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Protein

SCY1-like protein 2

Gene

Scyl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. May be a serine/threonine-protein kinase. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SCY1-like protein 2
Alternative name(s):
Coated vesicle-associated kinase of 104 kDa
Gene namesi
Name:Scyl2
Synonyms:Cvak104, D10Ertd802e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1289172 Scyl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524471 – 930SCY1-like protein 2Add BLAST930

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei658PhosphoserineCombined sources1
Modified residuei677PhosphoserineCombined sources1
Modified residuei708PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CFE4
PaxDbiQ8CFE4
PeptideAtlasiQ8CFE4
PRIDEiQ8CFE4

PTM databases

iPTMnetiQ8CFE4
PhosphoSitePlusiQ8CFE4

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000069539 Expressed in 237 organ(s), highest expression level in secondary oocyte
CleanExiMM_SCYL2
ExpressionAtlasiQ8CFE4 baseline and differential
GenevisibleiQ8CFE4 MM

Interactioni

Subunit structurei

Interacts with clathrin and AP2B1; the interaction mediates the association with the AP-2 complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229417, 1 interactor
IntActiQ8CFE4, 3 interactors
MINTiQ8CFE4
STRINGi10090.ENSMUSP00000133992

Structurei

3D structure databases

ProteinModelPortaliQ8CFE4
SMRiQ8CFE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 327Protein kinasePROSITE-ProRule annotationAdd BLAST296
Repeati443 – 479HEATAdd BLAST37

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated

Phylogenomic databases

eggNOGiKOG2137 Eukaryota
ENOG410XQ9T LUCA
GeneTreeiENSGT00880000138031
HOGENOMiHOG000013212
HOVERGENiHBG055627
InParanoidiQ8CFE4
KOiK17541
OrthoDBiEOG091G01WY
PhylomeDBiQ8CFE4
TreeFamiTF314178

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CFE4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESMLNKLKS TVTKVTADVT SAVMGNPVTR EFDVGRHIAS GGNGLAWKIF
60 70 80 90 100
NGTKKSTKQE VAVFVFDKKL IDKYQKFEKD QIIDSLKRGV QQLTRLRHPR
110 120 130 140 150
LLTVQHPLEE SRDCLAFCTE PVFASLANVL GNWENLPSSI SPDIKDYKLY
160 170 180 190 200
DVETKYGLLQ VSEGLSFLHS SVKMVHGNVT PENVILNKSG AWKIMGFDFC
210 220 230 240 250
VSSSNPSEQE PKFPCKEWDP NLPSLCLPNP EYLAPEYILS VSCETASDMY
260 270 280 290 300
SLGAVMYAVF NQGRPIFEVN KQDIYKSFSR QLDQLSRLGS SSLTSIPEEV
310 320 330 340 350
REHVKLLLNV TPTVRPDADQ MTKIPFFDDV GAVTLQYFDT LFQRDNLQKS
360 370 380 390 400
QFFKGLPKVL PKLPKRVIVQ RILPCLTSEF VNPDMVPFVL PNVLLIAEEC
410 420 430 440 450
TKEEYIKLIL PELGPVFKQQ EPIQILLIFL QKMDLLLTKT PPDEIKNSVL
460 470 480 490 500
PMVYRALEAP SIQIQELCLN IIPTFANLID YPSMKNALIP RIKNACLQTS
510 520 530 540 550
SLAVRVNSLV CLGKILEYLD KWFVLDDILP FLQQIPSKEP AVLMGILGIY
560 570 580 590 600
KCTFTHKKLG ITKEQLAGKV LPHLIPLSIE NNLNLNQFSS FIAVIKEMLS
610 620 630 640 650
RLESEHRTKL EQLHVMQEQQ RSLDIGNQMS TSEETKVAHS GSQQIDKVFN
660 670 680 690 700
NIGADLLSGS ESENREDGMQ GKQKRGSLTL EEKQKLAKEQ EQAQKLKSQQ
710 720 730 740 750
PLKPQVHTPI APIKQTKDLT DTLMENMSSL TSLSVSTPKI SASSTFTPVP
760 770 780 790 800
STGLGMMFST PIDNTKRNLT NGLNANMGFQ TSGFSMPVNP NQNFFSGTGT
810 820 830 840 850
AGVTTMSLGA PPTMSNFSPL TIPPASVKQP QQRPTDMSAL NNLFGPQKPK
860 870 880 890 900
VSMNQLSQQK PNQWLNQFAP PQGSPVMGSA AMGTQGNVMG QAAFGMQGNP
910 920 930
FFNPQNFAQP PPTTMTSSSS ASNDLKDLFG
Length:930
Mass (Da):103,317
Last modified:March 1, 2003 - v1
Checksum:i1771D113D098189E
GO
Isoform 2 (identifier: Q8CFE4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-423: Missing.
     424-424: Q → M
     643-643: Missing.

Show »
Length:506
Mass (Da):55,421
Checksum:i5E0BABC979AF3FE4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E8J9G5E8J9_MOUSE
SCY1-like protein 2
Scyl2
929Annotation score:
Q80UY7Q80UY7_MOUSE
SCY1-like protein 2
Scyl2 D10Ertd802e
274Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0209801 – 423Missing in isoform 2. 1 PublicationAdd BLAST423
Alternative sequenceiVSP_020981424Q → M in isoform 2. 1 Publication1
Alternative sequenceiVSP_020982643Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136092 mRNA Translation: BAE22815.1
AK139747 mRNA Translation: BAE24123.1
BC030932 mRNA Translation: AAH30932.1
BC042443 mRNA Translation: AAH42443.1
CCDSiCCDS36027.1 [Q8CFE4-1]
RefSeqiNP_932138.1, NM_198021.2 [Q8CFE4-1]
UniGeneiMm.27651

Genome annotation databases

EnsembliENSMUST00000174252; ENSMUSP00000133992; ENSMUSG00000069539 [Q8CFE4-1]
GeneIDi213326
KEGGimmu:213326
UCSCiuc007gsl.1 mouse [Q8CFE4-2]
uc007gsm.1 mouse [Q8CFE4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136092 mRNA Translation: BAE22815.1
AK139747 mRNA Translation: BAE24123.1
BC030932 mRNA Translation: AAH30932.1
BC042443 mRNA Translation: AAH42443.1
CCDSiCCDS36027.1 [Q8CFE4-1]
RefSeqiNP_932138.1, NM_198021.2 [Q8CFE4-1]
UniGeneiMm.27651

3D structure databases

ProteinModelPortaliQ8CFE4
SMRiQ8CFE4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229417, 1 interactor
IntActiQ8CFE4, 3 interactors
MINTiQ8CFE4
STRINGi10090.ENSMUSP00000133992

PTM databases

iPTMnetiQ8CFE4
PhosphoSitePlusiQ8CFE4

Proteomic databases

EPDiQ8CFE4
PaxDbiQ8CFE4
PeptideAtlasiQ8CFE4
PRIDEiQ8CFE4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000174252; ENSMUSP00000133992; ENSMUSG00000069539 [Q8CFE4-1]
GeneIDi213326
KEGGimmu:213326
UCSCiuc007gsl.1 mouse [Q8CFE4-2]
uc007gsm.1 mouse [Q8CFE4-1]

Organism-specific databases

CTDi55681
MGIiMGI:1289172 Scyl2

Phylogenomic databases

eggNOGiKOG2137 Eukaryota
ENOG410XQ9T LUCA
GeneTreeiENSGT00880000138031
HOGENOMiHOG000013212
HOVERGENiHBG055627
InParanoidiQ8CFE4
KOiK17541
OrthoDBiEOG091G01WY
PhylomeDBiQ8CFE4
TreeFamiTF314178

Miscellaneous databases

ChiTaRSiScyl2 mouse
PROiPR:Q8CFE4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069539 Expressed in 237 organ(s), highest expression level in secondary oocyte
CleanExiMM_SCYL2
ExpressionAtlasiQ8CFE4 baseline and differential
GenevisibleiQ8CFE4 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCYL2_MOUSE
AccessioniPrimary (citable) accession number: Q8CFE4
Secondary accession number(s): Q3UT57, Q3UWU9, Q8K0M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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