Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Poly [ADP-ribose] polymerase 11

Gene

Parp11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (PubMed:25673562). In vitro, exhibits mono(ADP-ribosyl) transferase activity (By similarity).By similarity1 Publication

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • mRNA transport Source: UniProtKB-KW
  • nuclear envelope organization Source: MGI
  • protein transport Source: UniProtKB-KW
  • spermatogenesis Source: UniProtKB-KW

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processDifferentiation, mRNA transport, Protein transport, Spermatogenesis, Translocation, Transport
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 11 (EC:2.4.2.30)
Short name:
PARP-11
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 11
Short name:
ARTD11
Gene namesi
Name:Parp11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2141505 Parp11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

Pathology & Biotechi

Disruption phenotypei

Knockout mice are viable and are born in normal Mendelian ratios. Knockout males, but not females, exhibit a striking fertility defect, with the majority of males being sterile and a minority producing infrequent and small litters. Sperm from mutant mice exhibits mild to severe teratozoospermia, with structural defects in elongating spermatid nuclear envelope and chromatin detachment associated with abnormal nuclear shaping.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002734201 – 331Poly [ADP-ribose] polymerase 11Add BLAST331

Post-translational modificationi

In vitro, can undergo mono-ADP-ribosylation.By similarity

Keywords - PTMi

ADP-ribosylation

Proteomic databases

PaxDbiQ8CFF0
PRIDEiQ8CFF0

PTM databases

PhosphoSitePlusiQ8CFF0

Expressioni

Tissue specificityi

Predominantly expressed in testis, preferentially in postmeiotic germ cells. Also detectable in other tissues, including liver, lung, spleen, thymus and brain.1 Publication

Developmental stagei

Undetectable in testis until postnatal day 18. Sharply up-regulated from postnatal days 18 to 21. This timeframe corresponds to the appearance of the first spermatids of the first wave of spermatogenesis just before initiation of elongation. Remains elevated in adult animals.1 Publication

Gene expression databases

BgeeiENSMUSG00000037997
CleanExiMM_PARP11
ExpressionAtlasiQ8CFF0 baseline and differential
GenevisibleiQ8CFF0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036127

Structurei

3D structure databases

ProteinModelPortaliQ8CFF0
SMRiQ8CFF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 99WWEPROSITE-ProRule annotationAdd BLAST85
Domaini116 – 331PARP catalyticPROSITE-ProRule annotationAdd BLAST216

Phylogenomic databases

eggNOGiENOG410IJ12 Eukaryota
ENOG4110TY6 LUCA
GeneTreeiENSGT00760000119084
HOGENOMiHOG000237349
HOVERGENiHBG056772
InParanoidiQ8CFF0
KOiK15259
OMAiDTNIQCS
OrthoDBiEOG091G14UY
PhylomeDBiQ8CFF0
TreeFamiTF338389

Family and domain databases

Gene3Di3.30.720.50, 1 hit
InterProiView protein in InterPro
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004170 WWE-dom
IPR037197 WWE_dom_sf
PfamiView protein in Pfam
PF00644 PARP, 1 hit
PF02825 WWE, 1 hit
SUPFAMiSSF117839 SSF117839, 1 hit
PROSITEiView protein in PROSITE
PS51059 PARP_CATALYTIC, 1 hit
PS50918 WWE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CFF0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFHKTEEFFP KKTDSDVDDM DTSDTQWGWF YLAECGKWHM FQPDTNIQCS
60 70 80 90 100
VSSEDIEKSF KTNPCGSISF TTSKFSYKID FAEMKQMNLV TGKQRLIKRA
110 120 130 140 150
PFSISAFSYI CENEAIPMPT HWENVNPDVP YQLVSLQNQT HEYNEVASLF
160 170 180 190 200
GKTMDRNRIK RIQRIQNLDL WEFFCRKKAQ LKKKRGVPQI NEQMLFHGTS
210 220 230 240 250
SEFVEAICIH NFDWRINGVH GAVFGKGTYF ARDAAYSSRF CKDDIKHGNT
260 270 280 290 300
FQIHGVSLQQ RHLFRTYKSM FLARVLIGDY INGDSKYMRP PSKDGSYVNL
310 320 330
YDSCVDDTWN PKIFVVFDAN QIYPEYLIDF H
Length:331
Mass (Da):38,737
Last modified:March 1, 2003 - v1
Checksum:i70CF1926D8363C8F
GO
Isoform 2 (identifier: Q8CFF0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Note: No experimental confirmation available.
Show »
Length:248
Mass (Da):29,053
Checksum:i533F35E23F303A69
GO
Isoform 3 (identifier: Q8CFF0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-331: Missing.

Note: No experimental confirmation available.
Show »
Length:176
Mass (Da):20,772
Checksum:i0B286F82B97AA7B3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0225571 – 83Missing in isoform 2. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_022558177 – 331Missing in isoform 3. 1 PublicationAdd BLAST155

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133697 mRNA Translation: BAE21788.1
AK151393 mRNA Translation: BAE30362.1
BC040269 mRNA Translation: AAH40269.1
CCDSiCCDS20565.1 [Q8CFF0-1]
CCDS85162.1 [Q8CFF0-2]
RefSeqiNP_001333441.1, NM_001346512.1 [Q8CFF0-2]
NP_001333442.1, NM_001346513.1 [Q8CFF0-2]
NP_852067.1, NM_181402.3 [Q8CFF0-1]
XP_006505294.1, XM_006505231.3 [Q8CFF0-1]
XP_006505295.1, XM_006505232.3 [Q8CFF0-1]
XP_006505296.1, XM_006505233.3 [Q8CFF0-1]
UniGeneiMm.110818

Genome annotation databases

EnsembliENSMUST00000039680; ENSMUSP00000036127; ENSMUSG00000037997 [Q8CFF0-1]
ENSMUST00000112191; ENSMUSP00000107810; ENSMUSG00000037997 [Q8CFF0-2]
ENSMUST00000112193; ENSMUSP00000107812; ENSMUSG00000037997 [Q8CFF0-3]
ENSMUST00000112195; ENSMUSP00000107814; ENSMUSG00000037997 [Q8CFF0-3]
GeneIDi101187
KEGGimmu:101187
UCSCiuc009dvw.1 mouse [Q8CFF0-1]
uc009dvz.1 mouse [Q8CFF0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPAR11_MOUSE
AccessioniPrimary (citable) accession number: Q8CFF0
Secondary accession number(s): Q3UAF2, Q3UZR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health