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Entry version 166 (22 Apr 2020)
Sequence version 2 (04 Jan 2005)
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Protein

Myocyte-specific enhancer factor 2C

Gene

Mef2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18 (PubMed:11554755). May also be involved in neurogenesis and in the development of cortical architecture. Isoforms that lack the repressor domain are more active than isoform 1 (By similarity). Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells.By similarity8 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi58 – 86Mef2-typeSequence analysisAdd BLAST29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processApoptosis, Differentiation, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-525793 Myogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myocyte-specific enhancer factor 2CCurated
Alternative name(s):
Myocyte enhancer factor 2CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mef2cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:99458 Mef2c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show impairment in hippocampal-dependent learning and also increase in the number of excitatory synapses and potentiation of basal and evoked synaptic transmission. Mice surviving to adulthood manifest smaller, apparently less mature neurons and smaller whole brain size, with resultant aberrant electrophysiology and behavior. Mice exhibit thrombocytopenia and a defect in B-lymphopoiesis.3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi3R → T: Increased mobility in differentiating cells. Greatly reduced DNA binding. 1 Publication1
Mutagenesisi4K → Q: 7-fold increase in DNA binding. 1 Publication1
Mutagenesisi4K → R: Reduced acetylation by 30%. Some loss of DNA binding and transactivation activity. 1 Publication1
Mutagenesisi59 – 60ST → CR: Reduced DNA binding activity. 2
Mutagenesisi59 – 60ST → DD: Enhanced DNA binding activity. 2
Mutagenesisi59S → A: Reduced DNA binding activity. 1 Publication1
Mutagenesisi59S → D: Enhanced DNA binding activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001994341 – 474Myocyte-specific enhancer factor 2CAdd BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4N6-acetyllysine1 Publication1
Modified residuei59Phosphoserine; by CK21 Publication1
Modified residuei98PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei116N6-acetyllysineBy similarity1
Modified residuei119N6-acetyllysineBy similarity1
Modified residuei222PhosphoserineCombined sources1
Modified residuei228PhosphoserineBy similarity1
Modified residuei234N6-acetyllysineBy similarity1
Modified residuei239N6-acetyllysineBy similarity1
Modified residuei240PhosphoserineCombined sources1
Modified residuei252N6-acetyllysineBy similarity1
Modified residuei264N6-acetyllysineBy similarity1
Modified residuei293Phosphothreonine; by MAPK14By similarity1
Modified residuei300Phosphothreonine; by MAPK14By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki391Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei396Phosphoserine; by CDK5By similarity1
Modified residuei420Phosphoserine; by MAPK7By similarity1
Modified residuei446PhosphoserineBy similarity1
Isoform 4 (identifier: Q8CFN5-4)
Modified residuei108PhosphothreonineCombined sources1
Isoform 5 (identifier: Q8CFN5-5)
Modified residuei108PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation on Ser-59 enhances DNA binding activity (By similarity). Phosphorylation on Ser-396 is required for Lys-391 sumoylation and inhibits transcriptional activity.By similarity1 Publication
Acetylated by p300 on several sites in diffentiating myocytes (By similarity). Acetylation on Lys-4 increases DNA binding and transactivation.By similarity1 Publication
Sumoylated on Lys-391 with SUMO2 but not by SUMO1 represses transcriptional activity.By similarity
Proteolytically cleaved in cerebellar granule neurons, probably by caspase 7, following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei433 – 434CleavageCurated2

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CFN5

PeptideAtlas

More...
PeptideAtlasi
Q8CFN5

PRoteomics IDEntifications database

More...
PRIDEi
Q8CFN5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CFN5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CFN5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed though mainly restricted to skeletal and cardiac muscle, brain, neurons and lymphocytes. Beta domain-lacking isoforms are the most predominantly expressed in all tissues including skeletal and cardiac muscle and brain. Only brain expresses all isoforms. Expression occurs primarily in the internal granule cell layer of the olfactory bulb, cortex, thalamus, hippocampus and cerebellum. Low levels in the cerebellum and hindbrain. Expressed throughout the cortex, including the frontal and entorhinal cortex, dentate gyrus, and basolateral amygdala. Selectively expressed in B-cells but not in T-cells, and its expression increases as B-cells mature.6 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in developing endothelial cells and smooth muscle cells, as well as in surrounding mesenchyme, during embryogenesis. Up-regulated during myogenesis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000005583 Expressed in cerebral cortex and 350 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CFN5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8CFN5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation.

Interacts with EP300 in differentiating cells; the interaction acetylates MEF2C leading to increased DNA binding and activation (By similarity).

Interacts with HDAC7 and CARM1 (PubMed:11279209, PubMed:11713257).

Interacts with HDAC4, HDAC7 AND HDAC9; the interaction with HDACs represses transcriptional activity (By similarity).

Interacts with LPIN1 (PubMed:19753306).

Interacts with MYOCD (PubMed:16818234).

Interacts with AKAP13 (PubMed:20139090).

Interacts with FOXK1; the interaction inhibits MEF2C transactivation activity (PubMed:22956541).

Interacts (via N-terminus) with HABP4; this interaction decreases DNA-binding activity of MEF2C in myocardial cells in response to mechanical stress (By similarity).

Interacts with JPH2; interaction specifically takes place with the Junctophilin-2 N-terminal fragment cleavage product of JPH2 (PubMed:30409805).

Interacts (via MADS box) with SOX18 (PubMed:11554755).

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

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GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
201383, 12 interactors

Database of interacting proteins

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DIPi
DIP-49524N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q8CFN5

Protein interaction database and analysis system

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IntActi
Q8CFN5, 8 interactors

Molecular INTeraction database

More...
MINTi
Q8CFN5

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000132547

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q8CFN5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1474
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8CFN5

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 57MADS-boxPROSITE-ProRule annotationAdd BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni271 – 278Beta domainBy similarity8
Regioni368 – 399Transcription repressorBy similarityAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 31Lys-rich (basic)Add BLAST28
Compositional biasi146 – 183Ser-richAdd BLAST38

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MEF2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0014 Eukaryota
COG5068 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157492

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8CFN5

KEGG Orthology (KO)

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KOi
K04454

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8CFN5

TreeFam database of animal gene trees

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TreeFami
TF314067

Family and domain databases

Conserved Domains Database

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CDDi
cd00265 MADS_MEF2_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.1810.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR022102 HJURP_C
IPR033896 MADS_MEF2-like
IPR002100 TF_MADSbox
IPR036879 TF_MADSbox_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF12347 HJURP_C, 1 hit
PF00319 SRF-TF, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00404 MADSDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00432 MADS, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55455 SSF55455, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00350 MADS_BOX_1, 1 hit
PS50066 MADS_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 21 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CFN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS
60 70 80 90 100
TNKLFQYAST DMDKVLLKYT EYNEPHESRT NSDIVETLRK KGLNGCDSPD
110 120 130 140 150
PDADDSVGHS PESEDKYRKI NEDIDLMISR QRLCAVPPPS FEMPVTIPVS
160 170 180 190 200
SHNSLVYSNP VSTLGNPNLL PLAHPSLQRN SMSPGVTHRP PSAGNTGGLM
210 220 230 240 250
GGDLTSGAGT SAGNGYGNPR NSPGLLVSPG NLNKNIQAKS PPPMNLGMNN
260 270 280 290 300
RKPDLRVLIP PGSKNTMPSV SEDVDLLLNQ RINNSQSAQS LATPVVSVAT
310 320 330 340 350
PTLPGQGMGG YPSAISTTYG TEYSLSSADL SSLSGFNTAS ALHLGSVTGW
360 370 380 390 400
QQQHLHNMPP SALSQLGACT STHLSQSSNL SLPSTQSLSI KSEPVSPPRD
410 420 430 440 450
RTTTPSRYPQ HTTRHEAGRS PVDSLSSCSS SYDGSDREDH RNEFHSPIGL
460 470
TRPSPDERES PSVKRMRLSE GWAT
Length:474
Mass (Da):51,278
Last modified:January 4, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCEFC2DB21E89632A
GO
Isoform 2 (identifier: Q8CFN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-278: Missing.

Show »
Length:466
Mass (Da):50,393
Checksum:iF06A89C9ACD779AE
GO
Isoform 3 (identifier: Q8CFN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-399: Missing.

Show »
Length:442
Mass (Da):47,956
Checksum:i40EFBF02BF3E775C
GO
Isoform 4 (identifier: Q8CFN5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-97: TLRKKGLNGCD → ALNKKENKGSE
     103-118: ADDSVGHSPESEDKYR → SSYALTPRTEEKYK
     123-134: DIDLMISRQRLC → EFDNMIKSHKIP
     271-278: Missing.
     368-399: Missing.

Show »
Length:432
Mass (Da):46,961
Checksum:iDCB2EBCE61A35215
GO
Isoform 5 (identifier: Q8CFN5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-97: TLRKKGLNGCD → ALNKKENKGSE
     103-118: ADDSVGHSPESEDKYR → SSYALTPRTEEKYK
     123-134: DIDLMISRQRLC → EFDNMIKSHKIP

Show »
Length:472
Mass (Da):51,168
Checksum:i1B618AB137809260
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0H2UH28A0A0H2UH28_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
484Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JEC2A0A0G2JEC2_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
434Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0H2UKB6A0A0H2UKB6_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
464Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JDK0A0A0G2JDK0_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JDQ1A0A0G2JDQ1_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
400Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JDT0A0A0G2JDT0_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
418Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JE18A0A0G2JE18_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
394Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JES4A0A0G2JES4_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JET3A0A0G2JET3_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFI7A0A0G2JFI7_MOUSE
Myocyte-specific enhancer factor 2C
Mef2c
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti141F → L in AAH37731 (PubMed:15489334).Curated1
Sequence conflicti211S → P (PubMed:8506376).Curated1
Sequence conflicti428C → S (PubMed:8506376).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01250187 – 97TLRKKGLNGCD → ALNKKENKGSE in isoform 4 and isoform 5. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_012502103 – 118ADDSV…EDKYR → SSYALTPRTEEKYK in isoform 4 and isoform 5. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_012503123 – 134DIDLM…RQRLC → EFDNMIKSHKIP in isoform 4 and isoform 5. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_012504271 – 278Missing in isoform 2 and isoform 4. 2 Publications8
Alternative sequenceiVSP_012505368 – 399Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK009139 mRNA Translation: BAB26099.1
BC026841 mRNA Translation: AAH26841.1
BC037731 mRNA Translation: AAH37731.1
BC057650 mRNA Translation: AAH57650.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS26664.1 [Q8CFN5-4]
CCDS49320.1 [Q8CFN5-2]
CCDS84042.1 [Q8CFN5-1]
CCDS84043.1 [Q8CFN5-3]
CCDS84045.1 [Q8CFN5-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001334493.1, NM_001347564.1 [Q8CFN5-1]
NP_001334495.1, NM_001347566.1 [Q8CFN5-1]
NP_001334496.1, NM_001347567.1 [Q8CFN5-1]
NP_001334497.1, NM_001347568.1 [Q8CFN5-5]
NP_001334498.1, NM_001347569.1 [Q8CFN5-5]
NP_001334500.1, NM_001347571.1 [Q8CFN5-3]
NP_001334501.1, NM_001347572.1 [Q8CFN5-3]
NP_001334502.1, NM_001347573.1 [Q8CFN5-3]
NP_001334503.1, NM_001347574.1 [Q8CFN5-3]
NP_001334504.1, NM_001347575.1 [Q8CFN5-3]
NP_001334505.1, NM_001347576.1 [Q8CFN5-3]
NP_001334506.1, NM_001347577.1 [Q8CFN5-3]
NP_079558.1, NM_025282.3 [Q8CFN5-4]
XP_006517186.1, XM_006517123.2 [Q8CFN5-1]
XP_006517187.1, XM_006517124.3 [Q8CFN5-1]
XP_006517189.1, XM_006517126.2 [Q8CFN5-5]
XP_006517195.1, XM_006517132.3 [Q8CFN5-4]
XP_011242794.1, XM_011244492.2 [Q8CFN5-1]
XP_017170894.1, XM_017315405.1 [Q8CFN5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000185052; ENSMUSP00000138826; ENSMUSG00000005583 [Q8CFN5-5]
ENSMUST00000197146; ENSMUSP00000143227; ENSMUSG00000005583 [Q8CFN5-3]
ENSMUST00000197681; ENSMUSP00000143420; ENSMUSG00000005583 [Q8CFN5-3]
ENSMUST00000198199; ENSMUSP00000143742; ENSMUSG00000005583 [Q8CFN5-4]
ENSMUST00000199019; ENSMUSP00000143401; ENSMUSG00000005583 [Q8CFN5-1]
ENSMUST00000199105; ENSMUSP00000143212; ENSMUSG00000005583 [Q8CFN5-1]
ENSMUST00000199450; ENSMUSP00000143315; ENSMUSG00000005583 [Q8CFN5-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
17260

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:17260

UCSC genome browser

More...
UCSCi
uc007rie.2 mouse [Q8CFN5-4]
uc007rih.2 mouse [Q8CFN5-5]
uc007rii.3 mouse [Q8CFN5-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009139 mRNA Translation: BAB26099.1
BC026841 mRNA Translation: AAH26841.1
BC037731 mRNA Translation: AAH37731.1
BC057650 mRNA Translation: AAH57650.1
CCDSiCCDS26664.1 [Q8CFN5-4]
CCDS49320.1 [Q8CFN5-2]
CCDS84042.1 [Q8CFN5-1]
CCDS84043.1 [Q8CFN5-3]
CCDS84045.1 [Q8CFN5-5]
RefSeqiNP_001334493.1, NM_001347564.1 [Q8CFN5-1]
NP_001334495.1, NM_001347566.1 [Q8CFN5-1]
NP_001334496.1, NM_001347567.1 [Q8CFN5-1]
NP_001334497.1, NM_001347568.1 [Q8CFN5-5]
NP_001334498.1, NM_001347569.1 [Q8CFN5-5]
NP_001334500.1, NM_001347571.1 [Q8CFN5-3]
NP_001334501.1, NM_001347572.1 [Q8CFN5-3]
NP_001334502.1, NM_001347573.1 [Q8CFN5-3]
NP_001334503.1, NM_001347574.1 [Q8CFN5-3]
NP_001334504.1, NM_001347575.1 [Q8CFN5-3]
NP_001334505.1, NM_001347576.1 [Q8CFN5-3]
NP_001334506.1, NM_001347577.1 [Q8CFN5-3]
NP_079558.1, NM_025282.3 [Q8CFN5-4]
XP_006517186.1, XM_006517123.2 [Q8CFN5-1]
XP_006517187.1, XM_006517124.3 [Q8CFN5-1]
XP_006517189.1, XM_006517126.2 [Q8CFN5-5]
XP_006517195.1, XM_006517132.3 [Q8CFN5-4]
XP_011242794.1, XM_011244492.2 [Q8CFN5-1]
XP_017170894.1, XM_017315405.1 [Q8CFN5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5F28X-ray2.90A/B/C/D1-95[»]
SMRiQ8CFN5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi201383, 12 interactors
DIPiDIP-49524N
ELMiQ8CFN5
IntActiQ8CFN5, 8 interactors
MINTiQ8CFN5
STRINGi10090.ENSMUSP00000132547

PTM databases

iPTMnetiQ8CFN5
PhosphoSitePlusiQ8CFN5

Proteomic databases

PaxDbiQ8CFN5
PeptideAtlasiQ8CFN5
PRIDEiQ8CFN5

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
755 1243 antibodies

Genome annotation databases

EnsembliENSMUST00000185052; ENSMUSP00000138826; ENSMUSG00000005583 [Q8CFN5-5]
ENSMUST00000197146; ENSMUSP00000143227; ENSMUSG00000005583 [Q8CFN5-3]
ENSMUST00000197681; ENSMUSP00000143420; ENSMUSG00000005583 [Q8CFN5-3]
ENSMUST00000198199; ENSMUSP00000143742; ENSMUSG00000005583 [Q8CFN5-4]
ENSMUST00000199019; ENSMUSP00000143401; ENSMUSG00000005583 [Q8CFN5-1]
ENSMUST00000199105; ENSMUSP00000143212; ENSMUSG00000005583 [Q8CFN5-1]
ENSMUST00000199450; ENSMUSP00000143315; ENSMUSG00000005583 [Q8CFN5-2]
GeneIDi17260
KEGGimmu:17260
UCSCiuc007rie.2 mouse [Q8CFN5-4]
uc007rih.2 mouse [Q8CFN5-5]
uc007rii.3 mouse [Q8CFN5-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4208
MGIiMGI:99458 Mef2c

Phylogenomic databases

eggNOGiKOG0014 Eukaryota
COG5068 LUCA
GeneTreeiENSGT00940000157492
InParanoidiQ8CFN5
KOiK04454
PhylomeDBiQ8CFN5
TreeFamiTF314067

Enzyme and pathway databases

ReactomeiR-MMU-525793 Myogenesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mef2c mouse

Protein Ontology

More...
PROi
PR:Q8CFN5
RNActiQ8CFN5 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000005583 Expressed in cerebral cortex and 350 other tissues
ExpressionAtlasiQ8CFN5 baseline and differential
GenevisibleiQ8CFN5 MM

Family and domain databases

CDDicd00265 MADS_MEF2_like, 1 hit
Gene3Di3.40.1810.10, 1 hit
InterProiView protein in InterPro
IPR022102 HJURP_C
IPR033896 MADS_MEF2-like
IPR002100 TF_MADSbox
IPR036879 TF_MADSbox_sf
PfamiView protein in Pfam
PF12347 HJURP_C, 1 hit
PF00319 SRF-TF, 1 hit
PRINTSiPR00404 MADSDOMAIN
SMARTiView protein in SMART
SM00432 MADS, 1 hit
SUPFAMiSSF55455 SSF55455, 1 hit
PROSITEiView protein in PROSITE
PS00350 MADS_BOX_1, 1 hit
PS50066 MADS_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEF2C_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CFN5
Secondary accession number(s): Q8R0H1, Q9D7L0, Q9QW20
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: April 22, 2020
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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