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Protein

Ciliogenesis and planar polarity effector 1

Gene

Cplane1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in ciliogenesis. Involved in the establishment of cell polarity required for directional cell migration (PubMed:25877302). Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779).1 Publication1 Publication

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Ciliogenesis and planar polarity effector 1Curated
Alternative name(s):
Protein C5orf42 homolog
Protein JBTS172 Publications
Gene namesi
Name:Cplane1Imported
Synonyms:Jbts171 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1920942 Cplane1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei593 – 613HelicalSequence analysisAdd BLAST21
Transmembranei632 – 652HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Jbts17 are the cause of the Hug (Heart under glass) phenotype which is a model of Joubert syndrome. Hug mice die prenatally and show skelatal dysplasia, craniofacial defects, polydactyly, cystic kidney, cerebellar hypoplasia and congenital heart defects of varying degrees. Most severely affected mutants die at mid-gestation with a transparent chest wall due to complete failure to form the rib cage. The phenotype is consistent with the spectrum of MKS-BBS-Joubert syndrome phenotypes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003443661 – 3214Ciliogenesis and planar polarity effector 1Add BLAST3214

Proteomic databases

EPDiQ8CE72
MaxQBiQ8CE72
PaxDbiQ8CE72
PRIDEiQ8CE72

PTM databases

iPTMnetiQ8CE72
PhosphoSitePlusiQ8CE72

Expressioni

Gene expression databases

BgeeiENSMUSG00000039801 Expressed in 224 organ(s), highest expression level in embryo
GenevisibleiQ8CE72 MM

Interactioni

Subunit structurei

Interacts with FUZ; INTU and WDPCP; the interactors are proposed to form the core CPLANE (ciliogenesis and planar polarity effectors) complex (PubMed:27158779).

Protein-protein interaction databases

BioGridi216193, 2 interactors
IntActiQ8CE72, 1 interactor
STRINGi10090.ENSMUSP00000106247

Structurei

3D structure databases

SMRiQ8CE72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG9U Eukaryota
ENOG410XTEK LUCA
GeneTreeiENSGT00800000124150
HOGENOMiHOG000170536
HOVERGENiHBG108704
InParanoidiQ8CE72
KOiK22859
OMAiAPNHMEL
OrthoDBiEOG091G05WO
TreeFamiTF351288

Family and domain databases

InterProiView protein in InterPro
IPR028236 CPLANE1
PANTHERiPTHR14492 PTHR14492, 1 hit
PfamiView protein in Pfam
PF15392 Joubert, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8CE72-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEMRLEVLTS TSIKQKKPWP RVSWLGQENE AVFLLDEKFI NEINLLSGRT
60 70 80 90 100
KKKIPSLQPL LKDVVFLATS TNDVWLSGVL TTGELFLWNK DQDCLKKIHV
110 120 130 140 150
TEKPKEAIKA AVASSSRLYL YVAENGKRIL LITSSGCILL WEYLELKNIL
160 170 180 190 200
SSKSLSLVGQ WSQIVPEEAV SLPSTKDKEA VVAAVFVKNE LLGDCCLCSF
210 220 230 240 250
TFYSGECLKL TFLDIQWYEN IFTSVRSLLF RVHWAQQECP LCSLIPRCAS
260 270 280 290 300
VKSRGALISA FSRDGLALAV TLNQKDPTAT QVLFINTLNF VTLCGGLKGC
310 320 330 340 350
SNKNPVVPAT LTRSYWVGDI SWTHDSLFLT CVLKRGSLVL LTCLGELLTL
360 370 380 390 400
VTFGCSIEFG PAEFIPLHPL ITYRPQQLPF QDSNNCVDSS ASESDPLRQR
410 420 430 440 450
FSIKAHSRLP YLIISDGYMV TTLRFLDNQS PTMLMRSLLL DSTQRLEKAY
460 470 480 490 500
QSMMLSEPKD KGLNFRSLDS LRSSLLKHQG KESSVHCTVP RFLQAEETMK
510 520 530 540 550
LNETTDFQDF EGEETNEVEQ FVNNSFSFCN QKKDLPFDIV KEGRLEFASM
560 570 580 590 600
FDTVHAKDAS KETDRNTAEL HRIQKTLLAA WTIGISKNVT EKKLMLNYTI
610 620 630 640 650
LCITHFFYIL QFIKCPVPKF DLFLNKSLKR NAWVLCVFQL FHQCLSVHYW
660 670 680 690 700
DMRYRQNMGH LIRLTANTVK LLLTQRQEHG SFSERLLACL SLLRTVTVHL
710 720 730 740 750
NGTCSLQPEA VPAAADESRP AELDSLMVPI FQASKENWPW DSSLKIYPQV
760 770 780 790 800
TNLVQKPGHR LIALWRLLYK KTLWYQAQLS QRTPDGDRRL TENIRHEVSV
810 820 830 840 850
VKTLLCHVQT NLQMAGDSLN QALELTPISG EECFLLASYE KSVCLWKKAL
860 870 880 890 900
QETQEKGGRR TCFLQLRYYL SLLYCHLYCY NLNDAQGLCD HLVRELLSRS
910 920 930 940 950
QLPVRESQDC SDCEIAVTGN VHPEAALRVV QCMARFMAAY FTNEPLFILP
960 970 980 990 1000
PHSVSVLPPL HVKTEHSLRL IPLQHSKVAS VIRDQNLSNV WTVEYTLELL
1010 1020 1030 1040 1050
FIGGLIPEAV WMAHKLGDWK TSVSIGVAYQ VFCKHDCNFA RSKKKGMDLP
1060 1070 1080 1090 1100
LNMIPAQIFQ EKLQCFLGQP VSLTKKNEKG SKYKQFTDPI EEEDASLLFG
1110 1120 1130 1140 1150
SVQEVLKASV MADADIVSET LQLLMDSAKD FSKKLWGLVP VDLYLPAPPL
1160 1170 1180 1190 1200
YCPQPAVLSE EHGDNLLLKA EKDNRQKLSG ILQRVLLLFR ASRCSFPVAQ
1210 1220 1230 1240 1250
WYILQLRWAR KVMQKIRVKG SLPSLGSFPE SLLNYCKGGI AFFRPGATGD
1260 1270 1280 1290 1300
HTLDEVSIKA LGCFRELCAL CWMLHVRDKL SYTCRQYQKA RENTKIEKDL
1310 1320 1330 1340 1350
EVGFDSCVVE HCFHALEWAC RMLPFSRFFN MEELIQDIIL SLIGELPPIR
1360 1370 1380 1390 1400
KVAEIFVKAF PNPEAIRVPL REKYHSLQQK LKHGVVKGPQ TEELMSTVMR
1410 1420 1430 1440 1450
HVRKVRVKAL KRVQRNIGAF EMDIWEPDEE DKPAATPAAD RFSLGPSVSS
1460 1470 1480 1490 1500
TLTLDLGSSL LHSDADTFSE TLSLEEKTWI HLYQRHTPSH MELALVGKKP
1510 1520 1530 1540 1550
SDKKKVSNQK ENSQRKEDDE TPGKEALPVI GVWEFERDDD EYISFLELFL
1560 1570 1580 1590 1600
SYILERDLCS SDPGIPFLTS FSGRLREHEL NSLLFDVHTT LKRRQSKTIS
1610 1620 1630 1640 1650
ENVYRAGSCF AVTPESQEPE NLSSLNSVGA RHFESQALSA SALGNQSGST
1660 1670 1680 1690 1700
LENPLQSGST SENPLQSDVM NWERRAGLFG LKQKPMYRVP DDKREKPTVQ
1710 1720 1730 1740 1750
RSSNHSFWVP ESIKPGRHRF RALEGSAGPP REDLPLALQS MFGDAGRLVE
1760 1770 1780 1790 1800
WMIRWSDRRL LCDPGVTPSS CKYSPVIRVK TSTAAILTSL WLLEQPYSAA
1810 1820 1830 1840 1850
YTAKNGIIKV LERHHTEPQV AAERESDVDA DCPAAVAAQE GTECWNRMPA
1860 1870 1880 1890 1900
EAENHDVKDT GDEIAPVTPG SERELVHADG RHSEAGSSTQ DEMDVHISDS
1910 1920 1930 1940 1950
EEGPVESLRG PSAVICRPES QLSSEHSEEE AQCSRKEPRD ASVDTNLTEQ
1960 1970 1980 1990 2000
KGAQISDLKE KSPTVLPLMS NGAQDTSQTP QKTQGNEHRA QLPDASESVR
2010 2020 2030 2040 2050
QMLQDEMFKL VQLQQINFLS LMQIVGPSVA SLPDMHGLLQ QAQSVRFGES
2060 2070 2080 2090 2100
QVSNSTKSDC IEVNSRQRVS ARAQSMGECT REPGKNSPAD HKRISRPDQD
2110 2120 2130 2140 2150
SSGDTQDIPH GSVPLCQLDG QPEVRGQTGA PRSFAPASFP PAPAADSGLQ
2160 2170 2180 2190 2200
LLFTPAAIQK TPQLIPPARA GAPGRGFPLL HFQPKRDFKP LSLPVGRIPQ
2210 2220 2230 2240 2250
VSFRPQAQPK EAWSLSDSCQ PPVSQRTVHT TLPSPSDSSH CNAEAMRKAE
2260 2270 2280 2290 2300
AVLTGIPKHV NMGQYAGQGY LTPQQDSSVF IKPENVFDVK PSPPETALQN
2310 2320 2330 2340 2350
SFGLPLLHLQ FKPPYVFSAP PRAFSRFPSV PGTEGRNQPQ LSLLHPCLPP
2360 2370 2380 2390 2400
ENTYKKPQLI PLENLLAFKR SQQKLAHSVS GQGDAAPHFV GVSMDAAGIT
2410 2420 2430 2440 2450
QGKQRQSRRA KRELQEGRAQ KPRRKPNVSF RPEDSLISND SEVIIEPKEQ
2460 2470 2480 2490 2500
LGHHDSQHLD KFDIPFEMLE DDINTSAGLH FMASVRKKAV GSHDASTNTD
2510 2520 2530 2540 2550
PDKEGPSQKA DSESSKNPQA TAASSGHEPL KVPQLLIPDI YLNVRLPSGI
2560 2570 2580 2590 2600
AEKPLSPSPP HMAGHKYIDV VDIEADDLLG LPACEEPSDE VTKQQSHPPH
2610 2620 2630 2640 2650
APSSAELHCM AASIVDAAPP HTFQSQESAS STRGLISEPA KVTQSCQSGE
2660 2670 2680 2690 2700
SWRKSVIEAK EPEIPSVAPP SDRQQDRDIL EQNFQFKEQS TKLDSVGQSL
2710 2720 2730 2740 2750
LWTLLQNASP ACPTPSPAVC PRPSSPACPP PSPAVCPPPS PAACPTPSPA
2760 2770 2780 2790 2800
AQKFEHLTAK LQEMDEQLVA VQTMAENIEQ DFPASQVLNL HWEKAGLGNH
2810 2820 2830 2840 2850
VGLSSGPDIE KLLASKAISI SEEVSLQTQE DVEEQKDAEE TSETEFSEAE
2860 2870 2880 2890 2900
NHSSQKTYAC PSVGSAACSS VGWNIPSPGL NDSNELLESG SEDQLQVTGL
2910 2920 2930 2940 2950
TDIADIIGDL ITKSGVSSHE LGLTECQARS ISRIQRPPDR GPRRTAEERR
2960 2970 2980 2990 3000
EIKAWMRRKQ KERMSEYLGQ LAERRGRERN PFCPTSSPFY MTSRQIRQRQ
3010 3020 3030 3040 3050
KMKREKDRLQ LSKHYSQRLS QAYSLMNELL SDSAHITAPA ENPLPPGPYR
3060 3070 3080 3090 3100
RQRGSSPKRE NAHGQSLPVN RPGGDRHISR SSHLCKGQPR GSSQLRGSQP
3110 3120 3130 3140 3150
PCQSQKPLRS RGAAGVGPPV QQACREDERE EMVVSPWTLP SEIHRILHGR
3160 3170 3180 3190 3200
PESLLQDMSP ADEEEPEPPL LAGGMDSVSE STGSILSKLD WKAVEDMVAS
3210
VEDKNLSVHW ALDQ
Length:3,214
Mass (Da):358,550
Last modified:September 5, 2012 - v4
Checksum:iB431ABFE11324D32
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BRY0A0A2I3BRY0_MOUSE
Ciliogenesis and planar polarity ef...
Cplane1 2410089E03Rik
31Annotation score:

Sequence cautioni

The sequence AAH58107 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE22427 differs from that shown. Contaminating sequence. Intron sequences at both 5' and 3' ends.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1061E → K in BAC26182 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti253S → P in Hug. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107747 Genomic DNA No translation available.
AC158971 Genomic DNA No translation available.
AK028897 mRNA Translation: BAC26182.2
AK135113 mRNA Translation: BAE22427.1 Sequence problems.
BC058107 mRNA Translation: AAH58107.1 Different initiation.
CCDSiCCDS49578.1
RefSeqiNP_001156378.1, NM_001162906.1
UniGeneiMm.164436
Mm.408215

Genome annotation databases

EnsembliENSMUST00000110617; ENSMUSP00000106247; ENSMUSG00000039801
GeneIDi73692
KEGGimmu:73692
UCSCiuc007ven.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107747 Genomic DNA No translation available.
AC158971 Genomic DNA No translation available.
AK028897 mRNA Translation: BAC26182.2
AK135113 mRNA Translation: BAE22427.1 Sequence problems.
BC058107 mRNA Translation: AAH58107.1 Different initiation.
CCDSiCCDS49578.1
RefSeqiNP_001156378.1, NM_001162906.1
UniGeneiMm.164436
Mm.408215

3D structure databases

SMRiQ8CE72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216193, 2 interactors
IntActiQ8CE72, 1 interactor
STRINGi10090.ENSMUSP00000106247

PTM databases

iPTMnetiQ8CE72
PhosphoSitePlusiQ8CE72

Proteomic databases

EPDiQ8CE72
MaxQBiQ8CE72
PaxDbiQ8CE72
PRIDEiQ8CE72

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110617; ENSMUSP00000106247; ENSMUSG00000039801
GeneIDi73692
KEGGimmu:73692
UCSCiuc007ven.2 mouse

Organism-specific databases

CTDi65250
MGIiMGI:1920942 Cplane1

Phylogenomic databases

eggNOGiENOG410IG9U Eukaryota
ENOG410XTEK LUCA
GeneTreeiENSGT00800000124150
HOGENOMiHOG000170536
HOVERGENiHBG108704
InParanoidiQ8CE72
KOiK22859
OMAiAPNHMEL
OrthoDBiEOG091G05WO
TreeFamiTF351288

Miscellaneous databases

PROiPR:Q8CE72
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039801 Expressed in 224 organ(s), highest expression level in embryo
GenevisibleiQ8CE72 MM

Family and domain databases

InterProiView protein in InterPro
IPR028236 CPLANE1
PANTHERiPTHR14492 PTHR14492, 1 hit
PfamiView protein in Pfam
PF15392 Joubert, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCPLN1_MOUSE
AccessioniPrimary (citable) accession number: Q8CE72
Secondary accession number(s): E9QL36, Q3UXY6, Q6PEE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: September 5, 2012
Last modified: November 7, 2018
This is version 99 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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