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Protein

Centrosomal protein of 57 kDa

Gene

Cep57

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2.2 Publications

GO - Molecular functioni

  • fibroblast growth factor binding Source: UniProtKB
  • gamma-tubulin binding Source: InterPro
  • microtubule binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • fibroblast growth factor receptor signaling pathway Source: UniProtKB
  • microtubule anchoring Source: InterPro
  • protein homooligomerization Source: UniProtKB
  • protein import into nucleus, translocation Source: UniProtKB
  • spermatid development Source: HGNC

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 57 kDa
Short name:
Cep57
Alternative name(s):
Testis-specific protein 57
Translokin
Gene namesi
Name:Cep57
Synonyms:Kiaa0092, Tsp57
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1915551 Cep57

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895331 – 500Centrosomal protein of 57 kDaAdd BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8CEE0
PRIDEiQ8CEE0

PTM databases

iPTMnetiQ8CEE0
PhosphoSitePlusiQ8CEE0

Expressioni

Tissue specificityi

Ubiquitous (at protein level). Expressed in testis, predominantly in round spermatids. Low expression is detected in other tissues.2 Publications

Gene expression databases

BgeeiENSMUSG00000031922 Expressed in 236 organ(s), highest expression level in testis
CleanExiMM_CEP57
ExpressionAtlasiQ8CEE0 baseline and differential
GenevisibleiQ8CEE0 MM

Interactioni

Subunit structurei

Interacts with FGF2 and RAP80. Does not interact with FGF1 or FGF2 isoform 24 kDa (By similarity). Homodimer and homooligomer. Interacts with microtubules.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216689, 1 interactor
STRINGi10090.ENSMUSP00000034398

Structurei

3D structure databases

ProteinModelPortaliQ8CEE0
SMRiQ8CEE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni58 – 239centrosome localization domain (CLD)Add BLAST182
Regioni278 – 491Mediates interaction with microtubulesAdd BLAST214

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili63 – 242Sequence analysisAdd BLAST180
Coiled coili389 – 449Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi259 – 266Poly-Lys8

Domaini

The C-terminal region mediates the interaction with microtubules and is able to nucleate and bundles microtubules in vitro.1 Publication
The centrosome localization domain (CLD) region mediates the localization to centrosomes and homooligomerization.1 Publication

Sequence similaritiesi

Belongs to the translokin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IESE Eukaryota
ENOG410XPJC LUCA
GeneTreeiENSGT00530000063695
HOVERGENiHBG050917
InParanoidiQ8CEE0
KOiK16762
OrthoDBiEOG091G07B7
PhylomeDBiQ8CEE0
TreeFamiTF329178

Family and domain databases

InterProiView protein in InterPro
IPR010597 Centrosomal_protein_57kDa
IPR025913 Cep57_CLD
IPR024957 Cep57_MT-bd_dom
PANTHERiPTHR19336:SF11 PTHR19336:SF11, 1 hit
PfamiView protein in Pfam
PF14073 Cep57_CLD, 1 hit
PF06657 Cep57_MT_bd, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CEE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAASVSAAS DSQFSSVLAE PSRSNGNMVR HSSSPYVLYP PDKPFLNSDL
60 70 80 90 100
RRSPNKPTFA YPESNSRAIF SALKNLQDKI RRLELERIQA EESVKTLSRE
110 120 130 140 150
TIEYKKVLDE QIQERENSKN EESKHNQELA SQLVAAENKC NLLEKQLEYM
160 170 180 190 200
RNMIKHAEME RTSVLEKQVS LERERQHDQT HVQSQLEKLD LLEQEYNKLT
210 220 230 240 250
AMQALAEKKM QELESKLREE EQERKRMQAR AAELQSGLEA NRLIFEDKTT
260 270 280 290 300
SCVSTSTRKI KKKKSKPPEK KGSRTYFGAQ PHYRLCLGDM PFVAGTSTSP
310 320 330 340 350
SHAVVANVQH VLHLMKHHSK ALCNDRVVNS VPLAKQACSR VSKSKKSVVP
360 370 380 390 400
PSSSVNEELS DVLQTLQDEF GQMSFDHQQL TKLIQESPTV ELKDNLECEL
410 420 430 440 450
EALVGRMEAK ANQITKVRKY QAQLEKQNID KQKKELKANK KTLDEEGNSS
460 470 480 490 500
GRSSGVPRTA SKKDLAKQRP GEKSRKNLQL LKDMQTIQNS LQSSNLCWDY
Length:500
Mass (Da):56,909
Last modified:December 21, 2004 - v2
Checksum:iD57490F4B22E7707
GO
Isoform 2 (identifier: Q8CEE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Show »
Length:473
Mass (Da):54,286
Checksum:iA86766EF40E0DB90
GO
Isoform 3 (identifier: Q8CEE0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-149: Missing.

Show »
Length:351
Mass (Da):39,996
Checksum:iB61E0BFD2C309ABC
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8JJE7B8JJE7_MOUSE
Centrosomal protein of 57 kDa
Cep57
474Annotation score:
B8JJF0B8JJF0_MOUSE
Centrosomal protein of 57 kDa
Cep57
282Annotation score:
D6RDR1D6RDR1_MOUSE
Centrosomal protein of 57 kDa
Cep57
296Annotation score:
D6RH89D6RH89_MOUSE
Centrosomal protein of 57 kDa
Cep57
210Annotation score:
F7BGJ9F7BGJ9_MOUSE
Centrosomal protein of 57 kDa
Cep57
231Annotation score:
D6RDE1D6RDE1_MOUSE
Centrosomal protein of 57 kDa
Cep57
122Annotation score:

Sequence cautioni

The sequence AAH50785 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC97863 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5S → P in BAB29596 (PubMed:16141072).Curated1
Sequence conflicti16 – 24SVLAEPSRS → VRGGGASRC in AAP32743 (PubMed:12954732).Curated9
Sequence conflicti295 – 296GT → EK in AAO73939 (PubMed:12717444).Curated2
Sequence conflicti353S → N in BAC25962 (PubMed:16141072).Curated1
Sequence conflicti386E → K in BAB29652 (PubMed:16141072).Curated1
Sequence conflicti417V → F in BAB29652 (PubMed:16141072).Curated1
Sequence conflicti425E → K in BAB29652 (PubMed:16141072).Curated1
Sequence conflicti431K → R in BAB29652 (PubMed:16141072).Curated1
Sequence conflicti435E → K in BAB29652 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0122651 – 149Missing in isoform 3. 2 PublicationsAdd BLAST149
Alternative sequenceiVSP_0122661 – 27Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY225093 mRNA Translation: AAO73939.1
AY251192 mRNA Translation: AAP32743.1
AK014873 mRNA Translation: BAB29596.1
AK014982 mRNA Translation: BAB29652.1
AK016484 mRNA Translation: BAB30264.1
AK028458 mRNA Translation: BAC25962.1
CT010488 Genomic DNA Translation: CAX15658.1
CH466522 Genomic DNA Translation: EDL24979.1
BC050785 mRNA Translation: AAH50785.1 Different initiation.
AK129053 mRNA Translation: BAC97863.1 Different initiation.
CCDSiCCDS52724.1 [Q8CEE0-1]
RefSeqiNP_001297650.1, NM_001310721.1
NP_080941.3, NM_026665.4 [Q8CEE0-1]
XP_006510712.1, XM_006510649.1 [Q8CEE0-3]
UniGeneiMm.157212

Genome annotation databases

EnsembliENSMUST00000034398; ENSMUSP00000034398; ENSMUSG00000031922 [Q8CEE0-1]
ENSMUST00000124883; ENSMUSP00000119081; ENSMUSG00000031922 [Q8CEE0-3]
ENSMUST00000148086; ENSMUSP00000114665; ENSMUSG00000031922 [Q8CEE0-2]
GeneIDi74360
KEGGimmu:74360
UCSCiuc009oea.2 mouse [Q8CEE0-3]
uc009oeb.2 mouse [Q8CEE0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY225093 mRNA Translation: AAO73939.1
AY251192 mRNA Translation: AAP32743.1
AK014873 mRNA Translation: BAB29596.1
AK014982 mRNA Translation: BAB29652.1
AK016484 mRNA Translation: BAB30264.1
AK028458 mRNA Translation: BAC25962.1
CT010488 Genomic DNA Translation: CAX15658.1
CH466522 Genomic DNA Translation: EDL24979.1
BC050785 mRNA Translation: AAH50785.1 Different initiation.
AK129053 mRNA Translation: BAC97863.1 Different initiation.
CCDSiCCDS52724.1 [Q8CEE0-1]
RefSeqiNP_001297650.1, NM_001310721.1
NP_080941.3, NM_026665.4 [Q8CEE0-1]
XP_006510712.1, XM_006510649.1 [Q8CEE0-3]
UniGeneiMm.157212

3D structure databases

ProteinModelPortaliQ8CEE0
SMRiQ8CEE0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216689, 1 interactor
STRINGi10090.ENSMUSP00000034398

PTM databases

iPTMnetiQ8CEE0
PhosphoSitePlusiQ8CEE0

Proteomic databases

PaxDbiQ8CEE0
PRIDEiQ8CEE0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034398; ENSMUSP00000034398; ENSMUSG00000031922 [Q8CEE0-1]
ENSMUST00000124883; ENSMUSP00000119081; ENSMUSG00000031922 [Q8CEE0-3]
ENSMUST00000148086; ENSMUSP00000114665; ENSMUSG00000031922 [Q8CEE0-2]
GeneIDi74360
KEGGimmu:74360
UCSCiuc009oea.2 mouse [Q8CEE0-3]
uc009oeb.2 mouse [Q8CEE0-1]

Organism-specific databases

CTDi9702
MGIiMGI:1915551 Cep57
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IESE Eukaryota
ENOG410XPJC LUCA
GeneTreeiENSGT00530000063695
HOVERGENiHBG050917
InParanoidiQ8CEE0
KOiK16762
OrthoDBiEOG091G07B7
PhylomeDBiQ8CEE0
TreeFamiTF329178

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRSiCep57 mouse
PROiPR:Q8CEE0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031922 Expressed in 236 organ(s), highest expression level in testis
CleanExiMM_CEP57
ExpressionAtlasiQ8CEE0 baseline and differential
GenevisibleiQ8CEE0 MM

Family and domain databases

InterProiView protein in InterPro
IPR010597 Centrosomal_protein_57kDa
IPR025913 Cep57_CLD
IPR024957 Cep57_MT-bd_dom
PANTHERiPTHR19336:SF11 PTHR19336:SF11, 1 hit
PfamiView protein in Pfam
PF14073 Cep57_CLD, 1 hit
PF06657 Cep57_MT_bd, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCEP57_MOUSE
AccessioniPrimary (citable) accession number: Q8CEE0
Secondary accession number(s): B8JJE6
, Q6ZQJ3, Q7TN18, Q80X65, Q810F2, Q9D4J4, Q9D5S4, Q9D5W5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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