UniProtKB - Q8CDC0 (SPB13_MOUSE)

BLAST

>sp|Q8CDC0|SPB13_MOUSE Serpin B13 OS=Mus musculus OX=10090 GN=Serpinb13 PE=2 SV=2
MDSLGTAATQFLFDLFKELNKTNDGNVFFSPVGISTAIGMIILGTRGATASELQKVLYTE
QGTESSRIKSEEEEIEKREEIHHQLQMLLTEISKFSNDYDLIISNRLFGEKTYLFLQKYI
DYVEKYYHASLEPVDFVNAADESRKKINSWVESQTNVKVKDLFPEGSLNSSTKLVLINTV
YFKGLWDREFKKEHTKEEDFWLNKNLSKPVQMMALCSSFNFTFLEDLQAKIVGIPYKNND
ISMFVLLPNDIDGLEKIMDKMSPEKLVEWTSPGHLEQRRVDLRLPRLQVEETYDLEPVLE
AVGIHSAFSEHADYSGMSARSGLHAQNFLHRSFLVVTEEGVEATAGTGVGLKVSSAASCE
LVHCNHPFLFFIRHRESDSILFFGKFSSP

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History
Entry version 110 (12 Sep 2018)
Sequence version 2 (05 Oct 2010)
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Protein

Serpin B13

Gene

Serpinb13

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

May play a role in the proliferation or differentiation of keratinocytes.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	354 – 355	Reactive bondBy similarity		2

GO - Molecular functionⁱ

cysteine-type endopeptidase inhibitor activity Source: MGI
protease binding Source: MGI
serine-type endopeptidase inhibitor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of endopeptidase activity Source: MGI
negative regulation of keratinocyte apoptotic process Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Protease inhibitor, Serine protease inhibitor

Molecular function

Protease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Reactomeⁱ	R-MMU-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

Reactomeⁱ

R-MMU-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I04.017

MEROPSⁱ

I04.017

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serpin B13
Gene namesⁱ	Name:Serpinb13
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:3042250 Serpinb13

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000094122	1 – 389	Serpin B13Add BLAST		389

Proteomic databases

PaxDbⁱ	Q8CDC0
PeptideAtlas More...PeptideAtlasⁱ	Q8CDC0
PRIDEⁱ	Q8CDC0

PTM databases

iPTMnetⁱ	Q8CDC0
PhosphoSitePlusⁱ	Q8CDC0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000048775 Expressed in 4 organ(s), highest expression level in zone of skin
ExpressionAtlasⁱ	Q8CDC0 baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

protease binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000027564

STRINGⁱ

10090.ENSMUSP00000027564

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8CDC0
SMRⁱ	Q8CDC0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG2392 Eukaryota COG4826 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118789
HOGENOMⁱ	HOG000238519
HOVERGENⁱ	HBG005957
InParanoidⁱ	Q8CDC0
KEGG Orthology (KO) More...KOⁱ	K13963
OMAⁱ	FKGQWDR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ION
PhylomeDBⁱ	Q8CDC0
TreeFamⁱ	TF352619

Family and domain databases

InterProⁱ	View protein in InterPro IPR023795 Serpin_CS IPR023796 Serpin_dom IPR000215 Serpin_fam IPR036186 Serpin_sf
PANTHERⁱ	PTHR11461 PTHR11461, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00079 Serpin, 1 hit
SMARTⁱ	View protein in SMART SM00093 SERPIN, 1 hit
SUPFAMⁱ	SSF56574 SSF56574, 1 hit
PROSITEⁱ	View protein in PROSITE PS00284 SERPIN, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q8CDC0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSLGTAATQ FLFDLFKELN KTNDGNVFFS PVGISTAIGM IILGTRGATA 
        60         70         80         90        100
SELQKVLYTE QGTESSRIKS EEEEIEKREE IHHQLQMLLT EISKFSNDYD 
       110        120        130        140        150
LIISNRLFGE KTYLFLQKYI DYVEKYYHAS LEPVDFVNAA DESRKKINSW 
       160        170        180        190        200
VESQTNVKVK DLFPEGSLNS STKLVLINTV YFKGLWDREF KKEHTKEEDF 
       210        220        230        240        250
WLNKNLSKPV QMMALCSSFN FTFLEDLQAK IVGIPYKNND ISMFVLLPND 
       260        270        280        290        300
IDGLEKIMDK MSPEKLVEWT SPGHLEQRRV DLRLPRLQVE ETYDLEPVLE 
       310        320        330        340        350
AVGIHSAFSE HADYSGMSAR SGLHAQNFLH RSFLVVTEEG VEATAGTGVG 
       360        370        380 
LKVSSAASCE LVHCNHPFLF FIRHRESDSI LFFGKFSSP

Length:389

Mass (Da):44,316

Last modified:October 5, 2010 - v2

Checksum:ⁱB2960B949EA5EFD9

Isoform 2 (identifier: Q8CDC0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-211: Missing.

« Hide

        10         20         30         40         50
MMALCSSFNF TFLEDLQAKI VGIPYKNNDI SMFVLLPNDI DGLEKIMDKM 
        60         70         80         90        100
SPEKLVEWTS PGHLEQRRVD LRLPRLQVEE TYDLEPVLEA VGIHSAFSEH 
       110        120        130        140        150
ADYSGMSARS GLHAQNFLHR SFLVVTEEGV EATAGTGVGL KVSSAASCEL 
       160        170 
VHCNHPFLFF IRHRESDSIL FFGKFSSP

Note: No experimental confirmation available.

Show »

Length:178

Mass (Da):19,935

Checksum:ⁱF1A3912EABAA4B93

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D6RHN5	D6RHN5_MOUSE		Serpin B13 Serpin B13	Serpinb13	110	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	295	L → Q in BAC27072 (PubMed:16141072).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_039855	1 – 211	Missing in isoform 2. 1 PublicationAdd BLAST		211

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK030670 mRNA Translation: BAC27072.1 CH466520 Genomic DNA Translation: EDL39854.1 BC117990 mRNA Translation: AAI17991.1 BC117991 mRNA Translation: AAI17992.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15213.1 [Q8CDC0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_766440.2, NM_172852.3 [Q8CDC0-1]
UniGeneⁱ	Mm.110886

Genome annotation databases

Ensemblⁱ	ENSMUST00000027564; ENSMUSP00000027564; ENSMUSG00000048775 [Q8CDC0-1]
GeneIDⁱ	241196
KEGGⁱ	mmu:241196
UCSC genome browser More...UCSCⁱ	uc007chf.1 mouse [Q8CDC0-1] uc011wqd.1 mouse [Q8CDC0-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8CDC0	Isoform 2 of Serpin B13		MOUSE		178	UniRef90_Q8CDC0
UPI000A30EB08		MUSPA		392
UPI000A31A54D		MUSCR		392
UPI000A30C1D4		MUSPA		389
UPI000A315407		MUSCR		389

Protein	Similar proteins		Species	Score	Length	Source
Q8CDC0	Serpin B3	)	HUMAN		390	UniRef50_P29508
SERPINB4 isoform 1		PONAB		390
Uncharacterized protein		NOMLE		390
Uncharacterized protein		PANTR		390
Serpin B13 (Predicted)		SORAR		176
+239

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK030670 mRNA Translation: BAC27072.1 CH466520 Genomic DNA Translation: EDL39854.1 BC117990 mRNA Translation: AAI17991.1 BC117991 mRNA Translation: AAI17992.1
CCDSⁱ	CCDS15213.1 [Q8CDC0-1]
RefSeqⁱ	NP_766440.2, NM_172852.3 [Q8CDC0-1]
UniGeneⁱ	Mm.110886

3D structure databases

ProteinModelPortalⁱ	Q8CDC0
SMRⁱ	Q8CDC0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000027564

STRINGⁱ

10090.ENSMUSP00000027564

Protein family/group databases

MEROPSⁱ	I04.017

MEROPSⁱ

I04.017

PTM databases

iPTMnetⁱ	Q8CDC0
PhosphoSitePlusⁱ	Q8CDC0

Proteomic databases

PaxDbⁱ	Q8CDC0
PeptideAtlasⁱ	Q8CDC0
PRIDEⁱ	Q8CDC0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000027564; ENSMUSP00000027564; ENSMUSG00000048775 [Q8CDC0-1]
GeneIDⁱ	241196
KEGGⁱ	mmu:241196
UCSCⁱ	uc007chf.1 mouse [Q8CDC0-1] uc011wqd.1 mouse [Q8CDC0-2]

Organism-specific databases

CTDⁱ	5275
MGIⁱ	MGI:3042250 Serpinb13

Phylogenomic databases

eggNOGⁱ	KOG2392 Eukaryota COG4826 LUCA
GeneTreeⁱ	ENSGT00760000118789
HOGENOMⁱ	HOG000238519
HOVERGENⁱ	HBG005957
InParanoidⁱ	Q8CDC0
KOⁱ	K13963
OMAⁱ	FKGQWDR
OrthoDBⁱ	EOG091G0ION
PhylomeDBⁱ	Q8CDC0
TreeFamⁱ	TF352619

Enzyme and pathway databases

Reactomeⁱ	R-MMU-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

Reactomeⁱ

R-MMU-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

Miscellaneous databases

ChiTaRSⁱ	Serpinb13 mouse
Protein Ontology More...PROⁱ	PR:Q8CDC0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000048775 Expressed in 4 organ(s), highest expression level in zone of skin
ExpressionAtlasⁱ	Q8CDC0 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR023795 Serpin_CS IPR023796 Serpin_dom IPR000215 Serpin_fam IPR036186 Serpin_sf
PANTHERⁱ	PTHR11461 PTHR11461, 1 hit
Pfamⁱ	View protein in Pfam PF00079 Serpin, 1 hit
SMARTⁱ	View protein in SMART SM00093 SERPIN, 1 hit
SUPFAMⁱ	SSF56574 SSF56574, 1 hit
PROSITEⁱ	View protein in PROSITE PS00284 SERPIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SPB13_MOUSE
Accessionⁱ	Q8CDC0Primary (citable) accession number: Q8CDC0 Secondary accession number(s): Q148S5, Q148S6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
	Last sequence update:	October 5, 2010
	Last modified:	September 12, 2018
	This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8CDC0 (SPB13_MOUSE)

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Serpin B13

Serpinb13

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ