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Protein

Neuritin

Gene

Nrn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Neuritin
Alternative name(s):
Candidate plasticity gene 15 protein
Gene namesi
Name:Nrn1
Synonyms:Cpg15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1915654 Nrn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000026251428 – 116NeuritinAdd BLAST89
PropeptideiPRO_0000262515117 – 142Removed in mature formSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi116GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ8CFV4
PaxDbiQ8CFV4
PRIDEiQ8CFV4

PTM databases

iPTMnetiQ8CFV4
PhosphoSitePlusiQ8CFV4
SwissPalmiQ8CFV4

Expressioni

Tissue specificityi

Expressed in the brain (at protein level).1 Publication

Inductioni

By synaptic activity through NMDA receptors and L-type voltage-sensitive calcium channels. By cAMP in active neurons.1 Publication

Gene expression databases

BgeeiENSMUSG00000039114 Expressed in 199 organ(s), highest expression level in liver
CleanExiMM_NRN1
ExpressionAtlasiQ8CFV4 baseline and differential
GenevisibleiQ8CFV4 MM

Interactioni

Subunit structurei

Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8CFV4, 1 interactor
STRINGi10090.ENSMUSP00000040900

Structurei

3D structure databases

SMRiQ8CFV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neuritin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXWR Eukaryota
ENOG410YHS3 LUCA
GeneTreeiENSGT00530000063853
HOGENOMiHOG000059601
HOVERGENiHBG052772
InParanoidiQ8CFV4
PhylomeDBiQ8CFV4
TreeFamiTF332589

Family and domain databases

InterProiView protein in InterPro
IPR026144 Neuritin_fam
PANTHERiPTHR15902 PTHR15902, 1 hit
PfamiView protein in Pfam
PF15056 NRN1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8CFV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLKLNGRYI SLILAVQIAY LVQAVRAAGK CDAVFKGFSD CLLKLGDSMA
60 70 80 90 100
NYPQGLDDKT NIKTVCTYWE DFHSCTVTAL TDCQEGAKDM WDKLRKESKN
110 120 130 140
LNIQGSLFEL CGSSNGAAGS LLPALSVLLV SLSAALATWF SF
Length:142
Mass (Da):15,353
Last modified:March 1, 2003 - v1
Checksum:i6E5CCE2C9822C6E6
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z4E2D3Z4E2_MOUSE
Neuritin
Nrn1
158Annotation score:
A0A286YD56A0A286YD56_MOUSE
Neuritin
Nrn1
151Annotation score:
A0A286YDV9A0A286YDV9_MOUSE
Neuritin
Nrn1
94Annotation score:
A0A286YCW7A0A286YCW7_MOUSE
Neuritin
Nrn1
140Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK161859 mRNA Translation: BAE36610.1
BC035531 mRNA Translation: AAH35531.1
AY150584 Genomic DNA Translation: AAN84528.1
CCDSiCCDS26455.1
RefSeqiNP_705757.1, NM_153529.2
UniGeneiMm.232930

Genome annotation databases

EnsembliENSMUST00000037623; ENSMUSP00000040900; ENSMUSG00000039114
GeneIDi68404
KEGGimmu:68404
UCSCiuc007qcm.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK161859 mRNA Translation: BAE36610.1
BC035531 mRNA Translation: AAH35531.1
AY150584 Genomic DNA Translation: AAN84528.1
CCDSiCCDS26455.1
RefSeqiNP_705757.1, NM_153529.2
UniGeneiMm.232930

3D structure databases

SMRiQ8CFV4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CFV4, 1 interactor
STRINGi10090.ENSMUSP00000040900

PTM databases

iPTMnetiQ8CFV4
PhosphoSitePlusiQ8CFV4
SwissPalmiQ8CFV4

Proteomic databases

MaxQBiQ8CFV4
PaxDbiQ8CFV4
PRIDEiQ8CFV4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037623; ENSMUSP00000040900; ENSMUSG00000039114
GeneIDi68404
KEGGimmu:68404
UCSCiuc007qcm.3 mouse

Organism-specific databases

CTDi51299
MGIiMGI:1915654 Nrn1

Phylogenomic databases

eggNOGiENOG410IXWR Eukaryota
ENOG410YHS3 LUCA
GeneTreeiENSGT00530000063853
HOGENOMiHOG000059601
HOVERGENiHBG052772
InParanoidiQ8CFV4
PhylomeDBiQ8CFV4
TreeFamiTF332589

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

PROiPR:Q8CFV4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039114 Expressed in 199 organ(s), highest expression level in liver
CleanExiMM_NRN1
ExpressionAtlasiQ8CFV4 baseline and differential
GenevisibleiQ8CFV4 MM

Family and domain databases

InterProiView protein in InterPro
IPR026144 Neuritin_fam
PANTHERiPTHR15902 PTHR15902, 1 hit
PfamiView protein in Pfam
PF15056 NRN1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNRN1_MOUSE
AccessioniPrimary (citable) accession number: Q8CFV4
Secondary accession number(s): Q7TSR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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