Plagl2 protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: MGI

GO - Biological processⁱ

• chylomicron assembly Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons."
    Van Dyck F., Braem C.V., Chen Z., Declercq J., Deckers R., Kim B.M., Ito S., Wu M.K., Cohen D.E., Dewerchin M., Derua R., Waelkens E., Fiette L., Roebroek A., Schuit F., Van de Ven W.J., Shivdasani R.A.
    Cell Metab 6:406-413(2007) [PubMed] [Europe PMC] [Abstract]
• lipid metabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons."
    Van Dyck F., Braem C.V., Chen Z., Declercq J., Deckers R., Kim B.M., Ito S., Wu M.K., Cohen D.E., Dewerchin M., Derua R., Waelkens E., Fiette L., Roebroek A., Schuit F., Van de Ven W.J., Shivdasani R.A.
    Cell Metab 6:406-413(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of intrinsic apoptotic signaling pathway Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis."
    Mizutani A., Furukawa T., Adachi Y., Ikehara S., Taketani S.
    J Biol Chem 277:15851-15858(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis."
    Mizutani A., Furukawa T., Adachi Y., Ikehara S., Taketani S.
    J Biol Chem 277:15851-15858(2002) [PubMed] [Europe PMC] [Abstract]
• post-embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • "Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons."
    Van Dyck F., Braem C.V., Chen Z., Declercq J., Deckers R., Kim B.M., Ito S., Wu M.K., Cohen D.E., Dewerchin M., Derua R., Waelkens E., Fiette L., Roebroek A., Schuit F., Van de Ven W.J., Shivdasani R.A.
    Cell Metab 6:406-413(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription, DNA-templated Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MTTFFTSVPP WIQDAKQEEE VGWKLVPRPR GREAESQVKC QCEISGTPFS 
        60         70         80         90        100
NGEKLRPHSL PHPEQRPYSC PQLHCGKAFA SKYKLYRHMA THSAQKPHQC 
       110        120        130        140        150
MYCDKMFHRK DHLRNHLQTH DPNKEALHCS ECGKNYNTKL GYRRHLAMHA 
       160        170        180        190 
ASSGDLSCNL DFLQVHHDTF VLLNWRGEEM KGIPYQPFPQ SLTPPWTS   

Sequence databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Organism-specific databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ