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Protein

CREB3 regulatory factor

Gene

Crebrf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processStress response, Transcription, Transcription regulation, Transport, Unfolded protein response

Enzyme and pathway databases

ReactomeiR-MMU-8874211 CREB3 factors activate genes

Names & Taxonomyi

Protein namesi
Recommended name:
CREB3 regulatory factor
Alternative name(s):
Luman recruitment factor
Short name:
LRF
Gene namesi
Name:Crebrf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1924378 Crebrf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002993071 – 640CREB3 regulatory factorAdd BLAST640

Post-translational modificationi

Probably degraded by the proteasome.By similarity

Proteomic databases

MaxQBiQ8CDG5
PaxDbiQ8CDG5
PeptideAtlasiQ8CDG5
PRIDEiQ8CDG5

PTM databases

iPTMnetiQ8CDG5
PhosphoSitePlusiQ8CDG5

Expressioni

Tissue specificityi

Highly expressed in intestin, testis, heart and kidney, weakly in brain adipose, colon, liver, lung and skeletal.1 Publication

Gene expression databases

BgeeiENSMUSG00000048249 Expressed in 272 organ(s), highest expression level in blood
CleanExiMM_A930001N09RIK
ExpressionAtlasiQ8CDG5 baseline and differential
GenevisibleiQ8CDG5 MM

Interactioni

Subunit structurei

Interacts (via leucine-zipper domain) with CREB3 (via leucine-zipper domain); the interaction promotes CREB3 degradation.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini522 – 585bZIPAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni524 – 533Basic motifBy similarity10
Regioni534 – 541Leucine-zipperBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi356 – 394Glu-richAdd BLAST39

Sequence similaritiesi

Belongs to the bZIP family. CREBRF subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IHZR Eukaryota
ENOG410Y9V2 LUCA
GeneTreeiENSGT00390000007125
HOGENOMiHOG000088620
HOVERGENiHBG106858
InParanoidiQ8CDG5
KOiK21554
OMAiLASCDIW
PhylomeDBiQ8CDG5
TreeFamiTF330810

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR039165 CREBRF
PANTHERiPTHR21552 PTHR21552, 1 hit
PROSITEiView protein in PROSITE
PS00036 BZIP_BASIC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8CDG5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPQPSVSGMD PPFGDAFRSH TFSEQTLMST DLLANSSDPD FMYELDREMN
60 70 80 90 100
YQQNPRDNFL SLEDCKDIEN LETFTDVLDN EDALTSNWEQ WDTYCEDLTK
110 120 130 140 150
YTKLTSCDIW GTKEVDYLGL DDFSSPYQDE EVISKTPTLA QLNSEDSQSV
160 170 180 190 200
SDSLYYPDSL FSVKQNPLPP SSFPSKKITN RAAAPVCSSK TLQAEVPSSD
210 220 230 240 250
CVQKASKPTS STQIMVKTNM YHNEKVNFHV ECKDYVKKAK VKINPVQQGR
260 270 280 290 300
PLLSQVHIDA AKENTCYCGA VAKRQERRGV EPHQGRGTPA LPFKETQELL
310 320 330 340 350
LSPLTQDSPG LVATAESGSL SASTSVSDSS QKKEEHNYSL FVSDNMREQP
360 370 380 390 400
TKYSPEDDED DEDEFDDEDH DEGFGSEHEL SENEEEEEEE EDYEDDRDDD
410 420 430 440 450
ISDTFSEPGY ENDSVEDLKE MTSISSRKRG KRRYFWEYSE QLTPSQQERI
460 470 480 490 500
LRPSEWNRDT LPSNMYQKNG LHHGKYAVKK SRRTDVEDLT PNPKKLLQIG
510 520 530 540 550
NELRKLNKVI SDLTPVSELP LTARPRSRKE KNKLASRACR LKKKAQYEAN
560 570 580 590 600
KVKLWGLNTE YDNLLFVINS IKQDIVNRVQ NPREEREPSM GQKLEILIKD
610 620 630 640
TLGLPVAGQT SEFVNQVLGK TAEGNPTGGL VGLRIPASKV
Length:640
Mass (Da):72,598
Last modified:March 1, 2003 - v1
Checksum:iFE02C532FA34E1DE
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8JJI2B8JJI2_MOUSE
CREB3 regulatory factor
Crebrf A930001N09Rik
653Annotation score:
B8JJI3B8JJI3_MOUSE
CREB3 regulatory factor
Crebrf A930001N09Rik
137Annotation score:
B8JJI0B8JJI0_MOUSE
CREB3 regulatory factor
Crebrf A930001N09Rik
351Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17F → V in AAI13192 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020796 mRNA Translation: BAB32214.1
AK030092 mRNA Translation: BAC26779.1
AK044760 mRNA Translation: BAC32070.1
CT025550 Genomic DNA No translation available.
BC113191 mRNA Translation: AAI13192.1
BC113192 mRNA Translation: AAI13193.1
CCDSiCCDS37516.1
RefSeqiNP_084146.1, NM_029870.2
XP_006525177.1, XM_006525114.2
XP_011245019.2, XM_011246717.2
XP_017173212.1, XM_017317723.1
UniGeneiMm.275414

Genome annotation databases

EnsembliENSMUST00000062519; ENSMUSP00000059102; ENSMUSG00000048249
GeneIDi77128
KEGGimmu:77128
UCSCiuc008bej.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020796 mRNA Translation: BAB32214.1
AK030092 mRNA Translation: BAC26779.1
AK044760 mRNA Translation: BAC32070.1
CT025550 Genomic DNA No translation available.
BC113191 mRNA Translation: AAI13192.1
BC113192 mRNA Translation: AAI13193.1
CCDSiCCDS37516.1
RefSeqiNP_084146.1, NM_029870.2
XP_006525177.1, XM_006525114.2
XP_011245019.2, XM_011246717.2
XP_017173212.1, XM_017317723.1
UniGeneiMm.275414

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8CDG5
PhosphoSitePlusiQ8CDG5

Proteomic databases

MaxQBiQ8CDG5
PaxDbiQ8CDG5
PeptideAtlasiQ8CDG5
PRIDEiQ8CDG5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062519; ENSMUSP00000059102; ENSMUSG00000048249
GeneIDi77128
KEGGimmu:77128
UCSCiuc008bej.1 mouse

Organism-specific databases

CTDi153222
MGIiMGI:1924378 Crebrf

Phylogenomic databases

eggNOGiENOG410IHZR Eukaryota
ENOG410Y9V2 LUCA
GeneTreeiENSGT00390000007125
HOGENOMiHOG000088620
HOVERGENiHBG106858
InParanoidiQ8CDG5
KOiK21554
OMAiLASCDIW
PhylomeDBiQ8CDG5
TreeFamiTF330810

Enzyme and pathway databases

ReactomeiR-MMU-8874211 CREB3 factors activate genes

Miscellaneous databases

PROiPR:Q8CDG5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048249 Expressed in 272 organ(s), highest expression level in blood
CleanExiMM_A930001N09RIK
ExpressionAtlasiQ8CDG5 baseline and differential
GenevisibleiQ8CDG5 MM

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR039165 CREBRF
PANTHERiPTHR21552 PTHR21552, 1 hit
PROSITEiView protein in PROSITE
PS00036 BZIP_BASIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRERF_MOUSE
AccessioniPrimary (citable) accession number: Q8CDG5
Secondary accession number(s): B8JJI1
, Q14DI2, Q8C8N7, Q9CTQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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