UniProtKB - Q8CDC0 (SPB13_MOUSE)
Protein
Serpin B13
Gene
Serpinb13
Organism
Mus musculus (Mouse)
Status
Functioni
May play a role in the proliferation or differentiation of keratinocytes.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 354 – 355 | Reactive bondBy similarity | 2 |
GO - Molecular functioni
- cysteine-type endopeptidase inhibitor activity Source: MGI
- protease binding Source: MGI
- serine-type endopeptidase inhibitor activity Source: GO_Central
GO - Biological processi
- negative regulation of endopeptidase activity Source: MGI
- negative regulation of keratinocyte apoptotic process Source: MGI
Keywordsi
Molecular function | Protease inhibitor, Serine protease inhibitor |
Enzyme and pathway databases
Reactomei | R-MMU-8939242, RUNX1 regulates transcription of genes involved in differentiation of keratinocytes |
Protein family/group databases
MEROPSi | I04.017 |
Names & Taxonomyi
Protein namesi | Recommended name: Serpin B13 |
Gene namesi | Name:Serpinb13 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3042250, Serpinb13 |
Subcellular locationi
Other locations
- Cytoplasm By similarity
Cytosol
- cytosol Source: MGI
Extracellular region or secreted
- extracellular space Source: GO_Central
Nucleus
- nuclear speck Source: MGI
- nucleoplasm Source: MGI
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094122 | 1 – 389 | Serpin B13Add BLAST | 389 |
Proteomic databases
PaxDbi | Q8CDC0 |
PeptideAtlasi | Q8CDC0 |
PRIDEi | Q8CDC0 |
PTM databases
iPTMneti | Q8CDC0 |
PhosphoSitePlusi | Q8CDC0 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000048775, Expressed in esophagus and 14 other tissues |
Interactioni
GO - Molecular functioni
- protease binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000027564 |
Miscellaneous databases
RNActi | Q8CDC0, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000162214 |
HOGENOMi | CLU_023330_0_2_1 |
InParanoidi | Q8CDC0 |
OMAi | IHHQFQK |
OrthoDBi | 1124079at2759 |
PhylomeDBi | Q8CDC0 |
TreeFami | TF352619 |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8CDC0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDSLGTAATQ FLFDLFKELN KTNDGNVFFS PVGISTAIGM IILGTRGATA
60 70 80 90 100
SELQKVLYTE QGTESSRIKS EEEEIEKREE IHHQLQMLLT EISKFSNDYD
110 120 130 140 150
LIISNRLFGE KTYLFLQKYI DYVEKYYHAS LEPVDFVNAA DESRKKINSW
160 170 180 190 200
VESQTNVKVK DLFPEGSLNS STKLVLINTV YFKGLWDREF KKEHTKEEDF
210 220 230 240 250
WLNKNLSKPV QMMALCSSFN FTFLEDLQAK IVGIPYKNND ISMFVLLPND
260 270 280 290 300
IDGLEKIMDK MSPEKLVEWT SPGHLEQRRV DLRLPRLQVE ETYDLEPVLE
310 320 330 340 350
AVGIHSAFSE HADYSGMSAR SGLHAQNFLH RSFLVVTEEG VEATAGTGVG
360 370 380
LKVSSAASCE LVHCNHPFLF FIRHRESDSI LFFGKFSSP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RHN5 | D6RHN5_MOUSE | Serpin B13 | Serpinb13 | 110 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 295 | L → Q in BAC27072 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039855 | 1 – 211 | Missing in isoform 2. 1 PublicationAdd BLAST | 211 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK030670 mRNA Translation: BAC27072.1 CH466520 Genomic DNA Translation: EDL39854.1 BC117990 mRNA Translation: AAI17991.1 BC117991 mRNA Translation: AAI17992.1 |
CCDSi | CCDS15213.1 [Q8CDC0-1] |
RefSeqi | NP_766440.2, NM_172852.3 [Q8CDC0-1] |
Genome annotation databases
Ensembli | ENSMUST00000027564; ENSMUSP00000027564; ENSMUSG00000048775 [Q8CDC0-1] |
GeneIDi | 241196 |
KEGGi | mmu:241196 |
UCSCi | uc007chf.1, mouse [Q8CDC0-1] uc011wqd.1, mouse [Q8CDC0-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK030670 mRNA Translation: BAC27072.1 CH466520 Genomic DNA Translation: EDL39854.1 BC117990 mRNA Translation: AAI17991.1 BC117991 mRNA Translation: AAI17992.1 |
CCDSi | CCDS15213.1 [Q8CDC0-1] |
RefSeqi | NP_766440.2, NM_172852.3 [Q8CDC0-1] |
3D structure databases
SMRi | Q8CDC0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000027564 |
Protein family/group databases
MEROPSi | I04.017 |
PTM databases
iPTMneti | Q8CDC0 |
PhosphoSitePlusi | Q8CDC0 |
Proteomic databases
PaxDbi | Q8CDC0 |
PeptideAtlasi | Q8CDC0 |
PRIDEi | Q8CDC0 |
Protocols and materials databases
Antibodypediai | 10046, 213 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000027564; ENSMUSP00000027564; ENSMUSG00000048775 [Q8CDC0-1] |
GeneIDi | 241196 |
KEGGi | mmu:241196 |
UCSCi | uc007chf.1, mouse [Q8CDC0-1] uc011wqd.1, mouse [Q8CDC0-2] |
Organism-specific databases
CTDi | 5275 |
MGIi | MGI:3042250, Serpinb13 |
Phylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000162214 |
HOGENOMi | CLU_023330_0_2_1 |
InParanoidi | Q8CDC0 |
OMAi | IHHQFQK |
OrthoDBi | 1124079at2759 |
PhylomeDBi | Q8CDC0 |
TreeFami | TF352619 |
Enzyme and pathway databases
Reactomei | R-MMU-8939242, RUNX1 regulates transcription of genes involved in differentiation of keratinocytes |
Miscellaneous databases
BioGRID-ORCSi | 241196, 0 hits in 17 CRISPR screens |
PROi | PR:Q8CDC0 |
RNActi | Q8CDC0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000048775, Expressed in esophagus and 14 other tissues |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SPB13_MOUSE | |
Accessioni | Q8CDC0Primary (citable) accession number: Q8CDC0 Secondary accession number(s): Q148S5, Q148S6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | October 5, 2010 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families