Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coiled-coil and C2 domain-containing protein 2A

Gene

Cc2d2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.2 Publications

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-5620912 Anchoring of the basal body to the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil and C2 domain-containing protein 2A
Gene namesi
Name:Cc2d2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1924487 Cc2d2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Embryos show randomized left-right axes, holoprosencephaly, microphthalmia and a variably expressive curved body axis. Cc2d2a null embryos also have cilia defects, which are exemplified by the absence of Arl13b staining in neural tube and surrounding mesenchyme.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172511 – 1633Coiled-coil and C2 domain-containing protein 2AAdd BLAST1633

Proteomic databases

PaxDbiQ8CFW7
PRIDEiQ8CFW7

PTM databases

iPTMnetiQ8CFW7
PhosphoSitePlusiQ8CFW7

Expressioni

Gene expression databases

BgeeiENSMUSG00000039765 Expressed in 227 organ(s), highest expression level in retina
CleanExiMM_CC2D2A
ExpressionAtlasiQ8CFW7 baseline and differential
GenevisibleiQ8CFW7 MM

Interactioni

Subunit structurei

Part of the tectonic-like complex (also named B9 complex).2 Publications

Protein-protein interaction databases

BioGridi231096, 2 interactors
CORUMiQ8CFW7
IntActiQ8CFW7, 7 interactors
STRINGi10090.ENSMUSP00000048320

Structurei

3D structure databases

ProteinModelPortaliQ8CFW7
SMRiQ8CFW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1068 – 1180C2Add BLAST113

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili440 – 501Sequence analysisAdd BLAST62
Coiled coili554 – 611Sequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi240 – 243Poly-Glu4

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3639 Eukaryota
ENOG410XQVY LUCA
GeneTreeiENSGT00510000046611
HOGENOMiHOG000068028
HOVERGENiHBG107545
InParanoidiQ8CFW7
KOiK19352
OMAiKYVHRSQ
OrthoDBiEOG091G0IID
PhylomeDBiQ8CFW7
TreeFamiTF324786

Family and domain databases

InterProiView protein in InterPro
IPR000008 C2_dom
IPR028928 CC2D2AN-C2
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF15625 CC2D2AN-C2, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CFW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNTNDEKMKI ISEDFTGDGV DTEAGRRKKN SKVRRQQRKK KPPASPPEEM
60 70 80 90 100
VSDKFQDGGQ QEVVEEEPET NLLSLTARRG PRSLPPIPSA SRTGFAEFSM
110 120 130 140 150
RERMREKLQA ARSKAESALL RDVPTPRPRR LRSPSREKET ETEFGTEPST
160 170 180 190 200
EVQDTQKEDD TKSYSRIKFR DSVRKIKSKP QLPPGFPSAE EAYNFFTFNF
210 220 230 240 250
DPEPEESEEK SPVKGGERAH HEDQEGEEGT QAQERAKKTE EEELLNGKDA
260 270 280 290 300
EDFLLGLDPT AHDFVAVRAA EYKSARIQLQ KEKEILFTPS RLTVPTYKKL
310 320 330 340 350
PENIQPRFLE DEGLYIGARP EVARTNENIM ENRLLIQEPG SKWFGDDGRI
360 370 380 390 400
LALPSPIKPF PSRPSLTTRE QSPKAGLETL YKKAEKYVHS RQHMIGSGDP
410 420 430 440 450
PGNFQLDIDI SGLIFTHHPC FSREHVLASK LAQLYDQYLA RQQRNKTKFL
460 470 480 490 500
TDKLQALRKA VQTSLNPEKP HQSLDTTQKT INEYKSEIRQ TRKLRDAEQE
510 520 530 540 550
KDRTLLKTII KVWKEMKSLR EFQRFTNTPL KLVLRKEKVD PKLDEDAYEA
560 570 580 590 600
EIQAEIHELL EEHMEEYATK MEEYRTSHQQ WKAWRKAQRA KKKKKKQTTE
610 620 630 640 650
EHLEEEEAEE SFPEEEVTKP IPPEPTDPAV IEQQVRERAA HSRRRPGEPT
660 670 680 690 700
LIPELSLAGN VTPNDQCPRV EVSRREDVRR RSVYLKVVFN SKEVSRTVSR
710 720 730 740 750
PLGADFRVHF GQIFNLQIFN WPESLMLQVY ETIGHSGTTL LAEVFLPIPE
760 770 780 790 800
TTLVTGRAPI EEVEFSSNQH VTLDHEGVGS GVPFSFEADG SNQLTLMTSG
810 820 830 840 850
KVSHSVAWAV GENGIPLIPP LSQQNIGFRS ALRRADAISS IGTSGLTDMK
860 870 880 890 900
KLAKWAAESK LDPNDPNHAP LMQLISVATS GESYVPDFFR LEQLQQEFNF
910 920 930 940 950
VSEEELNRSK RFRLLHLRSQ EVPEFRNYKQ IPAYDREIME KVFQDYEKRL
960 970 980 990 1000
RDRNVIETKD HLDMHRATVA KYLQQVREAV VNRFLTAKHH FLLTDLVVEE
1010 1020 1030 1040 1050
EVPNISSEGS GILGLSLFKL AEQKRPLRPR RKGRKKVTAQ NLSDGDIKLL
1060 1070 1080 1090 1100
VNIIRAYDIP VRKPVVSKFQ QPSRSSRTFS EKQTASPSTH SPLHNADYPL
1110 1120 1130 1140 1150
GQVLVRPFVE VSFQRTICHT TTAEGPNPSW NEELELPFRA PNGDYSTASL
1160 1170 1180 1190 1200
QSVKDDVYIN IFDEVLYDIL EDDRERGSGI HTRIERHWLG CVKIPFSTIY
1210 1220 1230 1240 1250
FQARIDGTFK IDIPPVLLGY SKERNIIMER AFDSARSLSE GSYITLFITI
1260 1270 1280 1290 1300
EPQLVPGEPM REKMSDMLKK FDTQEDEKLL QATEKFQAEC ALKFPQRQCL
1310 1320 1330 1340 1350
TTVTDMTGKT VFITRYLKPL NPPQELLHVY PNNPQATAEL VARYVSLIPF
1360 1370 1380 1390 1400
LPDSVSFAGV CDLWSTSDQF LDLLAGDEEE HAVLLCNYFL FLGKKAWLVM
1410 1420 1430 1440 1450
GSAIPEGPTA YVLTWEKNYY LIWNPCSGHC YGQFDAFCPL KSVGCLIGPD
1460 1470 1480 1490 1500
NIWFNIQHHD SPLRINFDVT KPKLWKSFFS RSLPYPGLSS VQPEELIYQH
1510 1520 1530 1540 1550
TDKAVAAELQ DRIEKILKEK IMDWRPRHLT RWNRYCTSTL RHFLPLLERS
1560 1570 1580 1590 1600
QGEDIEDDHR AELLKQLGDY RFSGFPLHMP YSEVKPLVEA VYSTGVHNID
1610 1620 1630
LPNVEFALAV YIHPYPKNVL SVWIYVASLV RNR
Length:1,633
Mass (Da):187,530
Last modified:March 1, 2003 - v1
Checksum:i33C9B365385B7BFB
GO
Isoform 2 (identifier: Q8CFW7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Show »
Length:1,584
Mass (Da):181,918
Checksum:iB419223CC2DBAF03
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6YZ61F6YZ61_MOUSE
Coiled-coil and C2 domain-containin...
Cc2d2a
1,457Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti345G → E in BAC36933 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0309251 – 49Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032290 mRNA Translation: AAH32290.1
AK077658 mRNA Translation: BAC36933.1
CCDSiCCDS39080.1 [Q8CFW7-1]
RefSeqiNP_758478.1, NM_172274.2 [Q8CFW7-1]
UniGeneiMm.44434
Mm.486802

Genome annotation databases

EnsembliENSMUST00000048150; ENSMUSP00000048320; ENSMUSG00000039765 [Q8CFW7-1]
GeneIDi231214
KEGGimmu:231214
UCSCiuc008xhp.2 mouse [Q8CFW7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032290 mRNA Translation: AAH32290.1
AK077658 mRNA Translation: BAC36933.1
CCDSiCCDS39080.1 [Q8CFW7-1]
RefSeqiNP_758478.1, NM_172274.2 [Q8CFW7-1]
UniGeneiMm.44434
Mm.486802

3D structure databases

ProteinModelPortaliQ8CFW7
SMRiQ8CFW7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231096, 2 interactors
CORUMiQ8CFW7
IntActiQ8CFW7, 7 interactors
STRINGi10090.ENSMUSP00000048320

PTM databases

iPTMnetiQ8CFW7
PhosphoSitePlusiQ8CFW7

Proteomic databases

PaxDbiQ8CFW7
PRIDEiQ8CFW7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048150; ENSMUSP00000048320; ENSMUSG00000039765 [Q8CFW7-1]
GeneIDi231214
KEGGimmu:231214
UCSCiuc008xhp.2 mouse [Q8CFW7-1]

Organism-specific databases

CTDi57545
MGIiMGI:1924487 Cc2d2a

Phylogenomic databases

eggNOGiKOG3639 Eukaryota
ENOG410XQVY LUCA
GeneTreeiENSGT00510000046611
HOGENOMiHOG000068028
HOVERGENiHBG107545
InParanoidiQ8CFW7
KOiK19352
OMAiKYVHRSQ
OrthoDBiEOG091G0IID
PhylomeDBiQ8CFW7
TreeFamiTF324786

Enzyme and pathway databases

ReactomeiR-MMU-5620912 Anchoring of the basal body to the plasma membrane

Miscellaneous databases

ChiTaRSiCc2d2a mouse
PROiPR:Q8CFW7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039765 Expressed in 227 organ(s), highest expression level in retina
CleanExiMM_CC2D2A
ExpressionAtlasiQ8CFW7 baseline and differential
GenevisibleiQ8CFW7 MM

Family and domain databases

InterProiView protein in InterPro
IPR000008 C2_dom
IPR028928 CC2D2AN-C2
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF15625 CC2D2AN-C2, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC2D2A_MOUSE
AccessioniPrimary (citable) accession number: Q8CFW7
Secondary accession number(s): Q8BP57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again