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Protein

Myocyte-specific enhancer factor 2C

Gene

Mef2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1, isoform 2 and isoform 5 (By similarity). Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells.By similarity7 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi58 – 86Mef2-typeSequence analysisAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processApoptosis, Differentiation, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-375170 CDO in myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Myocyte-specific enhancer factor 2CCurated
Alternative name(s):
Myocyte enhancer factor 2CImported
Gene namesi
Name:Mef2cImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:99458 Mef2c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice show impairment in hippocampal-dependent learning and also increase in the number of excitatory synapses and potentiation of basal and evoked synaptic transmission. Mice surviving to adulthood manifest smaller, apparently less mature neurons and smaller whole brain size, with resultant aberrant electrophysiology and behavior. Mice exhibit thrombocytopenia and a defect in B-lymphopoiesis.3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi3R → T: Increased mobility in differentiating cells. Greatly reduced DNA binding. 1 Publication1
Mutagenesisi4K → Q: 7-fold increase in DNA binding. 1 Publication1
Mutagenesisi4K → R: Reduced acetylation by 30%. Some loss of DNA binding and transactivation activity. 1 Publication1
Mutagenesisi59 – 60ST → CR: Reduced DNA binding activity. 2
Mutagenesisi59 – 60ST → DD: Enhanced DNA binding activity. 2
Mutagenesisi59S → A: Reduced DNA binding activity. 1 Publication1
Mutagenesisi59S → D: Enhanced DNA binding activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001994341 – 474Myocyte-specific enhancer factor 2CAdd BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4N6-acetyllysine1 Publication1
Modified residuei59Phosphoserine; by CK21 Publication1
Modified residuei98PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei116N6-acetyllysineBy similarity1
Modified residuei119N6-acetyllysineBy similarity1
Modified residuei222PhosphoserineCombined sources1
Modified residuei228PhosphoserineBy similarity1
Modified residuei234N6-acetyllysineBy similarity1
Modified residuei239N6-acetyllysineBy similarity1
Modified residuei240PhosphoserineCombined sources1
Modified residuei252N6-acetyllysineBy similarity1
Modified residuei264N6-acetyllysineBy similarity1
Modified residuei293Phosphothreonine; by MAPK14By similarity1
Modified residuei300Phosphothreonine; by MAPK14By similarity1
Cross-linki391Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei396Phosphoserine; by CDK5By similarity1
Modified residuei420Phosphoserine; by MAPK7By similarity1
Modified residuei446PhosphoserineBy similarity1
Isoform 4 (identifier: Q8CFN5-4)
Modified residuei108PhosphothreonineCombined sources1
Isoform 5 (identifier: Q8CFN5-5)
Modified residuei108PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylation on Ser-59 enhances DNA binding activity (By similarity). Phosphorylation on Ser-396 is required for Lys-391 sumoylation and inhibits transcriptional activity.By similarity1 Publication
Acetylated by p300 on several sites in diffentiating myocytes (By similarity). Acetylation on Lys-4 increases DNA binding and transactivation.By similarity1 Publication
Sumoylated on Lys-391 with SUMO2 but not by SUMO1 represses transcriptional activity.By similarity
Proteolytically cleaved in cerebellar granule neurons, probably by caspase 7, following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei433 – 434CleavageCurated2

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8CFN5
PeptideAtlasiQ8CFN5
PRIDEiQ8CFN5

PTM databases

iPTMnetiQ8CFN5
PhosphoSitePlusiQ8CFN5

Expressioni

Tissue specificityi

Widely expressed though mainly restricted to skeletal and cardiac muscle, brain, neurons and lymphocytes. Beta beta domain-lacking isoforms are the most predominantly expressed in all tissues including skeletal and cardiac muscle and brain. Only brain expresses all isoforms. Expression occurs primarily in the internal granule cell layer of the olfactory bulb, cortex, thalamus, hippocampus and cerebellum. Low levels in the cerebellum and hindbrain. Expressed throughout the cortex, including the frontal and entorhinal cortex, dentate gyrus, and basolateral amygdala. Selectively expressed in B-cells but not in T-cells, and its expression increases as B-cells mature.6 Publications

Developmental stagei

Expressed in developing endothelial cells and smooth muscle cells, as well as in surrounding mesenchyme, during embryogenesis. Up-regulated during myogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000005583 Expressed in 351 organ(s), highest expression level in cerebral cortex
CleanExiMM_MEF2C
ExpressionAtlasiQ8CFN5 baseline and differential
GenevisibleiQ8CFN5 MM

Interactioni

Subunit structurei

Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with EP300 in differentiating cells; the interaction acetylates MEF2C leading to increased DNA binding and activation (By similarity). Interacts with HDAC7 and CARM1 (PubMed:11279209, PubMed:11713257). Interacts with HDAC4, HDAC7 AND HDAC9; the interaction with HDACs represses transcriptional activity (By similarity). Interacts with LPIN1 (PubMed:19753306). Interacts with MYOCD (PubMed:16818234). Interacts with AKAP13 (PubMed:20139090). Interacts with FOXK1; the interaction inhibits MEF2C transactivation activity (PubMed:22956541). Interacts (via N-terminus) with HABP4; this interaction decreases DNA-binding activity of MEF2C in myocardial cells in response to mechanical stress (By similarity).By similarity6 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201383, 12 interactors
DIPiDIP-49524N
ELMiQ8CFN5
IntActiQ8CFN5, 8 interactors
MINTiQ8CFN5
STRINGi10090.ENSMUSP00000132547

Structurei

Secondary structure

1474
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8CFN5
SMRiQ8CFN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 57MADS-boxPROSITE-ProRule annotationAdd BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni271 – 278Beta domainBy similarity8
Regioni368 – 399Transcription repressorBy similarityAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 31Lys-rich (basic)Add BLAST28
Compositional biasi146 – 183Ser-richAdd BLAST38

Domaini

The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity.By similarity

Sequence similaritiesi

Belongs to the MEF2 family.Curated

Phylogenomic databases

eggNOGiKOG0014 Eukaryota
COG5068 LUCA
GeneTreeiENSGT00390000011828
HOGENOMiHOG000230620
HOVERGENiHBG053944
InParanoidiQ8CFN5
KOiK04454
OMAiHLVMPNS
PhylomeDBiQ8CFN5
TreeFamiTF314067

Family and domain databases

CDDicd00265 MADS_MEF2_like, 1 hit
Gene3Di3.40.1810.10, 1 hit
InterProiView protein in InterPro
IPR022102 HJURP_C
IPR033896 MADS_MEF2-like
IPR002100 TF_MADSbox
IPR036879 TF_MADSbox_sf
PfamiView protein in Pfam
PF12347 HJURP_C, 1 hit
PF00319 SRF-TF, 1 hit
PRINTSiPR00404 MADSDOMAIN
SMARTiView protein in SMART
SM00432 MADS, 1 hit
SUPFAMiSSF55455 SSF55455, 1 hit
PROSITEiView protein in PROSITE
PS00350 MADS_BOX_1, 1 hit
PS50066 MADS_BOX_2, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 21 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CFN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS
60 70 80 90 100
TNKLFQYAST DMDKVLLKYT EYNEPHESRT NSDIVETLRK KGLNGCDSPD
110 120 130 140 150
PDADDSVGHS PESEDKYRKI NEDIDLMISR QRLCAVPPPS FEMPVTIPVS
160 170 180 190 200
SHNSLVYSNP VSTLGNPNLL PLAHPSLQRN SMSPGVTHRP PSAGNTGGLM
210 220 230 240 250
GGDLTSGAGT SAGNGYGNPR NSPGLLVSPG NLNKNIQAKS PPPMNLGMNN
260 270 280 290 300
RKPDLRVLIP PGSKNTMPSV SEDVDLLLNQ RINNSQSAQS LATPVVSVAT
310 320 330 340 350
PTLPGQGMGG YPSAISTTYG TEYSLSSADL SSLSGFNTAS ALHLGSVTGW
360 370 380 390 400
QQQHLHNMPP SALSQLGACT STHLSQSSNL SLPSTQSLSI KSEPVSPPRD
410 420 430 440 450
RTTTPSRYPQ HTTRHEAGRS PVDSLSSCSS SYDGSDREDH RNEFHSPIGL
460 470
TRPSPDERES PSVKRMRLSE GWAT
Note: No experimental confirmation available.
Length:474
Mass (Da):51,278
Last modified:January 4, 2005 - v2
Checksum:iCEFC2DB21E89632A
GO
Isoform 2 (identifier: Q8CFN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-278: Missing.

Show »
Length:466
Mass (Da):50,393
Checksum:iF06A89C9ACD779AE
GO
Isoform 3 (identifier: Q8CFN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-399: Missing.

Show »
Length:442
Mass (Da):47,956
Checksum:i40EFBF02BF3E775C
GO
Isoform 4 (identifier: Q8CFN5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-97: TLRKKGLNGCD → ALNKKENKGSE
     103-118: ADDSVGHSPESEDKYR → SSYALTPRTEEKYK
     123-134: DIDLMISRQRLC → EFDNMIKSHKIP
     271-278: Missing.
     368-399: Missing.

Show »
Length:432
Mass (Da):46,961
Checksum:iDCB2EBCE61A35215
GO
Isoform 5 (identifier: Q8CFN5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-97: TLRKKGLNGCD → ALNKKENKGSE
     103-118: ADDSVGHSPESEDKYR → SSYALTPRTEEKYK
     123-134: DIDLMISRQRLC → EFDNMIKSHKIP

Show »
Length:472
Mass (Da):51,168
Checksum:i1B618AB137809260
GO

Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0H2UH28A0A0H2UH28_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
484Annotation score:
A0A0H2UKB6A0A0H2UKB6_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
464Annotation score:
A0A0G2JEC2A0A0G2JEC2_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
434Annotation score:
A0A0G2JET3A0A0G2JET3_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
129Annotation score:
A0A0G2JFX2A0A0G2JFX2_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
169Annotation score:
A0A0G2JDK0A0A0G2JDK0_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
126Annotation score:
A0A0G2JGK3A0A0G2JGK3_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
161Annotation score:
A0A0G2JGL3A0A0G2JGL3_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
194Annotation score:
A0A0G2JFI7A0A0G2JFI7_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
242Annotation score:
A0A0G2JE18A0A0G2JE18_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
394Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141F → L in AAH37731 (PubMed:15489334).Curated1
Sequence conflicti211S → P (PubMed:8506376).Curated1
Sequence conflicti428C → S (PubMed:8506376).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01250187 – 97TLRKKGLNGCD → ALNKKENKGSE in isoform 4 and isoform 5. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_012502103 – 118ADDSV…EDKYR → SSYALTPRTEEKYK in isoform 4 and isoform 5. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_012503123 – 134DIDLM…RQRLC → EFDNMIKSHKIP in isoform 4 and isoform 5. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_012504271 – 278Missing in isoform 2 and isoform 4. 2 Publications8
Alternative sequenceiVSP_012505368 – 399Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009139 mRNA Translation: BAB26099.1
BC026841 mRNA Translation: AAH26841.1
BC037731 mRNA Translation: AAH37731.1
BC057650 mRNA Translation: AAH57650.1
CCDSiCCDS26664.1 [Q8CFN5-4]
CCDS49320.1 [Q8CFN5-2]
CCDS84042.1 [Q8CFN5-1]
CCDS84043.1 [Q8CFN5-3]
CCDS84045.1 [Q8CFN5-5]
RefSeqiNP_001334493.1, NM_001347564.1 [Q8CFN5-1]
NP_001334495.1, NM_001347566.1 [Q8CFN5-1]
NP_001334496.1, NM_001347567.1 [Q8CFN5-1]
NP_001334497.1, NM_001347568.1 [Q8CFN5-5]
NP_001334498.1, NM_001347569.1 [Q8CFN5-5]
NP_001334500.1, NM_001347571.1 [Q8CFN5-3]
NP_001334501.1, NM_001347572.1 [Q8CFN5-3]
NP_001334502.1, NM_001347573.1 [Q8CFN5-3]
NP_001334503.1, NM_001347574.1 [Q8CFN5-3]
NP_001334504.1, NM_001347575.1 [Q8CFN5-3]
NP_001334505.1, NM_001347576.1 [Q8CFN5-3]
NP_001334506.1, NM_001347577.1 [Q8CFN5-3]
NP_079558.1, NM_025282.3 [Q8CFN5-4]
XP_006517186.1, XM_006517123.2 [Q8CFN5-1]
XP_006517187.1, XM_006517124.3 [Q8CFN5-1]
XP_006517189.1, XM_006517126.2 [Q8CFN5-5]
XP_006517195.1, XM_006517132.3 [Q8CFN5-4]
XP_011242794.1, XM_011244492.2 [Q8CFN5-1]
XP_017170894.1, XM_017315405.1 [Q8CFN5-1]
UniGeneiMm.24001
Mm.451574
Mm.487610

Genome annotation databases

EnsembliENSMUST00000185052; ENSMUSP00000138826; ENSMUSG00000005583 [Q8CFN5-5]
ENSMUST00000197146; ENSMUSP00000143227; ENSMUSG00000005583 [Q8CFN5-3]
ENSMUST00000197681; ENSMUSP00000143420; ENSMUSG00000005583 [Q8CFN5-3]
ENSMUST00000198199; ENSMUSP00000143742; ENSMUSG00000005583 [Q8CFN5-4]
ENSMUST00000199019; ENSMUSP00000143401; ENSMUSG00000005583 [Q8CFN5-1]
ENSMUST00000199105; ENSMUSP00000143212; ENSMUSG00000005583 [Q8CFN5-1]
ENSMUST00000199450; ENSMUSP00000143315; ENSMUSG00000005583 [Q8CFN5-2]
GeneIDi17260
KEGGimmu:17260
UCSCiuc007rie.2 mouse [Q8CFN5-4]
uc007rih.2 mouse [Q8CFN5-5]
uc007rii.3 mouse [Q8CFN5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009139 mRNA Translation: BAB26099.1
BC026841 mRNA Translation: AAH26841.1
BC037731 mRNA Translation: AAH37731.1
BC057650 mRNA Translation: AAH57650.1
CCDSiCCDS26664.1 [Q8CFN5-4]
CCDS49320.1 [Q8CFN5-2]
CCDS84042.1 [Q8CFN5-1]
CCDS84043.1 [Q8CFN5-3]
CCDS84045.1 [Q8CFN5-5]
RefSeqiNP_001334493.1, NM_001347564.1 [Q8CFN5-1]
NP_001334495.1, NM_001347566.1 [Q8CFN5-1]
NP_001334496.1, NM_001347567.1 [Q8CFN5-1]
NP_001334497.1, NM_001347568.1 [Q8CFN5-5]
NP_001334498.1, NM_001347569.1 [Q8CFN5-5]
NP_001334500.1, NM_001347571.1 [Q8CFN5-3]
NP_001334501.1, NM_001347572.1 [Q8CFN5-3]
NP_001334502.1, NM_001347573.1 [Q8CFN5-3]
NP_001334503.1, NM_001347574.1 [Q8CFN5-3]
NP_001334504.1, NM_001347575.1 [Q8CFN5-3]
NP_001334505.1, NM_001347576.1 [Q8CFN5-3]
NP_001334506.1, NM_001347577.1 [Q8CFN5-3]
NP_079558.1, NM_025282.3 [Q8CFN5-4]
XP_006517186.1, XM_006517123.2 [Q8CFN5-1]
XP_006517187.1, XM_006517124.3 [Q8CFN5-1]
XP_006517189.1, XM_006517126.2 [Q8CFN5-5]
XP_006517195.1, XM_006517132.3 [Q8CFN5-4]
XP_011242794.1, XM_011244492.2 [Q8CFN5-1]
XP_017170894.1, XM_017315405.1 [Q8CFN5-1]
UniGeneiMm.24001
Mm.451574
Mm.487610

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5F28X-ray2.90A/B/C/D1-95[»]
ProteinModelPortaliQ8CFN5
SMRiQ8CFN5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201383, 12 interactors
DIPiDIP-49524N
ELMiQ8CFN5
IntActiQ8CFN5, 8 interactors
MINTiQ8CFN5
STRINGi10090.ENSMUSP00000132547

PTM databases

iPTMnetiQ8CFN5
PhosphoSitePlusiQ8CFN5

Proteomic databases

PaxDbiQ8CFN5
PeptideAtlasiQ8CFN5
PRIDEiQ8CFN5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000185052; ENSMUSP00000138826; ENSMUSG00000005583 [Q8CFN5-5]
ENSMUST00000197146; ENSMUSP00000143227; ENSMUSG00000005583 [Q8CFN5-3]
ENSMUST00000197681; ENSMUSP00000143420; ENSMUSG00000005583 [Q8CFN5-3]
ENSMUST00000198199; ENSMUSP00000143742; ENSMUSG00000005583 [Q8CFN5-4]
ENSMUST00000199019; ENSMUSP00000143401; ENSMUSG00000005583 [Q8CFN5-1]
ENSMUST00000199105; ENSMUSP00000143212; ENSMUSG00000005583 [Q8CFN5-1]
ENSMUST00000199450; ENSMUSP00000143315; ENSMUSG00000005583 [Q8CFN5-2]
GeneIDi17260
KEGGimmu:17260
UCSCiuc007rie.2 mouse [Q8CFN5-4]
uc007rih.2 mouse [Q8CFN5-5]
uc007rii.3 mouse [Q8CFN5-3]

Organism-specific databases

CTDi4208
MGIiMGI:99458 Mef2c

Phylogenomic databases

eggNOGiKOG0014 Eukaryota
COG5068 LUCA
GeneTreeiENSGT00390000011828
HOGENOMiHOG000230620
HOVERGENiHBG053944
InParanoidiQ8CFN5
KOiK04454
OMAiHLVMPNS
PhylomeDBiQ8CFN5
TreeFamiTF314067

Enzyme and pathway databases

ReactomeiR-MMU-375170 CDO in myogenesis

Miscellaneous databases

PROiPR:Q8CFN5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005583 Expressed in 351 organ(s), highest expression level in cerebral cortex
CleanExiMM_MEF2C
ExpressionAtlasiQ8CFN5 baseline and differential
GenevisibleiQ8CFN5 MM

Family and domain databases

CDDicd00265 MADS_MEF2_like, 1 hit
Gene3Di3.40.1810.10, 1 hit
InterProiView protein in InterPro
IPR022102 HJURP_C
IPR033896 MADS_MEF2-like
IPR002100 TF_MADSbox
IPR036879 TF_MADSbox_sf
PfamiView protein in Pfam
PF12347 HJURP_C, 1 hit
PF00319 SRF-TF, 1 hit
PRINTSiPR00404 MADSDOMAIN
SMARTiView protein in SMART
SM00432 MADS, 1 hit
SUPFAMiSSF55455 SSF55455, 1 hit
PROSITEiView protein in PROSITE
PS00350 MADS_BOX_1, 1 hit
PS50066 MADS_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMEF2C_MOUSE
AccessioniPrimary (citable) accession number: Q8CFN5
Secondary accession number(s): Q8R0H1, Q9D7L0, Q9QW20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: November 7, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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