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Protein

Serpin B13

Gene

Serpinb13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in the proliferation or differentiation of keratinocytes.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei354 – 355Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

Protein family/group databases

MEROPSiI04.017

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B13
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3042250 Serpinb13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000941221 – 389Serpin B13Add BLAST389

Proteomic databases

PaxDbiQ8CDC0
PeptideAtlasiQ8CDC0
PRIDEiQ8CDC0

PTM databases

iPTMnetiQ8CDC0
PhosphoSitePlusiQ8CDC0

Expressioni

Gene expression databases

BgeeiENSMUSG00000048775
ExpressionAtlasiQ8CDC0 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027564

Structurei

3D structure databases

ProteinModelPortaliQ8CDC0
SMRiQ8CDC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiQ8CDC0
KOiK13963
OMAiFKGQWDR
OrthoDBiEOG091G0ION
PhylomeDBiQ8CDC0
TreeFamiTF352619

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CDC0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSLGTAATQ FLFDLFKELN KTNDGNVFFS PVGISTAIGM IILGTRGATA
60 70 80 90 100
SELQKVLYTE QGTESSRIKS EEEEIEKREE IHHQLQMLLT EISKFSNDYD
110 120 130 140 150
LIISNRLFGE KTYLFLQKYI DYVEKYYHAS LEPVDFVNAA DESRKKINSW
160 170 180 190 200
VESQTNVKVK DLFPEGSLNS STKLVLINTV YFKGLWDREF KKEHTKEEDF
210 220 230 240 250
WLNKNLSKPV QMMALCSSFN FTFLEDLQAK IVGIPYKNND ISMFVLLPND
260 270 280 290 300
IDGLEKIMDK MSPEKLVEWT SPGHLEQRRV DLRLPRLQVE ETYDLEPVLE
310 320 330 340 350
AVGIHSAFSE HADYSGMSAR SGLHAQNFLH RSFLVVTEEG VEATAGTGVG
360 370 380
LKVSSAASCE LVHCNHPFLF FIRHRESDSI LFFGKFSSP
Length:389
Mass (Da):44,316
Last modified:October 5, 2010 - v2
Checksum:iB2960B949EA5EFD9
GO
Isoform 2 (identifier: Q8CDC0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-211: Missing.

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):19,935
Checksum:iF1A3912EABAA4B93
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti295L → Q in BAC27072 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0398551 – 211Missing in isoform 2. 1 PublicationAdd BLAST211

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030670 mRNA Translation: BAC27072.1
CH466520 Genomic DNA Translation: EDL39854.1
BC117990 mRNA Translation: AAI17991.1
BC117991 mRNA Translation: AAI17992.1
CCDSiCCDS15213.1 [Q8CDC0-1]
RefSeqiNP_766440.2, NM_172852.3 [Q8CDC0-1]
UniGeneiMm.110886

Genome annotation databases

EnsembliENSMUST00000027564; ENSMUSP00000027564; ENSMUSG00000048775 [Q8CDC0-1]
GeneIDi241196
KEGGimmu:241196
UCSCiuc007chf.1 mouse [Q8CDC0-1]
uc011wqd.1 mouse [Q8CDC0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSPB13_MOUSE
AccessioniPrimary (citable) accession number: Q8CDC0
Secondary accession number(s): Q148S5, Q148S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 5, 2010
Last modified: February 28, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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