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UniProtKB - Q8CF89 (TAB1_MOUSE)

Entry version 134 (25 May 2022)
Sequence version 2 (25 Oct 2005)
Previous versions | rss
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Protein

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Gene

Tab1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Caution

Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphatase activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei482Required for interaction with MAP3K7By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-168638, NOD1/2 Signaling Pathway
R-MMU-2871837, FCERI mediated NF-kB activation
R-MMU-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-MMU-450302, activated TAK1 mediates p38 MAPK activation
R-MMU-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-MMU-5357956, TNFR1-induced NFkappaB signaling pathway
R-MMU-5607764, CLEC7A (Dectin-1) signaling
R-MMU-5689880, Ub-specific processing proteases
R-MMU-9020702, Interleukin-1 signaling
R-MMU-937042, IRAK2 mediated activation of TAK1 complex
R-MMU-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-MMU-9645460, Alpha-protein kinase 1 signaling pathway
R-MMU-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Alternative name(s):
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
TGF-beta-activated kinase 1-binding protein 1
Short name:
TAK1-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tab1
Synonyms:Map3k7ip1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1913763, Tab1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000022414

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000577981 – 502TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Add BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7PhosphoserineCombined sources1
Modified residuei436PhosphoserineBy similarity1
Modified residuei440PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Monoubiquitinated.By similarity

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8CF89

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8CF89

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8CF89

PeptideAtlas

More...PeptideAtlasi		Q8CF89

PRoteomics IDEntifications database

More...PRIDEi		Q8CF89

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		253463

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8CF89

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8CF89

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000022414, Expressed in ear vesicle and 254 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8CF89, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8CF89, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with XIAP and BIRC7.

Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		211528, 12 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q8CF89

Protein interaction database and analysis system

More...IntActi		Q8CF89, 12 interactors

Molecular INTeraction database

More...MINTi		Q8CF89

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000023050

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8CF89, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8CF89

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8CF89

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 365PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST338

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21
Regioni414 – 476DisorderedSequence analysisAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 20Polar residuesSequence analysisAdd BLAST20
Compositional biasi414 – 460Polar residuesSequence analysisAdd BLAST47

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0698, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00510000048276

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027717_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8CF89

Identification of Orthologs from Complete Genome Data

More...OMAi		NTRCLGN

Database of Orthologous Groups

More...OrthoDBi		755673at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8CF89

TreeFam database of animal gene trees

More...TreeFami		TF317785

Family and domain databases

Conserved Domains Database

More...CDDi		cd00143, PP2Cc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.60.40.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID50233

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015655, PP2C
IPR036457, PPM-type_dom_sf
IPR001932, PPM-type_phosphatase_dom

The PANTHER Classification System

More...PANTHERi		PTHR13832, PTHR13832, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00481, PP2C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00332, PP2Cc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81606, SSF81606, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51746, PPM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8CF89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE 
        60         70         80         90        100
DNWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNTEHTEA 
       110        120        130        140        150
DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK 
       160        170        180        190        200
ILERLKALER EISGGAMAVV AVLLNSKLYV ANVGTNRALL CKSTVDGLQV 
       210        220        230        240        250
TQLNMDHTTE NEDELFRLSQ LGLDAGKIKQ MGVICGQEST RRIGDYKVKY 
       260        270        280        290        300
GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH 
       310        320        330        340        350
GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAK 
       360        370        380        390        400
FCPRHEDMTL LVRNFGYPLG EMSQPTPTPA PGGRVYPVSV PYSSAQSTSK 
       410        420        430        440        450
TSVTLSLVMP SQGQMVNGSH SASTLDEATP TLTNQSPTLT LQSTNTHTQS 
       460        470        480        490        500
SSSSSDGGLF RSRPAHSLPP GEDGRVEPYV DFAEFYRLWS VDHGEQSVMT 

AP
Length:502
Mass (Da):54,616
Last modified:October 25, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7529D2E3CF30696
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VK36A0A2R8VK36_MOUSE
TGF-beta-activated kinase 1 and MAP...
Tab1
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti199Q → H in BAC43729 (PubMed:12464436).Curated1
Sequence conflicti210 – 212ENE → DND in BAC43729 (PubMed:12464436).Curated3
Sequence conflicti323L → P in BAC43729 (PubMed:12464436).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB088136 mRNA Translation: BAC43729.1
BC027054 mRNA Translation: AAH27054.1
BC041110 mRNA Translation: AAH41110.1
BC054369 mRNA Translation: AAH54369.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS27659.1

NCBI Reference Sequences

More...RefSeqi		NP_079885.2, NM_025609.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000023050; ENSMUSP00000023050; ENSMUSG00000022414

Database of genes from NCBI RefSeq genomes

More...GeneIDi		66513

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:66513

UCSC genome browser

More...UCSCi		uc007wve.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB088136 mRNA Translation: BAC43729.1
BC027054 mRNA Translation: AAH27054.1
BC041110 mRNA Translation: AAH41110.1
BC054369 mRNA Translation: AAH54369.1
CCDSiCCDS27659.1
RefSeqiNP_079885.2, NM_025609.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LOOX-ray1.95B384-412[»]
4LOPX-ray2.05K/L/M/N384-412[»]
4LOQX-ray2.32K/L/M/N384-412[»]
AlphaFoldDBiQ8CF89
SMRiQ8CF89
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi211528, 12 interactors
ELMiQ8CF89
IntActiQ8CF89, 12 interactors
MINTiQ8CF89
STRINGi10090.ENSMUSP00000023050

PTM databases

iPTMnetiQ8CF89
PhosphoSitePlusiQ8CF89

Proteomic databases

EPDiQ8CF89
MaxQBiQ8CF89
PaxDbiQ8CF89
PeptideAtlasiQ8CF89
PRIDEiQ8CF89
ProteomicsDBi253463

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12659, 633 antibodies from 44 providers

The DNASU plasmid repository

More...DNASUi		66513

Genome annotation databases

EnsembliENSMUST00000023050; ENSMUSP00000023050; ENSMUSG00000022414
GeneIDi66513
KEGGimmu:66513
UCSCiuc007wve.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10454
MGIiMGI:1913763, Tab1
VEuPathDBiHostDB:ENSMUSG00000022414

Phylogenomic databases

eggNOGiKOG0698, Eukaryota
GeneTreeiENSGT00510000048276
HOGENOMiCLU_027717_1_0_1
InParanoidiQ8CF89
OMAiNTRCLGN
OrthoDBi755673at2759
PhylomeDBiQ8CF89
TreeFamiTF317785

Enzyme and pathway databases

ReactomeiR-MMU-168638, NOD1/2 Signaling Pathway
R-MMU-2871837, FCERI mediated NF-kB activation
R-MMU-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-MMU-450302, activated TAK1 mediates p38 MAPK activation
R-MMU-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-MMU-5357956, TNFR1-induced NFkappaB signaling pathway
R-MMU-5607764, CLEC7A (Dectin-1) signaling
R-MMU-5689880, Ub-specific processing proteases
R-MMU-9020702, Interleukin-1 signaling
R-MMU-937042, IRAK2 mediated activation of TAK1 complex
R-MMU-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-MMU-9645460, Alpha-protein kinase 1 signaling pathway
R-MMU-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		66513, 15 hits in 74 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Tab1, mouse

Protein Ontology

More...PROi		PR:Q8CF89
RNActiQ8CF89, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000022414, Expressed in ear vesicle and 254 other tissues
ExpressionAtlasiQ8CF89, baseline and differential
GenevisibleiQ8CF89, MM

Family and domain databases

CDDicd00143, PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
IDEALiIID50233
InterProiView protein in InterPro
IPR015655, PP2C
IPR036457, PPM-type_dom_sf
IPR001932, PPM-type_phosphatase_dom
PANTHERiPTHR13832, PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481, PP2C, 1 hit
SMARTiView protein in SMART
SM00332, PP2Cc, 1 hit
SUPFAMiSSF81606, SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746, PPM_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAB1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CF89
Secondary accession number(s): Q7TQJ5, Q80V65, Q8R0D1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: May 25, 2022
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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