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UniProtKB - Q8CF89 (TAB1_MOUSE)
Protein
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Gene
Tab1
Organism
Mus musculus (Mouse)
Status
Functioni
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Caution
Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphatase activity.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 482 | Required for interaction with MAP3K7By similarity | 1 |
GO - Molecular functioni
- kinase activator activity Source: MGI
- mitogen-activated protein kinase p38 binding Source: MGI
- phosphatase activity Source: InterPro
- protein-containing complex binding Source: MGI
GO - Biological processi
- aorta development Source: MGI
- cardiac septum development Source: MGI
- coronary vasculature development Source: MGI
- heart morphogenesis Source: MGI
- in utero embryonic development Source: MGI
- lung development Source: MGI
- positive regulation of MAPK cascade Source: MGI
- positive regulation of MAP kinase activity Source: MGI
- positive regulation of protein serine/threonine kinase activity Source: MGI
- transforming growth factor beta receptor signaling pathway Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-168638, NOD1/2 Signaling Pathway R-MMU-2871837, FCERI mediated NF-kB activation R-MMU-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-MMU-450302, activated TAK1 mediates p38 MAPK activation R-MMU-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-MMU-5357956, TNFR1-induced NFkappaB signaling pathway R-MMU-5607764, CLEC7A (Dectin-1) signaling R-MMU-5689880, Ub-specific processing proteases R-MMU-9020702, Interleukin-1 signaling R-MMU-937042, IRAK2 mediated activation of TAK1 complex R-MMU-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex R-MMU-9645460, Alpha-protein kinase 1 signaling pathway R-MMU-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
Names & Taxonomyi
Protein namesi | Recommended name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Alternative name(s): Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 TGF-beta-activated kinase 1-binding protein 1 Short name: TAK1-binding protein 1 |
Gene namesi | Name:Tab1 Synonyms:Map3k7ip1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1913763, Tab1 |
VEuPathDBi | HostDB:ENSMUSG00000022414 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Nucleus
- nuclear speck Source: MGI
- nucleus Source: GO_Central
Other locations
- protein-containing complex Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057798 | 1 – 502 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Add BLAST | 502 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 7 | PhosphoserineCombined sources | 1 | |
Modified residuei | 436 | PhosphoserineBy similarity | 1 | |
Modified residuei | 440 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Monoubiquitinated.By similarity
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8CF89 |
MaxQBi | Q8CF89 |
PaxDbi | Q8CF89 |
PeptideAtlasi | Q8CF89 |
PRIDEi | Q8CF89 |
ProteomicsDBi | 253463 |
PTM databases
iPTMneti | Q8CF89 |
PhosphoSitePlusi | Q8CF89 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000022414, Expressed in ear vesicle and 254 other tissues |
ExpressionAtlasi | Q8CF89, baseline and differential |
Genevisiblei | Q8CF89, MM |
Interactioni
Subunit structurei
Interacts with XIAP and BIRC7.
Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 (By similarity).
By similarityBinary interactionsi
Q8CF89
With | #Exp. | IntAct |
---|---|---|
Map3k1 [P53349] | 4 | EBI-1778503,EBI-447913 |
Map3k7 [Q62073] | 2 | EBI-1778503,EBI-1775345 |
VRK2 - isoform 1 [Q86Y07-1] from Homo sapiens. | 2 | EBI-1778503,EBI-1207633 |
GO - Molecular functioni
- mitogen-activated protein kinase p38 binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 211528, 12 interactors |
ELMi | Q8CF89 |
IntActi | Q8CF89, 12 interactors |
MINTi | Q8CF89 |
STRINGi | 10090.ENSMUSP00000023050 |
Miscellaneous databases
RNActi | Q8CF89, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 365 | PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST | 338 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 414 – 476 | DisorderedSequence analysisAdd BLAST | 63 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 20 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 414 – 460 | Polar residuesSequence analysisAdd BLAST | 47 |
Phylogenomic databases
eggNOGi | KOG0698, Eukaryota |
GeneTreei | ENSGT00510000048276 |
HOGENOMi | CLU_027717_1_0_1 |
InParanoidi | Q8CF89 |
OMAi | NTRCLGN |
OrthoDBi | 755673at2759 |
PhylomeDBi | Q8CF89 |
TreeFami | TF317785 |
Family and domain databases
CDDi | cd00143, PP2Cc, 1 hit |
Gene3Di | 3.60.40.10, 1 hit |
IDEALi | IID50233 |
InterProi | View protein in InterPro IPR015655, PP2C IPR036457, PPM-type_dom_sf IPR001932, PPM-type_phosphatase_dom |
PANTHERi | PTHR13832, PTHR13832, 1 hit |
Pfami | View protein in Pfam PF00481, PP2C, 1 hit |
SMARTi | View protein in SMART SM00332, PP2Cc, 1 hit |
SUPFAMi | SSF81606, SSF81606, 1 hit |
PROSITEi | View protein in PROSITE PS51746, PPM_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8CF89-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE
60 70 80 90 100
DNWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNTEHTEA
110 120 130 140 150
DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK
160 170 180 190 200
ILERLKALER EISGGAMAVV AVLLNSKLYV ANVGTNRALL CKSTVDGLQV
210 220 230 240 250
TQLNMDHTTE NEDELFRLSQ LGLDAGKIKQ MGVICGQEST RRIGDYKVKY
260 270 280 290 300
GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH
310 320 330 340 350
GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAK
360 370 380 390 400
FCPRHEDMTL LVRNFGYPLG EMSQPTPTPA PGGRVYPVSV PYSSAQSTSK
410 420 430 440 450
TSVTLSLVMP SQGQMVNGSH SASTLDEATP TLTNQSPTLT LQSTNTHTQS
460 470 480 490 500
SSSSSDGGLF RSRPAHSLPP GEDGRVEPYV DFAEFYRLWS VDHGEQSVMT
AP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8VK36 | A0A2R8VK36_MOUSE | TGF-beta-activated kinase 1 and MAP... | Tab1 | 105 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 199 | Q → H in BAC43729 (PubMed:12464436).Curated | 1 | |
Sequence conflicti | 210 – 212 | ENE → DND in BAC43729 (PubMed:12464436).Curated | 3 | |
Sequence conflicti | 323 | L → P in BAC43729 (PubMed:12464436).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB088136 mRNA Translation: BAC43729.1 BC027054 mRNA Translation: AAH27054.1 BC041110 mRNA Translation: AAH41110.1 BC054369 mRNA Translation: AAH54369.1 |
CCDSi | CCDS27659.1 |
RefSeqi | NP_079885.2, NM_025609.2 |
Genome annotation databases
Ensembli | ENSMUST00000023050; ENSMUSP00000023050; ENSMUSG00000022414 |
GeneIDi | 66513 |
KEGGi | mmu:66513 |
UCSCi | uc007wve.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB088136 mRNA Translation: BAC43729.1 BC027054 mRNA Translation: AAH27054.1 BC041110 mRNA Translation: AAH41110.1 BC054369 mRNA Translation: AAH54369.1 |
CCDSi | CCDS27659.1 |
RefSeqi | NP_079885.2, NM_025609.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4LOO | X-ray | 1.95 | B | 384-412 | [»] | |
4LOP | X-ray | 2.05 | K/L/M/N | 384-412 | [»] | |
4LOQ | X-ray | 2.32 | K/L/M/N | 384-412 | [»] | |
AlphaFoldDBi | Q8CF89 | |||||
SMRi | Q8CF89 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 211528, 12 interactors |
ELMi | Q8CF89 |
IntActi | Q8CF89, 12 interactors |
MINTi | Q8CF89 |
STRINGi | 10090.ENSMUSP00000023050 |
PTM databases
iPTMneti | Q8CF89 |
PhosphoSitePlusi | Q8CF89 |
Proteomic databases
EPDi | Q8CF89 |
MaxQBi | Q8CF89 |
PaxDbi | Q8CF89 |
PeptideAtlasi | Q8CF89 |
PRIDEi | Q8CF89 |
ProteomicsDBi | 253463 |
Protocols and materials databases
Antibodypediai | 12659, 633 antibodies from 44 providers |
DNASUi | 66513 |
Genome annotation databases
Ensembli | ENSMUST00000023050; ENSMUSP00000023050; ENSMUSG00000022414 |
GeneIDi | 66513 |
KEGGi | mmu:66513 |
UCSCi | uc007wve.1, mouse |
Organism-specific databases
CTDi | 10454 |
MGIi | MGI:1913763, Tab1 |
VEuPathDBi | HostDB:ENSMUSG00000022414 |
Phylogenomic databases
eggNOGi | KOG0698, Eukaryota |
GeneTreei | ENSGT00510000048276 |
HOGENOMi | CLU_027717_1_0_1 |
InParanoidi | Q8CF89 |
OMAi | NTRCLGN |
OrthoDBi | 755673at2759 |
PhylomeDBi | Q8CF89 |
TreeFami | TF317785 |
Enzyme and pathway databases
Reactomei | R-MMU-168638, NOD1/2 Signaling Pathway R-MMU-2871837, FCERI mediated NF-kB activation R-MMU-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-MMU-450302, activated TAK1 mediates p38 MAPK activation R-MMU-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-MMU-5357956, TNFR1-induced NFkappaB signaling pathway R-MMU-5607764, CLEC7A (Dectin-1) signaling R-MMU-5689880, Ub-specific processing proteases R-MMU-9020702, Interleukin-1 signaling R-MMU-937042, IRAK2 mediated activation of TAK1 complex R-MMU-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex R-MMU-9645460, Alpha-protein kinase 1 signaling pathway R-MMU-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
Miscellaneous databases
BioGRID-ORCSi | 66513, 15 hits in 74 CRISPR screens |
ChiTaRSi | Tab1, mouse |
PROi | PR:Q8CF89 |
RNActi | Q8CF89, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022414, Expressed in ear vesicle and 254 other tissues |
ExpressionAtlasi | Q8CF89, baseline and differential |
Genevisiblei | Q8CF89, MM |
Family and domain databases
CDDi | cd00143, PP2Cc, 1 hit |
Gene3Di | 3.60.40.10, 1 hit |
IDEALi | IID50233 |
InterProi | View protein in InterPro IPR015655, PP2C IPR036457, PPM-type_dom_sf IPR001932, PPM-type_phosphatase_dom |
PANTHERi | PTHR13832, PTHR13832, 1 hit |
Pfami | View protein in Pfam PF00481, PP2C, 1 hit |
SMARTi | View protein in SMART SM00332, PP2Cc, 1 hit |
SUPFAMi | SSF81606, SSF81606, 1 hit |
PROSITEi | View protein in PROSITE PS51746, PPM_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TAB1_MOUSE | |
Accessioni | Q8CF89Primary (citable) accession number: Q8CF89 Secondary accession number(s): Q7TQJ5, Q80V65, Q8R0D1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | October 25, 2005 | |
Last modified: | May 25, 2022 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references