bifunctional protein1 Publication
    Including the following 2 domains:
    Hexose-6-phosphate dehydrogenase1 Publication
    Alternative name(s):
    Glucose 1-dehydrogenase1 Publication (EC:1.1.1.471 Publication)
    Glucose-6-phosphate dehydrogenase1 Publication (EC:1.1.1.3632 Publications)
    6-phosphogluconolactonase1 Publication (EC:3.1.1.311 Publication)
    Short name:
    6PGL1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:H6pdImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:2140356, H6pd

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Endoplasmic reticulum

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Mice lacking H6pd are born at the expected Mendelian frequency and do not show overt phenotype (PubMed:16356929). However, they display cellular inability to convert 11-dehydrocorticosterone (11-DHC) to corticosterone and present increased corticosterone to 11-DHC conversion associated with adrenal hyperplasia (PubMed:16356929). Mutant mice also display fasting hypoglycemia and perturbed lipid mobilization that are probably due to the aforementioned effect on corticosterone metabolism and blunted intracellular action of the hormone (PubMed:17656460, PubMed:18218694). Skeletal myopathy associated with a dysregulation of the expression of proteins associated with calcium homeostasis in the sarcoplasmic reticulum and an activation of the unfolded protein response are also observed (PubMed:18222920).4 Publications

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16By similarityAdd BLAST16
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023679417 – 789GDH/6PGL endoplasmic bifunctional proteinAdd BLAST773

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17Pyrrolidone carboxylic acidBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
    Modified residuei205N6-succinyllysineCombined sources1
    Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
    Modified residuei424N6-succinyllysineCombined sources1
    Glycosylationi681N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Glycoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q8CFX1

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q8CFX1

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q8CFX1

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8CFX1

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8CFX1

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    271657

    PTM databases

    GlyConnect protein glycosylation platform

    More...
    GlyConnecti
    2334, 2 N-Linked glycans (1 site)

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...
    GlyGeni
    Q8CFX1, 3 sites

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8CFX1

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8CFX1

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q8CFX1

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in liver (at protein level) (PubMed:4169027). Expressed in muscles (PubMed:18222920). Expressed in adipose tissues (PubMed:18218694).3 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000028980, Expressed in white adipose tissue and 237 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q8CFX1, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8CFX1, MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    1 Publication

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    Q8CFX1, 3 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q8CFX1

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000030830

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q8CFX1, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8CFX1

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni17 – 524Hexose-6-phosphate dehydrogenaseCuratedAdd BLAST508
    Regioni201 – 205Substrate bindingBy similarity5
    Regioni525 – 538LinkerCuratedAdd BLAST14
    Regioni539 – 7896-phosphogluconolactonaseCuratedAdd BLAST251

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0563, Eukaryota
    KOG3147, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00530000063435

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_018975_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8CFX1

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    ASWAFWT

    Database of Orthologous Groups

    More...
    OrthoDBi
    383995at2759

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd01400, 6PGL, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR005900, 6-phosphogluconolactonase_DevB
    IPR001282, G6P_DH
    IPR019796, G6P_DH_AS
    IPR022675, G6P_DH_C
    IPR022674, G6P_DH_NAD-bd
    IPR006148, Glc/Gal-6P_isomerase
    IPR036291, NAD(P)-bd_dom_sf
    IPR037171, NagB/RpiA_transferase-like

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR23429, PTHR23429, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02781, G6PD_C, 1 hit
    PF00479, G6PD_N, 1 hit
    PF01182, Glucosamine_iso, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00079, G6PDHDRGNASE

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF100950, SSF100950, 1 hit
    SSF51735, SSF51735, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR01198, pgl, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00069, G6P_DEHYDROGENASE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    Q8CFX1-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MLLAAMCLAL LGCLQAQELK GHVSIILLGA TGDLAKKYLW QGLFQLYLDE
    60 70 80 90 100
    AGKGHSFSFH GAALTAPQQG QKLMDKVLES LSCPKDLVPS RCDELKGQFL
    110 120 130 140 150
    QLSQYRQLKT VEDYQTLNKD IETQVQQDGL WEAGRIFYFS VPPFAYADIA
    160 170 180 190 200
    RNINSSCRPH PGAWLRVVFE KPFGHDHLSA QQLASELGSF FQEEEMYRVD
    210 220 230 240 250
    HYLGKQAVAQ ILPFRDQNRK ALDGLWNRHH VERVEIILKE TIDAEGRASF
    260 270 280 290 300
    YEEYGVIRDT LQNHLTEILT LVAMELPLNI SSSAAVLQHK LWAFQALRGL
    310 320 330 340 350
    QKSSAILGQY QAYSGQVRRE LQKPDGFQSL TPTFAGVLVH IDNLRWEGVP
    360 370 380 390 400
    FILMSGKALD ERVGYVRIVF KNRAYCTQSE RHWVPEQSRC LPQQIIFYIG
    410 420 430 440 450
    HGELGHPAIL VSRNLFKPSL PTQKWKEVQD QPGLRLFGRP LSDYYAYRPV
    460 470 480 490 500
    REQDAYSTLL SHIFHCRKES FITTENLLAS WVFWTPLLDS LAFEVPRPYP
    510 520 530 540 550
    GGAENGQLLD FEFSGGQLTF SQQQLEVLIP DLGSVPKPSD FQVLGARYRQ
    560 570 580 590 600
    SPLITAWPEE LISKLASDIE AAAVQAVRHF GKFHLALSGG SSPIALFQQL
    610 620 630 640 650
    ATGHYSFPWA HTHLWLVDER CVPLSDPDSN FQGLQAHLLQ HVRVPYYNIH
    660 670 680 690 700
    PMPVHLHQRL CAEEDQGAQT YASEISALVA NSSFDLVLLG MGTDGHTASL
    710 720 730 740 750
    FPQSPTGLDG DQLVVLTESP FRPHQRMSLS LPLINRAKKV AVLVMGRTKR
    760 770 780
    EITTLVSRVG HEPKKWPISG VVPLSGQLVW YMDYEAFLG
    Length:789
    Mass (Da):88,928
    Last modified:July 27, 2011 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE970CE8B35D3E1E5
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A2A7A7A2A7A7_MOUSE
    GDH/6PGL endoplasmic bifunctional p...
    H6pd
    797Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A2A7A8A2A7A8_MOUSE
    GDH/6PGL endoplasmic bifunctional p...
    H6pd
    171Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAC32260 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti77V → A in BAE35029 (PubMed:16141072).Curated1
    Sequence conflicti77V → A in CAQ51682 (PubMed:19468303).Curated1
    Sequence conflicti77V → A in AAH42677 (PubMed:15489334).Curated1
    Sequence conflicti106R → H in BAE35029 (PubMed:16141072).Curated1
    Sequence conflicti106R → H in CAQ51682 (PubMed:19468303).Curated1
    Sequence conflicti106R → H in AAH42677 (PubMed:15489334).Curated1
    Sequence conflicti285A → T in BAE35029 (PubMed:16141072).Curated1
    Sequence conflicti285A → T in CAQ51682 (PubMed:19468303).Curated1
    Sequence conflicti285A → T in AAH42677 (PubMed:15489334).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AK045199 mRNA Translation: BAC32260.1 Different initiation.
    AK159373 mRNA Translation: BAE35029.1
    AL606914 Genomic DNA Translation: CAM16119.1
    CU463327 Genomic DNA Translation: CAQ51682.1
    BC042677 mRNA Translation: AAH42677.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS71524.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001277933.1, NM_001291004.1
    NP_775547.2, NM_173371.4

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000084117; ENSMUSP00000081134; ENSMUSG00000028980

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    100198

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:100198

    UCSC genome browser

    More...
    UCSCi
    uc008vxh.2, mouse

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK045199 mRNA Translation: BAC32260.1 Different initiation.
    AK159373 mRNA Translation: BAE35029.1
    AL606914 Genomic DNA Translation: CAM16119.1
    CU463327 Genomic DNA Translation: CAQ51682.1
    BC042677 mRNA Translation: AAH42677.1
    CCDSiCCDS71524.1
    RefSeqiNP_001277933.1, NM_001291004.1
    NP_775547.2, NM_173371.4

    3D structure databases

    SMRiQ8CFX1
    ModBaseiSearch...

    Protein-protein interaction databases

    IntActiQ8CFX1, 3 interactors
    MINTiQ8CFX1
    STRINGi10090.ENSMUSP00000030830

    PTM databases

    GlyConnecti2334, 2 N-Linked glycans (1 site)
    GlyGeniQ8CFX1, 3 sites
    iPTMnetiQ8CFX1
    PhosphoSitePlusiQ8CFX1
    SwissPalmiQ8CFX1

    Proteomic databases

    EPDiQ8CFX1
    jPOSTiQ8CFX1
    MaxQBiQ8CFX1
    PaxDbiQ8CFX1
    PRIDEiQ8CFX1
    ProteomicsDBi271657

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    1350, 302 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    100198

    Genome annotation databases

    EnsembliENSMUST00000084117; ENSMUSP00000081134; ENSMUSG00000028980
    GeneIDi100198
    KEGGimmu:100198
    UCSCiuc008vxh.2, mouse

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    9563
    MGIiMGI:2140356, H6pd

    Phylogenomic databases

    eggNOGiKOG0563, Eukaryota
    KOG3147, Eukaryota
    GeneTreeiENSGT00530000063435
    HOGENOMiCLU_018975_0_0_1
    InParanoidiQ8CFX1
    OMAiASWAFWT
    OrthoDBi383995at2759

    Enzyme and pathway databases

    UniPathwayiUPA00115;UER00409
    SABIO-RKiQ8CFX1

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    100198, 0 hits in 52 CRISPR screens

    Protein Ontology

    More...
    PROi
    PR:Q8CFX1
    RNActiQ8CFX1, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000028980, Expressed in white adipose tissue and 237 other tissues
    ExpressionAtlasiQ8CFX1, baseline and differential
    GenevisibleiQ8CFX1, MM

    Family and domain databases

    CDDicd01400, 6PGL, 1 hit
    InterProiView protein in InterPro
    IPR005900, 6-phosphogluconolactonase_DevB
    IPR001282, G6P_DH
    IPR019796, G6P_DH_AS
    IPR022675, G6P_DH_C
    IPR022674, G6P_DH_NAD-bd
    IPR006148, Glc/Gal-6P_isomerase
    IPR036291, NAD(P)-bd_dom_sf
    IPR037171, NagB/RpiA_transferase-like
    PANTHERiPTHR23429, PTHR23429, 1 hit
    PfamiView protein in Pfam
    PF02781, G6PD_C, 1 hit
    PF00479, G6PD_N, 1 hit
    PF01182, Glucosamine_iso, 1 hit
    PRINTSiPR00079, G6PDHDRGNASE
    SUPFAMiSSF100950, SSF100950, 1 hit
    SSF51735, SSF51735, 1 hit
    TIGRFAMsiTIGR01198, pgl, 1 hit
    PROSITEiView protein in PROSITE
    PS00069, G6P_DEHYDROGENASE, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG6PE_MOUSE
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CFX1
    Secondary accession number(s): A2A7A9, B2KGW7, Q8BLH1
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: July 27, 2011
    Last modified: June 2, 2021
    This is version 133 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families
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