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Protein

Coiled-coil domain-containing protein 28B

Gene

Ccdc28b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex.1 Publication

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 28B
Gene namesi
Name:Ccdc28b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913514 Ccdc28b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340951 – 200Coiled-coil domain-containing protein 28BAdd BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei46PhosphoserineCombined sources1
Modified residuei115PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8CEG5
PaxDbiQ8CEG5
PeptideAtlasiQ8CEG5
PRIDEiQ8CEG5

PTM databases

iPTMnetiQ8CEG5
PhosphoSitePlusiQ8CEG5

Expressioni

Tissue specificityi

Expressed in the retina, pericardium and limb epithelium.1 Publication

Gene expression databases

BgeeiENSMUSG00000028795 Expressed in 250 organ(s), highest expression level in quadriceps femoris
CleanExiMM_CCDC28B
ExpressionAtlasiQ8CEG5 baseline and differential
GenevisibleiQ8CEG5 MM

Interactioni

Subunit structurei

Interacts with BBS1, BBS2, BBS4, BBS5, BBS6, BBS7 and TTC8/BBS8. Interacts with MAPKAP1/SIN1 isoform 1 and RICTOR (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030586

Structurei

3D structure databases

ProteinModelPortaliQ8CEG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili158 – 189Sequence analysisAdd BLAST32

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWRD Eukaryota
ENOG4111HYY LUCA
GeneTreeiENSGT00500000044870
HOGENOMiHOG000231321
HOVERGENiHBG061498
InParanoidiQ8CEG5
OMAiQRTKFKR
TreeFamiTF323549

Family and domain databases

InterProiView protein in InterPro
IPR025271 DUF4061
PfamiView protein in Pfam
PF13270 DUF4061, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8CEG5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDKKKKRSP KPCLTQPAQA PGTLRRVPVP TSHSGSLALG LPHLPSPKQR
60 70 80 90 100
AKFKRAGKEK CRPVLAGGGG GSAGTPLQHS FLTEVTDVYE MEGGLLNLLN
110 120 130 140 150
DFHSGRLQAF GKECSFEQLE HVREMQEKLA RLHFSLDVCG EEEDEEEEED
160 170 180 190 200
GVTEGLPEEQ KKTMADRNLD QLLSNLEDLS NSIQKLHLAE NAEPEDQPAA
Length:200
Mass (Da):22,033
Last modified:October 3, 2012 - v3
Checksum:i0D05C62109FC290A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9D1N8Q9D1N8_MOUSE
Coiled-coil domain-containing prote...
Ccdc28b
205Annotation score:
A2AE01A2AE01_MOUSE
Coiled-coil domain-containing prote...
Ccdc28b
104Annotation score:
E9Q567E9Q567_MOUSE
Coiled-coil domain-containing prote...
Ccdc28b
149Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17P → Q in BAE34319 (PubMed:16141072).Curated1
Sequence conflicti17P → Q in AAH28873 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028262 mRNA Translation: BAC25848.1
AK158016 mRNA Translation: BAE34319.1
AL671759 Genomic DNA No translation available.
BC028873 mRNA Translation: AAH28873.1
CCDSiCCDS18700.1
RefSeqiNP_079731.2, NM_025455.2
UniGeneiMm.383215

Genome annotation databases

EnsembliENSMUST00000030586; ENSMUSP00000030586; ENSMUSG00000028795
GeneIDi66264
KEGGimmu:66264
UCSCiuc008uxt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028262 mRNA Translation: BAC25848.1
AK158016 mRNA Translation: BAE34319.1
AL671759 Genomic DNA No translation available.
BC028873 mRNA Translation: AAH28873.1
CCDSiCCDS18700.1
RefSeqiNP_079731.2, NM_025455.2
UniGeneiMm.383215

3D structure databases

ProteinModelPortaliQ8CEG5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030586

PTM databases

iPTMnetiQ8CEG5
PhosphoSitePlusiQ8CEG5

Proteomic databases

MaxQBiQ8CEG5
PaxDbiQ8CEG5
PeptideAtlasiQ8CEG5
PRIDEiQ8CEG5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030586; ENSMUSP00000030586; ENSMUSG00000028795
GeneIDi66264
KEGGimmu:66264
UCSCiuc008uxt.1 mouse

Organism-specific databases

CTDi79140
MGIiMGI:1913514 Ccdc28b

Phylogenomic databases

eggNOGiENOG410IWRD Eukaryota
ENOG4111HYY LUCA
GeneTreeiENSGT00500000044870
HOGENOMiHOG000231321
HOVERGENiHBG061498
InParanoidiQ8CEG5
OMAiQRTKFKR
TreeFamiTF323549

Miscellaneous databases

ChiTaRSiCcdc28b mouse
PROiPR:Q8CEG5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028795 Expressed in 250 organ(s), highest expression level in quadriceps femoris
CleanExiMM_CCDC28B
ExpressionAtlasiQ8CEG5 baseline and differential
GenevisibleiQ8CEG5 MM

Family and domain databases

InterProiView protein in InterPro
IPR025271 DUF4061
PfamiView protein in Pfam
PF13270 DUF4061, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCC28B_MOUSE
AccessioniPrimary (citable) accession number: Q8CEG5
Secondary accession number(s): A2ADZ9, Q8K132
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 89 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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