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Protein

Solute carrier family 49 member A3

Gene

Slc49a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.1.28.2 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 49 member A3
Alternative name(s):
Major facilitator superfamily domain-containing protein 7A
Gene namesi
Name:Slc49a3
Synonyms:Mfsd7a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2442629 Mfsd7a

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002734091 – 516Solute carrier family 49 member A3Add BLAST516

Proteomic databases

MaxQBiQ8CE47
PaxDbiQ8CE47
PRIDEiQ8CE47

PTM databases

iPTMnetiQ8CE47
PhosphoSitePlusiQ8CE47

Expressioni

Gene expression databases

BgeeiENSMUSG00000029490 Expressed in 18 organ(s), highest expression level in zone of skin

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031455

Structurei

3D structure databases

ProteinModelPortaliQ8CE47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2563 Eukaryota
ENOG410XSTK LUCA
GeneTreeiENSGT00530000062892
HOGENOMiHOG000251610
HOVERGENiHBG079844
InParanoidiQ8CE47
KOiK12306
OMAiYVILAVC
OrthoDBiEOG091G0837
PhylomeDBiQ8CE47
TreeFamiTF314292

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CE47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGTMDRLED CNSPETSGTA GDALPSPRVY ARRWVFLLVV SLLSCSNAML
60 70 80 90 100
WLSFAPVADT IAQHFFLSMD QVNWLSLIYF VLSIPFGMAA IWVLDSVGLR
110 120 130 140 150
GATILGAWLN FSGSVLRAVP CLPVRIPSPF AFFMSGQSLC ALAQTLVVSS
160 170 180 190 200
PAKLAALWFP EHQRATANMI STMSNPLGLL IANVLSPALV KKADDIPMML
210 220 230 240 250
GIYIGPAALA CLLATVCLWE SVPPTPPSTG AANSTSESFL RGLKLLIQNK
260 270 280 290 300
AYVLLAVCFG GGIGVFSSFS ALLEQILCAS GYSNEFSGLC GALFIVFGIL
310 320 330 340 350
GALLLGLYVD RTKHFTEATK IGLCLTSMTS VAFALVSQLQ GQTLALAAIC
360 370 380 390 400
SLFGLFGFSV APVVMELAVE CSFPVGEGAS AGLIFVLGQA EGMLIMLLLT
410 420 430 440 450
ALTVRRTGPS FSTCQQGEDP LDWTVSLLLL AGLCTLFTCV LVIFFNTPYR
460 470 480 490 500
RLEAESGGSS SPTMCARDPR TVSPTQVPPL ETPGLTPPDE ALKEAPGPAS
510
VSKGHSEWAE TMPRDV
Length:516
Mass (Da):54,646
Last modified:March 1, 2003 - v1
Checksum:iFC00C76F548E9157
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210A → S in AAH94512 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029021 mRNA Translation: BAC26248.1
BC094512 mRNA Translation: AAH94512.1
CCDSiCCDS19511.1
RefSeqiNP_766471.1, NM_172883.2
UniGeneiMm.106818

Genome annotation databases

EnsembliENSMUST00000031455; ENSMUSP00000031455; ENSMUSG00000029490
GeneIDi243197
KEGGimmu:243197
UCSCiuc008yoc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029021 mRNA Translation: BAC26248.1
BC094512 mRNA Translation: AAH94512.1
CCDSiCCDS19511.1
RefSeqiNP_766471.1, NM_172883.2
UniGeneiMm.106818

3D structure databases

ProteinModelPortaliQ8CE47
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031455

Protein family/group databases

TCDBi2.A.1.28.2 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ8CE47
PhosphoSitePlusiQ8CE47

Proteomic databases

MaxQBiQ8CE47
PaxDbiQ8CE47
PRIDEiQ8CE47

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031455; ENSMUSP00000031455; ENSMUSG00000029490
GeneIDi243197
KEGGimmu:243197
UCSCiuc008yoc.1 mouse

Organism-specific databases

CTDi243197
MGIiMGI:2442629 Mfsd7a

Phylogenomic databases

eggNOGiKOG2563 Eukaryota
ENOG410XSTK LUCA
GeneTreeiENSGT00530000062892
HOGENOMiHOG000251610
HOVERGENiHBG079844
InParanoidiQ8CE47
KOiK12306
OMAiYVILAVC
OrthoDBiEOG091G0837
PhylomeDBiQ8CE47
TreeFamiTF314292

Miscellaneous databases

PROiPR:Q8CE47
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029490 Expressed in 18 organ(s), highest expression level in zone of skin

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS49A3_MOUSE
AccessioniPrimary (citable) accession number: Q8CE47
Secondary accession number(s): Q505K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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