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Entry version 92 (16 Oct 2019)
Sequence version 2 (01 May 2007)
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Protein

Coiled-coil domain-containing protein 73

Gene

Ccdc73

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 73
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ccdc73
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3606488 Ccdc73

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002852951 – 1066Coiled-coil domain-containing protein 73Add BLAST1066

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CDM4

PRoteomics IDEntifications database

More...
PRIDEi
Q8CDM4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CDM4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CDM4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000045106 Expressed in 50 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CDM4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CDM4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000106743

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CDM4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili47 – 134Sequence analysisAdd BLAST88
Coiled coili178 – 391Sequence analysisAdd BLAST214

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKRA Eukaryota
ENOG4112DB3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013482

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111435

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CDM4

Identification of Orthologs from Complete Genome Data

More...
OMAi
HASQAKD

Database of Orthologous Groups

More...
OrthoDBi
137572at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CDM4

TreeFam database of animal gene trees

More...
TreeFami
TF335743

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031650 CCDC73

The PANTHER Classification System

More...
PANTHERi
PTHR28660 PTHR28660, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15818 CCDC73, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8CDM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDSFNTTSS ASTFTLQSSS ETMVSIQLLD FRTSLLEALE ELRMRRKAET
60 70 80 90 100
QYEEQIAKII LETQELKWQK EALQNQKEAL IKQHKEAMGV LKNQLQMKMY
110 120 130 140 150
ALEEEKGKYK LATEIKEKEI EGLKETLKTL QVSQYSLQKK VSEMEQKAHL
160 170 180 190 200
YHLAKEDYHK QLNEIEKYYA AITNQFGLVR ENHVKLEQNV QEAIQLNKRL
210 220 230 240 250
STLNEKQESE IHSLKKELKK AASELIKSKV TCQHKMEEES IDLIIKEQKY
260 270 280 290 300
EELQERLNME LEVNKKINEE ITHIQEEKQD IIISFQHMQQ LLQQETQANT
310 320 330 340 350
EIDAELKVLR ENNQTLERDN ELQREKVKEN EEKFLSLEKE HERALGTWKK
360 370 380 390 400
HVEELSGEMN VIKNELSSLR ETHAKLQEHY NKLCEQKKTE EYKKFQNVPE
410 420 430 440 450
LNNENSDELT RKKSENIITQ KYNSGPEIWG KNTKSFCLDT EYREEEKKDL
460 470 480 490 500
PVGKTAEDLQ PFEISAKSEI NTMVSQDRNQ SGMSPHRVLC LDKDATDQEQ
510 520 530 540 550
TSDVTDSRKS VTVEVKDKLC LEKASGCSEF KSLNNFFLVV DESLETEMVR
560 570 580 590 600
LEGTEGLGLL HSGGDIPLDT RSNKASSNGM SNEMAHKRNY NTDGSESNPF
610 620 630 640 650
KQQSKLLPAD LENATEKEIT NQDQTKAGLD SFLDIKLNLD PCKKHGLQDS
660 670 680 690 700
SHVTLDVKHQ KIKQMVREES QCSTEPRSCY QLASKAPQKP GGTIACAAVV
710 720 730 740 750
SPLGPSASSD NKLTALKKSE NSINTLPTAA KPAPSPAERT TRTNTNDIQN
760 770 780 790 800
SSLRNHLGAS ESSVSVSDFQ VNQGDSHTSQ AKGLKTVVPL TTSSEKQPPS
810 820 830 840 850
ESQITETPKS GLSSLVDVTG RQCMWLNNRD KTEALNGILS GGTCHEGQLE
860 870 880 890 900
EAHLSPATPS ADSVSTSARS AFDLPSPDKP EKTPGYIKFV PLSPWPKVNQ
910 920 930 940 950
TKTVGTATPS IPLFLKEKTV DLSGSRVITP VTFCKNVVLD DTRKNIESDP
960 970 980 990 1000
TSNSRAADTM SNWSIHLDPK GQPREERNAT AQTVYDSSFP TEHVKAEPLI
1010 1020 1030 1040 1050
STVQQSHSQT VKVTDSPDPL TFSPGNNDWQ SLVMNRLTEI EKLLSLESDN
1060
QPKRRKVEEM LDNIID
Length:1,066
Mass (Da):120,389
Last modified:May 1, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF570EA3F7C641FE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6YTE1F6YTE1_MOUSE
Coiled-coil domain-containing prote...
Ccdc73
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A6Z7A2A6Z7_MOUSE
Coiled-coil domain containing 73
Ccdc73 RP23-198B6.1-002
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A6Z8A2A6Z8_MOUSE
Coiled-coil domain containing 73
Ccdc73 RP23-198B6.1-003
438Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC26648 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti367S → P in AAH95976 (PubMed:15489334).Curated1
Sequence conflicti615T → A in AAH95976 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL606494 Genomic DNA Translation: CAM17232.1
BC095976 mRNA Translation: AAH95976.1 Sequence problems.
AK029862 mRNA Translation: BAC26648.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16494.2

NCBI Reference Sequences

More...
RefSeqi
NP_808268.2, NM_177600.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000111114; ENSMUSP00000106743; ENSMUSG00000045106

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
211936

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:211936

UCSC genome browser

More...
UCSCi
uc008lkk.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606494 Genomic DNA Translation: CAM17232.1
BC095976 mRNA Translation: AAH95976.1 Sequence problems.
AK029862 mRNA Translation: BAC26648.1 Different initiation.
CCDSiCCDS16494.2
RefSeqiNP_808268.2, NM_177600.4

3D structure databases

SMRiQ8CDM4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106743

PTM databases

iPTMnetiQ8CDM4
PhosphoSitePlusiQ8CDM4

Proteomic databases

PaxDbiQ8CDM4
PRIDEiQ8CDM4

Genome annotation databases

EnsembliENSMUST00000111114; ENSMUSP00000106743; ENSMUSG00000045106
GeneIDi211936
KEGGimmu:211936
UCSCiuc008lkk.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
493860
MGIiMGI:3606488 Ccdc73

Phylogenomic databases

eggNOGiENOG410IKRA Eukaryota
ENOG4112DB3 LUCA
GeneTreeiENSGT00390000013482
HOGENOMiHOG000111435
InParanoidiQ8CDM4
OMAiHASQAKD
OrthoDBi137572at2759
PhylomeDBiQ8CDM4
TreeFamiTF335743

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ccdc73 mouse

Protein Ontology

More...
PROi
PR:Q8CDM4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000045106 Expressed in 50 organ(s), highest expression level in testis
ExpressionAtlasiQ8CDM4 baseline and differential
GenevisibleiQ8CDM4 MM

Family and domain databases

InterProiView protein in InterPro
IPR031650 CCDC73
PANTHERiPTHR28660 PTHR28660, 1 hit
PfamiView protein in Pfam
PF15818 CCDC73, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD73_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CDM4
Secondary accession number(s): A2A6Z9, Q501M4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: October 16, 2019
This is version 92 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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