Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Potassium voltage-gated channel subfamily V member 2

Gene

Kcnv2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily V member 2
Alternative name(s):
Voltage-gated potassium channel subunit Kv8.2
Gene namesi
Name:Kcnv2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2670981 Kcnv2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 163CytoplasmicSequence analysisAdd BLAST163
Transmembranei164 – 184Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini185 – 269ExtracellularSequence analysisAdd BLAST85
Transmembranei270 – 290Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini291 – 344CytoplasmicSequence analysisAdd BLAST54
Transmembranei345 – 365Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini366 – 391ExtracellularSequence analysisAdd BLAST26
Transmembranei392 – 412Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini413 – 427CytoplasmicSequence analysisAdd BLAST15
Transmembranei428 – 448Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini449 – 461ExtracellularSequence analysisAdd BLAST13
Intramembranei462 – 482Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Topological domaini483 – 488ExtracellularSequence analysis6
Transmembranei489 – 509Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini510 – 562CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003201441 – 562Potassium voltage-gated channel subfamily V member 2Add BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8CFS6
PRIDEiQ8CFS6

PTM databases

iPTMnetiQ8CFS6
PhosphoSitePlusiQ8CFS6

Expressioni

Gene expression databases

BgeeiENSMUSG00000047298
CleanExiMM_KCNV2
GenevisibleiQ8CFS6 MM

Interactioni

Subunit structurei

Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055091

Structurei

3D structure databases

ProteinModelPortaliQ8CFS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi474 – 479Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118981
HOGENOMiHOG000231016
HOVERGENiHBG095321
InParanoidiQ8CFS6
KOiK04935
OMAiSIPHAWW
OrthoDBiEOG091G0FP3
PhylomeDBiQ8CFS6
TreeFamiTF313103

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003971 K_chnl_volt-dep_Kv9
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01494 KV9CHANNEL
PR01491 KVCHANNEL
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CFS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKQSNERRW SLSYKPWSTP ETEDVPNTGS NQHRRSICSL GARTGSQASI
60 70 80 90 100
APQWTEGNYN YYIEEDEDCG EEGEDWKDDL AEENQKAECL TSLLDGHNDT
110 120 130 140 150
PAQMSTLKVN VGGHSYLLEC CELANYPKTR LGRLATSTTR RGQLGLCDDY
160 170 180 190 200
EAQTDEYFFD RDPAVFQLIY NFYTSGVLLV RDELCPRSFL EELGYWGVRL
210 220 230 240 250
KYTPRCCRIC FEERRDELSE QLKIQRELRA QAQAEEAEEL FRDMRFYGPQ
260 270 280 290 300
RQRLWNLMEK PFSSVAAKAM GVATNLFVLI SVVALALNTV EEMQHQAEQG
310 320 330 340 350
TGGGDPRPIL EHVEMLCVAF FTLEFLLRLA STPNLQRFAR SALNLVDLVA
360 370 380 390 400
ILPFYLQLLL ECFTSEDQRH NKDSPREHDL ETVGRVGKVG QVLRIMRLMR
410 420 430 440 450
IFRILKLARH STGLRAFGFT LRQCYQQVGC LMLFITMGIF SFSAAVYSVE
460 470 480 490 500
HDVPGTNFTS ILHAWWWAAV SISTVGYGDM YPETHLGRLF AFLCIAFGII
510 520 530 540 550
LNGMPISILY NKFSDYYSKL KAYEYTAIRR ERGKVNFMQR ATKKMAECLS
560
ESHAQSTTRQ EN
Length:562
Mass (Da):64,461
Last modified:March 1, 2003 - v1
Checksum:i4D06B01C93BF8C61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY238939 mRNA Translation: AAP70480.1
BC039042 mRNA Translation: AAH39042.1
CCDSiCCDS29722.1
RefSeqiNP_899002.1, NM_183179.1
UniGeneiMm.269759

Genome annotation databases

EnsembliENSMUST00000056708; ENSMUSP00000055091; ENSMUSG00000047298
GeneIDi240595
KEGGimmu:240595
UCSCiuc008hbw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKCNV2_MOUSE
AccessioniPrimary (citable) accession number: Q8CFS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health