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Entry version 130 (12 Aug 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Myelin transcription factor 1

Gene

Myt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri21 – 64CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri435 – 478CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri479 – 522CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri793 – 836CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri837 – 880CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri886 – 929CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri939 – 982CCHHC-type 7PROSITE-ProRule annotationAdd BLAST44

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin transcription factor 1
Short name:
MyT1
Alternative name(s):
Neural zinc finger factor 2
Short name:
NZF-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myt1
Synonyms:Kiaa0835, Nzf2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1100535, Myt1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000966771 – 1127Myelin transcription factor 1Add BLAST1127

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CFC2

PRoteomics IDEntifications database

More...
PRIDEi
Q8CFC2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CFC2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CFC2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is more predominant than isoform 2 at all stages of development and adulthood. Expressed in differentiated neurons especially at higher levels in newly generated ones.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 1 is detected in the earliest born neurons. At 9.5 dpc it is detected in the ventrolateral part of the spinal cord, which later become motor neurons and is also detected in the dispersed cells of the alar plate interneurons. During spinal cord development, the expression is highest in the latest born neurons (the subventricular zone). Detected in the early differentiated neurons within the neuroepithelium and the neural crest cells at 9.5 dpc. At 12.5 dpc, detected in the differentiated neurons within the forebrain, midbrain, and hindbrain. In these neurons, the expression level is highest in the latest born neurons and is also detected in the differentiated neurons of the sensory organs and the peripheral ganglia.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000010505, Expressed in pituitary gland and 178 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CFC2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CFC2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with STEAP3.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
201678, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000079900

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8CFC2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CFC2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8CFC2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi210 – 307Glu-richAdd BLAST98
Compositional biasi687 – 725Ser-richAdd BLAST39

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MYT1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri21 – 64CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri435 – 478CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri479 – 522CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri793 – 836CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri837 – 880CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri886 – 929CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri939 – 982CCHHC-type 7PROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3803, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156364

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CFC2

KEGG Orthology (KO)

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KOi
K23192

Identification of Orthologs from Complete Genome Data

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OMAi
IRLPHMD

Database of Orthologous Groups

More...
OrthoDBi
116799at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013681, Myelin_TF
IPR002515, Znf_C2H2C
IPR036060, Znf_C2H2C_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08474, MYT1, 2 hits
PF01530, zf-C2HC, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103637, SSF103637, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51802, ZF_CCHHC, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CFC2-1) [UniParc]FASTAAdd to basket
Also known as: NZF-2b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSESDDKRA RTRSKTLRGP PETTGADLSC PTPGCTGSGH VRGKYSRHRS
60 70 80 90 100
LQSCPLAKKR KLEDAETEHL VSKRKSHPLR LALDEGYRMD SDGSEDAEVK
110 120 130 140 150
DVSVSDESEG PLEEAEAEMS GQEEIHHPQT AEGKSLIKPH FDSNPTSSPS
160 170 180 190 200
GFSKSSYSSY QGIIATSLLN LGQIAEEALV KEDSVSVAKL SPTVVHQLQD
210 220 230 240 250
EAAMGVNSDE GEKDLFIQPE DVEEVIEVTS ERSQEPCPQS LKDMVSEESS
260 270 280 290 300
KQKGVLGHEE EGEEEEEDEE EEDEEEEEEG EEGEEEEEEE EEEEEEEDEE
310 320 330 340 350
EEEEEEEAAP NVIFGEDTSH TSVQKASPEF RGPELSSPKP EYSVIVEVRS
360 370 380 390 400
DDDKDEDSRS QKSAVTDESE MYDMMTRGNL GLLEQAIALK AEQVRAVCES
410 420 430 440 450
GCPPAEQGHL GPGEPGKMAK PLDVVRKSCY SKDPSRVEKR EIKCPTPGCD
460 470 480 490 500
GTGHVTGLYP HHRSLSGCPH KDRIPPEILA MHENVLKCPT PGCTGQGHVN
510 520 530 540 550
SNRNTHRSLS GCPIAAAEKL AKSHEKQQLQ TGDPPKNNSN SDRILRPMCF
560 570 580 590 600
VKQLEVPPYG SYRPNVAPAT PRANLAKELE KFSKVTFDYA SFDAQVFGKR
610 620 630 640 650
MLAPKIQTSE TSPKAFQCFD YSHDAEAAHM AATAILNLST RCWEMPENLS
660 670 680 690 700
TKPQDLPSKA VDIEVDENGT LDLSMHKHRK RENTFPSSSS CSSSPGVKSP
710 720 730 740 750
DVSQRQSSTS APSSSMTSPQ SSQASRQDEW DRPLDYTKPS RLREEEPEES
760 770 780 790 800
EPAAHSFASS EADDQEVSEE NFEERKYPGE VTLTNFKLKF LSKDIKKELL
810 820 830 840 850
TCPTPGCDGS GHITGNYASH RSLSGCPLAD KSLRNLMAAH SADLKCPTPG
860 870 880 890 900
CDGSGHITGN YASHRSLSGC PRAKKSGLKV APTKDDKEDP ELMKCPVPGC
910 920 930 940 950
VGLGHISGKY ASHRSASGCP LAARRQKEGA LNGSSFSWKS LKNEGPTCPT
960 970 980 990 1000
PGCDGSGHAN GSFLTHRSLS GCPRATFAGK KGKLSGDEIL SPKFKTSDVL
1010 1020 1030 1040 1050
ENDEEIKQLN QEIRDLNESN SEMEAAMVQL QSQISSMEKN LKNIEEENKL
1060 1070 1080 1090 1100
IEEQNEALFL ELSGLSQALI QSLANIRLPH MEPICEQNFD AYVNTLTDMY
1110 1120
SNQDCYQNPE NKGLLETIKQ AVRGIQV
Length:1,127
Mass (Da):123,576
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB46958837E50008
GO
Isoform 2 (identifier: Q8CFC2-2) [UniParc]FASTAAdd to basket
Also known as: NZF-2a

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: MSSESDDKRA...SNPTSSPSGF → MMDGIGIRTE...LQPHKQPFWL

Show »
Length:1,078
Mass (Da):118,701
Checksum:i6D414F1AE89BE01A
GO
Isoform 3 (identifier: Q8CFC2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     508-545: Missing.

Show »
Length:1,089
Mass (Da):119,547
Checksum:i13E8D20C1F5FFACA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0R0C1B0R0C1_MOUSE
Myelin transcription factor 1
Myt1
1,169Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SWU2F6SWU2_MOUSE
Myelin transcription factor 1
Myt1
787Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CGS5F7CGS5_MOUSE
Myelin transcription factor 1
Myt1
604Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0R0C6B0R0C6_MOUSE
Myelin transcription factor 1
Myt1
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GXW7V9GXW7_MOUSE
Myelin transcription factor 1
Myt1
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC41451 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti238P → R in AAC53456 (PubMed:9373037).Curated1
Sequence conflicti446T → A in AAC53456 (PubMed:9373037).Curated1
Sequence conflicti502N → Y in AAC53456 (PubMed:9373037).Curated1
Sequence conflicti701D → G in AAC53456 (PubMed:9373037).Curated1
Sequence conflicti879K → R in AAC53456 (PubMed:9373037).Curated1
Sequence conflicti1022E → G in AAC53456 (PubMed:9373037).Curated1
Sequence conflicti1039K → R in AAC53456 (PubMed:9373037).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0157201 – 152MSSES…SPSGF → MMDGIGIRTEKYQSNLAKID SFLVFESRQKADRMAYSSFP YFLSYSAESGQVGIGGELAT VGSRDLETFPHALFKAPLFL VLCRKKPHQAPFLLQPHKQP FWL in isoform 2. 1 PublicationAdd BLAST152
Alternative sequenceiVSP_015721508 – 545Missing in isoform 3. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF004294 mRNA Translation: AAC53456.1
AB082378 mRNA Translation: BAC16512.1
AB093267 mRNA Translation: BAC41451.2 Different initiation.
AL845173 Genomic DNA No translation available.
BC063252 mRNA Translation: AAH63252.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17223.1 [Q8CFC2-1]
CCDS50857.1 [Q8CFC2-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
T42712

NCBI Reference Sequences

More...
RefSeqi
NP_001165086.1, NM_001171615.1
NP_001165087.1, NM_001171616.1 [Q8CFC2-3]
NP_032691.2, NM_008665.4 [Q8CFC2-1]
XP_006500640.2, XM_006500577.3 [Q8CFC2-1]
XP_006500642.2, XM_006500579.3 [Q8CFC2-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000108756; ENSMUSP00000104387; ENSMUSG00000010505 [Q8CFC2-1]
ENSMUST00000108757; ENSMUSP00000104388; ENSMUSG00000010505 [Q8CFC2-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
17932

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:17932

UCSC genome browser

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UCSCi
uc008ons.2, mouse [Q8CFC2-1]
uc012cmw.1, mouse [Q8CFC2-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004294 mRNA Translation: AAC53456.1
AB082378 mRNA Translation: BAC16512.1
AB093267 mRNA Translation: BAC41451.2 Different initiation.
AL845173 Genomic DNA No translation available.
BC063252 mRNA Translation: AAH63252.1
CCDSiCCDS17223.1 [Q8CFC2-1]
CCDS50857.1 [Q8CFC2-3]
PIRiT42712
RefSeqiNP_001165086.1, NM_001171615.1
NP_001165087.1, NM_001171616.1 [Q8CFC2-3]
NP_032691.2, NM_008665.4 [Q8CFC2-1]
XP_006500640.2, XM_006500577.3 [Q8CFC2-1]
XP_006500642.2, XM_006500579.3 [Q8CFC2-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JX1NMR-A843-873[»]
2JYDNMR-A837-878[»]
2MF8NMR-A792-878[»]
SMRiQ8CFC2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi201678, 1 interactor
STRINGi10090.ENSMUSP00000079900

PTM databases

iPTMnetiQ8CFC2
PhosphoSitePlusiQ8CFC2

Proteomic databases

PaxDbiQ8CFC2
PRIDEiQ8CFC2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1424, 290 antibodies

Genome annotation databases

EnsembliENSMUST00000108756; ENSMUSP00000104387; ENSMUSG00000010505 [Q8CFC2-1]
ENSMUST00000108757; ENSMUSP00000104388; ENSMUSG00000010505 [Q8CFC2-3]
GeneIDi17932
KEGGimmu:17932
UCSCiuc008ons.2, mouse [Q8CFC2-1]
uc012cmw.1, mouse [Q8CFC2-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4661
MGIiMGI:1100535, Myt1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG3803, Eukaryota
GeneTreeiENSGT00940000156364
InParanoidiQ8CFC2
KOiK23192
OMAiIRLPHMD
OrthoDBi116799at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
17932, 2 hits in 20 CRISPR screens
EvolutionaryTraceiQ8CFC2

Protein Ontology

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PROi
PR:Q8CFC2
RNActiQ8CFC2, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000010505, Expressed in pituitary gland and 178 other tissues
ExpressionAtlasiQ8CFC2, baseline and differential
GenevisibleiQ8CFC2, MM

Family and domain databases

InterProiView protein in InterPro
IPR013681, Myelin_TF
IPR002515, Znf_C2H2C
IPR036060, Znf_C2H2C_sf
PfamiView protein in Pfam
PF08474, MYT1, 2 hits
PF01530, zf-C2HC, 7 hits
SUPFAMiSSF103637, SSF103637, 7 hits
PROSITEiView protein in PROSITE
PS51802, ZF_CCHHC, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYT1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CFC2
Secondary accession number(s): B0R0C3
, B0R0C4, O08995, Q8CFH1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2003
Last modified: August 12, 2020
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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