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Protein

Ragulator complex protein LAMTOR4

Gene

Lamtor4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy
R-MMU-165159 mTOR signalling
R-MMU-166208 mTORC1-mediated signalling
R-MMU-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-MMU-5628897 TP53 Regulates Metabolic Genes
R-MMU-8943724 Regulation of PTEN gene transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR4
Alternative name(s):
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4
Cleaved into the following chain:
Gene namesi
Name:Lamtor4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1913346 Lamtor4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004244991 – 99Ragulator complex protein LAMTOR4Add BLAST99
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00003258422 – 99Ragulator complex protein LAMTOR4, N-terminally processedAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylthreonine; in Ragulator complex protein LAMTOR4, N-terminally processedBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8CF66
MaxQBiQ8CF66
PaxDbiQ8CF66
PRIDEiQ8CF66
TopDownProteomicsiQ8CF66

PTM databases

PhosphoSitePlusiQ8CF66

Expressioni

Gene expression databases

BgeeiENSMUSG00000050552 Expressed in 280 organ(s), highest expression level in white adipose tissue
CleanExiMM_0910001L09RIK
GenevisibleiQ8CF66 MM

Interactioni

Subunit structurei

Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8CF66, 1 interactor
STRINGi10090.ENSMUSP00000056693

Structurei

3D structure databases

SMRiQ8CF66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMTOR4 family.Curated

Phylogenomic databases

eggNOGiENOG410IZEZ Eukaryota
ENOG4112495 LUCA
GeneTreeiENSGT00390000016053
HOGENOMiHOG000047533
HOVERGENiHBG107668
InParanoidiQ8CF66
KOiK20399
OMAiDESFMPN
OrthoDBiEOG091G13XE
TreeFamiTF324352

Family and domain databases

InterProiView protein in InterPro
IPR034601 LAMTOR4
PANTHERiPTHR33967 PTHR33967, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CF66-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSALTQGLE RIPDQLGYLV LSEGAVLASS GDLENDEQAA SAISELVSTA
60 70 80 90
CGFQLHHGTN IPFKRLSVVF GEHTLLVTVS GQRVFVVKRQ NRGREPIDV
Length:99
Mass (Da):10,678
Last modified:March 18, 2008 - v2
Checksum:i177FF7B0CCF8BD9C
GO

Sequence cautioni

The sequence BAC24993 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC25020 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC25306 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81G → R in BAC24993 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002488 mRNA Translation: BAC24993.1 Different initiation.
AK003086 mRNA Translation: BAC25020.1 Different initiation.
AK010598 mRNA Translation: BAC25306.1 Different initiation.
BC144958 mRNA Translation: AAI44959.1
CCDSiCCDS39342.1
RefSeqiNP_001074577.1, NM_001081108.2
UniGeneiMm.206901

Genome annotation databases

EnsembliENSMUST00000062067; ENSMUSP00000056693; ENSMUSG00000050552
GeneIDi66096
KEGGimmu:66096
UCSCiuc009afd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002488 mRNA Translation: BAC24993.1 Different initiation.
AK003086 mRNA Translation: BAC25020.1 Different initiation.
AK010598 mRNA Translation: BAC25306.1 Different initiation.
BC144958 mRNA Translation: AAI44959.1
CCDSiCCDS39342.1
RefSeqiNP_001074577.1, NM_001081108.2
UniGeneiMm.206901

3D structure databases

SMRiQ8CF66
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CF66, 1 interactor
STRINGi10090.ENSMUSP00000056693

PTM databases

PhosphoSitePlusiQ8CF66

Proteomic databases

EPDiQ8CF66
MaxQBiQ8CF66
PaxDbiQ8CF66
PRIDEiQ8CF66
TopDownProteomicsiQ8CF66

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062067; ENSMUSP00000056693; ENSMUSG00000050552
GeneIDi66096
KEGGimmu:66096
UCSCiuc009afd.2 mouse

Organism-specific databases

CTDi389541
MGIiMGI:1913346 Lamtor4

Phylogenomic databases

eggNOGiENOG410IZEZ Eukaryota
ENOG4112495 LUCA
GeneTreeiENSGT00390000016053
HOGENOMiHOG000047533
HOVERGENiHBG107668
InParanoidiQ8CF66
KOiK20399
OMAiDESFMPN
OrthoDBiEOG091G13XE
TreeFamiTF324352

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy
R-MMU-165159 mTOR signalling
R-MMU-166208 mTORC1-mediated signalling
R-MMU-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-MMU-5628897 TP53 Regulates Metabolic Genes
R-MMU-8943724 Regulation of PTEN gene transcription

Miscellaneous databases

ChiTaRSiLamtor4 mouse
PROiPR:Q8CF66
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050552 Expressed in 280 organ(s), highest expression level in white adipose tissue
CleanExiMM_0910001L09RIK
GenevisibleiQ8CF66 MM

Family and domain databases

InterProiView protein in InterPro
IPR034601 LAMTOR4
PANTHERiPTHR33967 PTHR33967, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLTOR4_MOUSE
AccessioniPrimary (citable) accession number: Q8CF66
Secondary accession number(s): B7ZN18, Q8CEW4, Q8CF77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 12, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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