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Protein

Retinol dehydrogenase 13

Gene

Rdh13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Does not exhibit retinol dehydrogenase (RDH) activity in vitro.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei174SubstrateBy similarity1
Active sitei200Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 51NAD or NADPBy similarity7

GO - Molecular functioni

GO - Biological processi

  • eye photoreceptor cell development Source: MGI
  • response to high light intensity Source: MGI
  • retina layer formation Source: MGI

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

ReactomeiR-MMU-5365859 RA biosynthesis pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 13 (EC:1.1.1.-)
Gene namesi
Name:Rdh13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1918732 Rdh13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000547692 – 334Retinol dehydrogenase 13Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8CEE7
MaxQBiQ8CEE7
PaxDbiQ8CEE7
PeptideAtlasiQ8CEE7
PRIDEiQ8CEE7

PTM databases

iPTMnetiQ8CEE7
PhosphoSitePlusiQ8CEE7

Expressioni

Gene expression databases

BgeeiENSMUSG00000008435 Expressed in 295 organ(s), highest expression level in retina
CleanExiMM_RDH13
ExpressionAtlasiQ8CEE7 baseline and differential
GenevisibleiQ8CEE7 MM

Interactioni

Protein-protein interaction databases

BioGridi224445, 1 interactor
IntActiQ8CEE7, 1 interactor
STRINGi10090.ENSMUSP00000008579

Structurei

3D structure databases

ProteinModelPortaliQ8CEE7
SMRiQ8CEE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1208 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00760000119068
HOVERGENiHBG078800
InParanoidiQ8CEE7
KOiK11161
OMAiGRIIMGC
OrthoDBiEOG091G0FGA
PhylomeDBiQ8CEE7
TreeFamiTF105429

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8CEE7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRFLLPVSV VGTVIGGTVL LKDYVAGGAC PSKATIPGKT VIVTGANTGI
60 70 80 90 100
GKQTALELAK RGGNVILACR DMEKCEVAAK DIRGETLNPR VRAERLDLAS
110 120 130 140 150
LKSIREFARK VIKEEERVDI LVNNAAVMRC PHWTTEDGFE MQFGVNYLGH
160 170 180 190 200
FLLTNLLLDK LKASAPSRII NLSSLAHVAG HIDFEDLNWQ MKKYDTKAAY
210 220 230 240 250
CQSKLAVVLF TKELSHRLQG SGVTVNALHP GVARTELGRH TGMHNSAFSG
260 270 280 290 300
FMLGPFFWLL FKSPQLAAQP STYLAVAEEL ENVSGKYFDG LREKAPSPEA
310 320 330
EDEEVARRLW TESARLVGLA MAHGSPGRGH AIPR
Length:334
Mass (Da):36,464
Last modified:March 1, 2003 - v1
Checksum:i4EBBCE1643C1FECE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1N8A0A0R4J1N8_MOUSE
Retinol dehydrogenase 13
Rdh13
299Annotation score:
D3YVJ8D3YVJ8_MOUSE
Retinol dehydrogenase 13
Rdh13
115Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114 – 148Missing in BAC28618 (PubMed:16141072).CuratedAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028434 mRNA Translation: BAC25950.1
AK034180 mRNA Translation: BAC28618.1
BC082583 mRNA Translation: AAH82583.1
CCDSiCCDS20735.1
RefSeqiNP_001277338.1, NM_001290409.1
NP_001277340.1, NM_001290411.1
NP_780581.1, NM_175372.4
UniGeneiMm.413106

Genome annotation databases

EnsembliENSMUST00000008579; ENSMUSP00000008579; ENSMUSG00000008435
GeneIDi108841
KEGGimmu:108841
UCSCiuc009exm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028434 mRNA Translation: BAC25950.1
AK034180 mRNA Translation: BAC28618.1
BC082583 mRNA Translation: AAH82583.1
CCDSiCCDS20735.1
RefSeqiNP_001277338.1, NM_001290409.1
NP_001277340.1, NM_001290411.1
NP_780581.1, NM_175372.4
UniGeneiMm.413106

3D structure databases

ProteinModelPortaliQ8CEE7
SMRiQ8CEE7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi224445, 1 interactor
IntActiQ8CEE7, 1 interactor
STRINGi10090.ENSMUSP00000008579

PTM databases

iPTMnetiQ8CEE7
PhosphoSitePlusiQ8CEE7

Proteomic databases

EPDiQ8CEE7
MaxQBiQ8CEE7
PaxDbiQ8CEE7
PeptideAtlasiQ8CEE7
PRIDEiQ8CEE7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008579; ENSMUSP00000008579; ENSMUSG00000008435
GeneIDi108841
KEGGimmu:108841
UCSCiuc009exm.2 mouse

Organism-specific databases

CTDi112724
MGIiMGI:1918732 Rdh13

Phylogenomic databases

eggNOGiKOG1208 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00760000119068
HOVERGENiHBG078800
InParanoidiQ8CEE7
KOiK11161
OMAiGRIIMGC
OrthoDBiEOG091G0FGA
PhylomeDBiQ8CEE7
TreeFamiTF105429

Enzyme and pathway databases

ReactomeiR-MMU-5365859 RA biosynthesis pathway

Miscellaneous databases

PROiPR:Q8CEE7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008435 Expressed in 295 organ(s), highest expression level in retina
CleanExiMM_RDH13
ExpressionAtlasiQ8CEE7 baseline and differential
GenevisibleiQ8CEE7 MM

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRDH13_MOUSE
AccessioniPrimary (citable) accession number: Q8CEE7
Secondary accession number(s): Q8CC07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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