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Protein

Zinc finger protein 276

Gene

Znf276

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri434 – 458C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri465 – 490C2H2-type 2PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri496 – 518C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 577C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 276
Short name:
Zfp-276
Gene namesi
Name:Znf276
Synonyms:Zfp276
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1888495 Zfp276

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473241 – 614Zinc finger protein 276Add BLAST614

Proteomic databases

PaxDbiQ8CE64
PeptideAtlasiQ8CE64
PRIDEiQ8CE64

PTM databases

iPTMnetiQ8CE64
PhosphoSitePlusiQ8CE64

Expressioni

Tissue specificityi

Found in all the examined tissues, with highest levels in kidney, liver, lung, and spleen.1 Publication

Developmental stagei

Expressed at low levels in all stages of embryonic development examined.1 Publication

Gene expression databases

BgeeiENSMUSG00000001065 Expressed in 221 organ(s), highest expression level in head
CleanExiMM_ZFP276
ExpressionAtlasiQ8CE64 baseline and differential
GenevisibleiQ8CE64 MM

Interactioni

Protein-protein interaction databases

BioGridi208217, 1 interactor
STRINGi10090.ENSMUSP00000001092

Structurei

3D structure databases

ProteinModelPortaliQ8CE64
SMRiQ8CE64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 153ZADAdd BLAST75

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri434 – 458C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri465 – 490C2H2-type 2PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri496 – 518C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 577C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063153
HOGENOMiHOG000155790
HOVERGENiHBG061026
InParanoidiQ8CE64
OMAiIQAVWGC
OrthoDBiEOG091G04WK
PhylomeDBiQ8CE64
TreeFamiTF332664

Family and domain databases

InterProiView protein in InterPro
IPR012934 Znf_AD
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF07776 zf-AD, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CE64-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRDRLGRFL SPGIARQRGG SGGGCGSGRT RGRPSRSGGT SADGAAAQLS
60 70 80 90 100
WGSMTRSCGD TGDDGTDEAG AGRTLAMGHC RLCHGKFSSR SLRSISDRVP
110 120 130 140 150
GETSERLSPG ERVFIRDFQR LLGVAVHQDP ALPQSVCKNC YTQFYQCHSL
160 170 180 190 200
LRTFLQRVNV SPAGQRKPCT KVGVQPTTVA EEGACVADLI ASSPRCLHGL
210 220 230 240 250
VGWVHEHAVS CGSLPSLQRT LSSEYCGIIQ AVWGCDQGHD FTMDTASSCR
260 270 280 290 300
ALFLDSALAV KWAWGKDLSP RLAQNSESNP TGAASRLCQA RETQVGSETK
310 320 330 340 350
TLPSVDVALL HSHGDSVGPG LGPCTQPHLA PSEAPGQLGE TQVPSSTSDD
360 370 380 390 400
RVKDEFSDLS EGDFLSEDES DKKQTPQSSD ESFEPYPEKK VSGKKSEGRE
410 420 430 440 450
AKRPEEPKIR KKPGPKPGWK KKLRCEREEL PTIYKCPYQG CTAVYRGADG
460 470 480 490 500
MKKHIKEHHE EVRERPCPHP GCNKVFMIDR YLQRHVKLIH TEVRNYICDE
510 520 530 540 550
CGQTFKQRKH LLVHQMRHSG AKPLQCEVCG FQCRQRASLK YHMTKHKAET
560 570 580 590 600
ELDFACDQCG RRFEKAHNLN VHMSMVHPLT QAQDRALPLE AEPPPGPLSP
610
SGTMEGQAVK PEPT
Length:614
Mass (Da):67,339
Last modified:June 12, 2007 - v3
Checksum:i1F5716CFADE16533
GO
Isoform 2 (identifier: Q8CE64-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     337-350: QLGETQVPSSTSDD → KQHLWLMLEQDSVF
     351-614: Missing.

Show »
Length:350
Mass (Da):37,228
Checksum:i01CDDE5D404D230D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z1K4D3Z1K4_MOUSE
Zinc finger protein (C2H2 type) 276
Zfp276
233Annotation score:

Sequence cautioni

The sequence AAG01634 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC31505 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti353K → R in BAC26204 (PubMed:16141072).Curated1
Sequence conflicti509 – 510KH → ND in AAG01634 (PubMed:10936049).Curated2
Sequence conflicti521A → G in AAG01634 (PubMed:10936049).Curated1
Sequence conflicti579L → W in AAG01634 (PubMed:10936049).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026106337 – 350QLGET…STSDD → KQHLWLMLEQDSVF in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_026107351 – 614Missing in isoform 2. 1 PublicationAdd BLAST264

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028939 mRNA Translation: BAC26204.1
AK043258 mRNA Translation: BAC31505.1 Different initiation.
AK133363 mRNA Translation: BAE21616.1
AK163486 mRNA Translation: BAE37365.1
AF178935 mRNA Translation: AAG01634.1 Different initiation.
CCDSiCCDS52699.1 [Q8CE64-1]
RefSeqiNP_065243.2, NM_020497.2 [Q8CE64-1]
UniGeneiMm.379084

Genome annotation databases

EnsembliENSMUST00000001092; ENSMUSP00000001092; ENSMUSG00000001065 [Q8CE64-1]
GeneIDi57247
KEGGimmu:57247
UCSCiuc009nva.2 mouse [Q8CE64-2]
uc009nvb.2 mouse [Q8CE64-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028939 mRNA Translation: BAC26204.1
AK043258 mRNA Translation: BAC31505.1 Different initiation.
AK133363 mRNA Translation: BAE21616.1
AK163486 mRNA Translation: BAE37365.1
AF178935 mRNA Translation: AAG01634.1 Different initiation.
CCDSiCCDS52699.1 [Q8CE64-1]
RefSeqiNP_065243.2, NM_020497.2 [Q8CE64-1]
UniGeneiMm.379084

3D structure databases

ProteinModelPortaliQ8CE64
SMRiQ8CE64
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208217, 1 interactor
STRINGi10090.ENSMUSP00000001092

PTM databases

iPTMnetiQ8CE64
PhosphoSitePlusiQ8CE64

Proteomic databases

PaxDbiQ8CE64
PeptideAtlasiQ8CE64
PRIDEiQ8CE64

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001092; ENSMUSP00000001092; ENSMUSG00000001065 [Q8CE64-1]
GeneIDi57247
KEGGimmu:57247
UCSCiuc009nva.2 mouse [Q8CE64-2]
uc009nvb.2 mouse [Q8CE64-1]

Organism-specific databases

CTDi57247
MGIiMGI:1888495 Zfp276

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063153
HOGENOMiHOG000155790
HOVERGENiHBG061026
InParanoidiQ8CE64
OMAiIQAVWGC
OrthoDBiEOG091G04WK
PhylomeDBiQ8CE64
TreeFamiTF332664

Miscellaneous databases

PROiPR:Q8CE64
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001065 Expressed in 221 organ(s), highest expression level in head
CleanExiMM_ZFP276
ExpressionAtlasiQ8CE64 baseline and differential
GenevisibleiQ8CE64 MM

Family and domain databases

InterProiView protein in InterPro
IPR012934 Znf_AD
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF07776 zf-AD, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN276_MOUSE
AccessioniPrimary (citable) accession number: Q8CE64
Secondary accession number(s): Q3TQL7
, Q3V088, Q80ZN3, Q8C912, Q9ESV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: June 12, 2007
Last modified: November 7, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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