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Protein

Thioredoxin-like protein 1

Gene

Txnl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Active thioredoxin with a redox potential of about -250 mV.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein 1
Alternative name(s):
32 kDa thioredoxin-related protein
Gene namesi
Name:Txnl1
Synonyms:Trp32, Txnl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1860078 Txnl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001200171 – 289Thioredoxin-like protein 1Add BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 37Redox-activeBy similarity
Modified residuei113PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ8CDN6
MaxQBiQ8CDN6
PaxDbiQ8CDN6
PRIDEiQ8CDN6

2D gel databases

REPRODUCTION-2DPAGEiQ8CDN6

PTM databases

iPTMnetiQ8CDN6
PhosphoSitePlusiQ8CDN6
SwissPalmiQ8CDN6

Expressioni

Gene expression databases

BgeeiENSMUSG00000024583 Expressed in 284 organ(s), highest expression level in female gonad
CleanExiMM_TXNL1
GenevisibleiQ8CDN6 MM

Interactioni

Subunit structurei

Component of the 19S regulatory cap of the 26S proteasome. Interacts with PSMD14/RPN11. Interacts with, and reduces EEF1A1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi207304, 3 interactors
IntActiQ8CDN6, 2 interactors
MINTiQ8CDN6
STRINGi10090.ENSMUSP00000025476

Structurei

3D structure databases

ProteinModelPortaliQ8CDN6
SMRiQ8CDN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 109ThioredoxinAdd BLAST108
Domaini115 – 285PITHPROSITE-ProRule annotationAdd BLAST171

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0908 Eukaryota
ENOG410YQ2G LUCA
GeneTreeiENSGT00530000063008
HOVERGENiHBG055982
InParanoidiQ8CDN6
OMAiPIFEMFP
OrthoDBiEOG091G0G71
PhylomeDBiQ8CDN6
TreeFamiTF314399

Family and domain databases

Gene3Di2.60.120.470, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR010400 PITH_dom
IPR037047 PITH_dom_sf
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF06201 PITH, 1 hit
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51532 PITH, 1 hit
PS00194 THIOREDOXIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CDN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGVKPVGSD PDFQPELSGA GSRLAVVKFT MRGCGPCLRI APAFSSMSNK
60 70 80 90 100
YPQAVFLEVD VHQCQGTAAT NNISATPTFL FFRNKVRIDQ YQGADAVGLE
110 120 130 140 150
EKIKQHLEND PGSNEDADIP KGYMDLMPFI NKAGCECLNE SDEHGFDNCL
160 170 180 190 200
RKDMSFLESD CDEQLLITVA FNQPVKLYSM KFQGPDNGQG PKYVKIFINL
210 220 230 240 250
PRSMDFEEAE RSEPTQALEL TEDDIKEDGI VPLRYVKFQN VNSVTLFVQS
260 270 280
NQGEEETTRI SYFTFIGTPV QATNMNDFKR VVGKKGESH
Length:289
Mass (Da):32,237
Last modified:January 23, 2007 - v3
Checksum:i4BE29C6C1D1DFA0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251N → K in AAC40183 (PubMed:9668102).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052660 mRNA Translation: AAC40183.1
AK029807 mRNA Translation: BAC26626.1
AK150326 mRNA Translation: BAE29469.1
AK167954 mRNA Translation: BAE39954.1
AK168712 mRNA Translation: BAE40554.1
BC061123 mRNA Translation: AAH61123.1
CCDSiCCDS29297.1
RefSeqiNP_058072.2, NM_016792.4
UniGeneiMm.19169

Genome annotation databases

EnsembliENSMUST00000025476; ENSMUSP00000025476; ENSMUSG00000024583
GeneIDi53382
KEGGimmu:53382
UCSCiuc008fdx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052660 mRNA Translation: AAC40183.1
AK029807 mRNA Translation: BAC26626.1
AK150326 mRNA Translation: BAE29469.1
AK167954 mRNA Translation: BAE39954.1
AK168712 mRNA Translation: BAE40554.1
BC061123 mRNA Translation: AAH61123.1
CCDSiCCDS29297.1
RefSeqiNP_058072.2, NM_016792.4
UniGeneiMm.19169

3D structure databases

ProteinModelPortaliQ8CDN6
SMRiQ8CDN6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207304, 3 interactors
IntActiQ8CDN6, 2 interactors
MINTiQ8CDN6
STRINGi10090.ENSMUSP00000025476

PTM databases

iPTMnetiQ8CDN6
PhosphoSitePlusiQ8CDN6
SwissPalmiQ8CDN6

2D gel databases

REPRODUCTION-2DPAGEiQ8CDN6

Proteomic databases

EPDiQ8CDN6
MaxQBiQ8CDN6
PaxDbiQ8CDN6
PRIDEiQ8CDN6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025476; ENSMUSP00000025476; ENSMUSG00000024583
GeneIDi53382
KEGGimmu:53382
UCSCiuc008fdx.1 mouse

Organism-specific databases

CTDi9352
MGIiMGI:1860078 Txnl1

Phylogenomic databases

eggNOGiKOG0908 Eukaryota
ENOG410YQ2G LUCA
GeneTreeiENSGT00530000063008
HOVERGENiHBG055982
InParanoidiQ8CDN6
OMAiPIFEMFP
OrthoDBiEOG091G0G71
PhylomeDBiQ8CDN6
TreeFamiTF314399

Miscellaneous databases

ChiTaRSiTxnl1 mouse
PROiPR:Q8CDN6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024583 Expressed in 284 organ(s), highest expression level in female gonad
CleanExiMM_TXNL1
GenevisibleiQ8CDN6 MM

Family and domain databases

Gene3Di2.60.120.470, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR010400 PITH_dom
IPR037047 PITH_dom_sf
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF06201 PITH, 1 hit
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51532 PITH, 1 hit
PS00194 THIOREDOXIN_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTXNL1_MOUSE
AccessioniPrimary (citable) accession number: Q8CDN6
Secondary accession number(s): O70379, Q3TI92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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