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Entry version 132 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Phosphatidylinositide phosphatase SAC2

Gene

Inpp5f

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869668, PubMed:25869669).

Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (By similarity).

Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895).

Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (By similarity).

Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (PubMed:19875726).

May play a role as negative regulator of axon regeneration after central nervous system injuries (PubMed:26203138).

By similarity5 Publications

Caution

INPP5F has been initially described as an inositol polyphosphate 5-phosphatase.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.25, 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1660516, Synthesis of PIPs at the early endosome membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositide phosphatase SAC2 (EC:3.1.3.25By similarity1 Publication)
Alternative name(s):
Inositol polyphosphate 5-phosphatase FImported
Sac domain-containing inositol phosphatase 2
Sac domain-containing phosphoinositide 4-phosphatase 21 Publication
Short name:
hSAC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Inpp5fImported
Synonyms:Kiaa0966, Sac2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2141867, Inpp5f

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Coated pit, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Animals develop normal corticospinal tract and raphespinal tract. Mutants show greater axonal growth and functional recovery after central nervous system trauma (PubMed:26203138). Knockout mice have normal cardiac form and function but show augmented hypertrophy and reactivation of the fetal gene program in response to stress compared to wild-type littermates (PubMed:19875726).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi460D → A: Has a diffuse cytosolic localization. 1 Publication1
Mutagenesisi460D → N: Loss of inositol 4-phosphatase activity. No effect on subcellular localization. No effect on interaction with OCRL, INPP5B and IPP4A. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003316221 – 1132Phosphatidylinositide phosphatase SAC2Add BLAST1132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei714PhosphoserineCombined sources1
Modified residuei827PhosphoserineCombined sources1
Modified residuei830PhosphoserineCombined sources1
Modified residuei879PhosphoserineCombined sources1
Modified residuei882PhosphoserineCombined sources1
Modified residuei908PhosphoserineCombined sources1
Modified residuei911PhosphoserineCombined sources1
Modified residuei1103PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8CDA1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CDA1

PeptideAtlas

More...
PeptideAtlasi
Q8CDA1

PRoteomics IDEntifications database

More...
PRIDEi
Q8CDA1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
260812 [Q8CDA1-1]
260813 [Q8CDA1-2]
260814 [Q8CDA1-3]
260815 [Q8CDA1-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CDA1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CDA1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain and hypothalamus, expressed in lung and pancreas, and detected at low levels in liver and heart (at protein level).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in the absence of histone deacetylase 2/HDAC2 in the heart from HDAC2-null mice.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000042105, Expressed in central nervous system and 273 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CDA1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with OCRL and RAB5.

Interacts with INPP5B and INPP4A (PubMed:25869668).

Interacts with STAT3; the interaction is independent of STAT3 'TYR-705' phosphorylation status (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000045910

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8CDA1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CDA1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini167 – 518SACPROSITE-ProRule annotationAdd BLAST352
Domaini593 – 760hSac2PROSITE-ProRule annotationAdd BLAST168

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni250 – 269DisorderedSequence analysisAdd BLAST20
Regioni833 – 872DisorderedSequence analysisAdd BLAST40
Regioni908 – 951DisorderedSequence analysisAdd BLAST44
Regioni981 – 1016DisorderedSequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi853 – 872Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi981 – 997Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi998 – 1016Polar residuesSequence analysisAdd BLAST19

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1890, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155996

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_044255_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CDA1

Identification of Orthologs from Complete Genome Data

More...
OMAi
DNCCLEL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CDA1

TreeFam database of animal gene trees

More...
TreeFami
TF313543

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034753, hSac2
IPR022158, Inositol_phosphatase
IPR002013, SAC_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12456, hSac2, 1 hit
PF02383, Syja_N, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51791, HSAC2, 1 hit
PS50275, SAC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CDA1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELFQAKDHY ILQQGERALW CSRRDGGLQL RPATDLLLAW NPICLGLVEG
60 70 80 90 100
VIGKIQLHSD LPWWLILIRQ KALVGKLPGD HEVCKVTKIA VLSLSEMEPQ
110 120 130 140 150
ELELELCKKH HFGINKPEKI IPSPDDSKFL LKTFTNIKSN VSAPNKKKVK
160 170 180 190 200
ESKEKEKLER RLLEELLKMF MDSESFYYSL TYDLTNSVQR QSTGERDGRP
210 220 230 240 250
LWQKVDDRFF WNKYMIQALT EIGTPDVDFW IIPIIQGFVQ IEELVVNYNE
260 270 280 290 300
SSDDDKSSPE TPPQDSTCVD DIHPRFLVAL ISRRSRHRAG MRYKRRGVDK
310 320 330 340 350
NGNVANYVET EQLIHVHHHT LSFIQTRGSV PVFWSQVGYR YNPRPRLDKS
360 370 380 390 400
EKETVDCFCA HFEEQLKIYK KQVIVNLVDQ AGREKIIGDA YLKQVLLFNN
410 420 430 440 450
PKLTYVSFDF HEHCRGMKFE NVQTLTDAIH DIIIDMKWCW VDQAGVICKQ
460 470 480 490 500
EGIFRVNCMD CLDRTNVVQA AIARVVMEQQ LKKLGVMPPE QPLPVKCNRT
510 520 530 540 550
YQIMWANNGD SISRQYAGTA ALKGDFTRTG ERKLAGVMKD GVNSANRYYL
560 570 580 590 600
SRFKDAYRQA VIDLMQGVPV TEDLYSIFTK EKEHEALHKE SQRSHQELIS
610 620 630 640 650
QLLQSYMQLL LPGDEKFHGG WALVDCDPSL TDAAHRDVEV LLLLSNAAYY
660 670 680 690 700
VAYYDDEVDK VNQYQRLGLE DLERIEIGPE PTLFGKPKFS CMRLHYRCKE
710 720 730 740 750
AGGYFHTLRA VPRSPEEDGK DTLQCIAEML QITKQAMGLD VPIIEKKLER
760 770 780 790 800
KSSKPHEDII GIRSQNQGSL AQGKSFLMSK FSSLNQKVKQ TKSNVNIGNL
810 820 830 840 850
RKLGNFTKPE MKVNFLKPNL KVNLWKSDSS LETMENPGVM GNKVQGESDG
860 870 880 890 900
DISSDNDSYH SDEFLTNSKS EEDKQLANSL ESVGPIDYIL PSCGIIVSAP
910 920 930 940 950
RLGSRSQSAS SIDVSTHAPS EAAAGPGSEL GKGLESPLKK SPSADSIHTR
960 970 980 990 1000
TGFTKPMDVY CQRFVQDAQN KMNDLSEIRS VAQKSEEGSH KTNRVSNEET
1010 1020 1030 1040 1050
QSEPMGQTPP RPSQLNVSCS VAGPPFLSVE PVHSVLSQKT PSSGSSLLEL
1060 1070 1080 1090 1100
EAGLCVTPSS ESSSSRAVSP FAKIRSSMVQ VANITQAGLT HGINLAVAKV
1110 1120 1130
QKSPAEPEAV NEIQQNELKN MFTQCQTRII QI
Length:1,132
Mass (Da):127,608
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4EDEA936E95D486C
GO
Isoform 2 (identifier: Q8CDA1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-627: Missing.
     628-629: PS → MH

Show »
Length:505
Mass (Da):55,241
Checksum:iD23C6ACE913BFB85
GO
Isoform 3 (identifier: Q8CDA1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-691: Missing.

Show »
Length:441
Mass (Da):47,885
Checksum:i4C855E8EBE10F926
GO
Isoform 4 (identifier: Q8CDA1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     373-414: VIVNLVDQAG...YVSFDFHEHC → RIWVWSQHPL...REEKRREEVT
     415-1132: Missing.

Show »
Length:414
Mass (Da):48,995
Checksum:i851CDFAF785F1EF6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YU13A0A0J9YU13_MOUSE
Phosphatidylinositide phosphatase S...
Inpp5f
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC28723 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti728E → D in AAH67200 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0332701 – 691Missing in isoform 3. 1 PublicationAdd BLAST691
Alternative sequenceiVSP_0332711 – 627Missing in isoform 2. 1 PublicationAdd BLAST627
Alternative sequenceiVSP_033272373 – 414VIVNL…FHEHC → RIWVWSQHPLTQREEKRREE KRREEKRREEKRREEKRREE VT in isoform 4. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_033273415 – 1132Missing in isoform 4. 1 PublicationAdd BLAST718
Alternative sequenceiVSP_033274628 – 629PS → MH in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK129249 mRNA Translation: BAC98059.1
AK030870 mRNA Translation: BAC27166.1
AK034482 mRNA Translation: BAC28723.1 Frameshift.
AK047166 mRNA Translation: BAC32978.1
AK150418 mRNA Translation: BAE29542.1
BC067200 mRNA Translation: AAH67200.1
BC125437 mRNA Translation: AAI25438.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS21899.1 [Q8CDA1-1]
CCDS85430.1 [Q8CDA1-2]

NCBI Reference Sequences

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RefSeqi
NP_001333446.1, NM_001346517.1 [Q8CDA1-2]
NP_848756.2, NM_178641.5 [Q8CDA1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000043138; ENSMUSP00000045910; ENSMUSG00000042105 [Q8CDA1-1]
ENSMUST00000118605; ENSMUSP00000113700; ENSMUSG00000042105 [Q8CDA1-2]
ENSMUST00000151237; ENSMUSP00000146197; ENSMUSG00000042105 [Q8CDA1-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
101490

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:101490

UCSC genome browser

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UCSCi
uc009jzc.1, mouse [Q8CDA1-1]
uc009jzf.1, mouse [Q8CDA1-3]
uc009jzg.1, mouse [Q8CDA1-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129249 mRNA Translation: BAC98059.1
AK030870 mRNA Translation: BAC27166.1
AK034482 mRNA Translation: BAC28723.1 Frameshift.
AK047166 mRNA Translation: BAC32978.1
AK150418 mRNA Translation: BAE29542.1
BC067200 mRNA Translation: AAH67200.1
BC125437 mRNA Translation: AAI25438.1
CCDSiCCDS21899.1 [Q8CDA1-1]
CCDS85430.1 [Q8CDA1-2]
RefSeqiNP_001333446.1, NM_001346517.1 [Q8CDA1-2]
NP_848756.2, NM_178641.5 [Q8CDA1-1]

3D structure databases

SMRiQ8CDA1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045910

PTM databases

iPTMnetiQ8CDA1
PhosphoSitePlusiQ8CDA1

Proteomic databases

jPOSTiQ8CDA1
PaxDbiQ8CDA1
PeptideAtlasiQ8CDA1
PRIDEiQ8CDA1
ProteomicsDBi260812 [Q8CDA1-1]
260813 [Q8CDA1-2]
260814 [Q8CDA1-3]
260815 [Q8CDA1-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32161, 92 antibodies

The DNASU plasmid repository

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DNASUi
101490

Genome annotation databases

EnsembliENSMUST00000043138; ENSMUSP00000045910; ENSMUSG00000042105 [Q8CDA1-1]
ENSMUST00000118605; ENSMUSP00000113700; ENSMUSG00000042105 [Q8CDA1-2]
ENSMUST00000151237; ENSMUSP00000146197; ENSMUSG00000042105 [Q8CDA1-3]
GeneIDi101490
KEGGimmu:101490
UCSCiuc009jzc.1, mouse [Q8CDA1-1]
uc009jzf.1, mouse [Q8CDA1-3]
uc009jzg.1, mouse [Q8CDA1-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22876
MGIiMGI:2141867, Inpp5f

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG1890, Eukaryota
GeneTreeiENSGT00940000155996
HOGENOMiCLU_044255_0_0_1
InParanoidiQ8CDA1
OMAiDNCCLEL
PhylomeDBiQ8CDA1
TreeFamiTF313543

Enzyme and pathway databases

BRENDAi3.1.3.25, 3474
ReactomeiR-MMU-1660516, Synthesis of PIPs at the early endosome membrane

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
101490, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Inpp5f, mouse

Protein Ontology

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PROi
PR:Q8CDA1
RNActiQ8CDA1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000042105, Expressed in central nervous system and 273 other tissues
GenevisibleiQ8CDA1, MM

Family and domain databases

InterProiView protein in InterPro
IPR034753, hSac2
IPR022158, Inositol_phosphatase
IPR002013, SAC_dom
PfamiView protein in Pfam
PF12456, hSac2, 1 hit
PF02383, Syja_N, 1 hit
PROSITEiView protein in PROSITE
PS51791, HSAC2, 1 hit
PS50275, SAC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAC2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CDA1
Secondary accession number(s): Q3UCS0
, Q6NX83, Q6ZQ16, Q8C8G7, Q8CBW2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: June 2, 2021
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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