UniProtKB - Q8CE64 (ZN276_MOUSE)

BLAST

>sp|Q8CE64|ZN276_MOUSE Zinc finger protein 276 OS=Mus musculus OX=10090 GN=Znf276 PE=1 SV=3
MKRDRLGRFLSPGIARQRGGSGGGCGSGRTRGRPSRSGGTSADGAAAQLSWGSMTRSCGD
TGDDGTDEAGAGRTLAMGHCRLCHGKFSSRSLRSISDRVPGETSERLSPGERVFIRDFQR
LLGVAVHQDPALPQSVCKNCYTQFYQCHSLLRTFLQRVNVSPAGQRKPCTKVGVQPTTVA
EEGACVADLIASSPRCLHGLVGWVHEHAVSCGSLPSLQRTLSSEYCGIIQAVWGCDQGHD
FTMDTASSCRALFLDSALAVKWAWGKDLSPRLAQNSESNPTGAASRLCQARETQVGSETK
TLPSVDVALLHSHGDSVGPGLGPCTQPHLAPSEAPGQLGETQVPSSTSDDRVKDEFSDLS
EGDFLSEDESDKKQTPQSSDESFEPYPEKKVSGKKSEGREAKRPEEPKIRKKPGPKPGWK
KKLRCEREELPTIYKCPYQGCTAVYRGADGMKKHIKEHHEEVRERPCPHPGCNKVFMIDR
YLQRHVKLIHTEVRNYICDECGQTFKQRKHLLVHQMRHSGAKPLQCEVCGFQCRQRASLK
YHMTKHKAETELDFACDQCGRRFEKAHNLNVHMSMVHPLTQAQDRALPLEAEPPPGPLSP
SGTMEGQAVKPEPT

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History
Entry version 125 (07 Nov 2018)
Sequence version 3 (12 Jun 2007)
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Protein

Zinc finger protein 276

Gene

Znf276

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	434 – 458	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	465 – 490	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	496 – 518	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	524 – 546	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	554 – 577	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 276 Short name: Zfp-276
Gene namesⁱ	Name:Znf276 Synonyms:Zfp276
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:1888495 Zfp276

Keywords - Cellular componentⁱ

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047324	1 – 614	Zinc finger protein 276Add BLAST		614

Proteomic databases

PaxDbⁱ	Q8CE64
PeptideAtlas More...PeptideAtlasⁱ	Q8CE64
PRIDEⁱ	Q8CE64

PTM databases

iPTMnetⁱ	Q8CE64
PhosphoSitePlusⁱ	Q8CE64

Expressionⁱ

Tissue specificityⁱ

Found in all the examined tissues, with highest levels in kidney, liver, lung, and spleen.1 Publication

Developmental stageⁱ

Expressed at low levels in all stages of embryonic development examined.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000001065 Expressed in 221 organ(s), highest expression level in head
CleanExⁱ	MM_ZFP276
ExpressionAtlasⁱ	Q8CE64 baseline and differential
Genevisibleⁱ	Q8CE64 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	208217, 1 interactor
STRINGⁱ	10090.ENSMUSP00000001092

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8CE64
SMRⁱ	Q8CE64
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	79 – 153	ZADAdd BLAST		75

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	434 – 458	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	465 – 490	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	496 – 518	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	524 – 546	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	554 – 577	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063153
HOGENOMⁱ	HOG000155790
HOVERGENⁱ	HBG061026
InParanoidⁱ	Q8CE64
OMAⁱ	IQAVWGC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04WK
PhylomeDBⁱ	Q8CE64
TreeFamⁱ	TF332664

Family and domain databases

InterProⁱ	View protein in InterPro IPR012934 Znf_AD IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07776 zf-AD, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 5 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q8CE64-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRDRLGRFL SPGIARQRGG SGGGCGSGRT RGRPSRSGGT SADGAAAQLS 
        60         70         80         90        100
WGSMTRSCGD TGDDGTDEAG AGRTLAMGHC RLCHGKFSSR SLRSISDRVP 
       110        120        130        140        150
GETSERLSPG ERVFIRDFQR LLGVAVHQDP ALPQSVCKNC YTQFYQCHSL 
       160        170        180        190        200
LRTFLQRVNV SPAGQRKPCT KVGVQPTTVA EEGACVADLI ASSPRCLHGL 
       210        220        230        240        250
VGWVHEHAVS CGSLPSLQRT LSSEYCGIIQ AVWGCDQGHD FTMDTASSCR 
       260        270        280        290        300
ALFLDSALAV KWAWGKDLSP RLAQNSESNP TGAASRLCQA RETQVGSETK 
       310        320        330        340        350
TLPSVDVALL HSHGDSVGPG LGPCTQPHLA PSEAPGQLGE TQVPSSTSDD 
       360        370        380        390        400
RVKDEFSDLS EGDFLSEDES DKKQTPQSSD ESFEPYPEKK VSGKKSEGRE 
       410        420        430        440        450
AKRPEEPKIR KKPGPKPGWK KKLRCEREEL PTIYKCPYQG CTAVYRGADG 
       460        470        480        490        500
MKKHIKEHHE EVRERPCPHP GCNKVFMIDR YLQRHVKLIH TEVRNYICDE 
       510        520        530        540        550
CGQTFKQRKH LLVHQMRHSG AKPLQCEVCG FQCRQRASLK YHMTKHKAET 
       560        570        580        590        600
ELDFACDQCG RRFEKAHNLN VHMSMVHPLT QAQDRALPLE AEPPPGPLSP 
       610 
SGTMEGQAVK PEPT

Length:614

Mass (Da):67,339

Last modified:June 12, 2007 - v3

Checksum:ⁱ1F5716CFADE16533

Isoform 2 (identifier: Q8CE64-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
337-350: QLGETQVPSSTSDD → KQHLWLMLEQDSVF
351-614: Missing.

« Hide

        10         20         30         40         50
MKRDRLGRFL SPGIARQRGG SGGGCGSGRT RGRPSRSGGT SADGAAAQLS 
        60         70         80         90        100
WGSMTRSCGD TGDDGTDEAG AGRTLAMGHC RLCHGKFSSR SLRSISDRVP 
       110        120        130        140        150
GETSERLSPG ERVFIRDFQR LLGVAVHQDP ALPQSVCKNC YTQFYQCHSL 
       160        170        180        190        200
LRTFLQRVNV SPAGQRKPCT KVGVQPTTVA EEGACVADLI ASSPRCLHGL 
       210        220        230        240        250
VGWVHEHAVS CGSLPSLQRT LSSEYCGIIQ AVWGCDQGHD FTMDTASSCR 
       260        270        280        290        300
ALFLDSALAV KWAWGKDLSP RLAQNSESNP TGAASRLCQA RETQVGSETK 
       310        320        330        340        350
TLPSVDVALL HSHGDSVGPG LGPCTQPHLA PSEAPGKQHL WLMLEQDSVF

Show »

Length:350

Mass (Da):37,228

Checksum:ⁱ01CDDE5D404D230D

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D3Z1K4	D3Z1K4_MOUSE		Zinc finger protein (C2H2 type) 276 Zinc finger protein (C2H2 type) 276	Zfp276	233	Annotation score:

Sequence cautionⁱ

The sequence AAG01634 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAC31505 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	353	K → R in BAC26204 (PubMed:16141072).Curated	1
Sequence conflictⁱ	509 – 510	KH → ND in AAG01634 (PubMed:10936049).Curated	2
Sequence conflictⁱ	521	A → G in AAG01634 (PubMed:10936049).Curated	1
Sequence conflictⁱ	579	L → W in AAG01634 (PubMed:10936049).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_026106	337 – 350	QLGET…STSDD → KQHLWLMLEQDSVF in isoform 2. 1 PublicationAdd BLAST		14
Alternative sequenceⁱVSP_026107	351 – 614	Missing in isoform 2. 1 PublicationAdd BLAST		264

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK028939 mRNA Translation: BAC26204.1 AK043258 mRNA Translation: BAC31505.1 Different initiation. AK133363 mRNA Translation: BAE21616.1 AK163486 mRNA Translation: BAE37365.1 AF178935 mRNA Translation: AAG01634.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS52699.1 [Q8CE64-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_065243.2, NM_020497.2 [Q8CE64-1]
UniGeneⁱ	Mm.379084

Genome annotation databases

Ensemblⁱ	ENSMUST00000001092; ENSMUSP00000001092; ENSMUSG00000001065 [Q8CE64-1]
GeneIDⁱ	57247
KEGGⁱ	mmu:57247
UCSC genome browser More...UCSCⁱ	uc009nva.2 mouse [Q8CE64-2] uc009nvb.2 mouse [Q8CE64-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8CE64	Zinc finger protein (C2H2 type) 276		MOUSE		372	UniRef100_Q8CE64

Protein	Similar proteins		Species	Score	Length	Source
Q8CE64	Zinc finger protein (C2H2 type) 276		MOUSE		372	UniRef90_Q8CE64
zinc finger protein 276 isoform X1		MESAU		617
Zinc finger protein		CRIGR		617
Uncharacterized protein		NEOLE		613
Zinc finger protein (C2H2 type) 276		RAT		609
+12

Protein	Similar proteins		Species	Score	Length	Source
Q8CE64	Zinc finger protein 276		HUMAN		614	UniRef50_Q8N554
Uncharacterized protein		Cebus capucinus imitator		616
ZNF276 isoform 4		PANTR		614
Uncharacterized protein		CERAT		613
ZNF276 isoform 5		PONAB		613
+143
Q8CE64-2	Uncharacterized protein		MACFA		280	UniRef50_Q8CE64-2
Zinc finger protein 276 (Fragment)		NEOVI		290
Zinc finger protein 276 (Fragment)		MUSPF		282

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK028939 mRNA Translation: BAC26204.1 AK043258 mRNA Translation: BAC31505.1 Different initiation. AK133363 mRNA Translation: BAE21616.1 AK163486 mRNA Translation: BAE37365.1 AF178935 mRNA Translation: AAG01634.1 Different initiation.
CCDSⁱ	CCDS52699.1 [Q8CE64-1]
RefSeqⁱ	NP_065243.2, NM_020497.2 [Q8CE64-1]
UniGeneⁱ	Mm.379084

3D structure databases

ProteinModelPortalⁱ	Q8CE64
SMRⁱ	Q8CE64
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	208217, 1 interactor
STRINGⁱ	10090.ENSMUSP00000001092

PTM databases

iPTMnetⁱ	Q8CE64
PhosphoSitePlusⁱ	Q8CE64

Proteomic databases

PaxDbⁱ	Q8CE64
PeptideAtlasⁱ	Q8CE64
PRIDEⁱ	Q8CE64

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000001092; ENSMUSP00000001092; ENSMUSG00000001065 [Q8CE64-1]
GeneIDⁱ	57247
KEGGⁱ	mmu:57247
UCSCⁱ	uc009nva.2 mouse [Q8CE64-2] uc009nvb.2 mouse [Q8CE64-1]

Organism-specific databases

CTDⁱ	57247
MGIⁱ	MGI:1888495 Zfp276

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00530000063153
HOGENOMⁱ	HOG000155790
HOVERGENⁱ	HBG061026
InParanoidⁱ	Q8CE64
OMAⁱ	IQAVWGC
OrthoDBⁱ	EOG091G04WK
PhylomeDBⁱ	Q8CE64
TreeFamⁱ	TF332664

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8CE64
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000001065 Expressed in 221 organ(s), highest expression level in head
CleanExⁱ	MM_ZFP276
ExpressionAtlasⁱ	Q8CE64 baseline and differential
Genevisibleⁱ	Q8CE64 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR012934 Znf_AD IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF07776 zf-AD, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 5 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN276_MOUSE
Accessionⁱ	Q8CE64Primary (citable) accession number: Q8CE64 Secondary accession number(s): Q3TQL7 , Q3V088, Q80ZN3, Q8C912, Q9ESV2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
	Last sequence update:	June 12, 2007
	Last modified:	November 7, 2018
	This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8CE64 (ZN276_MOUSE)

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Zinc finger protein 276

Znf276

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ