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Protein

Krueppel-like factor 17

Gene

Klf17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri256 – 280C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri286 – 310C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri316 – 338C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 17
Alternative name(s):
Germ cell-specific zinc finger protein
Zinc finger protein 393
Gene namesi
Name:Klf17
Synonyms:Gzf, Zfp393, Znf393
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2181068 Klf17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475561 – 341Krueppel-like factor 17Add BLAST341

Proteomic databases

PaxDbiQ8CFA7
PRIDEiQ8CFA7

PTM databases

PhosphoSitePlusiQ8CFA7

Expressioni

Tissue specificityi

Exclusively expressed in testis and ovary. Localized to step 3-8 spermatids in testis and growing oocytes in ovary.1 Publication

Gene expression databases

BgeeiENSMUSG00000048626 Expressed in 41 organ(s), highest expression level in secondary oocyte
CleanExiMM_KLF17
GenevisibleiQ8CFA7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052316

Structurei

3D structure databases

ProteinModelPortaliQ8CFA7
SMRiQ8CFA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri256 – 280C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri286 – 310C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri316 – 338C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000049152
HOVERGENiHBG080136
InParanoidiQ8CFA7
KOiK09211
OMAiWSFFRSD
OrthoDBiEOG091G0GDE
PhylomeDBiQ8CFA7
TreeFamiTF350556

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q8CFA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQDNKEQAM HQPPMDNKML VPVSNVPVSS GNSGFHQPPA TQYLPEMMRS
60 70 80 90 100
YMASAEELRC NEREWESQLI RSLPEHGVRC PSQLAPIPFQ NYCQRSIGRG
110 120 130 140 150
SHVMPVGSSG TLGVTISFSE NLMPQGGLPS SRGVSVMAHS SAPAMPYPMP
160 170 180 190 200
PTVPATTGSL KHGILLVPGM ASAGTHAVAP FMDQMLHSIN PCNPEMLPAR
210 220 230 240 250
FQQLLPLDSQ DSLVTESNTQ EEPFVREPPT PAPEGAESPS TSRGATRRQS
260 270 280 290 300
PVSRPYVCTY NSCGKSYTKR SHLVSHQRKH TGVKPFACDW NGCTWKFFRS
310 320 330 340
DELGRHKRIH TRYRPHKCDE CDREFMRSDH LRQHKRTHLP K
Length:341
Mass (Da):38,076
Last modified:November 8, 2005 - v2
Checksum:i03F400D4485DDE3A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141S → G in AAH64748 (PubMed:15489334).Curated1
Sequence conflicti165L → M in BAB31177 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508984 mRNA Translation: AAN31656.1
AK018361 mRNA Translation: BAB31177.1
AK139827 mRNA Translation: BAE24150.1
AL627128, AL671520 Genomic DNA Translation: CAM14707.1
AL671520, AL627128 Genomic DNA Translation: CAM27525.1
CH466552 Genomic DNA Translation: EDL30543.1
BC064748 mRNA Translation: AAH64748.1
CCDSiCCDS18537.1
RefSeqiNP_083692.2, NM_029416.2
UniGeneiMm.3848

Genome annotation databases

EnsembliENSMUST00000062747; ENSMUSP00000052316; ENSMUSG00000048626
GeneIDi75753
KEGGimmu:75753
UCSCiuc008uix.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508984 mRNA Translation: AAN31656.1
AK018361 mRNA Translation: BAB31177.1
AK139827 mRNA Translation: BAE24150.1
AL627128, AL671520 Genomic DNA Translation: CAM14707.1
AL671520, AL627128 Genomic DNA Translation: CAM27525.1
CH466552 Genomic DNA Translation: EDL30543.1
BC064748 mRNA Translation: AAH64748.1
CCDSiCCDS18537.1
RefSeqiNP_083692.2, NM_029416.2
UniGeneiMm.3848

3D structure databases

ProteinModelPortaliQ8CFA7
SMRiQ8CFA7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052316

PTM databases

PhosphoSitePlusiQ8CFA7

Proteomic databases

PaxDbiQ8CFA7
PRIDEiQ8CFA7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062747; ENSMUSP00000052316; ENSMUSG00000048626
GeneIDi75753
KEGGimmu:75753
UCSCiuc008uix.1 mouse

Organism-specific databases

CTDi128209
MGIiMGI:2181068 Klf17

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000049152
HOVERGENiHBG080136
InParanoidiQ8CFA7
KOiK09211
OMAiWSFFRSD
OrthoDBiEOG091G0GDE
PhylomeDBiQ8CFA7
TreeFamiTF350556

Miscellaneous databases

ChiTaRSiKlf17 mouse
PROiPR:Q8CFA7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048626 Expressed in 41 organ(s), highest expression level in secondary oocyte
CleanExiMM_KLF17
GenevisibleiQ8CFA7 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLF17_MOUSE
AccessioniPrimary (citable) accession number: Q8CFA7
Secondary accession number(s): B1ASI5
, Q3UT30, Q6P233, Q9D351
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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