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UniProtKB - Q8CFB4 (GBP5_MOUSE)

Entry version 141 (07 Oct 2020)
Sequence version 2 (27 Jul 2011)
Previous versions | rss
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Protein

Guanylate-binding protein 5

Gene

Gbp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, inflammasome activating agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, such as GBP1 and GBP2, does not produce GMP (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi45 – 52GTPBy similarity8
Nucleotide bindingi67 – 69GTPBy similarity3
Nucleotide bindingi97 – 101GTPBy similarity5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntimicrobial, Hydrolase
Biological processImmunity, Inflammatory response
LigandGTP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanylate-binding protein 5 (EC:3.6.5.-By similarity)
Alternative name(s):
GTP-binding protein 5
Short name:
GBP-5
Short name:
MuGBP-5
Guanine nucleotide-binding protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gbp5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2429943, Gbp5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant mice exhibit impaired host defense and NLRP3-dependent inflammatory responses. During LPS-induced sepsis, knockout animals show 60 to 75% reduction in IL1B and IL-18 serum levels compared to wild-type mice. Orogastric challenge with Listeria monocytogenes leads to higher bacterial burdens, discernible weight loss, and 50 to 80% fewer leukocytes expressing active CASP1 in mesenteric lymph nodes compared to wild-type counterparts.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001909701 – 587Guanylate-binding protein 5Add BLAST587
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000370786588 – 590Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei587Cysteine methyl esterSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi587S-geranylgeranyl cysteineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoprenylation is required for proper subcellular location.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8CFB4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8CFB4

PRoteomics IDEntifications database

More...PRIDEi		Q8CFB4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8CFB4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8CFB4

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8CFB4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Low expression, if any, in many tissues in the absence of stimulation.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Strongly up-regulated by IFNG and, at lower levels, by LPS. The LPS-induced increase is attenuated in the presence of dexamethasone. Up-regulated by TNF in certain strains. Up-regulation by a combination of IFNG and TNF is synergistic, even in strains that do not respond to TNF alone.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000105504, Expressed in spleen and 48 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Heterodimer with other family members, including GBP1, GBP2, GBP3 and GBP4 (By similarity). Dimerization is nucleotide-dependent (By similarity). Dimerization regulates subcellular location. May also form tetramers (dimer of dimers) in the presence of GTP (By similarity).

Interacts with NLRP3, possibly in its tetrameric form, and promotes PYCARD/ASC polymerization (PubMed:22461501).

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8CFB4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8CFB4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 277GB1/RHD3-type GPROSITE-ProRule annotationAdd BLAST243

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 310GTPase domain (Globular)By similarityAdd BLAST310
Regioni1 – 306NLRP3-bindingBy similarityAdd BLAST306
Regioni529 – 590Required for tetramerization, but not for dimerizationBy similarityAdd BLAST62

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162684

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018608_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8CFB4

KEGG Orthology (KO)

More...KOi		K20898

Identification of Orthologs from Complete Genome Data

More...OMAi		ICPDLVW

TreeFam database of animal gene trees

More...TreeFami		TF331602

Family and domain databases

Conserved Domains Database

More...CDDi		cd16269, GBP_C, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030386, G_GB1_RHD3_dom
IPR037684, GBP_C
IPR003191, Guanylate-bd/ATL_C
IPR036543, Guanylate-bd_C_sf
IPR015894, Guanylate-bd_N
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02263, GBP, 1 hit
PF02841, GBP_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48340, SSF48340, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51715, G_GB1_RHD3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CFB4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPEIHMPEP LCLIGSTEGH LVTNQEALKI LSAITQPVVV VAIVGLYRTG 
        60         70         80         90        100
KSYLMNKLAG KEKGFSVGST VQSHTKGIWM WCVPHPQKPD HTLVLLDTEG 
       110        120        130        140        150
LGDVEKDDKK NDTQIFALAI LLSSTFVYNT MNKIDQGAID LLHNVTELTD 
       160        170        180        190        200
LLRTRNSSDS NQTEGEGPAD MSFFPDLVWT LRDFFLDLQA NGHAITSDEY 
       210        220        230        240        250
LENSLKLKQG SDERTQTFNL PRLCIQKFFP VKKCFVFDAP ALGSKLSQLP 
       260        270        280        290        300
TLSNEELNSD FVQDLSEFCS HIFTQSKTKT LPGGIQVNGP RLESLVLTYV 
       310        320        330        340        350
DAINSGALPS IENTVVTLAR RENSAAVQKA IGHYDQLMSE KVQLPTETLQ 
       360        370        380        390        400
ELLDLHRTCE REAIEIFRKH SFKDEGEFFQ KELESLLSAK QDEICKKNAD 
       410        420        430        440        450
ASAALCSTLL GSIFKPLEQE VAQEFYHKPG GHKLFLQRME QLKANYRQQP 
       460        470        480        490        500
GKGTQAEEVL QTYLNAKETV SRTILQTDQV LTDKEIQSKA EQERAEAARL 
       510        520        530        540        550
EAQRLEAIRI QEEQRKAEME RQHQEQLRQI ALEKARVAQE QQWILKQRAQ 
       560        570        580        590
EEADRIKAEQ EAQLRALQQQ LQHMREMNHH RRHHHDCVIS
Length:590
Mass (Da):66,930
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCEBC9CD65F183436
GO
Isoform 2 (identifier: Q8CFB4-2) [UniParc]FASTAAdd to basket
Also known as: GBP-5a

The sequence of this isoform differs from the canonical sequence as follows:
     64-175: Missing.
     551-590: EEADRIKAEQ...RRHHHDCVIS → GRCPVIWCLD...ALTRKVAGCL

Show »
Length:612
Mass (Da):68,036
Checksum:i9CA68C1BD7FF433E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BMN7Q8BMN7_MOUSE
Guanylate-binding protein 5
Gbp5
724Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti488 – 490SKA → T in AAN46362 (Ref. 2) Curated3
Sequence conflicti488S → K in AAN31451 (PubMed:12396730).Curated1
Sequence conflicti488S → K in AAN52282 (PubMed:12396730).Curated1
Sequence conflicti488S → K in AAH58555 (PubMed:15489334).Curated1
Sequence conflicti501E → K in AAN31451 (PubMed:12396730).Curated1
Sequence conflicti501E → K in AAN52282 (PubMed:12396730).Curated1
Sequence conflicti501E → K in AAH58555 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05788964 – 175Missing in isoform 2. Add BLAST112
Alternative sequenceiVSP_057890551 – 590EEADR…DCVIS → GRCPVIWCLDLLLAEDEGPK QDLSQKLCCFGQEGGRLSGA EDGAASEALWISPFPETAGL CIPHCHPSNLPSVESRSQGG SRRGLRHKPLRPGGPLCTHQ EGARLSGAEDGTASEALWLS PVLETVGLFIPHPHPCSLPS TDSRSEGGSRRGLRQKPLGL VDPCALTRKVAGCL in isoform 2. Add BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF422243 mRNA Translation: AAN31451.1
AF487898 mRNA Translation: AAN52282.1
AY128412 Genomic DNA Translation: AAN46362.1
AC102108 Genomic DNA No translation available.
BC058555 mRNA Translation: AAH58555.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS17877.1 [Q8CFB4-1]

NCBI Reference Sequences

More...RefSeqi		NP_705792.2, NM_153564.2 [Q8CFB4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000090127; ENSMUSP00000087587; ENSMUSG00000105504 [Q8CFB4-1]
ENSMUST00000197459; ENSMUSP00000142938; ENSMUSG00000105504 [Q8CFB4-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		229898

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:229898

UCSC genome browser

More...UCSCi		uc008rop.1, mouse [Q8CFB4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF422243 mRNA Translation: AAN31451.1
AF487898 mRNA Translation: AAN52282.1
AY128412 Genomic DNA Translation: AAN46362.1
AC102108 Genomic DNA No translation available.
BC058555 mRNA Translation: AAH58555.1
CCDSiCCDS17877.1 [Q8CFB4-1]
RefSeqiNP_705792.2, NM_153564.2 [Q8CFB4-1]

3D structure databases

SMRiQ8CFB4
ModBaseiSearch...

PTM databases

iPTMnetiQ8CFB4
PhosphoSitePlusiQ8CFB4
SwissPalmiQ8CFB4

Proteomic databases

EPDiQ8CFB4
PaxDbiQ8CFB4
PRIDEiQ8CFB4

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33615, 302 antibodies

Genome annotation databases

EnsembliENSMUST00000090127; ENSMUSP00000087587; ENSMUSG00000105504 [Q8CFB4-1]
ENSMUST00000197459; ENSMUSP00000142938; ENSMUSG00000105504 [Q8CFB4-2]
GeneIDi229898
KEGGimmu:229898
UCSCiuc008rop.1, mouse [Q8CFB4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		115362
MGIiMGI:2429943, Gbp5

Phylogenomic databases

GeneTreeiENSGT00940000162684
HOGENOMiCLU_018608_2_2_1
InParanoidiQ8CFB4
KOiK20898
OMAiICPDLVW
TreeFamiTF331602

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		229898, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Gbp5, mouse

Protein Ontology

More...PROi		PR:Q8CFB4
RNActiQ8CFB4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000105504, Expressed in spleen and 48 other tissues

Family and domain databases

CDDicd16269, GBP_C, 1 hit
InterProiView protein in InterPro
IPR030386, G_GB1_RHD3_dom
IPR037684, GBP_C
IPR003191, Guanylate-bd/ATL_C
IPR036543, Guanylate-bd_C_sf
IPR015894, Guanylate-bd_N
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF02263, GBP, 1 hit
PF02841, GBP_C, 1 hit
SUPFAMiSSF48340, SSF48340, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51715, G_GB1_RHD3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGBP5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CFB4
Secondary accession number(s): E9QJR4, Q8CFA4, Q8CFA8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: July 27, 2011
Last modified: October 7, 2020
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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