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Entry version 126 (16 Oct 2019)
Sequence version 2 (15 Aug 2003)
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Protein

Stonin-1

Gene

Ston1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the endocytic machinery.By similarity

Miscellaneous

In contrast to other members of the family, it does not contain NPF (Asn-Pro-Phe) sites and thereby does not interact with EPS15, EPS15R and ITSN1.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Stonin-1
Alternative name(s):
Stoned B-like factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ston1
Synonyms:Salf, Sblf, Stn1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924307 Ston1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001857371 – 730Stonin-1Add BLAST730

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8CDJ8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CDJ8

PeptideAtlas

More...
PeptideAtlasi
Q8CDJ8

PRoteomics IDEntifications database

More...
PRIDEi
Q8CDJ8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CDJ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CDJ8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8CDJ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000033855 Expressed in 57 organ(s), highest expression level in fibroblast

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CDJ8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CDJ8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8CDJ8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000067027

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini269 – 402SHDPROSITE-ProRule annotationAdd BLAST134
Domaini407 – 710MHDPROSITE-ProRule annotationAdd BLAST304

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Stoned B family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2677 Eukaryota
ENOG410XQHF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158817

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000133061

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CDJ8

KEGG Orthology (KO)

More...
KOi
K20067

Identification of Orthologs from Complete Genome Data

More...
OMAi
ICHKLER

Database of Orthologous Groups

More...
OrthoDBi
1059322at2759

TreeFam database of animal gene trees

More...
TreeFami
TF318623

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR028565 MHD
IPR012320 SHD_dom
IPR031232 Ston1
IPR017110 Stonin

The PANTHER Classification System

More...
PANTHERi
PTHR10529:SF339 PTHR10529:SF339, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00928 Adap_comp_sub, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037099 Stonin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49447 SSF49447, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51072 MHD, 1 hit
PS51070 SHD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8CDJ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYSTNPGSWV TFDDDPAFQS SQKRKDFSLE TQGVCRPNGL KLTLPTLRDP
60 70 80 90 100
PSTPSSASST PLSSPMVDFY FSPGPPSNSP LSTPTKDFPG FPGIPKAGTH
110 120 130 140 150
VLYPIPECSS SSAPTTAGGV GPPLLLTKPD CSPHVSLPSS HSHTQPTPTL
160 170 180 190 200
GFTEDAGPQR VQSEARQFEY FQDHCAFSNP FWKDEGSASP FPLDSLASRK
210 220 230 240 250
PFSPKDKEVP IGHKSLTQCS LDYICEKLEH LHSAETQDPL GDLSMQDPYA
260 270 280 290 300
GDTVSFVPHS LFRSQPRAGW SFMLRIPEKK NMMSSRQWGP IFLKVLPGGI
310 320 330 340 350
LQMYYEKGLE KPFKEFQLDP HCRLSEPKLE NFSMAGKIHT VKVEHVSYSE
360 370 380 390 400
KRKYHAKTEV VHEPEVEQML KLGSTEHRDF LEFLTTVEEE LIKLPATAKP
410 420 430 440 450
KNKSYEEQEI CLDIQDSLWG KVTKEGQLVE SAVVTQICCL CFLNGPAECF
460 470 480 490 500
LALNDRELQK RDECYFEKEP EKKGIAILDY HFHTCVKAEE FEQSRIIKFV
510 520 530 540 550
PLDACRFELM RFKTSYEAGE LPFAVKSVVT VQGAYVELQA FVNMTPAAQG
560 570 580 590 600
SPHAGALRSC NNIMIHFPVP AQWIKALWTR NLQRQKSLKA KMNRRACLGS
610 620 630 640 650
LQEPESEPVI QVTVGSAKYE SAYRAVVWKI DRLPDKNSSP DQPHCLSYKL
660 670 680 690 700
ELGSDQEVPS DWYPFATVQF SMLEACASRT EVRSLGVESD AQPQKHVCQR
710 720 730
ACYNIQVEIE KKWIQVDGED ADKTGGCVTQ
Length:730
Mass (Da):81,793
Last modified:August 15, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC55399706280B81
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z0U0D3Z0U0_MOUSE
Stonin-1
Ston1
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti278E → V in BAC26699 (PubMed:16141072).Curated1
Sequence conflicti322C → F in BAC26699 (PubMed:16141072).Curated1
Sequence conflicti603E → D in BAB29639 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK014958 mRNA Translation: BAB29639.1
AK029878 mRNA Translation: BAC26656.1
AK029959 mRNA Translation: BAC26699.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50207.1

NCBI Reference Sequences

More...
RefSeqi
NP_084134.2, NM_029858.2
XP_006525174.1, XM_006525111.2
XP_006525175.1, XM_006525112.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000064035; ENSMUSP00000067027; ENSMUSG00000033855
ENSMUST00000150023; ENSMUSP00000122928; ENSMUSG00000033855
ENSMUST00000163588; ENSMUSP00000131703; ENSMUSG00000033855

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
77057

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:77057

UCSC genome browser

More...
UCSCi
uc012ayo.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014958 mRNA Translation: BAB29639.1
AK029878 mRNA Translation: BAC26656.1
AK029959 mRNA Translation: BAC26699.1
CCDSiCCDS50207.1
RefSeqiNP_084134.2, NM_029858.2
XP_006525174.1, XM_006525111.2
XP_006525175.1, XM_006525112.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ8CDJ8, 1 interactor
STRINGi10090.ENSMUSP00000067027

PTM databases

iPTMnetiQ8CDJ8
PhosphoSitePlusiQ8CDJ8
SwissPalmiQ8CDJ8

Proteomic databases

MaxQBiQ8CDJ8
PaxDbiQ8CDJ8
PeptideAtlasiQ8CDJ8
PRIDEiQ8CDJ8

Genome annotation databases

EnsembliENSMUST00000064035; ENSMUSP00000067027; ENSMUSG00000033855
ENSMUST00000150023; ENSMUSP00000122928; ENSMUSG00000033855
ENSMUST00000163588; ENSMUSP00000131703; ENSMUSG00000033855
GeneIDi77057
KEGGimmu:77057
UCSCiuc012ayo.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11037
MGIiMGI:1924307 Ston1

Phylogenomic databases

eggNOGiKOG2677 Eukaryota
ENOG410XQHF LUCA
GeneTreeiENSGT00940000158817
HOGENOMiHOG000133061
InParanoidiQ8CDJ8
KOiK20067
OMAiICHKLER
OrthoDBi1059322at2759
TreeFamiTF318623

Enzyme and pathway databases

ReactomeiR-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ston1 mouse

Protein Ontology

More...
PROi
PR:Q8CDJ8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000033855 Expressed in 57 organ(s), highest expression level in fibroblast
ExpressionAtlasiQ8CDJ8 baseline and differential
GenevisibleiQ8CDJ8 MM

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR028565 MHD
IPR012320 SHD_dom
IPR031232 Ston1
IPR017110 Stonin
PANTHERiPTHR10529:SF339 PTHR10529:SF339, 1 hit
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PIRSFiPIRSF037099 Stonin, 1 hit
SUPFAMiSSF49447 SSF49447, 1 hit
PROSITEiView protein in PROSITE
PS51072 MHD, 1 hit
PS51070 SHD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTON1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CDJ8
Secondary accession number(s): Q8CDL8, Q9D5T3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: October 16, 2019
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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