Phosphatidylinositide phosphatase SAC2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• inositol monophosphate 1-phosphatase activity Source: UniProtKB-EC
• inositol monophosphate 3-phosphatase activity Source: UniProtKB-EC
• inositol monophosphate 4-phosphatase activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 25869669
• phosphatidylinositol-4-phosphate phosphatase activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• phosphatidylinositol phosphate 4-phosphatase activity Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • 25869669
• phosphatidylinositol phosphate 5-phosphatase activity Source: Ensembl
• protein homodimerization activity Source: MGI

GO - Biological processⁱ

• adult locomotory behavior Source: ParkinsonsUK-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 26203138
• cardiac muscle hypertrophy in response to stress Source: MGIInferred from mutant phenotypeⁱ
  • 19875726
• clathrin-dependent endocytosis Source: UniProtKBInferred from direct assayⁱ
  • 25869668
• negative regulation of axon regeneration Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • 26203138
• negative regulation of peptidyl-serine phosphorylation Source: MGI
• negative regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
• phosphatidylinositol catabolic process Source: MGIInferred from mutant phenotypeⁱ
  • 19875726
• phosphatidylinositol dephosphorylation Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • 25869669
• phosphatidylinositol-mediated signaling Source: MGIInferred from mutant phenotypeⁱ
  • 19875726
• positive regulation of receptor recycling Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • 25869669
• regulation of cell motility Source: UniProtKBInferred from mutant phenotypeⁱ
  • 25869669
• regulation of endocytic recycling Source: UniProtKBInferred from mutant phenotypeⁱ
  • 25869669
• regulation of protein kinase B signaling Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• protein homodimerization activity Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MELFQAKDHY ILQQGERALW CSRRDGGLQL RPATDLLLAW NPICLGLVEG 
        60         70         80         90        100
VIGKIQLHSD LPWWLILIRQ KALVGKLPGD HEVCKVTKIA VLSLSEMEPQ 
       110        120        130        140        150
ELELELCKKH HFGINKPEKI IPSPDDSKFL LKTFTNIKSN VSAPNKKKVK 
       160        170        180        190        200
ESKEKEKLER RLLEELLKMF MDSESFYYSL TYDLTNSVQR QSTGERDGRP 
       210        220        230        240        250
LWQKVDDRFF WNKYMIQALT EIGTPDVDFW IIPIIQGFVQ IEELVVNYNE 
       260        270        280        290        300
SSDDDKSSPE TPPQDSTCVD DIHPRFLVAL ISRRSRHRAG MRYKRRGVDK 
       310        320        330        340        350
NGNVANYVET EQLIHVHHHT LSFIQTRGSV PVFWSQVGYR YNPRPRLDKS 
       360        370        380        390        400
EKETVDCFCA HFEEQLKIYK KQVIVNLVDQ AGREKIIGDA YLKQVLLFNN 
       410        420        430        440        450
PKLTYVSFDF HEHCRGMKFE NVQTLTDAIH DIIIDMKWCW VDQAGVICKQ 
       460        470        480        490        500
EGIFRVNCMD CLDRTNVVQA AIARVVMEQQ LKKLGVMPPE QPLPVKCNRT 
       510        520        530        540        550
YQIMWANNGD SISRQYAGTA ALKGDFTRTG ERKLAGVMKD GVNSANRYYL 
       560        570        580        590        600
SRFKDAYRQA VIDLMQGVPV TEDLYSIFTK EKEHEALHKE SQRSHQELIS 
       610        620        630        640        650
QLLQSYMQLL LPGDEKFHGG WALVDCDPSL TDAAHRDVEV LLLLSNAAYY 
       660        670        680        690        700
VAYYDDEVDK VNQYQRLGLE DLERIEIGPE PTLFGKPKFS CMRLHYRCKE 
       710        720        730        740        750
AGGYFHTLRA VPRSPEEDGK DTLQCIAEML QITKQAMGLD VPIIEKKLER 
       760        770        780        790        800
KSSKPHEDII GIRSQNQGSL AQGKSFLMSK FSSLNQKVKQ TKSNVNIGNL 
       810        820        830        840        850
RKLGNFTKPE MKVNFLKPNL KVNLWKSDSS LETMENPGVM GNKVQGESDG 
       860        870        880        890        900
DISSDNDSYH SDEFLTNSKS EEDKQLANSL ESVGPIDYIL PSCGIIVSAP 
       910        920        930        940        950
RLGSRSQSAS SIDVSTHAPS EAAAGPGSEL GKGLESPLKK SPSADSIHTR 
       960        970        980        990       1000
TGFTKPMDVY CQRFVQDAQN KMNDLSEIRS VAQKSEEGSH KTNRVSNEET 
      1010       1020       1030       1040       1050
QSEPMGQTPP RPSQLNVSCS VAGPPFLSVE PVHSVLSQKT PSSGSSLLEL 
      1060       1070       1080       1090       1100
EAGLCVTPSS ESSSSRAVSP FAKIRSSMVQ VANITQAGLT HGINLAVAKV 
      1110       1120       1130 
QKSPAEPEAV NEIQQNELKN MFTQCQTRII QI                    

        10         20         30         40         50
MHLTDAAHRD VEVLLLLSNA AYYVAYYDDE VDKVNQYQRL GLEDLERIEI 
        60         70         80         90        100
GPEPTLFGKP KFSCMRLHYR CKEAGGYFHT LRAVPRSPEE DGKDTLQCIA 
       110        120        130        140        150
EMLQITKQAM GLDVPIIEKK LERKSSKPHE DIIGIRSQNQ GSLAQGKSFL 
       160        170        180        190        200
MSKFSSLNQK VKQTKSNVNI GNLRKLGNFT KPEMKVNFLK PNLKVNLWKS 
       210        220        230        240        250
DSSLETMENP GVMGNKVQGE SDGDISSDND SYHSDEFLTN SKSEEDKQLA 
       260        270        280        290        300
NSLESVGPID YILPSCGIIV SAPRLGSRSQ SASSIDVSTH APSEAAAGPG 
       310        320        330        340        350
SELGKGLESP LKKSPSADSI HTRTGFTKPM DVYCQRFVQD AQNKMNDLSE 
       360        370        380        390        400
IRSVAQKSEE GSHKTNRVSN EETQSEPMGQ TPPRPSQLNV SCSVAGPPFL 
       410        420        430        440        450
SVEPVHSVLS QKTPSSGSSL LELEAGLCVT PSSESSSSRA VSPFAKIRSS 
       460        470        480        490        500
MVQVANITQA GLTHGINLAV AKVQKSPAEP EAVNEIQQNE LKNMFTQCQT 

RIIQI                                                  

        10         20         30         40         50
MRLHYRCKEA GGYFHTLRAV PRSPEEDGKD TLQCIAEMLQ ITKQAMGLDV 
        60         70         80         90        100
PIIEKKLERK SSKPHEDIIG IRSQNQGSLA QGKSFLMSKF SSLNQKVKQT 
       110        120        130        140        150
KSNVNIGNLR KLGNFTKPEM KVNFLKPNLK VNLWKSDSSL ETMENPGVMG 
       160        170        180        190        200
NKVQGESDGD ISSDNDSYHS DEFLTNSKSE EDKQLANSLE SVGPIDYILP 
       210        220        230        240        250
SCGIIVSAPR LGSRSQSASS IDVSTHAPSE AAAGPGSELG KGLESPLKKS 
       260        270        280        290        300
PSADSIHTRT GFTKPMDVYC QRFVQDAQNK MNDLSEIRSV AQKSEEGSHK 
       310        320        330        340        350
TNRVSNEETQ SEPMGQTPPR PSQLNVSCSV AGPPFLSVEP VHSVLSQKTP 
       360        370        380        390        400
SSGSSLLELE AGLCVTPSSE SSSSRAVSPF AKIRSSMVQV ANITQAGLTH 
       410        420        430        440 
GINLAVAKVQ KSPAEPEAVN EIQQNELKNM FTQCQTRIIQ I          

        10         20         30         40         50
MELFQAKDHY ILQQGERALW CSRRDGGLQL RPATDLLLAW NPICLGLVEG 
        60         70         80         90        100
VIGKIQLHSD LPWWLILIRQ KALVGKLPGD HEVCKVTKIA VLSLSEMEPQ 
       110        120        130        140        150
ELELELCKKH HFGINKPEKI IPSPDDSKFL LKTFTNIKSN VSAPNKKKVK 
       160        170        180        190        200
ESKEKEKLER RLLEELLKMF MDSESFYYSL TYDLTNSVQR QSTGERDGRP 
       210        220        230        240        250
LWQKVDDRFF WNKYMIQALT EIGTPDVDFW IIPIIQGFVQ IEELVVNYNE 
       260        270        280        290        300
SSDDDKSSPE TPPQDSTCVD DIHPRFLVAL ISRRSRHRAG MRYKRRGVDK 
       310        320        330        340        350
NGNVANYVET EQLIHVHHHT LSFIQTRGSV PVFWSQVGYR YNPRPRLDKS 
       360        370        380        390        400
EKETVDCFCA HFEEQLKIYK KQRIWVWSQH PLTQREEKRR EEKRREEKRR 
       410 
EEKRREEKRR EEVT                                        

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot