UniProtKB - Q8CFE6 (S38A2_MOUSE)
Protein
Sodium-coupled neutral amino acid transporter 2
Gene
Slc38a2
Organism
Mus musculus (Mouse)
Status
Functioni
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.1 Publication
Activity regulationi
Inhibited by N-methyl-D-glucamine and choline.By similarity
GO - Molecular functioni
- amino acid transmembrane transporter activity Source: MGI
- L-glutamine transmembrane transporter activity Source: UniProtKB
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- alanine transport Source: MGI
- amino acid transmembrane transport Source: GO_Central
- amino acid transport Source: MGI
- cellular response to amino acid starvation Source: Ensembl
- cellular response to mechanical stimulus Source: Ensembl
- cerebral cortex development Source: Ensembl
- female pregnancy Source: Ensembl
- glutamine transport Source: UniProtKB
- glycine betaine transport Source: MGI
- sodium ion transport Source: UniProtKB-KW
Keywordsi
Biological process | Amino-acid transport, Ion transport, Sodium transport, Symport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-MMU-210500 Glutamate Neurotransmitter Release Cycle R-MMU-352230 Amino acid transport across the plasma membrane |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium-coupled neutral amino acid transporter 2Alternative name(s): Amino acid transporter A2 Solute carrier family 38 member 2 System A amino acid transporter 2 System A transporter 1 System N amino acid transporter 2 |
Gene namesi | Name:Slc38a2 Synonyms:Ata2, Kiaa1382, Sat2, Snat2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915010 Slc38a2 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
Note: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
- sarcolemma Source: MGI
Other locations
- axon Source: MGI
- brush border Source: MGI
- dendrite Source: MGI
- neuronal cell body Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 76 | CytoplasmicSequence analysisAdd BLAST | 76 | |
Transmembranei | 77 – 97 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 98 – 102 | ExtracellularSequence analysis | 5 | |
Transmembranei | 103 – 123 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 124 – 158 | CytoplasmicSequence analysisAdd BLAST | 35 | |
Transmembranei | 159 – 179 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 180 – 188 | ExtracellularSequence analysis | 9 | |
Transmembranei | 189 – 209 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 210 – 217 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 218 – 238 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 239 – 289 | ExtracellularSequence analysisAdd BLAST | 51 | |
Transmembranei | 290 – 310 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 311 – 326 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 327 – 347 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 348 – 368 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 369 – 389 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 390 – 410 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 411 – 431 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 432 – 433 | ExtracellularSequence analysis | 2 | |
Transmembranei | 434 – 454 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 455 – 471 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 472 – 492 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 493 – 504 | ExtracellularSequence analysisAdd BLAST | 12 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000311370 | 1 – 504 | Sodium-coupled neutral amino acid transporter 2Add BLAST | 504 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 12 | PhosphoserineBy similarity | 1 | |
Modified residuei | 21 | PhosphoserineCombined sources | 1 | |
Modified residuei | 22 | PhosphoserineBy similarity | 1 | |
Modified residuei | 55 | PhosphoserineCombined sources | 1 | |
Disulfide bondi | 245 ↔ 278 | PROSITE-ProRule annotation | ||
Glycosylationi | 254 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 258 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8CFE6 |
MaxQBi | Q8CFE6 |
PaxDbi | Q8CFE6 |
PeptideAtlasi | Q8CFE6 |
PRIDEi | Q8CFE6 |
PTM databases
iPTMneti | Q8CFE6 |
PhosphoSitePlusi | Q8CFE6 |
SwissPalmi | Q8CFE6 |
Expressioni
Tissue specificityi
Expressed in cerebral and cerebellar astrocytes and neurons.1 Publication
Inductioni
Up-regulated upon amino acid deprivation.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000022462 Expressed in 301 organ(s), highest expression level in brain blood vessel |
Genevisiblei | Q8CFE6 MM |
Interactioni
Protein-protein interaction databases
BioGridi | 212424, 1 interactor |
STRINGi | 10090.ENSMUSP00000023099 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 96 | Regulates protein turnover upon amino acid deprivationBy similarityAdd BLAST | 96 |
Sequence similaritiesi
Belongs to the amino acid/polyamine transporter 2 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1305 Eukaryota COG0814 LUCA |
GeneTreei | ENSGT00940000155486 |
InParanoidi | Q8CFE6 |
KOi | K14207 |
OMAi | IVFAYTC |
OrthoDBi | 1109791at2759 |
PhylomeDBi | Q8CFE6 |
TreeFami | TF328787 |
Family and domain databases
InterProi | View protein in InterPro IPR013057 AA_transpt_TM |
Pfami | View protein in Pfam PF01490 Aa_trans, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8CFE6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKTEMGRFN ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN
60 70 80 90 100
FLLESNLGKK KYETDFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG
110 120 130 140 150
IALFIILLTF VSIFSLYSVH LLLKTANEGG SLLYEQLGHK AYGLAGKLAA
160 170 180 190 200
SGSITMQNIG AMSSYLFIVK YELPLVIKAL MNIEDTNGLW YLNGDYLVLL
210 220 230 240 250
VSLVLILPLS LLRNLGYLGY TSGLSLLCMI FFLIVVICKK FQIPCPVEAA
260 270 280 290 300
LVANETVNGT FTQAALALAF NSTADDACRP RYFIFNSQTV YAVPILTFSF
310 320 330 340 350
VCHPAVLPIY EELKSRSRRR MMNVSKISFF AMFLMYLLAA LFGYLTFYGH
360 370 380 390 400
VESELLHTYS EIVGTDILLL VVRLAVLVAV TLTVPVVIFP IRSSVTHLLC
410 420 430 440 450
PTKEFSWLRH SIITVTILSF TNLLVIFVPT IRDIFGFIGA SAAAMLIFIL
460 470 480 490 500
PSAFYIKLVK KEPMRSVQKI GALCFLLSGI VVMIGSMGLI VLDWVHDASA
AGGH
Sequence cautioni
The sequence BAC98152 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 245 | C → R in BAC27479 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK129342 mRNA Translation: BAC98152.1 Different initiation. AK031615 mRNA Translation: BAC27479.1 AK033812 mRNA Translation: BAC28483.1 AK169378 mRNA Translation: BAE41125.1 BC041108 mRNA Translation: AAH41108.1 BC048178 mRNA Translation: AAH48178.1 BC049271 mRNA Translation: AAH49271.1 BC057454 mRNA Translation: AAH57454.1 |
CCDSi | CCDS27778.1 |
RefSeqi | NP_780330.2, NM_175121.3 |
Genome annotation databases
Ensembli | ENSMUST00000023099; ENSMUSP00000023099; ENSMUSG00000022462 |
GeneIDi | 67760 |
KEGGi | mmu:67760 |
UCSCi | uc007xkm.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK129342 mRNA Translation: BAC98152.1 Different initiation. AK031615 mRNA Translation: BAC27479.1 AK033812 mRNA Translation: BAC28483.1 AK169378 mRNA Translation: BAE41125.1 BC041108 mRNA Translation: AAH41108.1 BC048178 mRNA Translation: AAH48178.1 BC049271 mRNA Translation: AAH49271.1 BC057454 mRNA Translation: AAH57454.1 |
CCDSi | CCDS27778.1 |
RefSeqi | NP_780330.2, NM_175121.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 212424, 1 interactor |
STRINGi | 10090.ENSMUSP00000023099 |
PTM databases
iPTMneti | Q8CFE6 |
PhosphoSitePlusi | Q8CFE6 |
SwissPalmi | Q8CFE6 |
Proteomic databases
EPDi | Q8CFE6 |
MaxQBi | Q8CFE6 |
PaxDbi | Q8CFE6 |
PeptideAtlasi | Q8CFE6 |
PRIDEi | Q8CFE6 |
Genome annotation databases
Ensembli | ENSMUST00000023099; ENSMUSP00000023099; ENSMUSG00000022462 |
GeneIDi | 67760 |
KEGGi | mmu:67760 |
UCSCi | uc007xkm.1 mouse |
Organism-specific databases
CTDi | 54407 |
MGIi | MGI:1915010 Slc38a2 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG1305 Eukaryota COG0814 LUCA |
GeneTreei | ENSGT00940000155486 |
InParanoidi | Q8CFE6 |
KOi | K14207 |
OMAi | IVFAYTC |
OrthoDBi | 1109791at2759 |
PhylomeDBi | Q8CFE6 |
TreeFami | TF328787 |
Enzyme and pathway databases
Reactomei | R-MMU-210500 Glutamate Neurotransmitter Release Cycle R-MMU-352230 Amino acid transport across the plasma membrane |
Miscellaneous databases
ChiTaRSi | Slc38a2 mouse |
PROi | PR:Q8CFE6 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022462 Expressed in 301 organ(s), highest expression level in brain blood vessel |
Genevisiblei | Q8CFE6 MM |
Family and domain databases
InterProi | View protein in InterPro IPR013057 AA_transpt_TM |
Pfami | View protein in Pfam PF01490 Aa_trans, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S38A2_MOUSE | |
Accessioni | Q8CFE6Primary (citable) accession number: Q8CFE6 Secondary accession number(s): Q3TEX3 Q8CD21 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | October 16, 2019 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot