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UniProtKB - Q8CE64 (ZN276_MOUSE)
Protein
Zinc finger protein 276
Gene
Znf276
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 80 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 83 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 137 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 140 | ZincPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 434 – 458 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 465 – 490 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 496 – 518 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 524 – 546 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 554 – 577 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- chromatin insulator sequence binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
- zinc ion binding Source: InterPro
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 276Short name: Zfp-276 |
Gene namesi | Name:Znf276 Synonyms:Zfp276 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1888495, Zfp276 |
VEuPathDBi | HostDB:ENSMUSG00000001065 |
Subcellular locationi
Nucleus
- Nucleus Curated
Other locations
- kinetochore By similarity
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- chromosome Source: GO_Central
- kinetochore Source: UniProtKB
Keywords - Cellular componenti
Centromere, Chromosome, Kinetochore, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047324 | 1 – 614 | Zinc finger protein 276Add BLAST | 614 |
Proteomic databases
MaxQBi | Q8CE64 |
PaxDbi | Q8CE64 |
PeptideAtlasi | Q8CE64 |
PRIDEi | Q8CE64 |
ProteomicsDBi | 275069 [Q8CE64-1] 275070 [Q8CE64-2] |
PTM databases
iPTMneti | Q8CE64 |
PhosphoSitePlusi | Q8CE64 |
Expressioni
Tissue specificityi
Found in all the examined tissues, with highest levels in kidney, liver, lung, and spleen.1 Publication
Developmental stagei
Expressed at low levels in all stages of embryonic development examined.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000001065, Expressed in granulocyte and 250 other tissues |
ExpressionAtlasi | Q8CE64, baseline and differential |
Genevisiblei | Q8CE64, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 208217, 17 interactors |
IntActi | Q8CE64, 1 interactor |
STRINGi | 10090.ENSMUSP00000001092 |
Miscellaneous databases
RNActi | Q8CE64, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 78 – 164 | ZADPROSITE-ProRule annotationAdd BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 46 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 271 – 422 | DisorderedSequence analysisAdd BLAST | 152 | |
Regioni | 588 – 614 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 271 – 301 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 347 – 422 | Basic and acidic residuesSequence analysisAdd BLAST | 76 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 434 – 458 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 465 – 490 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 496 – 518 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 524 – 546 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 554 – 577 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158841 |
HOGENOMi | CLU_040755_0_0_1 |
InParanoidi | Q8CE64 |
OMAi | LAVKWAW |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8CE64 |
TreeFami | TF332664 |
Family and domain databases
InterProi | View protein in InterPro IPR012934, Znf_AD IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF07776, zf-AD, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS51915, ZAD, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8CE64-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKRDRLGRFL SPGIARQRGG SGGGCGSGRT RGRPSRSGGT SADGAAAQLS
60 70 80 90 100
WGSMTRSCGD TGDDGTDEAG AGRTLAMGHC RLCHGKFSSR SLRSISDRVP
110 120 130 140 150
GETSERLSPG ERVFIRDFQR LLGVAVHQDP ALPQSVCKNC YTQFYQCHSL
160 170 180 190 200
LRTFLQRVNV SPAGQRKPCT KVGVQPTTVA EEGACVADLI ASSPRCLHGL
210 220 230 240 250
VGWVHEHAVS CGSLPSLQRT LSSEYCGIIQ AVWGCDQGHD FTMDTASSCR
260 270 280 290 300
ALFLDSALAV KWAWGKDLSP RLAQNSESNP TGAASRLCQA RETQVGSETK
310 320 330 340 350
TLPSVDVALL HSHGDSVGPG LGPCTQPHLA PSEAPGQLGE TQVPSSTSDD
360 370 380 390 400
RVKDEFSDLS EGDFLSEDES DKKQTPQSSD ESFEPYPEKK VSGKKSEGRE
410 420 430 440 450
AKRPEEPKIR KKPGPKPGWK KKLRCEREEL PTIYKCPYQG CTAVYRGADG
460 470 480 490 500
MKKHIKEHHE EVRERPCPHP GCNKVFMIDR YLQRHVKLIH TEVRNYICDE
510 520 530 540 550
CGQTFKQRKH LLVHQMRHSG AKPLQCEVCG FQCRQRASLK YHMTKHKAET
560 570 580 590 600
ELDFACDQCG RRFEKAHNLN VHMSMVHPLT QAQDRALPLE AEPPPGPLSP
610
SGTMEGQAVK PEPT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3Z1K4 | D3Z1K4_MOUSE | Zinc finger protein (C2H2 type) 276 | Zfp276 | 233 | Annotation score: |
Sequence cautioni
The sequence AAG01634 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC31505 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 353 | K → R in BAC26204 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 509 – 510 | KH → ND in AAG01634 (PubMed:10936049).Curated | 2 | |
Sequence conflicti | 521 | A → G in AAG01634 (PubMed:10936049).Curated | 1 | |
Sequence conflicti | 579 | L → W in AAG01634 (PubMed:10936049).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026106 | 337 – 350 | QLGET…STSDD → KQHLWLMLEQDSVF in isoform 2. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_026107 | 351 – 614 | Missing in isoform 2. 1 PublicationAdd BLAST | 264 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028939 mRNA Translation: BAC26204.1 AK043258 mRNA Translation: BAC31505.1 Different initiation. AK133363 mRNA Translation: BAE21616.1 AK163486 mRNA Translation: BAE37365.1 AF178935 mRNA Translation: AAG01634.1 Different initiation. |
CCDSi | CCDS52699.1 [Q8CE64-1] |
RefSeqi | NP_065243.2, NM_020497.2 [Q8CE64-1] |
Genome annotation databases
Ensembli | ENSMUST00000001092; ENSMUSP00000001092; ENSMUSG00000001065 [Q8CE64-1] |
GeneIDi | 57247 |
KEGGi | mmu:57247 |
UCSCi | uc009nva.2, mouse [Q8CE64-2] uc009nvb.2, mouse [Q8CE64-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028939 mRNA Translation: BAC26204.1 AK043258 mRNA Translation: BAC31505.1 Different initiation. AK133363 mRNA Translation: BAE21616.1 AK163486 mRNA Translation: BAE37365.1 AF178935 mRNA Translation: AAG01634.1 Different initiation. |
CCDSi | CCDS52699.1 [Q8CE64-1] |
RefSeqi | NP_065243.2, NM_020497.2 [Q8CE64-1] |
3D structure databases
SMRi | Q8CE64 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 208217, 17 interactors |
IntActi | Q8CE64, 1 interactor |
STRINGi | 10090.ENSMUSP00000001092 |
PTM databases
iPTMneti | Q8CE64 |
PhosphoSitePlusi | Q8CE64 |
Proteomic databases
MaxQBi | Q8CE64 |
PaxDbi | Q8CE64 |
PeptideAtlasi | Q8CE64 |
PRIDEi | Q8CE64 |
ProteomicsDBi | 275069 [Q8CE64-1] 275070 [Q8CE64-2] |
Protocols and materials databases
Antibodypediai | 17483, 129 antibodies from 19 providers |
DNASUi | 57247 |
Genome annotation databases
Ensembli | ENSMUST00000001092; ENSMUSP00000001092; ENSMUSG00000001065 [Q8CE64-1] |
GeneIDi | 57247 |
KEGGi | mmu:57247 |
UCSCi | uc009nva.2, mouse [Q8CE64-2] uc009nvb.2, mouse [Q8CE64-1] |
Organism-specific databases
CTDi | 57247 |
MGIi | MGI:1888495, Zfp276 |
VEuPathDBi | HostDB:ENSMUSG00000001065 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158841 |
HOGENOMi | CLU_040755_0_0_1 |
InParanoidi | Q8CE64 |
OMAi | LAVKWAW |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8CE64 |
TreeFami | TF332664 |
Miscellaneous databases
BioGRID-ORCSi | 57247, 0 hits in 63 CRISPR screens |
PROi | PR:Q8CE64 |
RNActi | Q8CE64, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000001065, Expressed in granulocyte and 250 other tissues |
ExpressionAtlasi | Q8CE64, baseline and differential |
Genevisiblei | Q8CE64, MM |
Family and domain databases
InterProi | View protein in InterPro IPR012934, Znf_AD IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF07776, zf-AD, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS51915, ZAD, 1 hit PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN276_MOUSE | |
Accessioni | Q8CE64Primary (citable) accession number: Q8CE64 Secondary accession number(s): Q3TQL7 Q9ESV2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2004 |
Last sequence update: | June 12, 2007 | |
Last modified: | February 23, 2022 | |
This is version 143 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot