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Entry version 149 (12 Aug 2020)
Sequence version 3 (27 Jul 2011)
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Protein

PAS domain-containing serine/threonine-protein kinase

Gene

Pask

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Protein kinase activity is inhibited by the first PAS domain: binding of an unidentified ligand desinhibits the protein kinase activity. May be activated by autophosphorylation on Thr-1221 and Thr-1225. Autophosphorylation is enhanced upon phosphatidylinositol monophosphate (phosphatidylinositol 4-phosphate) binding and inhibited upon phosphatidylinositol bi- and tri-phosphate binding. In contrast, phosphorylation of target proteins is inhibited upon all phosphatidylinositol-binding (phosphatidylinositol mono- bi- and tri-phosphate) (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1088ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1188Proton acceptorPROSITE-ProRule annotation1
Binding sitei1206ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1065 – 1073ATPPROSITE-ProRule annotation9
Nucleotide bindingi1142 – 1149ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Lipid-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PAS domain-containing serine/threonine-protein kinase (EC:2.7.11.1)
Short name:
PAS-kinase
Short name:
PASKIN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pask
Synonyms:Kiaa0135
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2155936, Pask

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype under normal conditions: mice show normal development, growth and reproduction. Fertility and sperm production and motility are not affected in males. Under high-fat diet, mice seem to be protected from deleterious effects, including obesity, liver triglyceride accumulation and insulin resistance (PubMed:17878307). In contrast, the lean phenotype appears only after feeding a high-fat diet: under normal chow diet, body weight, fat composition, oxygen consumption are not distinguishable from wild-type mice (PubMed:17192472). The only difference between these 2 experiments is that mice were backcrossed into C57BL/6 5 times in the first study (PubMed:17878307), while the 10th backcross was used in the second study (PubMed:17192472). Female but not male mice show an increased ventilatory response to acute hypoxia and fail to reach ventilatory acclimatization to chronic hypoxia.4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000864811 – 1383PAS domain-containing serine/threonine-protein kinaseAdd BLAST1383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei19PhosphoserineCombined sources1
Modified residuei31PhosphothreonineCombined sources1
Modified residuei1000PhosphoserineBy similarity1
Modified residuei1221Phosphothreonine; by autocatalysisBy similarity1
Modified residuei1225Phosphothreonine; by autocatalysisBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated on Thr-1221 and Thr-1225. Autophosphorylation is activated by phospholipids (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8CEE6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8CEE6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8CEE6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CEE6

PRoteomics IDEntifications database

More...
PRIDEi
Q8CEE6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CEE6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CEE6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Strongly up-regulated in postmeiotic germ cells during spermatogenesis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026274, Expressed in spermatocyte and 187 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CEE6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
234624, 6 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000027493

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8CEE6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CEE6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini117 – 188PAS 1PROSITE-ProRule annotationAdd BLAST72
Domaini333 – 400PAS 2PROSITE-ProRule annotationAdd BLAST68
Domaini1059 – 1311Protein kinasePROSITE-ProRule annotationAdd BLAST253

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein kinase domain mediates binding to phosphatidylinositol.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1152, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159035

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006086_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8CEE6

KEGG Orthology (KO)

More...
KOi
K08801

Identification of Orthologs from Complete Genome Data

More...
OMAi
ISPQESF

Database of Orthologous Groups

More...
OrthoDBi
297397at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323242

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00130, PAS, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13426, PAS_9, 2 hits
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00091, PAS, 2 hits
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55785, SSF55785, 1 hit
SSF56112, SSF56112, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00229, sensory_box, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50112, PAS, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8CEE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDRGPPVFA EDWKCLSESP PVQEGPAAQA TFEPSKPLSI AHKHLSRKNG
60 70 80 90 100
LSRLCQSRMA LSEDRWSSYC LSSLAAQNIC TSKLHCAAAP EYADPTAGPL
110 120 130 140 150
GSTSCCSLLR GLASGCSGSL LSTPVCNPNK AVFTVDAKTT EILVANDKAC
160 170 180 190 200
SLLGYSSHDL IGQKLAQFFL KSDSEVVEAL SEEHVEADGH AAVVFGTVVD
210 220 230 240 250
IVSRIGEKIP VSVWIKRLQQ DRGLCCVVVL EPVERVSAWV AFQSDGTITS
260 270 280 290 300
CDSLFAHLHG FTSPKDVVGQ CVIDLIPSMQ LPPPGQHIPK SLKIQRSVGR
310 320 330 340 350
ARDGTTFPLS LKLKSKPSGR AVADSEAASE PGYQASVWVF CTISGLITLL
360 370 380 390 400
PDGTIYGVNH SFALMLFGYG KTELLGKNIT FLIPGFYHYM DLTYDSSVQL
410 420 430 440 450
PDLVNCLDIG RKSGPGEMNS DAQHNWELAS GAQGPRIDVV LARDHMPSQD
460 470 480 490 500
ETLKLVGGQV SSRTQTRLET GYKILPSSAC QPSLGVDSNP EDGEQSLLTD
510 520 530 540 550
QQSIPKRNLP AHGGQNQLDT SEISLPVLKE HLLSEIQKNI SEESPLTHRK
560 570 580 590 600
WLSKVQQNPT KGSLPIHEEQ LLFAGQHIHV LGKEDPSAAE SYRESLLEES
610 620 630 640 650
KSKPVDAKLF ASCEDSEPLV SVKDRGSSVD TCNLHQEAQL ELMGVSSPNP
660 670 680 690 700
WADATMPEPH TTGQIAGGSL TYCPQYRSEW ASQQRGQDSA PSPSGMACVL
710 720 730 740 750
LGTPTLDEPW PGVRNDREEL QTCLIKEQLS KSSCEGNLGI SRVELVPEEH
760 770 780 790 800
PPFTAPVSFC DLGGRDLHAS RSGSSSACYA LATDLPGVLE AVEAQEADVN
810 820 830 840 850
SYSWNLKELF LKDQTDRTPS HCSCTTSELS EAPSLSVVGS DLDVGILHRQ
860 870 880 890 900
TSDILVDREM LLLTGTYFDL SEGQRFQEMG AGHDRAELSN ISLVSSEHYE
910 920 930 940 950
TSDIESPGCD PPLPDPGPND MCLSAEKPRP SAQITSTPVA RGATSLQQEI
960 970 980 990 1000
QEGIYSGSCY HRDGLQLSIQ FEVKRVELQG SATLFCCWLV KDLFHSHRDS
1010 1020 1030 1040 1050
ATRTRLFLAS LPSSTHSMPE LSGSSFGEVL RAKPWFEESP TPAELEGLAA
1060 1070 1080 1090 1100
CEGEYDYKYN TISPLGSGAF GFVWTAVEKE CNKEVVVKFI KKEKVLEDCW
1110 1120 1130 1140 1150
IEDPKLGRVT LEIAILSKVD HANIIKVLDI FENQEFFQLV MEKHGSGMDL
1160 1170 1180 1190 1200
FAFIDHHPCL DEPLASFIFR QLVSAVGYLH SQGIIHRDIK DENIVIAEDF
1210 1220 1230 1240 1250
TIKLIDFGSA AYLERGKLFY TFCGTIEYCA PEVLIGNPYR GPELEMWSLG
1260 1270 1280 1290 1300
VTLYTLIFEE NPFCEVEETM EAVIHPPFLV SQELMSLLSG LLQPCPEQRT
1310 1320 1330 1340 1350
TLEKLIRDPW VTQPVNLASY TWEEVCRTNQ PESGLLSAAS LEIGSRSPSE
1360 1370 1380
MAQREGLCGP PAPRETRGDQ HCLHLKDPSL PVS
Length:1,383
Mass (Da):151,250
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD020885E8C2C2E19
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YUI8D3YUI8_MOUSE
PAS domain-containing serine/threon...
Pask
27Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti587S → L in BAC25951 (PubMed:16141072).Curated1
Sequence conflicti832A → V in CAC45054 (PubMed:11688972).Curated1
Sequence conflicti832A → V in BAC97873 (PubMed:14621295).Curated1
Sequence conflicti1186H → R in BAC25951 (PubMed:16141072).Curated1
Sequence conflicti1293Q → H in BAC25951 (PubMed:16141072).Curated1
Sequence conflicti1296P → L in CAC45054 (PubMed:11688972).Curated1
Sequence conflicti1330Q → H in BAC25951 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ318757 Genomic DNA Translation: CAC45054.2
AK028435 mRNA Translation: BAC25951.1
AK129063 mRNA Translation: BAC97873.1
AC124669 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS15186.1

NCBI Reference Sequences

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RefSeqi
NP_543126.2, NM_080850.2
XP_006529728.1, XM_006529665.3
XP_006529729.1, XM_006529666.2
XP_006529730.1, XM_006529667.2
XP_017176526.1, XM_017321037.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000027493; ENSMUSP00000027493; ENSMUSG00000026274

Database of genes from NCBI RefSeq genomes

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GeneIDi
269224

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:269224

UCSC genome browser

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UCSCi
uc007cdt.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318757 Genomic DNA Translation: CAC45054.2
AK028435 mRNA Translation: BAC25951.1
AK129063 mRNA Translation: BAC97873.1
AC124669 Genomic DNA No translation available.
CCDSiCCDS15186.1
RefSeqiNP_543126.2, NM_080850.2
XP_006529728.1, XM_006529665.3
XP_006529729.1, XM_006529666.2
XP_006529730.1, XM_006529667.2
XP_017176526.1, XM_017321037.1

3D structure databases

SMRiQ8CEE6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi234624, 6 interactors
STRINGi10090.ENSMUSP00000027493

PTM databases

iPTMnetiQ8CEE6
PhosphoSitePlusiQ8CEE6

Proteomic databases

EPDiQ8CEE6
jPOSTiQ8CEE6
MaxQBiQ8CEE6
PaxDbiQ8CEE6
PRIDEiQ8CEE6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
20301, 194 antibodies

Genome annotation databases

EnsembliENSMUST00000027493; ENSMUSP00000027493; ENSMUSG00000026274
GeneIDi269224
KEGGimmu:269224
UCSCiuc007cdt.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23178
MGIiMGI:2155936, Pask

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG1152, Eukaryota
GeneTreeiENSGT00940000159035
HOGENOMiCLU_006086_0_0_1
InParanoidiQ8CEE6
KOiK08801
OMAiISPQESF
OrthoDBi297397at2759
TreeFamiTF323242

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
269224, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Pask, mouse

Protein Ontology

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PROi
PR:Q8CEE6
RNActiQ8CEE6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026274, Expressed in spermatocyte and 187 other tissues
GenevisibleiQ8CEE6, MM

Family and domain databases

CDDicd00130, PAS, 2 hits
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF13426, PAS_9, 2 hits
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00091, PAS, 2 hits
SM00220, S_TKc, 1 hit
SUPFAMiSSF55785, SSF55785, 1 hit
SSF56112, SSF56112, 1 hit
TIGRFAMsiTIGR00229, sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50112, PAS, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPASK_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CEE6
Secondary accession number(s): E9QM58, Q91YD8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: July 27, 2011
Last modified: August 12, 2020
This is version 149 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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