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Protein

Orexigenic neuropeptide QRFP

Gene

Qrfp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stimulates feeding and grooming behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-MMU-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Orexigenic neuropeptide QRFP
Alternative name(s):
P518
Cleaved into the following chain:
Alternative name(s):
Neuropeptide RF-amide
Pyroglutamylated arginine-phenylalanine-amide peptide
Gene namesi
Name:QrfpImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:3630329 Qrfp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000001008818 – 79By similarityAdd BLAST62
PeptideiPRO_000001008980 – 122QRF-amideCuratedAdd BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122Phenylalanine amideBy similarity1

Keywords - PTMi

Amidation

Proteomic databases

PaxDbiQ8CE23
PRIDEiQ8CE23

Expressioni

Tissue specificityi

Expressed in the brain with highest levels in the periventricular hypothalamic nucleus and lateral hypothalamic areas. Expressed at moderate levels in the adrenal gland, eye, heart, intestine, liver, lung, kidney, mesenteric lymph node, ovary, placenta, Peyer patches, skin, spleen, stomach, testis, thymus and uterus.2 Publications

Gene expression databases

BgeeiENSMUSG00000043102 Expressed in 16 organ(s), highest expression level in thymus
CleanExiMM_QRFP

Interactioni

Subunit structurei

Ligand for the G-protein coupled receptor QRFPR/GPR103.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055746

Family & Domainsi

Sequence similaritiesi

Belongs to the RFamide neuropeptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZA2 Eukaryota
ENOG410YYZS LUCA
GeneTreeiENSGT00390000015756
HOGENOMiHOG000231990
HOVERGENiHBG053386
InParanoidiQ8CE23
OMAiCRFRFGR
OrthoDBiEOG091G16YK
PhylomeDBiQ8CE23
TreeFamiTF336317

Family and domain databases

InterProiView protein in InterPro
IPR024565 P518
PANTHERiPTHR36476 PTHR36476, 1 hit
PfamiView protein in Pfam
PF11109 RFamide_26RFa, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD786889 PD786889, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CE23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGFRPLLSL LLPLSACFPL LDRRGPTDIG DIGARMNWAQ LAEGHPPNSV
60 70 80 90 100
QNPQPQALLV VAREQQASHR EHTGFRLGRQ DGSSEAAGFL PADSEKASGP
110 120
LGTLAEELSS YSRRKGGFSF RFGR
Length:124
Mass (Da):13,485
Last modified:March 1, 2003 - v1
Checksum:i2BA6A90F3575EF20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB109628 mRNA Translation: BAC98937.1
AK029144 mRNA Translation: BAC26323.1
AL929275 Genomic DNA No translation available.
CCDSiCCDS15902.1
RefSeqiNP_906269.1, NM_183424.4
UniGeneiMm.185027

Genome annotation databases

EnsembliENSMUST00000057407; ENSMUSP00000055746; ENSMUSG00000043102
GeneIDi227717
KEGGimmu:227717
UCSCiuc008jed.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB109628 mRNA Translation: BAC98937.1
AK029144 mRNA Translation: BAC26323.1
AL929275 Genomic DNA No translation available.
CCDSiCCDS15902.1
RefSeqiNP_906269.1, NM_183424.4
UniGeneiMm.185027

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055746

Proteomic databases

PaxDbiQ8CE23
PRIDEiQ8CE23

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057407; ENSMUSP00000055746; ENSMUSG00000043102
GeneIDi227717
KEGGimmu:227717
UCSCiuc008jed.1 mouse

Organism-specific databases

CTDi347148
MGIiMGI:3630329 Qrfp

Phylogenomic databases

eggNOGiENOG410IZA2 Eukaryota
ENOG410YYZS LUCA
GeneTreeiENSGT00390000015756
HOGENOMiHOG000231990
HOVERGENiHBG053386
InParanoidiQ8CE23
OMAiCRFRFGR
OrthoDBiEOG091G16YK
PhylomeDBiQ8CE23
TreeFamiTF336317

Enzyme and pathway databases

ReactomeiR-MMU-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-MMU-416476 G alpha (q) signalling events

Miscellaneous databases

PROiPR:Q8CE23
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043102 Expressed in 16 organ(s), highest expression level in thymus
CleanExiMM_QRFP

Family and domain databases

InterProiView protein in InterPro
IPR024565 P518
PANTHERiPTHR36476 PTHR36476, 1 hit
PfamiView protein in Pfam
PF11109 RFamide_26RFa, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD786889 PD786889, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOX26_MOUSE
AccessioniPrimary (citable) accession number: Q8CE23
Secondary accession number(s): A2AV24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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