Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GATOR complex protein WDR24

Gene

Wdr24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux.By similarity

GO - Biological processi

Keywordsi

Biological processAutophagy

Names & Taxonomyi

Protein namesi
Recommended name:
GATOR complex protein WDR24Curated
Alternative name(s):
WD repeat-containing protein 24Imported
Gene namesi
Name:Wdr24Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2446285 Wdr24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513761 – 790GATOR complex protein WDR24Add BLAST790

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei470PhosphoserineBy similarity1
Modified residuei496PhosphoserineBy similarity1
Modified residuei581PhosphothreonineBy similarity1
Modified residuei594PhosphoserineCombined sources1
Modified residuei598PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CFJ9
MaxQBiQ8CFJ9
PaxDbiQ8CFJ9
PeptideAtlasiQ8CFJ9
PRIDEiQ8CFJ9

PTM databases

iPTMnetiQ8CFJ9
PhosphoSitePlusiQ8CFJ9

Expressioni

Gene expression databases

BgeeiENSMUSG00000025737 Expressed in 234 organ(s), highest expression level in intestine
CleanExiMM_WDR24
GenevisibleiQ8CFJ9 MM

Interactioni

Subunit structurei

Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers. The GATOR2 complex interacts with CASTOR2 and CASTOR1; the interaction is negatively regulated by arginine. The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids.By similarity

Protein-protein interaction databases

BioGridi234581, 1 interactor
STRINGi10090.ENSMUSP00000026833

Structurei

3D structure databases

ProteinModelPortaliQ8CFJ9
SMRiQ8CFJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati72 – 112WD 1Add BLAST41
Repeati118 – 158WD 2Add BLAST41
Repeati161 – 201WD 3Add BLAST41
Repeati205 – 245WD 4Add BLAST41
Repeati249 – 291WD 5Add BLAST43
Repeati295 – 338WD 6Add BLAST44

Sequence similaritiesi

Belongs to the WD repeat WDR24 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0269 Eukaryota
ENOG410XSJ6 LUCA
GeneTreeiENSGT00910000144183
HOGENOMiHOG000234392
HOVERGENiHBG080644
InParanoidiQ8CFJ9
KOiK20408
OMAiTLCQHLF
OrthoDBiEOG091G0052
PhylomeDBiQ8CFJ9
TreeFamiTF314190

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR037590 WDR24
PANTHERiPTHR22850:SF131 PTHR22850:SF131, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CFJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKMSRVSTA LSGSALTGRT MHCHLDAPAN AISVCRDAAQ VVVAGRSIFK
60 70 80 90 100
IYAIEEEQFV EKLNLRVGRK PSLNLSCADV VWHQMDENLL ATAATNGVVV
110 120 130 140 150
TWNLGRPSRN KQDQLFTEHK RTVNKVCFHP TEAHVLLSGS QDGFMKCFDL
160 170 180 190 200
RRKDSVSTFS GQSESVRDVQ FSIRDYFTFA STFENGNVQL WDIRRPDRCE
210 220 230 240 250
RMFTAHNGPV FCCDWHPEDR GWLATGGRDK MVKVWDMTTH RAKEIHCVQT
260 270 280 290 300
IASVARVKWR PECRHHLATC SMMVDHNIYV WDVRRPFVPA AMFEEHRDVT
310 320 330 340 350
TGIAWRHPHD PSFLLSGSKD STLCQHLFRD ASQPVERANP EGLCYGLFGD
360 370 380 390 400
LAFAVKESLV AAESGRKPYA GDRRHPIFFK RKLDPAEPFS GLASSALSVF
410 420 430 440 450
ETESSGGSMS WFVDTAERYV LAGRPLAELC DHNAKVAREL GRNQVAQTWT
460 470 480 490 500
MLRIIYCSPG LVSSANLNHS VGKGSSCGLP LMNSFNLKDM GPGLGSETRL
510 520 530 540 550
DRSKGDTRSD AALLDSSATL VTNEDNEETE GSDVPADYLL GDVEGEDDEL
560 570 580 590 600
YPLDTEHVHS EEPEYVLPQE AFPLRHEIVD TPSGPEHLQD KADSPHVSGN
610 620 630 640 650
EADTASLAPV DSSSSLLSVS HALYDSRLPP DFFSVLVRDM LRFYAEQGDV
660 670 680 690 700
QMAVSVLIVL GERVRKDIDE QTQEHWYTSY IDLLQRFCLW NVSNEVVKLS
710 720 730 740 750
TSRAVSCLNQ ASTTLHVNCS HCKRPMSSRG WVCDRCHRCA SMCAVCHHVV
760 770 780 790
KGLFVWCQGC SHGGHLQHIM KWLEGSSHCP AGCGHLCEYS
Length:790
Mass (Da):88,184
Last modified:March 1, 2003 - v1
Checksum:iAF4A5E490357D57D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC037651 mRNA Translation: AAH37651.1
CCDSiCCDS28531.1
RefSeqiNP_776102.1, NM_173741.3
UniGeneiMm.95512

Genome annotation databases

EnsembliENSMUST00000026833; ENSMUSP00000026833; ENSMUSG00000025737
GeneIDi268933
KEGGimmu:268933
UCSCiuc008bcd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC037651 mRNA Translation: AAH37651.1
CCDSiCCDS28531.1
RefSeqiNP_776102.1, NM_173741.3
UniGeneiMm.95512

3D structure databases

ProteinModelPortaliQ8CFJ9
SMRiQ8CFJ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234581, 1 interactor
STRINGi10090.ENSMUSP00000026833

PTM databases

iPTMnetiQ8CFJ9
PhosphoSitePlusiQ8CFJ9

Proteomic databases

EPDiQ8CFJ9
MaxQBiQ8CFJ9
PaxDbiQ8CFJ9
PeptideAtlasiQ8CFJ9
PRIDEiQ8CFJ9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026833; ENSMUSP00000026833; ENSMUSG00000025737
GeneIDi268933
KEGGimmu:268933
UCSCiuc008bcd.2 mouse

Organism-specific databases

CTDi84219
MGIiMGI:2446285 Wdr24

Phylogenomic databases

eggNOGiKOG0269 Eukaryota
ENOG410XSJ6 LUCA
GeneTreeiENSGT00910000144183
HOGENOMiHOG000234392
HOVERGENiHBG080644
InParanoidiQ8CFJ9
KOiK20408
OMAiTLCQHLF
OrthoDBiEOG091G0052
PhylomeDBiQ8CFJ9
TreeFamiTF314190

Miscellaneous databases

PROiPR:Q8CFJ9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025737 Expressed in 234 organ(s), highest expression level in intestine
CleanExiMM_WDR24
GenevisibleiQ8CFJ9 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR037590 WDR24
PANTHERiPTHR22850:SF131 PTHR22850:SF131, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR24_MOUSE
AccessioniPrimary (citable) accession number: Q8CFJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again