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Entry version 139 (12 Aug 2020)
Sequence version 2 (05 Feb 2008)
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Protein

Histone-lysine N-methyltransferase SETD1B

Gene

Setd1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Methyltransferase, RNA-binding, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3214841, PKMTs methylate histone lysines
R-MMU-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETD1B (EC:2.1.1.354By similarity)
Alternative name(s):
SET domain-containing protein 1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Setd1b
Synonyms:Kiaa1076, Set1b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2652820, Setd1b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003169941 – 1985Histone-lysine N-methyltransferase SETD1BAdd BLAST1985

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei977PhosphoserineBy similarity1
Modified residuei985PhosphoserineBy similarity1
Modified residuei1022PhosphoserineBy similarity1
Modified residuei1283PhosphoserineCombined sources1
Modified residuei1301PhosphoserineCombined sources1
Modified residuei1354PhosphoserineBy similarity1
Modified residuei1678PhosphoserineCombined sources1
Modified residuei1682PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8CFT2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CFT2

PeptideAtlas

More...
PeptideAtlasi
Q8CFT2

PRoteomics IDEntifications database

More...
PRIDEi
Q8CFT2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CFT2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CFT2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038384, Expressed in mesenteric lymph node and 257 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CFT2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.

Interacts with HCFC1. and ASH2L/ASH2.

Interacts (via the RRM domain) with WDR82.

Interacts (via the RRM domain) with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) only in the presence of WDR82. Binds specifically to CTD heptad repeats phosphorylated on 'Ser-5' of each heptad.

Interacts with RBM15 (By similarity).

Interacts (via WIN motif) with WDR5 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
228940, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000133933

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8CFT2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CFT2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini92 – 180RRMPROSITE-ProRule annotationAdd BLAST89
Domaini1846 – 1963SETPROSITE-ProRule annotationAdd BLAST118
Domaini1969 – 1985Post-SETPROSITE-ProRule annotationAdd BLAST17

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1764 – 1769WDR5 interaction motif (WIN)By similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi373 – 1690Pro-richAdd BLAST1318
Compositional biasi1031 – 1179Ser-richAdd BLAST149
Compositional biasi1059 – 1331Glu-richAdd BLAST273

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1080, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154575

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001226_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8CFT2

KEGG Orthology (KO)

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KOi
K11422

Identification of Orthologs from Complete Genome Data

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OMAi
RIWTRLE

Database of Orthologous Groups

More...
OrthoDBi
1234689at2759

TreeFam database of animal gene trees

More...
TreeFami
TF106436

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12549, RRM_Set1B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024657, COMPASS_Set1_N-SET
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR003616, Post-SET_dom
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034468, Set1B_RRM
IPR001214, SET_dom
IPR037842, SETD1B

The PANTHER Classification System

More...
PANTHERi
PTHR45814:SF1, PTHR45814:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11764, N-SET, 1 hit
PF00076, RRM_1, 1 hit
PF00856, SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01291, N-SET, 1 hit
SM00508, PostSET, 1 hit
SM00360, RRM, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50868, POST_SET, 1 hit
PS50102, RRM, 1 hit
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CFT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENSHPHHHH QQPPPQPGPS GERRNHHWRS YKLMIDPALK KGHHKLYRYD
60 70 80 90 100
GQHFSLAMSS NRPVEIVEDP RVVGIWTKNK ELELSVPKFK IDEFYVGPVP
110 120 130 140 150
PKQVTFAKLN DNVRENFLRD MCKKYGEVEE VEILYNPKTK KHLGIAKVVF
160 170 180 190 200
ATVRGAKEAV QHLHSTSVMG NIIHVELDTK GETRMRFYEL LVTGRYTPQT
210 220 230 240 250
LPVGELDAIS PIVSETLQLS DALKRLKDGS LSAGCGSGSS SVTPNSGGTP
260 270 280 290 300
FSQDTAYSSC RLDTPNSYGQ GTPITPRLGT PFSQDSSYSS RQPTPSYLFS
310 320 330 340 350
QDPTATFKAR RHESKFTDAY NRRHEHHYVH NSAVAGATAP FRGSSDLSFG
360 370 380 390 400
TVGSSGTPFK AQSQDATTFA HTPPPAQTAT ASGFKSAFSP YQTPAPPFPP
410 420 430 440 450
PPEEPTATAA FGSRDSGEFR RAPAPPPLPP AEPPAKEKPG TPPGPPPPDS
460 470 480 490 500
NSMELGGRPT FGWSPEPCDS PGTPTLESSP AGPEKPHDSL DSRIEMLLKE
510 520 530 540 550
QRTKLPFLRE QDSDTEIQME GSPISSSSSQ LSPLSHFGTN SQPGFRGPSP
560 570 580 590 600
PSSRPSSTGL EDISPTPLPD SDEDEDLGLG LGPRPPPEPG PPDPMGLLGQ
610 620 630 640 650
TAEVDLDLAG DRTPTSERMD EGQQSSGEDM EISDDEMPSA PITSADCPKP
660 670 680 690 700
MVVTPGAGAV AAPNVLAPNL PLPPPPGFPP LPPPPPPPPP QPGFPMPPPL
710 720 730 740 750
PPPPPPPPPA HPAVTVPPPP LPAPPGVPPP PILPPLPPFP PGLFPVMQVD
760 770 780 790 800
MSHVLGGQWG GMPMSFQMQT QMLSRLMTGQ GACPYPPFMA AAAAAASAGL
810 820 830 840 850
QFVNLPPYRS PFSLSNSGPG RGQHWPPLPK FDPSVPPPGY IPRQEDPHKA
860 870 880 890 900
TVDGVLLVVL KELKAIMKRD LNRKMVEVVA FRAFDEWWDK KERMAKASLT
910 920 930 940 950
PVKSGEHKDE DRPKPKDRIA SCLLESWGKG EGLGYEGLGL GIGLRGAIRL
960 970 980 990 1000
PSFKVKRKEP PDTASSGDQK RLRPSTSVDE EDEESERERD RDIADAPCEL
1010 1020 1030 1040 1050
TKRDPKSVGV RRRPGRPLEL DSGGEEDEKE SLSASSSSSA SSSSGSSTTS
1060 1070 1080 1090 1100
PSSSASDKEE EDRESTEEEE EEEEEEAEEE EEEGPRSRIS SPSSSSSSDK
1110 1120 1130 1140 1150
DDEDDNEADS DGQIDSDIDD QGAPLSEASE KDNGDSEEEE TESITTSKAP
1160 1170 1180 1190 1200
AESSSSSSES SGSSEFESSS ESESSSSSSE DEEEMTVPGV EEEEEEEEEE
1210 1220 1230 1240 1250
EKETAMAAAT VVAMAEESMP PAGGQDFEQD RAEVPLGPRG PMRESLGTEE
1260 1270 1280 1290 1300
EVDIEAEDEV PEMQAPELEE PPLPMGARKL EGSPEPPEEP GPNTQGDMLL
1310 1320 1330 1340 1350
SPELPARETE EAQLPSPPEH GPESDLDMEP EPPPMLSLPL QPPLPPPRLL
1360 1370 1380 1390 1400
RPPSPPPEPE TPEPPKPPVP LEPPPEDHPP RTPGLCGSLA KSQSTETVPA
1410 1420 1430 1440 1450
TPGGEPPLSG SSSGLSLSSP QVPGSPFSYP SPSPGLSSGG LPRTPGRDFS
1460 1470 1480 1490 1500
FTPTFPEPSG PLLLPVCPLP TGRRDERTGP LASPVLLETG LPLPLPLPLP
1510 1520 1530 1540 1550
LPLALPVPVL RAQPRPPPQL PPLLPATLAP CPTPIKRKPG RPRRSPPSML
1560 1570 1580 1590 1600
SLDGPLVRPP PGPALGRDLL LLPGQPPAPI FPSAHDPRAV TLDFRNTGIP
1610 1620 1630 1640 1650
APPPPLPPQP PPPPPPPPVE STKLPFKELD NQWPSEAIPP GPRRDEVTEE
1660 1670 1680 1690 1700
YVDLAKVRGP WRRPPKKRHE DLVAPSASPE PSPPQPLFRP RSEFEEMTIL
1710 1720 1730 1740 1750
YDIWNGGIDE EDIRFLCVTY ERLLQQDNGM DWLNDTLWVY HPSTSLSSAK
1760 1770 1780 1790 1800
KKKREDGIRE HVTGCARSEG FYTIDKKDKL RYLNSSRAST DEPPMDTQGM
1810 1820 1830 1840 1850
SIPAQPHAST RAGSERRSEQ RRLLSSFTGS CDSDLLKFNQ LKFRKKKLKF
1860 1870 1880 1890 1900
CKSHIHDWGL FAMEPIAADE MVIEYVGQNI RQVIADMREK RYEDEGIGSS
1910 1920 1930 1940 1950
YMFRVDHDTI IDATKCGNFA RFINHSCNPN CYAKVITVES QKKIVIYSKQ
1960 1970 1980
HINVNEEITY DYKFPIEDVK IPCLCGSENC RGTLN
Length:1,985
Mass (Da):215,352
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i760EA261769292EC
GO
Isoform 2 (identifier: Q8CFT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1139-1179: Missing.

Show »
Length:1,944
Mass (Da):211,286
Checksum:iE2BD1B70C876448C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZ56G3UZ56_MOUSE
Histone-lysine N-methyltransferase ...
Setd1b
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1222A → V in BAC65717 (PubMed:12693553).Curated1
Sequence conflicti1411S → G in BAC65717 (PubMed:12693553).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0308511139 – 1179Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC158114 Genomic DNA No translation available.
BC038367 mRNA Translation: AAH38367.2
BC040775 mRNA Translation: AAH40775.1
BC041681 mRNA Translation: AAH41681.1
AK122435 mRNA Translation: BAC65717.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59684.1 [Q8CFT2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001035488.2, NM_001040398.2 [Q8CFT2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000056053; ENSMUSP00000134686; ENSMUSG00000038384 [Q8CFT2-1]
ENSMUST00000163030; ENSMUSP00000133933; ENSMUSG00000038384 [Q8CFT2-1]
ENSMUST00000174836; ENSMUSP00000134461; ENSMUSG00000038384 [Q8CFT2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
208043

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:208043

UCSC genome browser

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UCSCi
uc008zng.2, mouse [Q8CFT2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158114 Genomic DNA No translation available.
BC038367 mRNA Translation: AAH38367.2
BC040775 mRNA Translation: AAH40775.1
BC041681 mRNA Translation: AAH41681.1
AK122435 mRNA Translation: BAC65717.1
CCDSiCCDS59684.1 [Q8CFT2-1]
RefSeqiNP_001035488.2, NM_001040398.2 [Q8CFT2-1]

3D structure databases

SMRiQ8CFT2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi228940, 2 interactors
STRINGi10090.ENSMUSP00000133933

PTM databases

iPTMnetiQ8CFT2
PhosphoSitePlusiQ8CFT2

Proteomic databases

jPOSTiQ8CFT2
PaxDbiQ8CFT2
PeptideAtlasiQ8CFT2
PRIDEiQ8CFT2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
9774, 109 antibodies

Genome annotation databases

EnsembliENSMUST00000056053; ENSMUSP00000134686; ENSMUSG00000038384 [Q8CFT2-1]
ENSMUST00000163030; ENSMUSP00000133933; ENSMUSG00000038384 [Q8CFT2-1]
ENSMUST00000174836; ENSMUSP00000134461; ENSMUSG00000038384 [Q8CFT2-2]
GeneIDi208043
KEGGimmu:208043
UCSCiuc008zng.2, mouse [Q8CFT2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23067
MGIiMGI:2652820, Setd1b

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG1080, Eukaryota
GeneTreeiENSGT00940000154575
HOGENOMiCLU_001226_0_0_1
InParanoidiQ8CFT2
KOiK11422
OMAiRIWTRLE
OrthoDBi1234689at2759
TreeFamiTF106436

Enzyme and pathway databases

ReactomeiR-MMU-3214841, PKMTs methylate histone lysines
R-MMU-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
208043, 4 hits in 20 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Setd1b, mouse

Protein Ontology

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PROi
PR:Q8CFT2
RNActiQ8CFT2, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038384, Expressed in mesenteric lymph node and 257 other tissues
GenevisibleiQ8CFT2, MM

Family and domain databases

CDDicd12549, RRM_Set1B, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR024657, COMPASS_Set1_N-SET
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR003616, Post-SET_dom
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034468, Set1B_RRM
IPR001214, SET_dom
IPR037842, SETD1B
PANTHERiPTHR45814:SF1, PTHR45814:SF1, 1 hit
PfamiView protein in Pfam
PF11764, N-SET, 1 hit
PF00076, RRM_1, 1 hit
PF00856, SET, 1 hit
SMARTiView protein in SMART
SM01291, N-SET, 1 hit
SM00508, PostSET, 1 hit
SM00360, RRM, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50868, POST_SET, 1 hit
PS50102, RRM, 1 hit
PS50280, SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSET1B_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CFT2
Secondary accession number(s): Q80TK9, Q8CFQ8, Q8CGD1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: August 12, 2020
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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